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Quaternary ammonium compound-resistance protein QacC (Ethidium bromide resistance protein) (Multidrug resistance protein) (Quaternary ammonium determinant C)

 QACC_STAAU              Reviewed;         107 AA.
P14319;
01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
01-JAN-1990, sequence version 1.
12-SEP-2018, entry version 98.
RecName: Full=Quaternary ammonium compound-resistance protein QacC {ECO:0000305};
AltName: Full=Ethidium bromide resistance protein;
AltName: Full=Multidrug resistance protein;
AltName: Full=Quaternary ammonium determinant C;
Name=qacC {ECO:0000303|PubMed:1840534};
Synonyms=ebr {ECO:0000303|PubMed:1505735, ECO:0000303|PubMed:2602117},
smr {ECO:0000303|PubMed:1615062};
Staphylococcus aureus.
Plasmid pTZ20, Plasmid pWBG32, Plasmid pSK89, Plasmid pTZ22, and
Plasmid pKH8.
Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
Staphylococcus.
NCBI_TaxID=1280;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=L20A; PLASMID=pTZ20;
PubMed=2602117; DOI=10.1093/nar/17.23.10103;
Sasatsu M., Shima K., Shibata Y., Kono M.;
"Nucleotide sequence of a gene that encodes resistance to ethidium
bromide from a transferable plasmid in Staphylococcus aureus.";
Nucleic Acids Res. 17:10103-10103(1989).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
PLASMID=pWBG32;
PubMed=1615062; DOI=10.1016/0147-619X(92)90012-Y;
Grinius L., Dreguniene G., Goldberg E.B., Liao C.H., Projan S.J.;
"A staphylococcal multidrug resistance gene product is a member of a
new protein family.";
Plasmid 27:119-129(1992).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PLASMID=pSK89;
PubMed=1840534; DOI=10.1016/0378-1119(91)90224-Y;
Littlejohn T.G., DiBerardino D., Messerotti L.J., Spiers S.J.,
Skurray R.A.;
"Structure and evolution of a family of genes encoding antiseptic and
disinfectant resistance in Staphylococcus aureus.";
Gene 101:59-66(1991).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=N20; PLASMID=pTZ22;
PubMed=1505735; DOI=10.1016/0378-1097(92)90514-O;
Sasatsu M., Shibata Y., Noguchi N., Kono M.;
"High-level resistance to ethidium bromide and antiseptics in
Staphylococcus aureus.";
FEMS Microbiol. Lett. 72:109-113(1992).
[5]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=SA2; PLASMID=pKH8;
Moon K.H., Im S.H., Yoon S.J., Kim W.K., Shin C.K., Lee D.W.;
Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases.
[6]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Leelaporn A., Firth N., Paulsen I.T., Hettiaratchi A., Skurray R.A.;
Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases.
[7]
FUNCTION.
PubMed=2778425; DOI=10.1099/00221287-135-1-1;
Tennent J.M., Lyon B.R., Midgley M., Jones I.G., Purewal A.S.,
Skurray R.A.;
"Physical and biochemical characterization of the qacA gene encoding
antiseptic and disinfectant resistance in Staphylococcus aureus.";
J. Gen. Microbiol. 135:1-10(1989).
[8]
FUNCTION, ACTIVITY REGULATION, SUBCELLULAR LOCATION, TOPOLOGY, AND
MUTAGENESIS OF PRO-31; CYS-42; TYR-59 AND TRP-62.
PubMed=7751293; DOI=10.1128/jb.177.10.2827-2833.1995;
Paulsen I.T., Brown M.H., Dunstan S.J., Skurray R.A.;
"Molecular characterization of the staphylococcal multidrug resistance
export protein QacC.";
J. Bacteriol. 177:2827-2833(1995).
-!- FUNCTION: Multidrug exporter. Is implicated for the resistance to
bacteriocidal quaternary ammonium compounds and ethidium bromide.
{ECO:0000269|PubMed:1615062, ECO:0000269|PubMed:7751293,
ECO:0000305|PubMed:2778425}.
-!- ACTIVITY REGULATION: Ethidium export is inhibited by N-
ethylmaleimide (NEM). {ECO:0000269|PubMed:7751293}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:7751293};
Multi-pass membrane protein {ECO:0000269|PubMed:7751293}.
-!- SIMILARITY: Belongs to the small multidrug resistance (SMR)
protein family. {ECO:0000305}.
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EMBL; M37888; AAA26666.1; -; Genomic_DNA.
EMBL; X15574; CAA33598.1; -; Genomic_DNA.
EMBL; M33479; AAA26668.1; -; Genomic_DNA.
EMBL; M37889; AAB02114.1; -; Genomic_DNA.
EMBL; X62587; CAA44471.1; -; Genomic_DNA.
EMBL; X62587; CAA44472.1; -; Genomic_DNA.
EMBL; U50077; AAB07747.1; -; Genomic_DNA.
EMBL; U15783; AAA60379.1; -; Genomic_DNA.
PIR; JQ1439; JQ1439.
RefSeq; NP_863640.1; NC_005024.1.
RefSeq; NP_878005.1; NC_005054.1.
RefSeq; WP_001146389.1; NZ_PNGH01000025.1.
RefSeq; YP_002790936.1; NC_012547.1.
RefSeq; YP_006938404.1; NC_013339.1.
RefSeq; YP_006938512.1; NC_013342.1.
RefSeq; YP_006938611.1; NC_013344.1.
RefSeq; YP_006938730.1; NC_013350.1.
RefSeq; YP_534903.1; NC_007928.1.
ProteinModelPortal; P14319; -.
SMR; P14319; -.
TCDB; 2.A.7.1.1; the drug/metabolite transporter (dmt) superfamily.
GeneID; 13875573; -.
GeneID; 13875683; -.
GeneID; 13875784; -.
GeneID; 13875911; -.
GeneID; 2598266; -.
GeneID; 2598368; -.
GeneID; 3978602; -.
GeneID; 7751503; -.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
InterPro; IPR000390; Small_multidrug_res.
PANTHER; PTHR30561; PTHR30561; 1.
Pfam; PF00893; Multi_Drug_Res; 1.
1: Evidence at protein level;
Cell membrane; Membrane; Plasmid; Transmembrane; Transmembrane helix;
Transport.
CHAIN 1 107 Quaternary ammonium compound-resistance
protein QacC.
/FTId=PRO_0000108083.
TOPO_DOM 1 2 Cytoplasmic.
{ECO:0000269|PubMed:7751293}.
TRANSMEM 3 20 Helical. {ECO:0000255}.
TOPO_DOM 21 29 Extracellular.
{ECO:0000269|PubMed:7751293}.
TRANSMEM 30 47 Helical. {ECO:0000255}.
TOPO_DOM 48 56 Cytoplasmic.
{ECO:0000269|PubMed:7751293}.
TRANSMEM 57 75 Helical. {ECO:0000255}.
TOPO_DOM 76 85 Extracellular.
{ECO:0000269|PubMed:7751293}.
TRANSMEM 86 103 Helical. {ECO:0000255}.
TOPO_DOM 104 107 Cytoplasmic.
{ECO:0000269|PubMed:7751293}.
MUTAGEN 31 31 P->A,G: Decrease in resistance to
ethidium bromide, but does not affect
resistance to quaternary ammonium
compounds. {ECO:0000269|PubMed:7751293}.
MUTAGEN 42 42 C->A,G: Decrease in resistance to
ethidium bromide, but does not affect
resistance to quaternary ammonium
compounds. {ECO:0000269|PubMed:7751293}.
MUTAGEN 42 42 C->D,E,I,K,L,P,R,V: Confers sensitivity
to ethidium bromide and quaternary
ammonium compounds.
{ECO:0000269|PubMed:7751293}.
MUTAGEN 42 42 C->S: Confers sensitivity to ethidium
bromide, but does not affect resistance
to quaternary ammonium compounds.
{ECO:0000269|PubMed:7751293}.
MUTAGEN 42 42 C->T: No change in activity.
{ECO:0000269|PubMed:7751293}.
MUTAGEN 59 59 Y->S,W: Confers sensitivity to ethidium
bromide and quaternary ammonium
compounds. {ECO:0000269|PubMed:7751293}.
MUTAGEN 62 62 W->F,Y: Confers sensitivity to ethidium
bromide and quaternary ammonium
compounds. {ECO:0000269|PubMed:7751293}.
SEQUENCE 107 AA; 11673 MW; 9A0155B54A052E1F CRC64;
MPYIYLIIAI STEVIGSAFL KSSEGFSKFI PSLGTIISFG ICFYFLSKTM QHLPLNITYA
TWAGLGLVLT TVVSIIIFKE QINLITIVSI VLIIVGVVSL NIFGTSH


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