Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Radiation-inducible immediate-early gene IEX-1 (Immediate early protein GLY96) (Immediate early response 3 protein)

 IEX1_MOUSE              Reviewed;         153 AA.
P46694;
01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
01-NOV-1995, sequence version 1.
30-AUG-2017, entry version 100.
RecName: Full=Radiation-inducible immediate-early gene IEX-1;
AltName: Full=Immediate early protein GLY96;
AltName: Full=Immediate early response 3 protein;
Name=Ier3; Synonyms=Gly96, Iex1;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=BALB/cJ;
PubMed=8437864;
Charles C.H., Yoon J.K., Simske J.S., Lau L.F.;
"Genomic structure, cDNA sequence, and expression of gly96, a growth
factor-inducible immediate-early gene encoding a short-lived
glycosylated protein.";
Oncogene 8:797-801(1993).
[2]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brown adipose tissue, Heart, and Kidney;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
[3]
FUNCTION.
PubMed=22565310; DOI=10.1172/JCI60144;
Hamidi T., Algul H., Cano C.E., Sandi M.J., Molejon M.I., Riemann M.,
Calvo E.L., Lomberk G., Dagorn J.C., Weih F., Urrutia R., Schmid R.M.,
Iovanna J.L.;
"Nuclear protein 1 promotes pancreatic cancer development and protects
cells from stress by inhibiting apoptosis.";
J. Clin. Invest. 122:2092-2103(2012).
-!- FUNCTION: May play a role in the ERK signaling pathway by
inhibiting the dephosphorylation of ERK by phosphatase PP2A-
PPP2R5C holoenzyme. Acts also as an ERK downstream effector
mediating survival (By similarity). As a member of the
NUPR1/RELB/IER3 survival pathway, may allow the development of
pancreatic intraepithelial neoplasias. {ECO:0000250,
ECO:0000269|PubMed:22565310}.
-!- SUBUNIT: Interacts with the PPP2R5C-PP2A holoenzyme and ERK
kinases; regulates ERK dephosphorylation. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type II
membrane protein {ECO:0000250}.
-!- TISSUE SPECIFICITY: Expressed predominantly in the lung, testes
and the uterus.
-!- INDUCTION: By serum growth factors and TPA.
-!- PTM: Glycosylated.
-!- SIMILARITY: Belongs to the IER3 family. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; X67644; -; NOT_ANNOTATED_CDS; mRNA.
PIR; S33363; S33363.
UniGene; Mm.25613; -.
STRING; 10090.ENSMUSP00000003635; -.
iPTMnet; P46694; -.
PhosphoSitePlus; P46694; -.
PaxDb; P46694; -.
PeptideAtlas; P46694; -.
PRIDE; P46694; -.
MGI; MGI:104814; Ier3.
eggNOG; ENOG410IZ8Q; Eukaryota.
eggNOG; ENOG410Z2E4; LUCA.
HOVERGEN; HBG000172; -.
InParanoid; P46694; -.
PhylomeDB; P46694; -.
ChiTaRS; Ier3; mouse.
PRO; PR:P46694; -.
Proteomes; UP000000589; Unplaced.
CleanEx; MM_IER3; -.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005739; C:mitochondrion; IEA:GOC.
GO; GO:0005634; C:nucleus; IDA:MGI.
GO; GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage; IDA:MGI.
GO; GO:0007095; P:mitotic G2 DNA damage checkpoint; IMP:MGI.
GO; GO:0045820; P:negative regulation of glycolytic process; IMP:MGI.
GO; GO:0050728; P:negative regulation of inflammatory response; IMP:MGI.
GO; GO:1901029; P:negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; IDA:MGI.
GO; GO:0003085; P:negative regulation of systemic arterial blood pressure; IMP:MGI.
GO; GO:0045732; P:positive regulation of protein catabolic process; IDA:MGI.
GO; GO:0006282; P:regulation of DNA repair; IMP:MGI.
GO; GO:0046822; P:regulation of nucleocytoplasmic transport; IMP:MGI.
GO; GO:2000377; P:regulation of reactive oxygen species metabolic process; IDA:MGI.
GO; GO:2001020; P:regulation of response to DNA damage stimulus; IMP:MGI.
GO; GO:0001562; P:response to protozoan; IMP:MGI.
InterPro; IPR024829; IEX-1.
PANTHER; PTHR16915; PTHR16915; 1.
PRINTS; PR02100; GENEIEX1.
1: Evidence at protein level;
Complete proteome; Glycoprotein; Membrane; Phosphoprotein;
Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix.
CHAIN 1 153 Radiation-inducible immediate-early gene
IEX-1.
/FTId=PRO_0000084160.
TOPO_DOM 1 85 Cytoplasmic. {ECO:0000255}.
TRANSMEM 86 102 Helical; Signal-anchor for type II
membrane protein. {ECO:0000255}.
TOPO_DOM 103 153 Extracellular. {ECO:0000255}.
MOD_RES 31 31 Phosphoserine.
{ECO:0000244|PubMed:21183079}.
CARBOHYD 137 137 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
SEQUENCE 153 AA; 16875 MW; F4429E3B0120DE11 CRC64;
MCHSRNHLHT MTGLRAPSPA PSTGPELRRG SGPEIFTFDP LPERAVVSTA RLNTSRGHRK
RSRRVLYPRV VRRQLPTEEP NIAKRVLFLL FAIIFCQILM AEEGVSQPLA PEDATSAVTP
EPISAPITAP PVLEPLNLTS ESSDYALDLK AFL


