Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

RAC-alpha serine/threonine-protein kinase

 G3H397_CRIGR            Unreviewed;       480 AA.
G3H397;
16-NOV-2011, integrated into UniProtKB/TrEMBL.
16-NOV-2011, sequence version 1.
25-OCT-2017, entry version 40.
SubName: Full=RAC-alpha serine/threonine-protein kinase {ECO:0000313|EMBL:EGV94901.1};
ORFNames=I79_004712 {ECO:0000313|EMBL:EGV94901.1};
Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Cricetidae; Cricetinae; Cricetulus.
NCBI_TaxID=10029 {ECO:0000313|EMBL:EGV94901.1, ECO:0000313|Proteomes:UP000001075};
[1] {ECO:0000313|Proteomes:UP000001075}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
PubMed=21804562; DOI=10.1038/nbt.1932;
Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W.,
Xie M., Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B.,
Koh W., Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J.,
Quake S.R., Famili I., Palsson B.O., Wang J.;
"The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell
line.";
Nat. Biotechnol. 29:735-741(2011).
-!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
{ECO:0000256|SAAS:SAAS00935732}.
-!- SIMILARITY: Belongs to the protein kinase superfamily.
{ECO:0000256|RuleBase:RU000304}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; JH000123; EGV94901.1; -; Genomic_DNA.
RefSeq; XP_003498790.1; XM_003498742.3.
RefSeq; XP_007620726.1; XM_007622536.2.
Ensembl; ENSCGRT00000016091; ENSCGRP00000015855; ENSCGRG00000011507.
GeneID; 100769460; -.
KEGG; cge:100769460; -.
CTD; 207; -.
InParanoid; G3H397; -.
KO; K04456; -.
Proteomes; UP000001075; Unassembled WGS sequence.
GO; GO:0005911; C:cell-cell junction; IEA:Ensembl.
GO; GO:0036064; C:ciliary basal body; IEA:Ensembl.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
GO; GO:0005634; C:nucleus; IEA:Ensembl.
GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
GO; GO:0043234; C:protein complex; IEA:Ensembl.
GO; GO:0005819; C:spindle; IEA:Ensembl.
GO; GO:0031982; C:vesicle; IEA:Ensembl.
GO; GO:0071889; F:14-3-3 protein binding; IEA:Ensembl.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0030235; F:nitric-oxide synthase regulator activity; IEA:Ensembl.
GO; GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IEA:Ensembl.
GO; GO:0043325; F:phosphatidylinositol-3,4-bisphosphate binding; IEA:Ensembl.
GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO; GO:0004712; F:protein serine/threonine/tyrosine kinase activity; IEA:Ensembl.
GO; GO:0006924; P:activation-induced cell death of T cells; IEA:Ensembl.
GO; GO:0008637; P:apoptotic mitochondrial changes; IEA:Ensembl.
GO; GO:0071276; P:cellular response to cadmium ion; IEA:Ensembl.
GO; GO:0036294; P:cellular response to decreased oxygen levels; IEA:Ensembl.
GO; GO:0071364; P:cellular response to epidermal growth factor stimulus; IEA:Ensembl.
GO; GO:0097011; P:cellular response to granulocyte macrophage colony-stimulating factor stimulus; IEA:Ensembl.
GO; GO:1990090; P:cellular response to nerve growth factor stimulus; IEA:Ensembl.
GO; GO:0071380; P:cellular response to prostaglandin E stimulus; IEA:Ensembl.
GO; GO:0034614; P:cellular response to reactive oxygen species; IEA:Ensembl.
GO; GO:0071356; P:cellular response to tumor necrosis factor; IEA:Ensembl.
GO; GO:0035924; P:cellular response to vascular endothelial growth factor stimulus; IEA:Ensembl.
GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; IEA:Ensembl.
GO; GO:0072655; P:establishment of protein localization to mitochondrion; IEA:Ensembl.
GO; GO:0097194; P:execution phase of apoptosis; IEA:Ensembl.
