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R-spondin-3 (Cabriolet) (Roof plate-specific spondin-3)

 RSPO3_DANRE             Reviewed;         317 AA.
Q5R328; A4QNT6;
16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
23-OCT-2007, sequence version 2.
28-FEB-2018, entry version 80.
RecName: Full=R-spondin-3;
AltName: Full=Cabriolet;
AltName: Full=Roof plate-specific spondin-3;
Flags: Precursor;
Name=rspo3; ORFNames=sb:cb387, zgc:162040;
Danio rerio (Zebrafish) (Brachydanio rerio).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
Cyprinidae; Danio.
NCBI_TaxID=7955;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Embryo;
Mieda M., Hirate Y., Aoki M., Sasaki K., Okamoto H.;
"Nucleopondin, a novel nuclear protein with a thrombospondin type I
repeat, is expressed in dynamic spatial and temporal patterns in
zebrafish and mouse development.";
Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=WIK;
NIH - Zebrafish Gene Collection (ZGC) project;
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Activator of the canonical Wnt signaling pathway by
acting as a ligand for lgr4-6 receptors, which acts as a key
regulator of angiogenesis. Upon binding to lgr4-6 (lgr4, lgr5 or
lgr6), lgr4-6 associate with phosphorylated lrp6 and frizzled
receptors that are activated by extracellular Wnt receptors,
triggering the canonical Wnt signaling pathway to increase
expression of target genes. Acts both in the canonical. Wnt/beta-
catenin-dependent pathway and in non-canonical Wnt signaling
pathway. Acts as a key regulator of angiogenesis by controlling
vascular stability and pruning: acts by activating the non-
canonical Wnt signaling pathway in endothelial cells.
{ECO:0000250|UniProtKB:Q2TJ95, ECO:0000250|UniProtKB:Q9BXY4}.
-!- SUBUNIT: Binds heparin. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q2TJ95}.
-!- DOMAIN: The FU repeats are required for activation and
stabilization of beta-catenin. {ECO:0000250|UniProtKB:Q2TJ95}.
-!- SIMILARITY: Belongs to the R-spondin family. {ECO:0000305}.
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EMBL; AB035930; BAD74061.1; -; mRNA.
EMBL; BC139514; AAI39515.1; -; mRNA.
RefSeq; NP_001017358.1; NM_001017358.1.
UniGene; Dr.75336; -.
ProteinModelPortal; Q5R328; -.
SMR; Q5R328; -.
STRING; 7955.ENSDARP00000058577; -.
PaxDb; Q5R328; -.
GeneID; 100007702; -.
KEGG; dre:100007702; -.
CTD; 84870; -.
ZFIN; ZDB-GENE-030131-9814; rspo3.
eggNOG; KOG3525; Eukaryota.
eggNOG; COG1404; LUCA.
HOGENOM; HOG000290668; -.
HOVERGEN; HBG082751; -.
InParanoid; Q5R328; -.
PhylomeDB; Q5R328; -.
PRO; PR:Q5R328; -.
Proteomes; UP000000437; Unplaced.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
GO; GO:0001974; P:blood vessel remodeling; ISS:UniProtKB.
GO; GO:0060829; P:negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation; IMP:ZFIN.
GO; GO:2000054; P:negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification; IMP:ZFIN.
GO; GO:2000052; P:positive regulation of non-canonical Wnt signaling pathway; ISS:UniProtKB.
GO; GO:0048919; P:posterior lateral line neuromast development; IMP:ZFIN.
GO; GO:0002040; P:sprouting angiogenesis; ISS:UniProtKB.
GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
Gene3D; 2.20.100.10; -; 1.
InterPro; IPR006212; Furin_repeat.
InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
InterPro; IPR000884; TSP1_rpt.
InterPro; IPR036383; TSP1_rpt_sf.
Pfam; PF15913; Furin-like_2; 1.
SMART; SM00261; FU; 3.
SMART; SM00209; TSP1; 1.
SUPFAM; SSF57184; SSF57184; 1.
SUPFAM; SSF82895; SSF82895; 1.
PROSITE; PS50092; TSP1; 1.
2: Evidence at transcript level;
Complete proteome; Disulfide bond; Glycoprotein; Heparin-binding;
Reference proteome; Repeat; Secreted; Sensory transduction; Signal;
Wnt signaling pathway.
SIGNAL 1 20 {ECO:0000255}.
CHAIN 21 317 R-spondin-3.
/FTId=PRO_0000234445.
REPEAT 34 86 FU 1.
REPEAT 92 135 FU 2.
REPEAT 139 183 FU 3.
DOMAIN 194 254 TSP type-1. {ECO:0000255|PROSITE-
ProRule:PRU00210}.
CARBOHYD 184 184 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 300 300 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 41 48 {ECO:0000255|PROSITE-ProRule:PRU00210}.
DISULFID 45 54 {ECO:0000255|PROSITE-ProRule:PRU00210}.
DISULFID 57 76 {ECO:0000255|PROSITE-ProRule:PRU00210}.
DISULFID 80 95 {ECO:0000255|PROSITE-ProRule:PRU00210}.
DISULFID 98 105 {ECO:0000255|PROSITE-ProRule:PRU00210}.
DISULFID 102 111 {ECO:0000255|PROSITE-ProRule:PRU00210}.
DISULFID 114 125 {ECO:0000255|PROSITE-ProRule:PRU00210}.
DISULFID 129 189 {ECO:0000255|PROSITE-ProRule:PRU00210}.
DISULFID 195 237 {ECO:0000255|PROSITE-ProRule:PRU00210}.
DISULFID 206 213 {ECO:0000255|PROSITE-ProRule:PRU00210}.
DISULFID 246 253 {ECO:0000255|PROSITE-ProRule:PRU00210}.
CONFLICT 298 298 N -> S (in Ref. 1; BAD74061).
{ECO:0000305}.
SEQUENCE 317 AA; 35943 MW; 72A788840768CACE CRC64;
MQLQLISIVL ILHFMEYTNC QHHGSRHRGN KQVSGVSSQG CQGGCQTCSV YNGCLTCKPK
LFIHLERDGM RQIGVCLASC PNGFYGTRSP DRNDCIKCGS ECDSCFNRNF CLRCRAGSYL
HKGKCMESCP DGLVPSDTKK ECVAACPALC DLCQNSDTCT RCVPGHFLHA GQCHHVCPDE
FEPNDSMECI PTVHCEVSEW SEWGTCSRSG KTCGFKWGEE TRTRKVLQNP SPMGSPCPPT
SEKRECFVKK KRCKPPKGQR RGEKKKRFNL QEKVTAEARR ERKREREKET IDREESENRN
KTEQRRRRDQ SRDAGTV


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