Related products :

Catalog number Product name Quantity
18-003-43783 Krueppel-like factor 11 - Transforming growth factor-beta-inducible early growth response protein 2; TGFB-inducible early growth response protein 2; TIEG-2 Polyclonal 0.1 mg Protein A
U0688h CLIA EGR-alpha,Homo sapiens,Human,KLF10,Krueppel-like factor 10,TGFB-inducible early growth response protein 1,TIEG,TIEG1,TIEG-1,Transforming growth factor-beta-inducible early growth response protein 96T
U0688r CLIA Cpg20,Klf10,Krueppel-like factor 10,Rat,Rattus norvegicus,TGFB-inducible early growth response protein 1,Tieg,Tieg1,TIEG-1,Transforming growth factor-beta-inducible early growth response protein 96T
E0688r ELISA Cpg20,Klf10,Krueppel-like factor 10,Rat,Rattus norvegicus,TGFB-inducible early growth response protein 1,Tieg,Tieg1,TIEG-1,Transforming growth factor-beta-inducible early growth response protein 96T
E0688h ELISA EGR-alpha,Homo sapiens,Human,KLF10,Krueppel-like factor 10,TGFB-inducible early growth response protein 1,TIEG,TIEG1,TIEG-1,Transforming growth factor-beta-inducible early growth response protei 96T
EIAAB24752 Early response 1,Er1,hMi-er1,Homo sapiens,Human,KIAA1610,Mesoderm induction early response protein 1,MIER1,Mi-er1
E0688h ELISA kit EGR-alpha,Homo sapiens,Human,KLF10,Krueppel-like factor 10,TGFB-inducible early growth response protein 1,TIEG,TIEG1,TIEG-1,Transforming growth factor-beta-inducible early growth response p 96T
EIAAB24753 Early response 1,Er1,Kiaa1610,Mesoderm induction early response protein 1,Mier1,Mi-er1,Mouse,Mus musculus
E0688r ELISA kit Cpg20,Klf10,Krueppel-like factor 10,Rat,Rattus norvegicus,TGFB-inducible early growth response protein 1,Tieg,Tieg1,TIEG-1,Transforming growth factor-beta-inducible early growth response pr 96T
EIAAB12630 Early growth response protein 4,Early response protein NGFI-C,Egr4,EGR-4,Egr-4,Nerve growth factor-induced protein C,Ngfic,NGFI-C,Rat,Rattus norvegicus
E0609m Mouse ELISA Kit FOR Radiation-inducible immediate-early gene IEX-1 96T
TFP11_CHICK Mouse ELISA Kit FOR Radiation-inducible immediate-early gene IEX-1 96T
G6168 Radiation-inducible immediate-early gene IEX-1 (IER3), Mouse, ELISA Kit 96T
G6167 Radiation-inducible immediate-early gene IEX-1 (IER3), Human, ELISA Kit 96T
CSB-EL011002MO Mouse Radiation-inducible immediate-early gene IEX-1(IER3) ELISA kit 96T
CSB-EL011002HU Human Radiation-inducible immediate-early gene IEX-1(IER3) ELISA kit 96T
bs-1838P Peptides: TIEG1_KLF10(TGF-beta inducible early response gene 1) Protein Length:12-25 amino acids. 200ug lyophilized
CSB-EL011002MO Mouse Radiation-inducible immediate-early gene IEX-1(IER3) ELISA kit SpeciesMouse 96T
CSB-EL011002HU Human Radiation-inducible immediate-early gene IEX-1(IER3) ELISA kit SpeciesHuman 96T
AS03 033 Antibody: Elip1 | early light inducible protein 1, Immunogen: Short peptide chosen from a sequence of early light-induced protein 1 of Arabidopsis thaliana At3g22840, Host: rabbit, polyclonal, Confirm 200
AS03 036 Antibody: Elip2 | early light inducible protein 2, Immunogen: Short peptide chosen from a sequence of early light-induced protein 2 of Arabidopsis thaliana AAD28779.1, Host: rabbit, polyclonal, Confir 200
IEX1_HUMAN ELISA Kit FOR Radiation-inducible immediate-early gene IEX-1; organism: Human; gene name: IER3 96T
IEX1_MOUSE ELISA Kit FOR Radiation-inducible immediate-early gene IEX-1; organism: Mouse; gene name: Ier3 96T
E10190h Human TGF Beta Inducible Early Response Gene 2 ELI 96T
E13812351 TGF beta Inducible Early Response Gene 1 ELISA Kit 1


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur