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Putative oxidoreductase GLYR1 (EC 1.-.-.-) (Glyoxylate reductase 1 homolog) (Nuclear protein NP60)

 GLYR1_BOVIN             Reviewed;         553 AA.
A4FUF0; Q58DC3;
04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
17-APR-2007, sequence version 1.
22-NOV-2017, entry version 87.
RecName: Full=Putative oxidoreductase GLYR1;
EC=1.-.-.-;
AltName: Full=Glyoxylate reductase 1 homolog;
AltName: Full=Nuclear protein NP60;
Name=GLYR1; Synonyms=NP60;
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
PubMed=16305752; DOI=10.1186/1471-2164-6-166;
Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
"Characterization of 954 bovine full-CDS cDNA sequences.";
BMC Genomics 6:166-166(2005).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
STRAIN=Hereford; TISSUE=Uterus;
NIH - Mammalian Gene Collection (MGC) project;
Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Putative oxidoreductase that is recruited on chromatin
and promotes KDM1B demethylase activity. Recognizes and binds
trimethylated 'Lys-36' of histone H3 (H3K36me3). Regulates p38 MAP
kinase activity by mediating stress activation of p38alpha/MAPK14
and specifically regulating MAPK14 signaling. Indirectly promotes
phosphorylation of MAPK14 and activation of ATF2. The
phosphorylation of MAPK14 requires upstream activity of MAP2K4 and
MAP2K6. {ECO:0000250|UniProtKB:Q49A26}.
-!- SUBUNIT: Interacts with MAPK14. Interacts with KDM1B at
nucleosomes; this interaction stimulates H3K4me1 and H3K4me2
demethylation. {ECO:0000250|UniProtKB:Q49A26}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q49A26}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=A4FUF0-1; Sequence=Displayed;
Name=2;
IsoId=A4FUF0-2; Sequence=VSP_029705;
Note=No experimental confirmation available.;
-!- DOMAIN: The A.T hook DNA-binding domain is required for the
interaction with MAPK14. {ECO:0000250|UniProtKB:Q49A26}.
-!- DOMAIN: The PWWP domain probably mediates the binding to H3K36me3.
{ECO:0000250|UniProtKB:Q49A26}.
-!- MISCELLANEOUS: The conserved NAD-binding sites and sequence
similarity to plant dehydrogenases suggest that this protein may
have oxidoreductase activity. {ECO:0000250|UniProtKB:Q49A26}.
-!- SIMILARITY: Belongs to the 3-hydroxyisobutyrate dehydrogenase
family. NP60 subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; BT021674; AAX46521.1; -; mRNA.
EMBL; BC114770; AAI14771.1; -; mRNA.
RefSeq; NP_001035658.2; NM_001040568.2. [A4FUF0-1]
UniGene; Bt.58736; -.
ProteinModelPortal; A4FUF0; -.
SMR; A4FUF0; -.
STRING; 9913.ENSBTAP00000002268; -.
PaxDb; A4FUF0; -.
PRIDE; A4FUF0; -.
Ensembl; ENSBTAT00000002268; ENSBTAP00000002268; ENSBTAG00000001731. [A4FUF0-1]
GeneID; 539636; -.
KEGG; bta:539636; -.
CTD; 84656; -.
eggNOG; KOG0409; Eukaryota.
eggNOG; KOG1904; Eukaryota.
eggNOG; COG2084; LUCA.
GeneTree; ENSGT00530000063270; -.
HOGENOM; HOG000219609; -.
InParanoid; A4FUF0; -.
OMA; NFAWIEE; -.
OrthoDB; EOG091G0MNC; -.
TreeFam; TF324195; -.
Proteomes; UP000009136; Chromosome 25.
Bgee; ENSBTAG00000001731; -.
ExpressionAtlas; A4FUF0; baseline.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
GO; GO:0000786; C:nucleosome; ISS:UniProtKB.
GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO; GO:0042393; F:histone binding; ISS:UniProtKB.
GO; GO:0035064; F:methylated histone binding; ISS:UniProtKB.
GO; GO:0051287; F:NAD binding; IEA:InterPro.
GO; GO:0004616; F:phosphogluconate dehydrogenase (decarboxylating) activity; IEA:InterPro.
CDD; cd05836; N_Pac_NP60; 1.
Gene3D; 1.10.1040.10; -; 1.
InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
InterPro; IPR013328; 6PGD_dom2.
