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RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase Akt-1) (xAkt) (Protein kinase B, alpha) (PKB alpha) (RAC-PK-alpha)

 AKT1_XENLA              Reviewed;         481 AA.
Q98TY9;
21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
01-JUN-2001, sequence version 1.
18-JUL-2018, entry version 109.
RecName: Full=RAC-alpha serine/threonine-protein kinase;
EC=2.7.11.1;
AltName: Full=Protein kinase Akt-1;
Short=xAkt;
AltName: Full=Protein kinase B, alpha;
Short=PKB alpha;
AltName: Full=RAC-PK-alpha;
Name=akt1 {ECO:0000250|UniProtKB:P31750};
Xenopus laevis (African clawed frog).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
Xenopus.
NCBI_TaxID=8355;
[1] {ECO:0000305, ECO:0000312|EMBL:AAG59601.1}
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, ENZYME REGULATION, AND TISSUE
SPECIFICITY.
TISSUE=Oocyte {ECO:0000269|PubMed:12374568};
PubMed=12374568; DOI=10.1042/BJ20021243;
Andersen C.B., Sakaue H., Nedachi T., Kovacina K.S., Clayberger C.,
Conti M., Roth R.A.;
"Protein kinase B/Akt is essential for the insulin- but not
progesterone-stimulated resumption of meiosis in Xenopus oocytes.";
Biochem. J. 369:227-238(2003).
-!- FUNCTION: AKT1 is one of several closely related serine/threonine-
protein kinases known as the AKT kinase, and which regulate many
processes including metabolism, proliferation, cell survival,
growth and angiogenesis. This is mediated through serine and/or
threonine phosphorylation of a range of downstream substrates.
Over 100 substrate candidates have been reported so far, but for
most of them, no isoform specificity has been reported. Signals
downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate
the effects of various growth factors such as platelet-derived
growth factor (PDGF), epidermal growth factor (EGF), insulin and
insulin-like growth factor I (IGF-I). Plays a role as a key
modulator of the AKT-mTOR signaling pathway controlling the tempo
of the process of newborn neurons integration during adult
neurogenesis, including correct neuron positioning, dendritic
development and synapse formation. Plays a role in glucose
transport by mediating insulin-induced translocation of the GLUT4
glucose transporter to the cell surface. Mediates the
antiapoptotic effects of IGF-I. Mediates insulin-stimulated
protein synthesis, partly by playing a role in both insulin-
induced phosphorylation of 4E-BP1 and in insulin-induced
activation of p70 S6 kinase. Promotes glycogen synthesis by
mediating the insulin-induced activation of glycogen synthase (By
similarity). Required for insulin-stimulated meiotic reinitiation
during oocyte maturation. {ECO:0000250,
ECO:0000269|PubMed:12374568}.
-!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
{ECO:0000250|UniProtKB:P31750}.
-!- ENZYME REGULATION: Activated in response to insulin. Three
specific sites, one in the kinase domain (Thr-309) and the two
other ones in the C-terminal regulatory region (Ser-474 and Tyr-
475), need to be phosphorylated for its full activation.
{ECO:0000269|PubMed:12374568}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus
{ECO:0000250}. Note=Nucleus after activation by integrin-linked
protein kinase 1 (ILK1). {ECO:0000250}.
-!- TISSUE SPECIFICITY: Expressed in the oocyte.
{ECO:0000269|PubMed:12374568}.
-!- DOMAIN: Binding of the PH domain to phosphatidylinositol 3,4,5-
trisphosphate (PI(3,4,5)P3) following phosphatidylinositol 3-
kinase alpha (PIK3CA) activity results in its targeting to the
plasma membrane. {ECO:0000250}.
-!- SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr
protein kinase family. RAC subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
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-----------------------------------------------------------------------
EMBL; AF317656; AAG59601.1; -; mRNA.
RefSeq; NP_001083878.1; NM_001090409.2.
UniGene; Xl.738; -.
ProteinModelPortal; Q98TY9; -.
SMR; Q98TY9; -.
GeneID; 399170; -.
KEGG; xla:399170; -.
CTD; 399170; -.
Xenbase; XB-GENE-484957; akt1.
HOVERGEN; HBG108317; -.
KO; K04456; -.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB.
GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
GO; GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.
GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-KW.
GO; GO:0008286; P:insulin receptor signaling pathway; ISS:UniProtKB.
GO; GO:0048009; P:insulin-like growth factor receptor signaling pathway; ISS:UniProtKB.
GO; GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
GO; GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; ISS:UniProtKB.
