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RNA-binding motif protein, Y chromosome, family 1 member F/J (Y chromosome RNA recognition motif 2)

 RBY1F_HUMAN             Reviewed;         496 AA.
Q15415; B2R916;
15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
15-JAN-2008, sequence version 2.
25-OCT-2017, entry version 141.
RecName: Full=RNA-binding motif protein, Y chromosome, family 1 member F/J;
AltName: Full=Y chromosome RNA recognition motif 2;
Name=RBMY1F; Synonyms=YRRM2;
and
Name=RBMY1J;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, AND TISSUE
SPECIFICITY.
TISSUE=Testis;
PubMed=8269511; DOI=10.1016/0092-8674(93)90616-X;
Ma K., Inglis J.D., Sharkey A., Bickmore W.A., Hill R.E.,
Prosser E.J., Speedson R.M., Thomson E.J., Jobling M.;
"A Y chromosome gene family with RNA-binding protein homology:
candidates for the azoospermia factor AZF controlling human
spermatogenesis.";
Cell 75:1287-1295(1993).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Testis;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=12815422; DOI=10.1038/nature01722;
Skaletsky H., Kuroda-Kawaguchi T., Minx P.J., Cordum H.S.,
Hillier L.W., Brown L.G., Repping S., Pyntikova T., Ali J., Bieri T.,
Chinwalla A., Delehaunty A., Delehaunty K., Du H., Fewell G.,
Fulton L., Fulton R., Graves T.A., Hou S.-F., Latrielle P.,
Leonard S., Mardis E., Maupin R., McPherson J., Miner T., Nash W.,
Nguyen C., Ozersky P., Pepin K., Rock S., Rohlfing T., Scott K.,
Schultz B., Strong C., Tin-Wollam A., Yang S.-P., Waterston R.H.,
Wilson R.K., Rozen S., Page D.C.;
"The male-specific region of the human Y chromosome is a mosaic of
discrete sequence classes.";
Nature 423:825-837(2003).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Testis;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
-!- FUNCTION: RNA-binding protein which may be involved in
spermatogenesis. Required for sperm development, possibly by
participating in pre-mRNA splicing in the testis.
{ECO:0000269|PubMed:8269511}.
-!- SUBUNIT: Interacts with splicing factor proteins SFRS3/SRP20,
TRA2B/SFRS10, KHDRBS1/SAM68 and KHDRBS3.
-!- INTERACTION:
Self; NbExp=3; IntAct=EBI-8642021, EBI-8642021;
Q8WTP8:AEN; NbExp=3; IntAct=EBI-8642021, EBI-8637627;
Q9NRW3:APOBEC3C; NbExp=5; IntAct=EBI-8642021, EBI-1044593;
Q14781:CBX2; NbExp=3; IntAct=EBI-8642021, EBI-745934;
Q14011:CIRBP; NbExp=3; IntAct=EBI-8642021, EBI-538850;
P49761:CLK3; NbExp=3; IntAct=EBI-8642021, EBI-745579;
Q9BTL3:FAM103A1; NbExp=3; IntAct=EBI-8642021, EBI-744023;
P61978:HNRNPK; NbExp=4; IntAct=EBI-8642021, EBI-304185;
P61978-2:HNRNPK; NbExp=4; IntAct=EBI-8642021, EBI-7060731;
Q8TBB1:LNX1; NbExp=4; IntAct=EBI-8642021, EBI-739832;
Q9Y5E9:PCDHB14; NbExp=7; IntAct=EBI-8642021, EBI-10329013;
Q8WWY3:PRPF31; NbExp=12; IntAct=EBI-8642021, EBI-1567797;
P79522:PRR3; NbExp=5; IntAct=EBI-8642021, EBI-2803328;
Q9Y272:RASD1; NbExp=5; IntAct=EBI-8642021, EBI-740818;
P98179:RBM3; NbExp=7; IntAct=EBI-8642021, EBI-2949699;
P38159:RBMX; NbExp=7; IntAct=EBI-8642021, EBI-743526;
P0DJD3-2:RBMY1A1; NbExp=4; IntAct=EBI-8642021, EBI-11994018;
P09012:SNRPA; NbExp=4; IntAct=EBI-8642021, EBI-607085;
P62995:TRA2B; NbExp=4; IntAct=EBI-8642021, EBI-725485;
Q96MU7:YTHDC1; NbExp=5; IntAct=EBI-8642021, EBI-2849854;
Q96PQ6:ZNF317; NbExp=4; IntAct=EBI-8642021, EBI-1210473;
Q66K41:ZNF385C; NbExp=3; IntAct=EBI-8642021, EBI-10219231;
Q96EG3:ZNF837; NbExp=4; IntAct=EBI-8642021, EBI-11962574;
-!- SUBCELLULAR LOCATION: Nucleus.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=Q15415-1; Sequence=Displayed;
Name=2;
IsoId=Q15415-2; Sequence=VSP_030217, VSP_030218;
-!- TISSUE SPECIFICITY: Testis-specific. {ECO:0000269|PubMed:8269511}.
-!- DEVELOPMENTAL STAGE: Expressed in all of the transcriptionally
active stages of germ cell development from spermatogonia through
spermatocytes to round spermatids.
-!- MISCELLANEOUS: The RBMY1 proteins are encoded by repeated regions
of the Y chromosome, mostly within the AZFb region. The exact
number of functional copies is unclear and may vary between
individuals, and some of them may represent pseudogenes. The
proteins are very similar, which makes the characterization of
each protein difficult. Thus, most experiments do not discriminate
between the different members. One can therefore suppose that
reported interactions with a RBMY1 protein involve all the
proteins.
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EMBL; X76060; CAA53660.1; -; mRNA.
EMBL; AK313597; BAG36363.1; -; mRNA.