InterPro; IPR006115; 6PGDH_NADP-bd.
InterPro; IPR036291; NAD(P)-bd_dom_sf.
InterPro; IPR029154; NADP-bd.
InterPro; IPR035501; NP60_PWWP.
InterPro; IPR000313; PWWP_dom.
Pfam; PF14833; NAD_binding_11; 1.
Pfam; PF03446; NAD_binding_2; 1.
Pfam; PF00855; PWWP; 1.
SMART; SM00293; PWWP; 1.
SUPFAM; SSF48179; SSF48179; 1.
SUPFAM; SSF51735; SSF51735; 1.
PROSITE; PS50812; PWWP; 1.
2: Evidence at transcript level;
Alternative splicing; Complete proteome; DNA-binding; Isopeptide bond;
NAD; Nucleus; Oxidoreductase; Phosphoprotein; Reference proteome;
Ubl conjugation.
CHAIN 1 553 Putative oxidoreductase GLYR1.
/FTId=PRO_0000312120.
DOMAIN 8 66 PWWP. {ECO:0000255|PROSITE-
ProRule:PRU00162}.
DNA_BIND 168 180 A.T hook. {ECO:0000305}.
NP_BIND 271 285 NAD. {ECO:0000250|UniProtKB:Q49A26}.
REGION 214 217 Interaction with histone H3.
{ECO:0000250|UniProtKB:Q49A26}.
REGION 216 225 Interaction with KDM1B.
{ECO:0000250|UniProtKB:Q49A26}.
BINDING 362 362 NAD. {ECO:0000250|UniProtKB:Q49A26}.
BINDING 505 505 NAD. {ECO:0000250|UniProtKB:Q49A26}.
SITE 217 217 Required to promote KDM1B demethylase
activity toward histone H3K4me1 and
H3K4me2. {ECO:0000250|UniProtKB:Q49A26}.
MOD_RES 130 130 Phosphoserine.
{ECO:0000250|UniProtKB:Q49A26}.
MOD_RES 167 167 Phosphoserine.
{ECO:0000250|UniProtKB:Q49A26}.
MOD_RES 540 540 Phosphoserine.
{ECO:0000250|UniProtKB:Q49A26}.
CROSSLNK 135 135 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:Q49A26}.
CROSSLNK 176 176 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:Q49A26}.
CROSSLNK 179 179 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:Q49A26}.
CROSSLNK 201 201 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:Q49A26}.
CROSSLNK 211 211 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:Q49A26}.
CROSSLNK 227 227 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:Q49A26}.
CROSSLNK 237 237 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:Q49A26}.
CROSSLNK 240 240 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:Q49A26}.
CROSSLNK 269 269 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:Q49A26}.
CROSSLNK 302 302 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:Q49A26}.
VAR_SEQ 270 553 Missing (in isoform 2).
{ECO:0000303|PubMed:16305752}.
/FTId=VSP_029705.
SEQUENCE 553 AA; 60556 MW; 7B07769AE69EC46E CRC64;
MAAVSLRLGD LVWGKLGRYP PWPGKIVNPP KDLKKPRGKK CFFVKFFGTE DHAWIKVEQL
KPYHAHKEEM IKINKGKRFQ QAVDAVEEFL RRAKGKDQTS SHSSADDKNR RNSSEERSRP
ISGDEKRKLS LSEGKVKKNM GEGKKRVPSG SSERGSKSPL KRAQEQSPRK RGRPPKDEKD
LSIPESSTVK GMMAGPMATF KWQPNVSEPV KDADPHFHHF LLSQTEKPAV CYQAITKKLK
ICEEETGSTS IQAADSTAVN GSVTPTDKKI GFLGLGLMGS GIVSNLLKMG HTVTVWNRTA
EKCDLFIQEG ARLGRTPAEV VSTCDITFAC VSDPKAAKDL VLGPSGVLQG IRPGKCYVDM
STVDADTVTE LAQVIVSRGG RFLEAPVSGN QQLSNDGMLV ILAAGDRGLY EDCSSCFQAM
GKTSFFLGEV GNAAKMMLIV NMVQGSFMAT IAEGLTLAQV TGQSQQTLLD ILNQGQLASI
FLDQKCQNIL QGNFKPDFYL KYIQKDLRLA IALGDAVNHP TPMAAAANEV YKRAKALDQS
DNDMSAVYRA YIH


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