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Putative olfactory receptor 3A4 (Olfactory receptor 17-24) (OR17-24) (Olfactory receptor 3A5)

 OR3A4_HUMAN             Reviewed;         348 AA.
P47883; Q96R24;
01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
24-NOV-2009, sequence version 4.
30-AUG-2017, entry version 121.
RecName: Full=Putative olfactory receptor 3A4;
AltName: Full=Olfactory receptor 17-24;
Short=OR17-24;
AltName: Full=Olfactory receptor 3A5;
Name=OR3A4P; Synonyms=OR3A4, OR3A5P;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16625196; DOI=10.1038/nature04689;
Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
"DNA sequence of human chromosome 17 and analysis of rearrangement in
the human lineage.";
Nature 440:1045-1049(2006).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 71-286, AND VARIANTS ALA-193 AND
LYS-237.
PubMed=8004088; DOI=10.1093/hmg/3.2.229;
Ben-Arie N., Lancet D., Taylor C., Khen M., Walker N., Ledbetter D.H.,
Carrozzo R., Patel K., Sheer D., Lehrach H., North M.A.;
"Olfactory receptor gene cluster on human chromosome 17: possible
duplication of an ancestral receptor repertoire.";
Hum. Mol. Genet. 3:229-235(1994).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 71-286, AND VARIANTS ALA-193 AND
LYS-237.
PubMed=12213199; DOI=10.1006/geno.2002.6830;
Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
Lehrach H., Lancet D., Shamir R.;
"DEFOG: a practical scheme for deciphering families of genes.";
Genomics 80:295-302(2002).
-!- FUNCTION: Odorant receptor. {ECO:0000305}.
-!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
{ECO:0000255|PROSITE-ProRule:PRU00521}.
-!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
-!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium
(HORDE);
URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR3A4";
-----------------------------------------------------------------------
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-----------------------------------------------------------------------
EMBL; AC087498; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC136874; -; NOT_ANNOTATED_CDS; mRNA.
EMBL; U04680; AAA18344.1; -; Genomic_DNA.
EMBL; AF399621; AAK95106.1; -; Genomic_DNA.
PIR; I38472; I38472.
UniGene; Hs.632245; -.
ProteinModelPortal; P47883; -.
DMDM; 269849760; -.
PeptideAtlas; P47883; -.
PRIDE; P47883; -.
GeneCards; OR3A4P; -.
H-InvDB; HIX0039265; -.
HGNC; HGNC:15510; OR3A4P.
neXtProt; NX_P47883; -.
HOVERGEN; HBG017625; -.
InParanoid; P47883; -.
PhylomeDB; P47883; -.
Reactome; R-HSA-381753; Olfactory Signaling Pathway.
PRO; PR:P47883; -.
Proteomes; UP000005640; Unplaced.
CleanEx; HS_OR3A4; -.
GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
GO; GO:0005886; C:plasma membrane; TAS:Reactome.
GO; GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
GO; GO:0007186; P:G-protein coupled receptor signaling pathway; IBA:GO_Central.
GO; GO:0007608; P:sensory perception of smell; NAS:UniProtKB.
InterPro; IPR000276; GPCR_Rhodpsn.
InterPro; IPR017452; GPCR_Rhodpsn_7TM.
InterPro; IPR000725; Olfact_rcpt.
Pfam; PF13853; 7tm_4; 1.
PRINTS; PR00237; GPCRRHODOPSN.
PRINTS; PR00245; OLFACTORYR.
PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
5: Uncertain;
Cell membrane; Complete proteome; Disulfide bond;
G-protein coupled receptor; Glycoprotein; Membrane; Olfaction;
Polymorphism; Receptor; Reference proteome; Sensory transduction;
Transducer; Transmembrane; Transmembrane helix.
CHAIN 1 348 Putative olfactory receptor 3A4.
/FTId=PRO_0000150522.
TOPO_DOM 1 28 Extracellular. {ECO:0000255}.
TRANSMEM 29 52 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 53 60 Cytoplasmic. {ECO:0000255}.
TRANSMEM 61 82 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 83 103 Extracellular. {ECO:0000255}.
TRANSMEM 104 123 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 124 143 Cytoplasmic. {ECO:0000255}.
TRANSMEM 144 161 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 162 199 Extracellular. {ECO:0000255}.
TRANSMEM 200 222 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 223 239 Cytoplasmic. {ECO:0000255}.
TRANSMEM 240 262 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 263 275 Extracellular. {ECO:0000255}.
TRANSMEM 276 295 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 296 348 Cytoplasmic. {ECO:0000255}.
CARBOHYD 8 8 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 100 192 {ECO:0000255|PROSITE-ProRule:PRU00521}.
VARIANT 42 42 I -> V (in dbSNP:rs9905684).
/FTId=VAR_060594.
VARIANT 86 86 S -> R (in dbSNP:rs9905086).
/FTId=VAR_060595.
VARIANT 103 103 E -> Q (in dbSNP:rs9903671).
/FTId=VAR_060596.
VARIANT 120 120 I -> V (in dbSNP:rs9906179).
/FTId=VAR_060597.
VARIANT 168 168 P -> T (in dbSNP:rs9911226).
/FTId=VAR_060598.
VARIANT 175 175 N -> S (in dbSNP:rs9912090).
/FTId=VAR_060599.
VARIANT 181 181 Y -> H (in dbSNP:rs2855677).
/FTId=VAR_060600.
VARIANT 193 193 S -> A (in dbSNP:rs231678).
{ECO:0000269|PubMed:12213199,
ECO:0000269|PubMed:8004088}.
/FTId=VAR_060601.
VARIANT 237 237 R -> K (in dbSNP:rs231677).
{ECO:0000269|PubMed:12213199,
ECO:0000269|PubMed:8004088}.
/FTId=VAR_060602.
VARIANT 300 300 V -> I (in dbSNP:rs8076130).
/FTId=VAR_060603.
SEQUENCE 348 AA; 37194 MW; 9F04037E0F2690F4 CRC64;
MDLGNSGNDS VVTKFVLLGL TETAALQPIL FVIFLLAYVT TIGGTLSILA AILMETKLHS
PMYFFLGNLS LPDVGCVSVT VPAMLSHFIS NDRSIPYKAC LSELFFFHLL AGADCFLLTI
MAYDRYLAIC QSLTYSSRMS WGIQQALVGM SCVFSFTNAL TQTVALSPLN FCGPNVINHF
YCDLPQPFQL SCSSVHLNGQ LLFVAAAFMG VAPLVLITVS YAHVAAAVLR IRSAEGRKKA
FSTCSSHLTV VGIFYGTGVF SYTRLGSVES SDKDKGIGIL NTVISPMLNP LIYWTSLLDV
GCISHCSSDA GVSPGPPVQS SLCCLQFTAL LSPPPGWGGL SPLNSHGL


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