Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Putative oxidoreductase GLYR1 (EC 1.-.-.-) (Glyoxylate reductase 1 homolog) (Nuclear protein NP60)

 GLYR1_RAT               Reviewed;         552 AA.
Q5RKH0;
04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
21-DEC-2004, sequence version 1.
22-NOV-2017, entry version 121.
RecName: Full=Putative oxidoreductase GLYR1;
EC=1.-.-.-;
AltName: Full=Glyoxylate reductase 1 homolog;
AltName: Full=Nuclear protein NP60;
Name=Glyr1; Synonyms=Np60;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Testis;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[2]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-130, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=22673903; DOI=10.1038/ncomms1871;
Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A.,
Lundby C., Olsen J.V.;
"Quantitative maps of protein phosphorylation sites across 14
different rat organs and tissues.";
Nat. Commun. 3:876-876(2012).
-!- FUNCTION: Putative oxidoreductase that is recruited on chromatin
and promotes KDM1B demethylase activity. Recognizes and binds
trimethylated 'Lys-36' of histone H3 (H3K36me3). Regulates p38 MAP
kinase activity by mediating stress activation of p38alpha/MAPK14
and specifically regulating MAPK14 signaling. Indirectly promotes
phosphorylation of MAPK14 and activation of ATF2. The
phosphorylation of MAPK14 requires upstream activity of MAP2K4 and
MAP2K6. {ECO:0000250|UniProtKB:Q49A26}.
-!- SUBUNIT: Interacts with MAPK14. Interacts with KDM1B at
nucleosomes; this interaction stimulates H3K4me1 and H3K4me2
demethylation. {ECO:0000250|UniProtKB:Q49A26}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q49A26}.
-!- DOMAIN: The A.T hook DNA-binding domain is required for the
interaction with MAPK14. {ECO:0000250|UniProtKB:Q49A26}.
-!- DOMAIN: The PWWP domain probably mediates the binding to H3K36me3.
{ECO:0000250|UniProtKB:Q49A26}.
-!- MISCELLANEOUS: The conserved NAD-binding sites and sequence
similarity to plant dehydrogenases suggest that this protein may
have oxidoreductase activity. {ECO:0000250|UniProtKB:Q49A26}.
-!- SIMILARITY: Belongs to the 3-hydroxyisobutyrate dehydrogenase
family. NP60 subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; BC085931; AAH85931.1; -; mRNA.
RefSeq; NP_001007801.1; NM_001007800.1.
UniGene; Rn.2639; -.
ProteinModelPortal; Q5RKH0; -.
SMR; Q5RKH0; -.
STRING; 10116.ENSRNOP00000004159; -.
iPTMnet; Q5RKH0; -.
PhosphoSitePlus; Q5RKH0; -.
PaxDb; Q5RKH0; -.
PRIDE; Q5RKH0; -.
Ensembl; ENSRNOT00000004159; ENSRNOP00000004159; ENSRNOG00000003065.
GeneID; 360477; -.
KEGG; rno:360477; -.
UCSC; RGD:1309459; rat.
CTD; 84656; -.
RGD; 1309459; Glyr1.
eggNOG; KOG0409; Eukaryota.
eggNOG; KOG1904; Eukaryota.
eggNOG; COG2084; LUCA.
GeneTree; ENSGT00530000063270; -.
HOGENOM; HOG000219609; -.
InParanoid; Q5RKH0; -.
OMA; NFAWIEE; -.
OrthoDB; EOG091G0MNC; -.
PhylomeDB; Q5RKH0; -.
TreeFam; TF324195; -.
PRO; PR:Q5RKH0; -.
Proteomes; UP000002494; Chromosome 10.
Bgee; ENSRNOG00000003065; -.
Genevisible; Q5RKH0; RN.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
GO; GO:0000786; C:nucleosome; ISS:UniProtKB.
GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO; GO:0042393; F:histone binding; ISS:UniProtKB.
GO; GO:0035064; F:methylated histone binding; ISS:UniProtKB.
GO; GO:0051287; F:NAD binding; IEA:InterPro.
GO; GO:0004616; F:phosphogluconate dehydrogenase (decarboxylating) activity; IEA:InterPro.
CDD; cd05836; N_Pac_NP60; 1.
Gene3D; 1.10.1040.10; -; 1.
InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
InterPro; IPR013328; 6PGD_dom2.
InterPro; IPR006115; 6PGDH_NADP-bd.
InterPro; IPR036291; NAD(P)-bd_dom_sf.
InterPro; IPR029154; NADP-bd.
InterPro; IPR035501; NP60_PWWP.
InterPro; IPR000313; PWWP_dom.
Pfam; PF14833; NAD_binding_11; 1.
Pfam; PF03446; NAD_binding_2; 1.
Pfam; PF00855; PWWP; 1.
SMART; SM00293; PWWP; 1.
SUPFAM; SSF48179; SSF48179; 1.
SUPFAM; SSF51735; SSF51735; 1.
PROSITE; PS50812; PWWP; 1.
1: Evidence at protein level;
Complete proteome; DNA-binding; Isopeptide bond; NAD; Nucleus;
Oxidoreductase; Phosphoprotein; Reference proteome; Ubl conjugation.
CHAIN 1 552 Putative oxidoreductase GLYR1.
/FTId=PRO_0000312123.
DOMAIN 8 66 PWWP. {ECO:0000255|PROSITE-
ProRule:PRU00162}.
DNA_BIND 167 179 A.T hook. {ECO:0000305}.
NP_BIND 270 284 NAD. {ECO:0000250|UniProtKB:Q49A26}.
REGION 213 216 Interaction with histone H3.
{ECO:0000250|UniProtKB:Q49A26}.
REGION 215 224 Interaction with KDM1B.
{ECO:0000250|UniProtKB:Q49A26}.
BINDING 361 361 NAD. {ECO:0000250|UniProtKB:Q49A26}.
BINDING 504 504 NAD. {ECO:0000250|UniProtKB:Q49A26}.
SITE 216 216 Required to promote KDM1B demethylase
activity toward histone H3K4me1 and
H3K4me2. {ECO:0000250|UniProtKB:Q49A26}.
MOD_RES 130 130 Phosphoserine.
{ECO:0000244|PubMed:22673903}.
MOD_RES 166 166 Phosphoserine.
{ECO:0000250|UniProtKB:Q49A26}.
MOD_RES 539 539 Phosphoserine.
{ECO:0000250|UniProtKB:Q49A26}.
CROSSLNK 135 135 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:Q49A26}.
CROSSLNK 175 175 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:Q49A26}.
CROSSLNK 178 178 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:Q49A26}.
CROSSLNK 200 200 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:Q49A26}.
CROSSLNK 210 210 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:Q49A26}.
CROSSLNK 226 226 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:Q49A26}.
CROSSLNK 236 236 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:Q49A26}.
CROSSLNK 239 239 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:Q49A26}.
CROSSLNK 268 268 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:Q49A26}.
CROSSLNK 301 301 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:Q49A26}.
SEQUENCE 552 AA; 60421 MW; 5970FC59C54895FA CRC64;
MAAVSLRLGD LVWGKLGRYP PWPGKIVNPP KDLKKPRGKK CFFVKFFGTE DHAWIKVEQL
KPYHAHKEEM IKINKGKRFQ QAVDAVEEFL RRAKGKDQTS SHTSADDKNR RNSSEERSRP
NSGDEKRKLS LSEGKVKKNM GEGKKRVTSG SADRGSKCLK RAQEQSPRKR GRPPKDEKDL
TIPESSTVKG MMAGPMAAFK WQPTASEPVK DADPHFHHFL LSQTEKPAVC YQAITKKLKI
CEEETGSTSI QAADSTAVNG SITPTDKKIG FLGLGLMGSG IVSNLLKMGH TVTVWNRTAE
KCDLFIQEGA RLGRTPAEVV STCDITFACV SDPKAAKDLV LGPSGVLQGI RPGKCYVDMS
TVDADTVTEL AQVIVSRGGR FLEAPVSGNQ QLSNDGMLVI LAAGDRGLYE DCSSCFQAMG
KTSFFLGEVG NAAKMMLIVN MVQGSFMATI AEGLTLAQVT GQSQQTLLDI LNQGQLASIF
LDQKCQNILQ GNFKPDFYLK YIQKDLRLAI ALGDAVNHPT PMAAAANEVY KRAKALDQSD
NDMSAVYRAY IH


Related products :

Catalog number Product name Quantity
