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Putative nucleotidyltransferase MAB21L1 (EC 2.7.7.-) (Protein mab-21-like 1)

 MB211_CHICK             Reviewed;         359 AA.
Q8AY65;
04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
01-MAR-2003, sequence version 1.
05-JUL-2017, entry version 67.
RecName: Full=Putative nucleotidyltransferase MAB21L1;
EC=2.7.7.- {ECO:0000305};
AltName: Full=Protein mab-21-like 1;
Name=MAB21L1;
Gallus gallus (Chicken).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
Phasianidae; Phasianinae; Gallus.
NCBI_TaxID=9031;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
Wong R.L.Y., Chow K.L.;
"Developmental expression of chicken MAB21 genes.";
Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Putative nucleotidyltransferase required for several
aspects of embryonic development including normal development of
the eye (By similarity). It is unclear whether it displays
nucleotidyltransferase activity in vivo. Binds single-stranded RNA
(ssRNA) (By similarity). {ECO:0000250|UniProtKB:O70299,
ECO:0000250|UniProtKB:Q13394}.
-!- SUBUNIT: Monomer. Homodecamer; composed of 2 back to back
homopentamers. The protein may exist as monomer in solution and
oiligomerizes upon ligand binding. {ECO:0000250|UniProtKB:Q13394}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O70299}.
-!- SIMILARITY: Belongs to the mab-21 family. {ECO:0000305}.
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EMBL; AY049705; AAL17977.1; -; mRNA.
RefSeq; NP_989864.1; NM_204533.1.
UniGene; Gga.32; -.
ProteinModelPortal; Q8AY65; -.
SMR; Q8AY65; -.
PaxDb; Q8AY65; -.
Ensembl; ENSGALT00000090221; ENSGALP00000059018; ENSGALG00000045052.
GeneID; 395208; -.
KEGG; gga:395208; -.
CTD; 4081; -.
eggNOG; KOG3963; Eukaryota.
eggNOG; ENOG410XNRJ; LUCA.
GeneTree; ENSGT00510000046791; -.
HOGENOM; HOG000007337; -.
HOVERGEN; HBG053080; -.
InParanoid; Q8AY65; -.
OMA; YFLPHVD; -.
OrthoDB; EOG091G0939; -.
PhylomeDB; Q8AY65; -.
PRO; PR:Q8AY65; -.
Proteomes; UP000000539; Chromosome 1.
Bgee; ENSGALG00000017059; -.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-KW.
GO; GO:0043010; P:camera-type eye development; IEA:Ensembl.
GO; GO:0008284; P:positive regulation of cell proliferation; IEA:Ensembl.
InterPro; IPR020950; Mab-21-like_1/2.
InterPro; IPR024810; Mab-21_dom.
PANTHER; PTHR10656:SF60; PTHR10656:SF60; 1.
Pfam; PF03281; Mab-21; 1.
SMART; SM01265; Mab-21; 1.
2: Evidence at transcript level;
Complete proteome; Developmental protein; Metal-binding;
Nucleotide-binding; Nucleotidyltransferase; Nucleus;
Reference proteome; Transferase.
CHAIN 1 359 Putative nucleotidyltransferase MAB21L1.
/FTId=PRO_0000312783.
NP_BIND 23 24 NTP. {ECO:0000250|UniProtKB:Q13394}.
NP_BIND 63 66 NTP. {ECO:0000250|UniProtKB:Q13394}.
NP_BIND 252 255 NTP. {ECO:0000250|UniProtKB:Q13394}.
METAL 73 73 Magnesium; catalytic.
{ECO:0000250|UniProtKB:Q8N884}.
METAL 75 75 Magnesium; catalytic.
{ECO:0000250|UniProtKB:Q8N884}.
BINDING 248 248 NTP. {ECO:0000250|UniProtKB:Q13394}.
SEQUENCE 359 AA; 40956 MW; A27C53FBC997A049 CRC64;
MIAAQAKLVY HLNKYYNEKC QARKAAIAKT IREVCKVVSD VLKEVEVQEP RFISSLNEMD
NRYEGLEVIS PTEFEVVLYL NQMGVFNFVD DGSLPGCAVL KLSDGRKRSM SLWVEFITAS
GYLSARKIRS RFQTLVAQAV DKCSYRDVVK MVADTSEVKL RIRDRYVVQI TPAFKCTGIW
PRSAAHWPLP HIPWPGPNRV AEVKAEGFNL LSKECHSLAG KQSSAESDAW VLQFAEAENR
LQMGGCRKKC LSILKTLRDR HLELPGQPLN NYHMKTLVSY ECEKHPRESD WDESCLGDRL
NGILLQLISC LQCRRCPHYF LPNLDLFQGK PHSALENAAK QTWRLAREIL TNPKSLEKL


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