GO; GO:0007281; P:germ cell development; IEA:Ensembl.
GO; GO:0042593; P:glucose homeostasis; IEA:Ensembl.
GO; GO:0006006; P:glucose metabolic process; IEA:Ensembl.
GO; GO:0015758; P:glucose transport; IEA:Ensembl.
GO; GO:0060709; P:glycogen cell differentiation involved in embryonic placenta development; IEA:Ensembl.
GO; GO:0005977; P:glycogen metabolic process; IEA:Ensembl.
GO; GO:0007249; P:I-kappaB kinase/NF-kappaB signaling; IEA:Ensembl.
GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
GO; GO:0008286; P:insulin receptor signaling pathway; IEA:Ensembl.
GO; GO:0048009; P:insulin-like growth factor receptor signaling pathway; IEA:Ensembl.
GO; GO:0035655; P:interleukin-18-mediated signaling pathway; IEA:Ensembl.
GO; GO:0060716; P:labyrinthine layer blood vessel development; IEA:Ensembl.
GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
GO; GO:0072656; P:maintenance of protein location in mitochondrion; IEA:Ensembl.
GO; GO:0001893; P:maternal placenta development; IEA:Ensembl.
GO; GO:0010507; P:negative regulation of autophagy; IEA:Ensembl.
GO; GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Ensembl.
GO; GO:0031999; P:negative regulation of fatty acid beta-oxidation; IEA:Ensembl.
GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
GO; GO:0010748; P:negative regulation of plasma membrane long-chain fatty acid transport; IEA:Ensembl.
GO; GO:0006469; P:negative regulation of protein kinase activity; IEA:Ensembl.
GO; GO:0090201; P:negative regulation of release of cytochrome c from mitochondria; IEA:Ensembl.
GO; GO:0038061; P:NIK/NF-kappaB signaling; IEA:Ensembl.
GO; GO:0001649; P:osteoblast differentiation; IEA:Ensembl.
GO; GO:0018105; P:peptidyl-serine phosphorylation; IEA:Ensembl.
GO; GO:0018107; P:peptidyl-threonine phosphorylation; IEA:Ensembl.
GO; GO:0032287; P:peripheral nervous system myelin maintenance; IEA:Ensembl.
GO; GO:0014065; P:phosphatidylinositol 3-kinase signaling; IEA:Ensembl.
GO; GO:0043536; P:positive regulation of blood vessel endothelial cell migration; IEA:Ensembl.
GO; GO:0030307; P:positive regulation of cell growth; IEA:Ensembl.
GO; GO:0031659; P:positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle; IEA:Ensembl.
GO; GO:0032079; P:positive regulation of endodeoxyribonuclease activity; IEA:Ensembl.
GO; GO:0001938; P:positive regulation of endothelial cell proliferation; IEA:Ensembl.
GO; GO:0045600; P:positive regulation of fat cell differentiation; IEA:Ensembl.
GO; GO:0010763; P:positive regulation of fibroblast migration; IEA:Ensembl.
GO; GO:0046326; P:positive regulation of glucose import; IEA:Ensembl.
GO; GO:0045725; P:positive regulation of glycogen biosynthetic process; IEA:Ensembl.
GO; GO:1903721; P:positive regulation of I-kappaB phosphorylation; IEA:Ensembl.
GO; GO:0046889; P:positive regulation of lipid biosynthetic process; IEA:Ensembl.
GO; GO:0010918; P:positive regulation of mitochondrial membrane potential; IEA:Ensembl.
GO; GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IEA:Ensembl.
GO; GO:0051000; P:positive regulation of nitric-oxide synthase activity; IEA:Ensembl.
GO; GO:0046622; P:positive regulation of organ growth; IEA:Ensembl.
GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:Ensembl.
GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:Ensembl.
GO; GO:1900182; P:positive regulation of protein localization to nucleus; IEA:Ensembl.
GO; GO:1903078; P:positive regulation of protein localization to plasma membrane; IEA:Ensembl.