GO; GO:0090201; P:negative regulation of release of cytochrome c from mitochondria; ISS:UniProtKB.
GO; GO:0001938; P:positive regulation of endothelial cell proliferation; ISS:UniProtKB.
GO; GO:2000010; P:positive regulation of protein localization to cell surface; ISS:UniProtKB.
GO; GO:0006468; P:protein phosphorylation; ISS:UniProtKB.
GO; GO:0042981; P:regulation of apoptotic process; ISS:UniProtKB.
GO; GO:0010975; P:regulation of neuron projection development; ISS:UniProtKB.
CDD; cd01241; PH_PKB; 1.
CDD; cd05594; STKc_PKB_alpha; 1.
Gene3D; 2.30.29.30; -; 1.
InterPro; IPR000961; AGC-kinase_C.
InterPro; IPR034676; Akt1.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR011993; PH-like_dom_sf.
InterPro; IPR001849; PH_domain.
InterPro; IPR039026; PH_PKB.
InterPro; IPR017892; Pkinase_C.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR039027; RAC_alpha/beta.
InterPro; IPR008271; Ser/Thr_kinase_AS.
PANTHER; PTHR24356:SF176; PTHR24356:SF176; 1.
Pfam; PF00169; PH; 1.
Pfam; PF00069; Pkinase; 1.
Pfam; PF00433; Pkinase_C; 1.
SMART; SM00233; PH; 1.
SMART; SM00133; S_TK_X; 1.
SMART; SM00220; S_TKc; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS51285; AGC_KINASE_CTER; 1.
PROSITE; PS50003; PH_DOMAIN; 1.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
2: Evidence at transcript level;
ATP-binding; Carbohydrate metabolism; Cytoplasm; Glucose metabolism;
Glycogen biosynthesis; Glycoprotein; Kinase; Neurogenesis;
Nucleotide-binding; Nucleus; Phosphoprotein;
Serine/threonine-protein kinase; Sugar transport; Transferase;
Transport.
CHAIN 1 481 RAC-alpha serine/threonine-protein
kinase. {ECO:0000305}.
/FTId=PRO_0000223507.
DOMAIN 5 108 PH. {ECO:0000255|PROSITE-
ProRule:PRU00145}.
DOMAIN 151 409 Protein kinase. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
DOMAIN 410 481 AGC-kinase C-terminal.
NP_BIND 157 165 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
ACT_SITE 275 275 Proton acceptor. {ECO:0000255|PROSITE-
ProRule:PRU00159, ECO:0000255|PROSITE-
ProRule:PRU10027}.
BINDING 180 180 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
MOD_RES 309 309 Phosphothreonine; by PDPK1.
{ECO:0000250}.
MOD_RES 474 474 Phosphoserine. {ECO:0000250}.
MOD_RES 475 475 Phosphotyrosine. {ECO:0000250}.
CARBOHYD 127 127 O-linked (GlcNAc) serine. {ECO:0000250}.
CARBOHYD 130 130 O-linked (GlcNAc) serine. {ECO:0000250}.
CARBOHYD 306 306 O-linked (GlcNAc) threonine.
{ECO:0000250}.
CARBOHYD 313 313 O-linked (GlcNAc) threonine.
{ECO:0000250}.
SEQUENCE 481 AA; 56042 MW; FF56CFB9A6454303 CRC64;
MNEVAIVKEG WLHKRGEYIK TWRPRYFLLK SDGTFIGYKE RPQDVDQLET PLNNFSVAKC
QLMKTERPKP NTFIIRCLQW TTVIERTFHV DSPEEREEWI QVIQHVADNL KKQEEEMMEV
RSGDSPSDNS GAEEMEVSHS KPKHKVTMNE FEYLKLLGKG TFGKVILVKE KATGRYYAMK
ILKKEVIVAK DEVAHTLTEN RVLQNSRHPF LTALKYSFQT HDRLCFVMEY ANGGELFFHL
SRERIFSEDR ARFYGAEIVS ALDYLHSEKN VVYRDLKLEN LMLDKDGHIK ITDFGLCKEG
IKDGATMKTF CGTPEYLAPE VLEDNDYGRA VDWWGLGVVM YEMMCGRLPF YNQDHEKLFE
LILMEEIRFP RTLLPEAKSL LSGLLKKDPK QRLGGGPDDA KEIMQHKFFA GIVWQDVYEK
KLVPPFKPQV TSETDTRYFD EEFTAQMITI TPPDQDDNFE FVDNERRPHF PQFSYSASGN
A


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