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Putative tetratricopeptide repeat protein 41 (TPR repeat protein 41) (Grp94-neighboring nucleotidase)

 TTC41_HUMAN             Reviewed;        1318 AA.
Q6P2S7; Q05DD4;
18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
01-JUL-2008, sequence version 3.
18-JUL-2018, entry version 94.
RecName: Full=Putative tetratricopeptide repeat protein 41 {ECO:0000250|UniProtKB:Q692V3};
Short=TPR repeat protein 41 {ECO:0000250|UniProtKB:Q692V3};
AltName: Full=Grp94-neighboring nucleotidase {ECO:0000250|UniProtKB:Q692V3};
Name=TTC41P {ECO:0000305};
Synonyms=GNN {ECO:0000250|UniProtKB:Q692V3};
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16541075; DOI=10.1038/nature04569;
Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M.,
Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B.,
Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D.,
Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z.,
Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H.,
Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H.,
Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V.,
Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J.,
Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A.,
Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M.,
Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E.,
Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M.,
Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R.,
Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J.,
Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C.,
Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M.,
Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M.,
Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P.,
Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L.,
Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E.,
Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C.,
Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F.,
Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M.,
Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S.,
Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D.,
Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I.,
Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T.,
Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S.,
Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D.,
Kucherlapati R., Weinstock G., Gibbs R.A.;
"The finished DNA sequence of human chromosome 12.";
Nature 440:346-351(2006).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND NUCLEOTIDE
SEQUENCE [LARGE SCALE MRNA] OF 854-1318 (ISOFORM 2).
TISSUE=Bone, and Glioblastoma;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=3;
Name=1;
IsoId=Q6P2S7-1; Sequence=Displayed;
Name=2;
IsoId=Q6P2S7-2; Sequence=VSP_034495, VSP_034496;
Note=No experimental confirmation available.;
Name=3;
IsoId=Q6P2S7-3; Sequence=VSP_034494;
Note=No experimental confirmation available.;
-!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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EMBL; AC012386; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AC012555; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AC084199; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC016335; -; NOT_ANNOTATED_CDS; mRNA.
EMBL; BC064342; -; NOT_ANNOTATED_CDS; mRNA.
UniGene; Hs.506549; -.
ProteinModelPortal; Q6P2S7; -.
SMR; Q6P2S7; -.
IntAct; Q6P2S7; 1.
iPTMnet; Q6P2S7; -.
PhosphoSitePlus; Q6P2S7; -.
DMDM; 193806376; -.
EPD; Q6P2S7; -.
PRIDE; Q6P2S7; -.
ProteomicsDB; 66919; -.
ProteomicsDB; 66920; -. [Q6P2S7-2]
ProteomicsDB; 66921; -. [Q6P2S7-3]
DisGeNET; 253724; -.
GeneCards; TTC41P; -.
HGNC; HGNC:49210; TTC41P.
neXtProt; NX_Q6P2S7; -.
HOVERGEN; HBG107956; -.
InParanoid; Q6P2S7; -.
PhylomeDB; Q6P2S7; -.
Proteomes; UP000005640; Unplaced.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
Gene3D; 1.25.40.10; -; 1.
InterPro; IPR025139; DUF4062.
InterPro; IPR027417; P-loop_NTPase.
InterPro; IPR011990; TPR-like_helical_dom_sf.
Pfam; PF13271; DUF4062; 1.
SUPFAM; SSF52540; SSF52540; 1.
5: Uncertain;
Alternative splicing; Complete proteome; Cytoplasm;
Reference proteome; Repeat; TPR repeat.
CHAIN 1 1318 Putative tetratricopeptide repeat protein
41.
/FTId=PRO_0000325940.
REPEAT 399 432 TPR 1.
REPEAT 653 684 TPR 2.
REPEAT 817 850 TPR 3.
REPEAT 858 891 TPR 4.
REPEAT 991 1027 TPR 5.
REPEAT 1045 1082 TPR 6.
VAR_SEQ 140 1318 Missing (in isoform 3).
{ECO:0000303|PubMed:15489334}.
/FTId=VSP_034494.
VAR_SEQ 1053 1053 G -> F (in isoform 2).
{ECO:0000303|PubMed:15489334}.
/FTId=VSP_034495.
VAR_SEQ 1054 1318 Missing (in isoform 2).
{ECO:0000303|PubMed:15489334}.
/FTId=VSP_034496.
SEQUENCE 1318 AA; 151684 MW; 846F27FF035FEAC5 CRC64;
MSQKTNENVE RYTQFLQKPQ KPIQPYICST LNDFQEERDF LANNIFPQLN ELCNSWGTYF
KAVDLSWSAL KAPKSLPTHL FRQYSCLRSQ RLKLCLDYVN SCFPFFICML GQTYGDFLPD
YSHFMTSKVT RLSSLSKVEN LYVAAKNGYP WVLENPSCSL TEFEIIQAAF LNESQFQYFY
FRTGTTLLKA LDDEKKGERL PSSSSTNEEE TLRIGKLKAK IISKGLPVRF YSDLHELGEL
VFKDWSVVIE KLHPATLMIE NIDYKHSFER FYHEEFTEKC KQMCVISKES DRTFEILEKF
ALKDVELDFN NVAADSSLDS VPRFFRINPT PTYKSILLLS REHGCGKSTL IANWVNYFKK
KHPSMLLIPH FVGSTCESSY IMSVIHYFIT ELQYRNYGTQ LETDILNEDS DGLVFSFLVE
VFIASISLKP CILVLDGIEE LIGIYGISGQ KVKDFSWLPH SLSPHCKFIM STVSSSLSYK
SLCARPDVRT VELISTGDEE TKLNIFRKHL SIPMMDPFEQ STQALRKKPD LSPLKLTILA
NELKEYRINH NEFQCMKEYL EAVSVQELWE LVLKRWIEDY SWTFQPKRAN SDTVASGEGL
DSWVADALCL LCLSHGGLAE DELLQLLDML GYRNHYKVTA LHWAAFRNAT KQWVQEKPNG
LLYFWHQSLS AVEHKLLGVI TPVESSPCSF QTPMNHKKTH FHQVLIRYFQ RQTSFWRVYQ
ELPWHMKMSG CLRGLCGFLS SPTITDFISK IQSLGFWTRL HLIHFWNVLL EAGYDVSEAY
LLSVAKIKAD QCHTMRKSGT LSVLQCRLIE LTVLDKCRLM FFIGSFLKFM GKTNEAEELF
LSVEDMLVQS QSMTDMLLKV QNAIGELYLE TGMTQEGFQY FQKAWSSMLR LSLSDLEDSR
DLVKQKVRVL DNLAKSASEE YLKENHILEY ATEISNLLDN NPRDQATMKY IEGVLMFVAG
NTSLAKMKLR ECLNIRKSLF GKKNMLVGEV MEFLADLLFF PQRDSKKSQR KQVLKYYKQV
IKIKENAETL AKSSLLRKQL SISLSDTLCK LAGHLLASDS CHHVMIEAVG YLYRSVDLRV
IHLGSSHSSI HGIHGILHLL REIEWIRSRR YWPQGMSQQH SEGSRNGFSL WEHLVKLNYH
SAQSSNTVSS AMCMNADKLH RARRMDLAPQ TISDKSKCAP GKGKKKPIIC ISAEEKIQRK
TQNNAEIWNG SGKEASKKKT DYSSNILSLG KMNGLIKLSR QRILLAKSES GEGEITTIYH
HPLPWPVSTK NPGESEFISE KWLFHSPDYI SISQKSFLQR RLHIETKLLK TSNDINKE


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