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RH-like protein (Rhesus-like protein)

 RHL_MACMU               Reviewed;         417 AA.
Q28849;
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
23-JAN-2007, sequence version 2.
10-MAY-2017, entry version 69.
RecName: Full=RH-like protein;
AltName: Full=Rhesus-like protein;
Macaca mulatta (Rhesus macaque).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
NCBI_TaxID=9544;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Bone marrow;
PubMed=7909570; DOI=10.1007/BF00166163;
Mouro I., le van Kim C., Cherif-Zahar B., Salvignol I., Blancher A.,
Cartron J.-P., Colin Y.;
"Molecular characterization of the Rh-like locus and gene transcripts
from the rhesus monkey (Macaca mulatta).";
J. Mol. Evol. 38:169-176(1994).
-!- FUNCTION: May be part of an oligomeric complex which is likely to
have a transport or channel function in the erythrocyte membrane.
-!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
-!- SIMILARITY: Belongs to the ammonium transporter (TC 2.A.49)
family. Rh subfamily. {ECO:0000305}.
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EMBL; S70343; AAB30637.1; -; mRNA.
RefSeq; NP_001028136.3; NM_001032964.3.
UniGene; Mmu.3395; -.
ProteinModelPortal; Q28849; -.
GeneID; 613023; -.
KEGG; mcc:613023; -.
CTD; 6006; -.
HOVERGEN; HBG004374; -.
KO; K06579; -.
Proteomes; UP000006718; Unplaced.
GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO; GO:0008519; F:ammonium transmembrane transporter activity; IBA:GO_Central.
GO; GO:0072488; P:ammonium transmembrane transport; IBA:GO_Central.
GO; GO:0015695; P:organic cation transport; IBA:GO_Central.
InterPro; IPR024041; NH4_transpt_AmtB-like_dom.
InterPro; IPR002229; RhesusRHD.
Pfam; PF00909; Ammonium_transp; 1.
PRINTS; PR00342; RHESUSRHD.
SUPFAM; SSF111352; SSF111352; 1.
2: Evidence at transcript level;
Complete proteome; Membrane; Polymorphism; Reference proteome;
Transmembrane; Transmembrane helix.
CHAIN 1 417 RH-like protein.
/FTId=PRO_0000168195.
TRANSMEM 12 32 Helical. {ECO:0000255}.
TRANSMEM 44 64 Helical. {ECO:0000255}.
TRANSMEM 77 97 Helical. {ECO:0000255}.
TRANSMEM 125 145 Helical. {ECO:0000255}.
TRANSMEM 172 192 Helical. {ECO:0000255}.
TRANSMEM 203 223 Helical. {ECO:0000255}.
TRANSMEM 238 258 Helical. {ECO:0000255}.
TRANSMEM 265 285 Helical. {ECO:0000255}.
TRANSMEM 287 307 Helical. {ECO:0000255}.
TRANSMEM 331 351 Helical. {ECO:0000255}.
TRANSMEM 358 378 Helical. {ECO:0000255}.
VARIANT 2 56 Missing (in Mac-B).
VARIANT 71 71 R -> K (in Mac-B).
VARIANT 107 107 A -> V (in Mac-B).
VARIANT 192 192 P -> L (in Mac-B).
VARIANT 262 262 G -> R (in Mac-B).
VARIANT 343 343 Y -> C (in Mac-B).
SEQUENCE 417 AA; 45803 MW; CE54577BBBE433AF CRC64;
MSSKYPRSVR CCLPLWALTL EAALILLFFF FTYYDASLED QKGLVASYQV CQDLTVMAVL
GLGFFTSNLR RNSWSSVAFN LFLLALGVQW AILLDGFLSQ FSPGKVAIKL FSIRLATRST
MSMLISMNAV LGKVNLVQLV VMELVELTVF GTMRIVINNI FKIDYGMNMM HIHVFAAYFG
LTVAWCLPKP LPKGTEDKYQ TTTSPSLFAM LGTLFLWMFW PTFNSALLLN PIERKNAVFS
TYYALAVSAV TAISVSSLAH PGGKINMTYM HNAALAGGVA LSASCHVIHS PWIAMVLGLV
AGLISIGGAK CLPVCFNRVL GIHESHSVHY TFGLPALLGE ITYIVLMALR VVWASSNMIG
FQVLLSTGTL SLAMAMSITS GLLTGLLLNL KIWKGPHVAK YFDDQAFWEF PHLAVGF


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