GO; GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; IEA:Ensembl.
GO; GO:0048661; P:positive regulation of smooth muscle cell proliferation; IEA:Ensembl.
GO; GO:0010765; P:positive regulation of sodium ion transport; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO; GO:0030163; P:protein catabolic process; IEA:Ensembl.
GO; GO:0000060; P:protein import into nucleus, translocation; IEA:Ensembl.
GO; GO:0043491; P:protein kinase B signaling; IEA:Ensembl.
GO; GO:0016567; P:protein ubiquitination; IEA:Ensembl.
GO; GO:0031641; P:regulation of myelination; IEA:Ensembl.
GO; GO:0010975; P:regulation of neuron projection development; IEA:Ensembl.
GO; GO:0034405; P:response to fluid shear stress; IEA:Ensembl.
GO; GO:0032094; P:response to food; IEA:Ensembl.
GO; GO:0060416; P:response to growth hormone; ISS:AgBase.
GO; GO:1990418; P:response to insulin-like growth factor stimulus; ISS:AgBase.
GO; GO:0070141; P:response to UV-A; IEA:Ensembl.
GO; GO:0051146; P:striated muscle cell differentiation; IEA:Ensembl.
CDD; cd05594; STKc_PKB_alpha; 1.
Gene3D; 2.30.29.30; -; 1.
InterPro; IPR000961; AGC-kinase_C.
InterPro; IPR034676; Akt1.
InterPro; IPR011009; Kinase-like_dom.
InterPro; IPR011993; PH_dom-like.
InterPro; IPR001849; PH_domain.
InterPro; IPR017892; Pkinase_C.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR008271; Ser/Thr_kinase_AS.
Pfam; PF00169; PH; 1.
Pfam; PF00069; Pkinase; 1.
Pfam; PF00433; Pkinase_C; 1.
SMART; SM00233; PH; 1.
SMART; SM00133; S_TK_X; 1.
SMART; SM00220; S_TKc; 1.
SUPFAM; SSF50729; SSF50729; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS51285; AGC_KINASE_CTER; 1.
PROSITE; PS50003; PH_DOMAIN; 1.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
3: Inferred from homology;
ATP-binding {ECO:0000256|RuleBase:RU000304,
ECO:0000256|SAAS:SAAS00593399};
Complete proteome {ECO:0000313|Proteomes:UP000001075};
Kinase {ECO:0000256|RuleBase:RU000304, ECO:0000256|SAAS:SAAS00593706};
Nucleotide-binding {ECO:0000256|RuleBase:RU000304,
ECO:0000256|SAAS:SAAS00593399};
Reference proteome {ECO:0000313|Proteomes:UP000001075};
Serine/threonine-protein kinase {ECO:0000256|RuleBase:RU000304,
ECO:0000256|SAAS:SAAS00593706};
Transferase {ECO:0000256|RuleBase:RU000304,
ECO:0000256|SAAS:SAAS00593706}.
DOMAIN 5 108 PH. {ECO:0000259|PROSITE:PS50003}.
DOMAIN 150 408 Protein kinase.
{ECO:0000259|PROSITE:PS50011}.
DOMAIN 409 480 AGC-kinase C-terminal.
{ECO:0000259|PROSITE:PS51285}.
