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Quinidine resistance protein 3 (Acids quinidine resistance protein 2)

 QDR3_YEAST              Reviewed;         689 AA.
P38227; D6VQ43;
01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
27-JUL-2011, sequence version 2.
28-FEB-2018, entry version 135.
RecName: Full=Quinidine resistance protein 3;
AltName: Full=Acids quinidine resistance protein 2;
Name=QDR3; Synonyms=AQR2; OrderedLocusNames=YBR043C; ORFNames=YBR0413;
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
NCBI_TaxID=559292;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 204508 / S288c;
PubMed=7813418;
Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C.,
Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M.,
Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M.,
Cziepluch C., Demolis N., Delaveau T., Doignon F., Domdey H.,
Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D.,
Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J.,
Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C.,
Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M.,
Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L.,
Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J.,
Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T.,
Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A.,
Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B.,
Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I.,
Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M.,
Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A.,
van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I.,
Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H.,
Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.;
"Complete DNA sequence of yeast chromosome II.";
EMBO J. 13:5795-5809(1994).
[2]
GENOME REANNOTATION, AND SEQUENCE REVISION TO 37.
STRAIN=ATCC 204508 / S288c;
PubMed=24374639; DOI=10.1534/g3.113.008995;
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M.,
Cherry J.M.;
"The reference genome sequence of Saccharomyces cerevisiae: Then and
now.";
G3 (Bethesda) 4:389-398(2014).
[3]
SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
PubMed=14562095; DOI=10.1038/nature02026;
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
Weissman J.S., O'Shea E.K.;
"Global analysis of protein localization in budding yeast.";
Nature 425:686-691(2003).
[4]
LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
PubMed=14562106; DOI=10.1038/nature02046;
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A.,
Dephoure N., O'Shea E.K., Weissman J.S.;
"Global analysis of protein expression in yeast.";
Nature 425:737-741(2003).
[5]
FUNCTION, AND SUBCELLULAR LOCATION.
PubMed=15649438; DOI=10.1016/j.bbrc.2004.12.097;
Tenreiro S., Vargas R.C., Teixeira M.C., Magnani C., Sa-Correia I.;
"The yeast multidrug transporter Qdr3 (Ybr043c): localization and role
as a determinant of resistance to quinidine, barban, cisplatin, and
bleomycin.";
Biochem. Biophys. Res. Commun. 327:952-959(2005).
[6]
TOPOLOGY [LARGE SCALE ANALYSIS].
STRAIN=ATCC 208353 / W303-1A;
PubMed=16847258; DOI=10.1073/pnas.0604075103;
Kim H., Melen K., Oesterberg M., von Heijne G.;
"A global topology map of the Saccharomyces cerevisiae membrane
proteome.";
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006).
[7]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=18407956; DOI=10.1074/mcp.M700468-MCP200;
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
"A multidimensional chromatography technology for in-depth
phosphoproteome analysis.";
Mol. Cell. Proteomics 7:1389-1396(2008).
[8]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-436, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=19779198; DOI=10.1126/science.1172867;
Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.;
"Global analysis of Cdk1 substrate phosphorylation sites provides
insights into evolution.";
Science 325:1682-1686(2009).
[9]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=22814378; DOI=10.1073/pnas.1210303109;
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E.,
Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K.,
Aldabe R.;
"N-terminal acetylome analyses and functional insights of the N-
terminal acetyltransferase NatB.";
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
-!- FUNCTION: Multidrug resistance transporter involved in resistance
and adaptation to quinidine and to the herbicide barban (4-chloro-
2-butynyl [3-chlorophenyl] carbamate).
{ECO:0000269|PubMed:15649438}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:14562095,
ECO:0000269|PubMed:15649438}; Multi-pass membrane protein
{ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:15649438}.
-!- MISCELLANEOUS: Present with 279 molecules/cell in log phase SD
medium. {ECO:0000269|PubMed:14562106}.
-!- SIMILARITY: Belongs to the major facilitator superfamily. CAR1
family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; Z35912; CAA84985.1; -; Genomic_DNA.
EMBL; BK006936; DAA07163.2; -; Genomic_DNA.
PIR; S45901; S45901.
RefSeq; NP_009599.2; NM_001178391.2.
ProteinModelPortal; P38227; -.
BioGrid; 32744; 51.
DIP; DIP-797N; -.
IntAct; P38227; 3.
MINT; P38227; -.
STRING; 4932.YBR043C; -.
TCDB; 2.A.1.2.43; the major facilitator superfamily (mfs).
iPTMnet; P38227; -.
MaxQB; P38227; -.
PaxDb; P38227; -.
PRIDE; P38227; -.
EnsemblFungi; YBR043C; YBR043C; YBR043C.
GeneID; 852331; -.
KEGG; sce:YBR043C; -.
EuPathDB; FungiDB:YBR043C; -.
SGD; S000000247; QDR3.
GeneTree; ENSGT00620000088227; -.
InParanoid; P38227; -.
OMA; IWYGWTA; -.
OrthoDB; EOG092C2079; -.
BioCyc; YEAST:G3O-29016-MONOMER; -.
PRO; PR:P38227; -.
Proteomes; UP000002311; Chromosome II.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IDA:SGD.
GO; GO:0015238; F:drug transmembrane transporter activity; IMP:SGD.
GO; GO:0015203; F:polyamine transmembrane transporter activity; IMP:SGD.
GO; GO:0030476; P:ascospore wall assembly; IGI:SGD.
GO; GO:0006855; P:drug transmembrane transport; IMP:SGD.
GO; GO:0010509; P:polyamine homeostasis; IMP:SGD.
CDD; cd06174; MFS; 1.
InterPro; IPR011701; MFS.
InterPro; IPR020846; MFS_dom.
InterPro; IPR036259; MFS_trans_sf.
Pfam; PF07690; MFS_1; 1.
SUPFAM; SSF103473; SSF103473; 2.
PROSITE; PS50850; MFS; 1.
1: Evidence at protein level;
Cell membrane; Complete proteome; Membrane; Phosphoprotein;
Reference proteome; Transmembrane; Transmembrane helix; Transport.
CHAIN 1 689 Quinidine resistance protein 3.
/FTId=PRO_0000173437.
TOPO_DOM 1 108 Extracellular. {ECO:0000255}.
TRANSMEM 109 131 Helical. {ECO:0000255}.
TOPO_DOM 132 139 Cytoplasmic. {ECO:0000255}.
TRANSMEM 140 163 Helical. {ECO:0000255}.
TOPO_DOM 164 175 Extracellular. {ECO:0000255}.
TRANSMEM 176 193 Helical. {ECO:0000255}.
TOPO_DOM 194 235 Cytoplasmic. {ECO:0000255}.
TRANSMEM 236 256 Helical. {ECO:0000255}.
TOPO_DOM 257 265 Extracellular. {ECO:0000255}.
TRANSMEM 266 283 Helical. {ECO:0000255}.
TOPO_DOM 284 475 Cytoplasmic. {ECO:0000255}.
TRANSMEM 476 493 Helical. {ECO:0000255}.
TOPO_DOM 494 510 Extracellular. {ECO:0000255}.
TRANSMEM 511 532 Helical. {ECO:0000255}.
TOPO_DOM 533 558 Cytoplasmic. {ECO:0000255}.
TRANSMEM 559 577 Helical. {ECO:0000255}.
TOPO_DOM 578 586 Extracellular. {ECO:0000255}.
TRANSMEM 587 609 Helical. {ECO:0000255}.
TOPO_DOM 610 624 Cytoplasmic. {ECO:0000255}.
TRANSMEM 625 642 Helical. {ECO:0000255}.
TOPO_DOM 643 648 Extracellular. {ECO:0000255}.
TRANSMEM 649 668 Helical. {ECO:0000255}.
TOPO_DOM 669 689 Cytoplasmic. {ECO:0000255}.
MOD_RES 436 436 Phosphoserine.
{ECO:0000244|PubMed:19779198}.
CONFLICT 37 37 S -> T (in Ref. 1; CAA84985).
{ECO:0000305}.
SEQUENCE 689 AA; 77287 MW; AA2C5D2D7175F176 CRC64;
MQAQGSQSNV GSLRSNCSDN SLPNNHVMMH CDESSGSPHS EHNDYSYEKT NLESTASNSR
EHRDNQLSRL KSEEYVVPKN QRRGLLPQLA IIPEFKDARD YPPMMKKMIV FLIAFSSMMG
PMGTSIIFPA INSITTEFKT SVIMVNVSIG VYLLSLGVFP LWWSSLSELE GRRTTYITSF
ALLFAFNIGS ALAPDINSFI ALRMLCGAAS ASVQSVGAGT VADLYISEDR GKNLSYYYLG
PLLAPLLSPI FGSLLVNRWP WRSTQWFMVI LSGCNVILLT VLLPETLRKQ DSKGAIAQIL
AERRIQVDNN ERGEIQEDYQ RGEDETDRIE NQVATLSTEK HNYVGEVRDQ DSLDLESHSS
PNTYDGRAGE TQLQRIYTEA SRSLYEYQLD DSGIDATTAQ VTRIRSTDPK LARSIRENSL
RKLQTNLEEQ VKKVLSSNGG EIAPKQVSAV RKVWDTFFVY FIKPLKSLHF LEYPPVALAI
TFSAISFSTV YFVNMTVEYK YSRPPYNFKP LYIGLLYIPN SVTYFFASIY GGRWVDMLLK
RYKEKYGILA PEARISWNVV TSVISFPIAL LIFGWCLDKK CHWVTPLIGT ALFGYAAMMT
IGATLSYLVD SLPGKGATGV ALNNLIRQIL AATAVFVTTP MLNGMGTGWA FTMLAFIVLG
ASSVLIILKK HGDYWRENYD LQKLYDKID


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