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RISC-loading complex subunit TARBP2

 M3W8A9_FELCA            Unreviewed;       366 AA.
M3W8A9;
01-MAY-2013, integrated into UniProtKB/TrEMBL.
01-MAY-2013, sequence version 1.
25-OCT-2017, entry version 38.
RecName: Full=RISC-loading complex subunit TARBP2 {ECO:0000256|HAMAP-Rule:MF_03034};
Name=TARBP2 {ECO:0000256|HAMAP-Rule:MF_03034,
ECO:0000313|Ensembl:ENSFCAP00000007182};
Felis catus (Cat) (Felis silvestris catus).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;
Felinae; Felis.
NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000007182, ECO:0000313|Proteomes:UP000011712};
[1] {ECO:0000313|Ensembl:ENSFCAP00000007182, ECO:0000313|Proteomes:UP000011712}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000007182,
ECO:0000313|Proteomes:UP000011712};
PubMed=17975172; DOI=10.1101/gr.6380007;
Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N.,
Schaffer A.A., Agarwala R., Narfstrom K., Murphy W.J., Giger U.,
Roca A.L., Antunes A., Menotti-Raymond M., Yuhki N.,
Pecon-Slattery J., Johnson W.E., Bourque G., Tesler G., O'Brien S.J.;
"Initial sequence and comparative analysis of the cat genome.";
Genome Res. 17:1675-1689(2007).
[2] {ECO:0000313|Ensembl:ENSFCAP00000007182}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000007182};
Hillier L.W., Warren W., Obrien S., Wilson R.K.;
"Sequence assembly of the Felis catus genome version 6.2.";
Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
[3] {ECO:0000313|Ensembl:ENSFCAP00000007182}
IDENTIFICATION.
STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000007182};
Ensembl;
Submitted (MAR-2013) to UniProtKB.
-!- FUNCTION: Required for formation of the RNA induced silencing
complex (RISC). Component of the RISC loading complex (RLC), also
known as the micro-RNA (miRNA) loading complex (miRLC), which is
composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1
and TARBP2 are required to process precursor miRNAs (pre-miRNAs)
to mature miRNAs and then load them onto AGO2. AGO2 bound to the
mature miRNA constitutes the minimal RISC and may subsequently
dissociate from DICER1 and TARBP2. May also play a role in the
production of short interfering RNAs (siRNAs) from double-stranded
RNA (dsRNA) by DICER1. {ECO:0000256|HAMAP-Rule:MF_03034}.
-!- SUBUNIT: Self-associates. Component of the RISC loading complex
(RLC), or micro-RNA (miRNA) loading complex (miRLC), which is
composed of DICER1, AGO2 and TARBP2. Note that the trimeric
RLC/miRLC is also referred to as RISC. Interacts with EIF2AK2/PKR
and inhibits its protein kinase activity. Interacts with DHX9 and
PRKRA. Interacts with DICER1, AGO2, MOV10, EIF6 and RPL7A (60S
ribosome subunit); they form a large RNA-induced silencing complex
(RISC). {ECO:0000256|HAMAP-Rule:MF_03034}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03034}.
Cytoplasm, perinuclear region {ECO:0000256|HAMAP-Rule:MF_03034}.
Nucleus {ECO:0000256|HAMAP-Rule:MF_03034}.
-!- SIMILARITY: Belongs to the TARBP2 family. {ECO:0000256|HAMAP-
Rule:MF_03034}.
-!- CAUTION: The sequence shown here is derived from an Ensembl
automatic analysis pipeline and should be considered as
preliminary data. {ECO:0000313|Ensembl:ENSFCAP00000007182}.
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EMBL; AANG02082742; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AANG02082743; -; NOT_ANNOTATED_CDS; Genomic_DNA.
RefSeq; XP_003988820.1; XM_003988771.4.
STRING; 9685.ENSFCAP00000007182; -.
Ensembl; ENSFCAT00000007759; ENSFCAP00000007182; ENSFCAG00000007757.
GeneID; 101087415; -.
KEGG; fca:101087415; -.
CTD; 6895; -.
eggNOG; KOG3732; Eukaryota.
eggNOG; ENOG410XSCK; LUCA.
GeneTree; ENSGT00900000141030; -.
InParanoid; M3W8A9; -.
KO; K18420; -.
OMA; PMEVQPP; -.
OrthoDB; EOG091G0I2L; -.
Proteomes; UP000011712; Chromosome B4.
Bgee; ENSFCAG00000007757; -.
GO; GO:0035068; C:micro-ribonucleoprotein complex; IEA:Ensembl.
GO; GO:0016604; C:nuclear body; IEA:Ensembl.
GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0016442; C:RISC complex; IEA:UniProtKB-UniRule.
GO; GO:0070578; C:RISC-loading complex; IEA:Ensembl.
GO; GO:0003725; F:double-stranded RNA binding; IEA:Ensembl.
GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
GO; GO:0035198; F:miRNA binding; IEA:UniProtKB-UniRule.
GO; GO:0070883; F:pre-miRNA binding; IEA:Ensembl.
GO; GO:0042803; F:protein homodimerization activity; IEA:UniProtKB-UniRule.
GO; GO:0047485; F:protein N-terminus binding; IEA:Ensembl.
GO; GO:0035197; F:siRNA binding; IEA:UniProtKB-UniRule.
GO; GO:0035280; P:miRNA loading onto RISC involved in gene silencing by miRNA; IEA:UniProtKB-UniRule.
GO; GO:0035264; P:multicellular organism growth; IEA:Ensembl.
GO; GO:0050689; P:negative regulation of defense response to virus by host; IEA:Ensembl.
GO; GO:0045727; P:positive regulation of translation; IEA:Ensembl.
GO; GO:0045070; P:positive regulation of viral genome replication; IEA:Ensembl.
GO; GO:0031054; P:pre-miRNA processing; IEA:UniProtKB-UniRule.
GO; GO:0030422; P:production of siRNA involved in RNA interference; IEA:UniProtKB-UniRule.
GO; GO:0046782; P:regulation of viral transcription; IEA:Ensembl.
GO; GO:0007338; P:single fertilization; IEA:Ensembl.
GO; GO:0035087; P:siRNA loading onto RISC involved in RNA interference; IEA:Ensembl.
GO; GO:0007286; P:spermatid development; IEA:Ensembl.
GO; GO:0030423; P:targeting of mRNA for destruction involved in RNA interference; IEA:UniProtKB-UniRule.
HAMAP; MF_03034; TRBP2; 1.
InterPro; IPR014720; dsRBD_dom.
InterPro; IPR028605; TRBP2.
PANTHER; PTHR10910:SF61; PTHR10910:SF61; 1.
Pfam; PF00035; dsrm; 2.
SMART; SM00358; DSRM; 3.
PROSITE; PS50137; DS_RBD; 3.
3: Inferred from homology;
Complete proteome {ECO:0000313|Proteomes:UP000011712};
Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03034};
Nucleus {ECO:0000256|HAMAP-Rule:MF_03034};
Reference proteome {ECO:0000313|Proteomes:UP000011712};
RNA-binding {ECO:0000256|HAMAP-Rule:MF_03034, ECO:0000256|PROSITE-
ProRule:PRU00266};
RNA-mediated gene silencing {ECO:0000256|HAMAP-Rule:MF_03034};
Translation regulation {ECO:0000256|HAMAP-Rule:MF_03034}.
DOMAIN 30 97 DRBM. {ECO:0000259|PROSITE:PS50137}.
DOMAIN 159 227 DRBM. {ECO:0000259|PROSITE:PS50137}.
DOMAIN 293 361 DRBM. {ECO:0000259|PROSITE:PS50137}.
REGION 22 105 Sufficient for interaction with PRKRA.
{ECO:0000256|HAMAP-Rule:MF_03034}.
REGION 152 234 Sufficient for interaction with PRKRA.
{ECO:0000256|HAMAP-Rule:MF_03034}.
REGION 228 366 Sufficient for interaction with DICER1.
{ECO:0000256|HAMAP-Rule:MF_03034}.
REGION 287 366 Sufficient for interaction with PRKRA.
{ECO:0000256|HAMAP-Rule:MF_03034}.
SEQUENCE 366 AA; 38799 MW; 64B0D12F177FB844 CRC64;
MSEEEQGSGT TTGCGLPSIE QMLAANPGKT PISLLQEYGT RIGKTPVYDL LKAEGQAHQP
NFTFRVTVGD TSCTGQGPSK KAAKHKAAEV ALKHLKGGSM LEPALEDSSS FSPLDSSLPE
DIPVFTAAVA ATPVPSAVPT RSPPMEVQPP VSPQQSECNP VGALQELVVQ KGWRLPEYTV
TQESGPAHRK EFTMTCRVER FVEIGSGTSK KLAKRNAAAK MLLRVHTVPL DARDGNEAEP
DDDHFSIGVG SRLDGLRNRG PGCTWDSLRN SVGEKILSLR SCSLGALGAL GPACCSVLSE
LSEEQAFHVS YLDIEELSLS GLCQCLVELS TQPATVCHGS AATREAARGE AACRALQYLK
IMAGSK


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