GM2A GLYR1 Gene glyoxylate reductase 1 homolog (Arabidopsis)
GLYR1_HUMAN ELISA Kit FOR Putative oxidoreductase GLYR1; organism: Human; gene name: GLYR1 96T
GLYR1_MOUSE ELISA Kit FOR Putative oxidoreductase GLYR1; organism: Mouse; gene name: Glyr1 96T
GLYR1_RAT ELISA Kit FOR Putative oxidoreductase GLYR1; organism: Rat; gene name: Glyr1 96T
GLYR1_MOUSE Mouse ELISA Kit FOR Putative oxidoreductase GLYR1 96T
bs-13451R Rabbit Anti-GLYR1-NP60 Polyclonal Antibody 100ul
bs-13451R-Cy3 Rabbit Anti-GLYR1-NP60 Polyclonal Antibody, Cy3 Conjugated 100ul
bs-13451R-Cy5 Rabbit Anti-GLYR1-NP60 Polyclonal Antibody, Cy5 Conjugated 100ul
bs-13451R-Cy5.5 Rabbit Anti-GLYR1-NP60 Polyclonal Antibody, Cy5.5 Conjugated 100ul
bs-13451R-Cy7 Rabbit Anti-GLYR1-NP60 Polyclonal Antibody, Cy7 Conjugated 100ul
AS09 542 Antibody: GLYR | glyoxylate reductase , Immunogen: native glyoxylate reductase purified from spinach, Host: rabbit, polyclonal, Confirmed reactivity: Spinacia oleracea 10 mg
AS09 543 Antibody: GLYR | glyoxylate reductase, Biotin conjugated, Immunogen: native glyoxylate reductase purified from spinach, Host: rabbit, polyclonal, Confirmed reactivity: Spinacia oleracea 1 ml
bs-13451R-A555 Rabbit Anti-GLYR1-NP60 Polyclonal Antibody, ALEXA FLUOR 555 Conjugated 100ul
bs-13451R-A647 Rabbit Anti-GLYR1-NP60 Polyclonal Antibody, ALEXA FLUOR 647 Conjugated 100ul
bs-13451R-A350 Rabbit Anti-GLYR1-NP60 Polyclonal Antibody, ALEXA FLUOR 350 Conjugated 100ul
bs-13451R-A488 Rabbit Anti-GLYR1-NP60 Polyclonal Antibody, ALEXA FLUOR 488 Conjugated 100ul
AS09 544 Antibody: GLYR | glyoxylate reductase, Affinity purified, Immunogen: native glyoxylate reductase purified from spinach, Host: rabbit, polyclonal, Confirmed reactivity: Spinacia oleracea 1 mg
E4291h Human Glyoxylate Reductase 1 Homolog ELISA Kit 96T
bs-13451R-Biotin Rabbit Anti-GLYR1-NP60 Polyclonal Antibody, Biotin Conjugated 100ul
bs-13451R-FITC Rabbit Anti-GLYR1-NP60 Polyclonal Antibody, FITC Conjugated 100ul
EIAAB33338 Cryzl1,Mouse,Mus musculus,QOH-1,Quinone oxidoreductase homolog 1,Quinone oxidoreductase-like protein 1,Zeta-crystallin homolog
EIAAB33339 Bos taurus,Bovine,CRYZL1,QOH-1,Quinone oxidoreductase homolog 1,Quinone oxidoreductase-like protein 1,Zeta-crystallin homolog
18-661-15152 Putative HLA-DR-associated protein - Potent heat-stable protein phosphatase 2A inhibitor I1PP2A; Acidic nuclear phosphoprotein pp32; Leucine-rich acidic nuclear protein; Lanp; Putative HLA-DR-associat 0.1 mg
18-661-15150 Putative HLA-DR-associated protein I - Potent heat-stable protein phosphatase 2A inhibitor I1PP2A; Acidic nuclear phosphoprotein pp32; Leucine-rich acidic nuclear protein; Lanp; Putative HLA-DR-associ 0.1 mg
18-661-15153 Putative HLA-DR-associated protein I - Potent heat-stable protein phosphatase 2A inhibitor I1PP2A; Acidic nuclear phosphoprotein pp32; Leucine-rich acidic nuclear protein; Lanp; Putative HLA-DR-associ 0.1 mg


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur