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RNA-directed RNA polymerase (EC 2.7.7.48) (Fragment)

 S4SHK7_9HEPC            Unreviewed;       172 AA.
S4SHK7;
16-OCT-2013, integrated into UniProtKB/TrEMBL.
16-OCT-2013, sequence version 1.
16-JAN-2019, entry version 17.
RecName: Full=RNA-directed RNA polymerase {ECO:0000256|RuleBase:RU363062};
EC=2.7.7.48 {ECO:0000256|RuleBase:RU363062};
Flags: Fragment;
Hepacivirus C.
Viruses; ssRNA viruses; ssRNA positive-strand viruses, no DNA stage;
Flaviviridae; Hepacivirus.
NCBI_TaxID=11103 {ECO:0000313|EMBL:AFN89161.1};
[1] {ECO:0000313|EMBL:AFN89161.1}
NUCLEOTIDE SEQUENCE.
STRAIN=5gen3agrn8 {ECO:0000313|EMBL:AFN89161.1};
Magiorkinis G., Magiorkinis E., Paraskevis D., Hatzakis A.;
"Measuring transmission diversity of chronic viral infections:
evidence of superspreading events as driving force of the hepatitis C
virus epidemic.";
Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
-!- CATALYTIC ACTIVITY:
Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:11128, Rhea:RHEA-
COMP:11129, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557,
ChEBI:CHEBI:83400; EC=2.7.7.48;
Evidence={ECO:0000256|RuleBase:RU363062,
ECO:0000256|SAAS:SAAS01125840};
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EMBL; JN563632; AFN89161.1; -; Genomic_RNA.
GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
GO; GO:0003723; F:RNA binding; IEA:InterPro.
GO; GO:0003968; F:RNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-KW.
GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
InterPro; IPR007094; RNA-dir_pol_PSvirus.
InterPro; IPR002166; RNA_pol_HCV.
Pfam; PF00998; RdRP_3; 1.
PROSITE; PS50507; RDRP_SSRNA_POS; 1.
4: Predicted;
Nucleotide-binding {ECO:0000256|RuleBase:RU363062,
ECO:0000256|SAAS:SAAS00515117};
Nucleotidyltransferase {ECO:0000256|RuleBase:RU363062,
ECO:0000256|SAAS:SAAS00515113};
RNA-directed RNA polymerase {ECO:0000256|RuleBase:RU363062,
ECO:0000256|SAAS:SAAS00515113};
Transferase {ECO:0000256|RuleBase:RU363062,
ECO:0000256|SAAS:SAAS00515113};
Viral RNA replication {ECO:0000256|RuleBase:RU363062,
ECO:0000256|SAAS:SAAS00515121}.
DOMAIN 1 108 RdRp catalytic.
{ECO:0000259|PROSITE:PS50507}.
NON_TER 1 1 {ECO:0000313|EMBL:AFN89161.1}.
NON_TER 172 172 {ECO:0000313|EMBL:AFN89161.1}.
SEQUENCE 172 AA; 18683 MW; 33346313929D2F46 CRC64;
DSTVTEQDIR VEEEIYQCCN LEPEARKVIS SLTERLYCGG PMFNSKGAQC GYRRCRASGV
LPTSFGNTIT CYIKATAAAR AAGLRNPDFL VCGDDLVVVA ESDGVAEDRA ALRAFTEAMT
RYSAPPGDAP QPTYDLELIT SCSSNVSVAR DNKGKRYYYL TRDATTPLAR AA


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