EMBL; AC023342; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AC007320; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC030018; AAH30018.1; -; mRNA.
EMBL; BC152392; AAI52393.1; -; mRNA.
CCDS; CCDS35483.1; -. [Q15415-1]
CCDS; CCDS35484.1; -. [Q15415-1]
PIR; B49418; B49418.
RefSeq; NP_001006117.2; NM_001006117.3. [Q15415-1]
RefSeq; NP_001290339.1; NM_001303410.1. [Q15415-2]
RefSeq; NP_689798.1; NM_152585.2. [Q15415-1]
UniGene; Hs.380450; -.
UniGene; Hs.567746; -.
ProteinModelPortal; Q15415; -.
SMR; Q15415; -.
BioGrid; 127736; 17.
IntAct; Q15415; 36.
STRING; 9606.ENSP00000307155; -.
iPTMnet; Q15415; -.
PhosphoSitePlus; Q15415; -.
BioMuta; RBMY1F; -.
DMDM; 166199747; -.
PaxDb; Q15415; -.
PeptideAtlas; Q15415; -.
PRIDE; Q15415; -.
DNASU; 159163; -.
DNASU; 378951; -.
Ensembl; ENST00000250831; ENSP00000250831; ENSG00000226941. [Q15415-1]
Ensembl; ENST00000303766; ENSP00000307155; ENSG00000169800. [Q15415-1]
GeneID; 159163; -.
GeneID; 378951; -.
KEGG; hsa:159163; -.
KEGG; hsa:378951; -.
UCSC; uc004fva.4; human. [Q15415-1]
CTD; 159163; -.
CTD; 378951; -.
EuPathDB; HostDB:ENSG00000169800.13; -.
EuPathDB; HostDB:ENSG00000226941.7; -.
GeneCards; RBMY1F; -.
GeneCards; RBMY1J; -.
HGNC; HGNC:23974; RBMY1F.
HGNC; HGNC:23917; RBMY1J.
HPA; HPA001534; -.
HPA; HPA053147; -.
MIM; 400006; gene.
neXtProt; NX_Q15415; -.
PharmGKB; PA134946298; -.
eggNOG; ENOG410J6JX; Eukaryota.
eggNOG; ENOG4111GI6; LUCA.
GeneTree; ENSGT00710000106295; -.
HOGENOM; HOG000276235; -.
HOVERGEN; HBG063314; -.
InParanoid; Q15415; -.
OMA; AAREYEN; -.
OrthoDB; EOG091G13K0; -.
PhylomeDB; Q15415; -.
TreeFam; TF331833; -.
PRO; PR:Q15415; -.
Proteomes; UP000005640; Chromosome Y.
Bgee; ENSG00000169800; -.
CleanEx; HS_RBMY1F; -.
ExpressionAtlas; Q15415; baseline.
Genevisible; Q15415; HS.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0042802; F:identical protein binding; IPI:IntAct.
GO; GO:0003723; F:RNA binding; NAS:UniProtKB.
GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
GO; GO:0007283; P:spermatogenesis; NAS:UniProtKB.
InterPro; IPR035979; RBD_domain_sf.
InterPro; IPR012604; RBM1CTR.
InterPro; IPR000504; RRM_dom.
Pfam; PF08081; RBM1CTR; 1.
Pfam; PF00076; RRM_1; 1.
SMART; SM00360; RRM; 1.
SUPFAM; SSF54928; SSF54928; 1.
PROSITE; PS50102; RRM; 1.
1: Evidence at protein level;
Alternative splicing; Complete proteome; mRNA processing;
mRNA splicing; Nucleus; Reference proteome; RNA-binding.
CHAIN 1 496 RNA-binding motif protein, Y chromosome,
family 1 member F/J.
/FTId=PRO_0000314164.
DOMAIN 8 85 RRM. {ECO:0000255|PROSITE-
ProRule:PRU00176}.
COMPBIAS 254 340 Arg-rich.
VAR_SEQ 397 419 YGTSHGAPPARGPRMSYGGSTCH -> DLSWCTTCKRASDV
LWWKHLPRI (in isoform 2).
{ECO:0000303|PubMed:8269511}.
/FTId=VSP_030217.
VAR_SEQ 420 496 Missing (in isoform 2).
{ECO:0000303|PubMed:8269511}.
/FTId=VSP_030218.
CONFLICT 7 7 P -> A (in Ref. 1; CAA53660).
{ECO:0000305}.
SEQUENCE 496 AA; 55728 MW; 66AC50828D44E9A8 CRC64;
MVEADHPGKL FIGGLNRETN EKMLKAVFGK HGPISEVLLI KDRTSKSRGF AFITFENPAD
AKNAAKDMNG TSLHGKAIKV EQAKKPSFQS GGRRRPPASS RNRSPSGSLR SARGSSGGTR
GWLPSHEGHL DDGGYTPDLK MSYSRGLIPV KRGPSSRSGG PPPKKSAPSA VARSNSWMGS
QGPMSQRREN YGVPPRRATI SSWRNDRMST RHDGYATNDG NHPSCQETRD YAPPSRGYAY
RDNGHSNRDE HSSRGYRNHR SSRETRDYAP PSRGHAYRDY GHSRRDESYS RGYRNHRSSR
ETREYAPPSR GHGYRDYGHS RRHESYSRGY RNHPSSRETR DYAPPHRDYA YRDYGHSSWD
EHSSRGYSYH DGYGEALGRD HSEHLSGSSY RDALQRYGTS HGAPPARGPR MSYGGSTCHA
YSNTRDRYGR SWESYSSCGD FHYCDREHVC RKDQRNPPSL GRVLPDPREA YGSSSYVASI
VDGGESRSEK GDSSRY


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