SEQUENCE 480 AA; 55760 MW; 09DF9726D691B7CE CRC64;
MNDVAIVKEG WLHKRGEYIK TWRPRYFLLK NDGTFIGYKE RPQDVEHRES PLNNFSVAQC
QLMKTERPRP NTFIIRCLQW TTVIERTFHV ETPEEREEWT TAIQTVADGL KRQEEETMDF
RSGSPSDNSG AEEMEVSLAK PKHRVTMNEF EYLKLLGKGT FGKVILVKEK ATGRYYAMKI
LKKEVIVAKD EVAHTLTENR VLQNSRHPFL TALKYSFQTH DRLCFVMEYA NGGELFFHLS
RERVFSEDRA RFYGAEIVSA LDYLHSEKNV VYRDLKLENL MLDKDGHIKI TDFGLCKEGI
KDGATMKTFC GTPEYLAPEV LEDNDYGRAV DWWGLGVVMY EMMCGRLPFY NQDHEKLFEL
ILMEEIRFPR TLGPEAKSLL SGLLKKDPTQ RLGGGSEDAK EIMQHRFFAN IVWQDVYEKK
LSPPFKPQVT SETDTRYFDE EFTAQMITIT PPDQDDSMEC VDSERRPHFP QFSYSASGTA


Related products :

Catalog number Product name Quantity
EIAAB31334 Bos taurus,Bovine,PKN,PKN1,PRK1,PRKCL1,Protein kinase C-like 1,Protein kinase C-like PKN,Protein kinase PKN-alpha,Protein-kinase C-related kinase 1,Serine_threonine-protein kinase N1,Serine-threonine
EH532 RAC-alpha serine per threonine-protein kinase Elisa Kit 96T
EM379 RAC-alpha serine per threonine-protein kinase Elisa Kit 96T
ER288 RAC-alpha serine per threonine-protein kinase Elisa Kit 96T
E15051m Rat ELISA Kit FOR Serine per threonine-protein kinase MRCK alpha 96T
G9925 Serine threonine-protein kinase MRCK alpha (CDC42BPA), Rat, ELISA Kit 96T
E0229h Human ELISA Kit FOR Serine per threonine-protein kinase MRCK alpha 96T
CSB-EL001553HU Human RAC-alpha serine per threonine-protein kinase(AKT1) ELISA kit 96T
abx108694 Polyclonal Rabbit RAC-alpha serine per threonine-protein kinase Antibody (HRP) 100 μg
E1983r Mouse ELISA Kit FOR Serine per threonine-protein kinase MRCK alpha 96T
CNGA1_CANFA Human ELISA Kit FOR Serine per threonine-protein kinase MRCK alpha 96T
ISPD_HUMAN Human ELISA Kit FOR Serine per threonine-protein kinase MRCK alpha 96T
G6126 RAC-alpha serine threonine-protein kinase (AKT1), Bovine, ELISA Kit 96T
G6127 RAC-alpha serine threonine-protein kinase (AKT1), Human, ELISA Kit 96T
abx110163 Polyclonal Rabbit RAC-alpha serine per threonine-protein kinase Antibody 100 μg
EIAAB31332 Mouse,Mus musculus,Pkn,Pkn1,Prk1,Prkcl1,Protein kinase C-like 1,Protein kinase C-like PKN,Protein-kinase C-related kinase 1,Serine_threonine-protein kinase N1,Serine-threonine protein kinase N
abx107274 Polyclonal Rabbit RAC-alpha serine per threonine-protein kinase Antibody (FITC) 100 μg
G9923 Serine threonine-protein kinase MRCK alpha (CDC42BPA), Human, ELISA Kit 96T
abx105858 Polyclonal Rabbit RAC-alpha serine per threonine-protein kinase Antibody (Biotin) 100 μg
G9924 Serine threonine-protein kinase MRCK alpha (CDC42BPA), Mouse, ELISA Kit 96T
E0382r ELISA Kit FOR RAC-alpha serine per threonine-protein kinase; organism: Rat; gene name: Akt1 96T
E0382m ELISA Kit FOR RAC-alpha serine per threonine-protein kinase; organism: Mouse; gene name: Akt1 96T
E0382h ELISA Kit FOR RAC-alpha serine per threonine-protein kinase; organism: Human; gene name: AKT1 96T
MRCKA_RAT ELISA Kit FOR Serine per threonine-protein kinase MRCK alpha; organism: Rat; gene name: Cdc42bpa 96T
MRCKA_MOUSE ELISA Kit FOR Serine per threonine-protein kinase MRCK alpha; organism: Mouse; gene name: Cdc42bpa 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur