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RB transcriptional corepressor 1
H0ZPQ2_TAEGU Unreviewed; 866 AA.
H0ZPQ2;
22-FEB-2012, integrated into UniProtKB/TrEMBL.
22-FEB-2012, sequence version 1.
28-MAR-2018, entry version 48.
SubName: Full=RB transcriptional corepressor 1 {ECO:0000313|Ensembl:ENSTGUP00000012584};
Name=RB1 {ECO:0000313|Ensembl:ENSTGUP00000012584};
Taeniopygia guttata (Zebra finch) (Poephila guttata).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea;
Estrildidae; Estrildinae; Taeniopygia.
NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000012584, ECO:0000313|Proteomes:UP000007754};
[1] {ECO:0000313|Ensembl:ENSTGUP00000012584, ECO:0000313|Proteomes:UP000007754}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=20360741; DOI=10.1038/nature08819;
Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C.,
London S.E., Li Y., Lin Y.C., George J., Sweedler J., Southey B.,
Gunaratne P., Watson M., Nam K., Backstrom N., Smeds L., Nabholz B.,
Itoh Y., Whitney O., Pfenning A.R., Howard J., Volker M.,
Skinner B.M., Griffin D.K., Ye L., McLaren W.M., Flicek P.,
Quesada V., Velasco G., Lopez-Otin C., Puente X.S., Olender T.,
Lancet D., Smit A.F., Hubley R., Konkel M.K., Walker J.A.,
Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z., Eichler E.E.,
Stapley J., Slate J., Ekblom R., Birkhead T., Burke T., Burt D.,
Scharff C., Adam I., Richard H., Sultan M., Soldatov A., Lehrach H.,
Edwards S.V., Yang S.P., Li X., Graves T., Fulton L., Nelson J.,
Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
"The genome of a songbird.";
Nature 464:757-762(2010).
[2] {ECO:0000313|Ensembl:ENSTGUP00000012584}
IDENTIFICATION.
Ensembl;
Submitted (JAN-2012) to UniProtKB.
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EMBL; ABQF01007189; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ABQF01007190; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ABQF01007191; -; NOT_ANNOTATED_CDS; Genomic_DNA.
STRING; 59729.ENSTGUP00000012584; -.
Ensembl; ENSTGUT00000012723; ENSTGUP00000012584; ENSTGUG00000012205.
eggNOG; KOG1010; Eukaryota.
eggNOG; ENOG410XQF7; LUCA.
GeneTree; ENSGT00530000063235; -.
InParanoid; H0ZPQ2; -.
OMA; TNILQYA; -.
OrthoDB; EOG091G0398; -.
TreeFam; TF105568; -.
Reactome; R-TGU-113501; Inhibition of replication initiation of damaged DNA by RB1/E2F1.
Reactome; R-TGU-2299718; Condensation of Prophase Chromosomes.
Reactome; R-TGU-69231; Cyclin D associated events in G1.
Proteomes; UP000007754; Chromosome 1.
GO; GO:0008024; C:cyclin/CDK positive transcription elongation factor complex; IEA:Ensembl.
GO; GO:0016605; C:PML body; IEA:Ensembl.
GO; GO:0035189; C:Rb-E2F complex; IEA:Ensembl.
GO; GO:0005819; C:spindle; IEA:Ensembl.
GO; GO:0001047; F:core promoter binding; IEA:Ensembl.
GO; GO:0097718; F:disordered domain specific binding; IEA:Ensembl.
GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
GO; GO:0061676; F:importin-alpha family protein binding; IEA:Ensembl.
GO; GO:0019900; F:kinase binding; IEA:Ensembl.
GO; GO:0051219; F:phosphoprotein binding; IEA:Ensembl.
GO; GO:0001102; F:RNA polymerase II activating transcription factor binding; IEA:Ensembl.
GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:Ensembl.
GO; GO:0007050; P:cell cycle arrest; IEA:Ensembl.
GO; GO:0051301; P:cell division; IEA:Ensembl.
GO; GO:0048667; P:cell morphogenesis involved in neuron differentiation; IEA:Ensembl.
GO; GO:0071466; P:cellular response to xenobiotic stimulus; IEA:Ensembl.
GO; GO:0048565; P:digestive tract development; IEA:Ensembl.
GO; GO:0043353; P:enucleate erythrocyte differentiation; IEA:Ensembl.
GO; GO:0034349; P:glial cell apoptotic process; IEA:Ensembl.
GO; GO:0097284; P:hepatocyte apoptotic process; IEA:Ensembl.
GO; GO:0034088; P:maintenance of mitotic sister chromatid cohesion; IEA:Ensembl.
GO; GO:0045445; P:myoblast differentiation; IEA:Ensembl.
GO; GO:0050680; P:negative regulation of epithelial cell proliferation; IEA:Ensembl.
GO; GO:2000134; P:negative regulation of G1/S transition of mitotic cell cycle; IEA:Ensembl.
GO; GO:0006469; P:negative regulation of protein kinase activity; IEA:Ensembl.
GO; GO:0045879; P:negative regulation of smoothened signaling pathway; IEA:Ensembl.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0071930; P:negative regulation of transcription involved in G1/S transition of mitotic cell cycle; IEA:Ensembl.
GO; GO:0051402; P:neuron apoptotic process; IEA:Ensembl.
GO; GO:0042551; P:neuron maturation; IEA:Ensembl.
GO; GO:0031175; P:neuron projection development; IEA:Ensembl.
GO; GO:0045651; P:positive regulation of macrophage differentiation; IEA:Ensembl.
GO; GO:0045842; P:positive regulation of mitotic metaphase/anaphase transition; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:2000679; P:positive regulation of transcription regulatory region DNA binding; IEA:Ensembl.
GO; GO:0071459; P:protein localization to chromosome, centromeric region; IEA:Ensembl.
GO; GO:0007265; P:Ras protein signal transduction; IEA:Ensembl.
GO; GO:0001558; P:regulation of cell growth; IEA:Ensembl.
GO; GO:0071922; P:regulation of cohesin loading; IEA:Ensembl.
GO; GO:0043550; P:regulation of lipid kinase activity; IEA:Ensembl.
GO; GO:0031134; P:sister chromatid biorientation; IEA:Ensembl.
GO; GO:0035914; P:skeletal muscle cell differentiation; IEA:Ensembl.
GO; GO:0051146; P:striated muscle cell differentiation; IEA:Ensembl.
GO; GO:0001894; P:tissue homeostasis; IEA:Ensembl.
InterPro; IPR013763; Cyclin-like.
InterPro; IPR036915; Cyclin-like_sf.
InterPro; IPR033057; RB1.
InterPro; IPR002720; RB_A.
InterPro; IPR002719; RB_B.
InterPro; IPR015030; RB_C.
InterPro; IPR028309; RB_fam.
InterPro; IPR024599; RB_N.
PANTHER; PTHR13742; PTHR13742; 1.
PANTHER; PTHR13742:SF17; PTHR13742:SF17; 1.
Pfam; PF11934; DUF3452; 1.
Pfam; PF01858; RB_A; 1.
Pfam; PF01857; RB_B; 1.
Pfam; PF08934; Rb_C; 1.
SMART; SM00385; CYCLIN; 1.
SMART; SM01367; DUF3452; 1.
SMART; SM01368; RB_A; 1.
SMART; SM01369; Rb_C; 1.
SUPFAM; SSF47954; SSF47954; 2.
4: Predicted;
Complete proteome {ECO:0000313|Proteomes:UP000007754};
Reference proteome {ECO:0000313|Proteomes:UP000007754}.
DOMAIN 21 173 DUF3452. {ECO:0000259|SMART:SM01367}.
DOMAIN 319 521 RB_A. {ECO:0000259|SMART:SM01368}.
DOMAIN 608 709 CYCLIN. {ECO:0000259|SMART:SM00385}.
DOMAIN 716 866 Rb_C. {ECO:0000259|SMART:SM01369}.
