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RAC-beta serine/threonine-protein kinase

 F8WHG5_MOUSE            Unreviewed;       438 AA.
F8WHG5;
21-SEP-2011, integrated into UniProtKB/TrEMBL.
21-SEP-2011, sequence version 1.
05-DEC-2018, entry version 62.
SubName: Full=RAC-beta serine/threonine-protein kinase {ECO:0000313|Ensembl:ENSMUSP00000083081};
Name=Akt2 {ECO:0000313|Ensembl:ENSMUSP00000083081,
ECO:0000313|MGI:MGI:104874};
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000083081, ECO:0000313|Proteomes:UP000000589};
[1] {ECO:0000313|Ensembl:ENSMUSP00000083081, ECO:0000313|Proteomes:UP000000589}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000083081,
ECO:0000313|Proteomes:UP000000589};
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
Lindblad-Toh K., Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of
the mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
[2] {ECO:0000213|PubMed:21183079}
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
[3] {ECO:0000313|Ensembl:ENSMUSP00000083081}
IDENTIFICATION.
STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000083081};
Ensembl;
Submitted (JUL-2011) to UniProtKB.
-!- CATALYTIC ACTIVITY:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
Evidence={ECO:0000256|SAAS:SAAS00935732};
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EMBL; AC074312; -; NOT_ANNOTATED_CDS; Genomic_DNA.
ProteinModelPortal; F8WHG5; -.
SMR; F8WHG5; -.
MaxQB; F8WHG5; -.
PeptideAtlas; F8WHG5; -.
PRIDE; F8WHG5; -.
Ensembl; ENSMUST00000085917; ENSMUSP00000083081; ENSMUSG00000004056.
MGI; MGI:104874; Akt2.
GeneTree; ENSGT00940000157189; -.
Proteomes; UP000000589; Chromosome 7.
Bgee; ENSMUSG00000004056; Expressed in 236 organ(s), highest expression level in brown adipose tissue.
ExpressionAtlas; F8WHG5; baseline and differential.
GO; GO:0005938; C:cell cortex; IEA:Ensembl.
GO; GO:0032587; C:ruffle membrane; IEA:Ensembl.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO; GO:0090630; P:activation of GTPase activity; IEA:Ensembl.
GO; GO:0071486; P:cellular response to high light intensity; IEA:Ensembl.
GO; GO:0006006; P:glucose metabolic process; IEA:Ensembl.
GO; GO:0008286; P:insulin receptor signaling pathway; IEA:Ensembl.
GO; GO:0065002; P:intracellular protein transmembrane transport; IEA:Ensembl.
GO; GO:0032287; P:peripheral nervous system myelin maintenance; IEA:Ensembl.
GO; GO:0001934; P:positive regulation of protein phosphorylation; IEA:Ensembl.
GO; GO:0090314; P:positive regulation of protein targeting to membrane; IEA:Ensembl.
GO; GO:0031340; P:positive regulation of vesicle fusion; IEA:Ensembl.
GO; GO:0043491; P:protein kinase B signaling; IEA:InterPro.
GO; GO:0072659; P:protein localization to plasma membrane; IEA:Ensembl.
GO; GO:0097473; P:retinal rod cell apoptotic process; IEA:Ensembl.
CDD; cd01241; PH_PKB; 1.
Gene3D; 2.30.29.30; -; 1.
InterPro; IPR000961; AGC-kinase_C.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR011993; PH-like_dom_sf.
InterPro; IPR001849; PH_domain.
InterPro; IPR039026; PH_PKB.
InterPro; IPR017892; Pkinase_C.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR039027; RAC_alpha/beta.
PANTHER; PTHR24356:SF176; PTHR24356:SF176; 2.
Pfam; PF00169; PH; 1.
Pfam; PF00069; Pkinase; 2.
Pfam; PF00433; Pkinase_C; 1.
SMART; SM00233; PH; 1.
SMART; SM00133; S_TK_X; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS51285; AGC_KINASE_CTER; 1.
PROSITE; PS50003; PH_DOMAIN; 1.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
1: Evidence at protein level;
ATP-binding {ECO:0000256|SAAS:SAAS00593399};
Complete proteome {ECO:0000313|Proteomes:UP000000589};
Kinase {ECO:0000256|SAAS:SAAS00593706};
Nucleotide-binding {ECO:0000256|SAAS:SAAS00593399};
Proteomics identification {ECO:0000213|EPD:F8WHG5,
ECO:0000213|MaxQB:F8WHG5, ECO:0000213|PeptideAtlas:F8WHG5};
Reference proteome {ECO:0000313|Proteomes:UP000000589};
Serine/threonine-protein kinase {ECO:0000256|SAAS:SAAS00593706};
Transferase {ECO:0000256|SAAS:SAAS00593706}.
DOMAIN 5 108 PH. {ECO:0000259|PROSITE:PS50003}.
DOMAIN 152 366 Protein kinase.
{ECO:0000259|PROSITE:PS50011}.
DOMAIN 367 438 AGC-kinase C-terminal.
{ECO:0000259|PROSITE:PS51285}.
SEQUENCE 438 AA; 51056 MW; D596E57AFD158D53 CRC64;
MNEVSVIKEG WLHKRGEYIK TWRPRYFLLK SDGSFIGYKE RPEAPDQTLP PLNNFSVAEC
QLMKTERPRP NTFVIRCLQW TTVIERTFHV DSPDEREEWM RAIQMVANSL KQRGPGEDAM
DYKCGSPSDS STSEMMEVAV NKARAKVTMN DFDYLKLLGK GTFGKVILVR EKATGRYYAM
KILRKEVIIA KDEVAHTVTE SRVLQNTRHP FLTALKYAFQ THDRLCFVME YANGGELFFH
LSRERVFTED RARFYGAEIV SALEYLHSRD VVYRDIKVLE DNDYGRAVDW WGLGVVMYEM
MCGRLPFYNQ DHERLFELIL MEEIRFPRTL GPEAKSLLAG LLKKDPKQRL GGGPSDAKEV
MEHRFFLSIN WQDVVQKKLL PPFKPQVTSE VDTRYFDDEF TAQSITITPP DRYDSLDPLE
LDQRTHFPQF SYSASIRE


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