SEQUENCE 866 AA; 99226 MW; 58956262CBB26CE6 CRC64;
CDALKVSESV RERAWKTYES LSAADGALAC NTKKKETWGV CIFIVAIDLD EVTFTFTELL
KSINMSVCTF FQFLKEVDVN MDTVSTKVDS TVSRLKKKYD VLFALYHKFE RTCGLIYLEQ
PSSEISAELS SILVLKNYWI TFLLAKGKVL QVEDDLVISF QLLLCVLDYF IKLSPPAMLK
EPYKSSVSAV TVNGSARTPR RGQNRSSRTA KQLDTDTKII EILCKEHDCN LDEVKNVYFT
SFIPFLNSAS ILASNGLPEV EVILKQYDEL YVKNKDIDAR LFLNHDETLQ PDVRACSQLE
RTPVKNNPDE EINIILPQTP VRAAMNNIQQ LIMILNSATD KPSDTLIKYF NNCTVNPKDS
ILKRVESFDH IFKKKFAEAV GQGWAETGSQ RYKLGVRLYY RVMESMLKSE EERLSVQNFS
KLLNDNIFHT SLLACALEVV MATYGRNASQ SDNTSAETDL SFPWILNVFD LKAFDFYKVI
ESFIRAEPSL TREMIKHLEH CEHRIMESLA WQSGSPLFDR IKESKEREGQ TDQPEPTSTP
NMPFQHNHTA ADLYLSPVKS PKKKASGPPL SATSPPDAQP AVTPQTQKVQ KSTSLSLFYK
KVYLLAYRRL HTLFLHLLSE HPELEPLIWT LFQHTLQNEY ELMRDRHLDQ IMMCSMYGIC
KVKNVDLQFK MIVSAYKELC NTNQETFKRV LIREEKYDSI IVFYNLVFMQ KLKTNILQYA
SSRPPTLSPI PHIPRSPYQF SNSPRRVPAG NNIYISPLKS PYKFSDGFQS PTKMTPRSRI
LVSIGESFGT YEKFQKINQM MCNSEYQLKR CAEAGAAAPK PLKRLRFDIE GTDEADGSKH
LPQESKFQQK LAERTSTRTR MQKQKL
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Pathways :
WP100: Glutathione metabolism
WP1016: Wnt Signaling Pathway
WP1039: Glutathione metabolism
WP104: Alanine and aspartate metabolism
WP1056: Complement and Coagulation Cascades
WP106: Alanine and aspartate metabolism
WP1126: Tryptophan metabolism
WP1135: Wnt Signaling Pathway
WP1172: Complement and Coagulation Cascades
WP1313: Insulin Signaling
WP1315: IL-5 Signaling Pathway
WP1318: Eicosanoid Synthesis
WP1321: Myometrial Relaxation and Contraction Pathways
WP1323: EGFR1 Signaling Pathway
WP1330: estrogen signalling
WP1331: Adipogenesis
WP1333: Hypothetical Network for Drug Addiction
WP1337: MAPK signaling pathway
WP1338: Peptide GPCRs
WP1339: Electron Transport Chain
WP1345: T Cell Receptor Signaling Pathway
WP1347: Triacylglyceride Synthesis
WP1349: Wnt Signaling Pathway
WP1350: Type II interferon signaling (IFNG)
WP1351: Apoptosis
Related Genes :
[43] DNA-directed DNA polymerase (EC 2.7.7.7) (EC 3.1.11.-) (Gp43)
[RB1] Retinoblastoma-associated protein (p105-Rb) (pRb) (Rb) (pp110)
[Rb1 Rb-1] Retinoblastoma-associated protein (pRb) (Rb) (pp105)
[Rb1 Rb-1] Retinoblastoma-associated protein (pRb) (Rb) (pp105)
[RB1CC1 KIAA0203 RBICC] RB1-inducible coiled-coil protein 1 (FAK family kinase-interacting protein of 200 kDa) (FIP200)
[Rb1cc1 Cc1 Kiaa0203] RB1-inducible coiled-coil protein 1 (Coiled-coil-forming protein 1) (FAK family kinase-interacting protein of 200 kDa) (FIP200) (LaXp180)
[RBAK ZNF769] RB-associated KRAB zinc finger protein (RB-associated KRAB repressor) (hRBaK) (Zinc finger protein 769)
[RB1 CK820_G0031644] RB transcriptional corepressor 1 (RB1 isoform 1) (Retinoblastoma 1)
[RB1] RB transcriptional corepressor 1
[RB1] RB transcriptional corepressor 1
[RB1] RB transcriptional corepressor 1
[RB1] RB transcriptional corepressor 1
[RB1] RB transcriptional corepressor 1
[RB1] RB transcriptional corepressor 1
[RB1] RB transcriptional corepressor 1
[RB1] RB transcriptional corepressor 1
[RB1] RB transcriptional corepressor 1
[RB1] RB transcriptional corepressor 1
[RB1] RB transcriptional corepressor 1
[RB1] RB transcriptional corepressor 1
[RB1] RB transcriptional corepressor 1
[RB1] RB transcriptional corepressor 1
[RB1] RB transcriptional corepressor 1
[RB1] RB transcriptional corepressor 1
[RB1] RB transcriptional corepressor 1
[BB4091] D-glycero-beta-D-manno-heptose-1,7-bisphosphate 7-phosphatase (EC 3.1.3.82) (D,D-heptose 1,7-bisphosphate phosphatase) (HBP phosphatase)
[RB1] RB transcriptional corepressor 1
[RB1] RB transcriptional corepressor 1
[RB1] RB transcriptional corepressor 1
[RB1] RB transcriptional corepressor 1
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