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Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1)

 RGL1_MOUSE              Reviewed;         768 AA.
Q60695; Q8VD09;
20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
27-JUL-2011, sequence version 2.
28-FEB-2018, entry version 142.
RecName: Full=Ral guanine nucleotide dissociation stimulator-like 1;
Short=RalGDS-like 1;
Name=Rgl1; Synonyms=Rgl;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=7935463; DOI=10.1128/MCB.14.11.7483;
Kikuchi A., Demo S.D., Ye Z.H., Chen Y.W., Williams L.T.;
"ralGDS family members interact with the effector loop of ras p21.";
Mol. Cell. Biol. 14:7483-7491(1994).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J; TISSUE=Amnion;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=FVB/N; TISSUE=Kidney;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
Thibault P.;
"The phagosomal proteome in interferon-gamma-activated macrophages.";
Immunity 30:143-154(2009).
[6]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-520, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain, Brown adipose tissue, Kidney, Liver, Lung, Pancreas,
Spleen, and Testis;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
[7]
STRUCTURE BY NMR OF 632-734.
PubMed=9891982; DOI=10.1016/S0014-5793(98)01596-8;
Kigawa T., Endo M., Ito Y., Shirouzu M., Kikuchi A., Yokoyama S.;
"Solution structure of the Ras-binding domain of RGL.";
FEBS Lett. 441:413-418(1998).
-!- FUNCTION: Probable guanine nucleotide exchange factor.
-!- SUBUNIT: Interacts with Ras.
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EMBL; U14103; AAA64950.1; -; mRNA.
EMBL; AK144218; BAE25780.1; -; mRNA.
EMBL; AK169109; BAE40891.1; -; mRNA.
EMBL; AK169180; BAE40958.1; -; mRNA.
EMBL; CH466520; EDL39452.1; -; Genomic_DNA.
EMBL; BC017678; AAH17678.1; -; mRNA.
CCDS; CCDS15365.1; -.
PIR; A56234; A56234.
RefSeq; NP_001333046.1; NM_001346117.1.
RefSeq; NP_001333047.1; NM_001346118.1.
RefSeq; NP_001333048.1; NM_001346119.1.
RefSeq; NP_058542.2; NM_016846.4.
UniGene; Mm.245270; -.
UniGene; Mm.462928; -.
PDB; 1EF5; NMR; -; A=632-734.
PDBsum; 1EF5; -.
ProteinModelPortal; Q60695; -.
SMR; Q60695; -.
STRING; 10090.ENSMUSP00000027760; -.
iPTMnet; Q60695; -.
PhosphoSitePlus; Q60695; -.
MaxQB; Q60695; -.
PaxDb; Q60695; -.
PRIDE; Q60695; -.
Ensembl; ENSMUST00000027760; ENSMUSP00000027760; ENSMUSG00000026482.
GeneID; 19731; -.
KEGG; mmu:19731; -.
UCSC; uc007czh.1; mouse.
CTD; 23179; -.
MGI; MGI:107484; Rgl1.
eggNOG; KOG3629; Eukaryota.
eggNOG; ENOG410ZUT5; LUCA.
GeneTree; ENSGT00910000143985; -.
HOGENOM; HOG000231592; -.
HOVERGEN; HBG005864; -.
InParanoid; Q60695; -.
KO; K17635; -.
TreeFam; TF315204; -.
ChiTaRS; Rgl1; mouse.
EvolutionaryTrace; Q60695; -.
PRO; PR:Q60695; -.
Proteomes; UP000000589; Chromosome 1.
Bgee; ENSMUSG00000026482; -.
ExpressionAtlas; Q60695; baseline and differential.
Genevisible; Q60695; MM.
GO; GO:0005622; C:intracellular; IEA:GOC.
GO; GO:0008321; F:Ral guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
CDD; cd00155; RasGEF; 1.
CDD; cd06224; REM; 1.
Gene3D; 1.10.840.10; -; 1.
InterPro; IPR000159; RA_dom.
InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
InterPro; IPR023578; Ras_GEF_dom_sf.
InterPro; IPR001895; RASGEF_cat_dom.
InterPro; IPR036964; RASGEF_cat_dom_sf.
InterPro; IPR030748; RGL1.
InterPro; IPR029071; Ubiquitin-like_domsf.
PANTHER; PTHR23113:SF199; PTHR23113:SF199; 1.
Pfam; PF00788; RA; 1.
Pfam; PF00617; RasGEF; 1.
Pfam; PF00618; RasGEF_N; 1.
SMART; SM00314; RA; 1.
SMART; SM00147; RasGEF; 1.
SMART; SM00229; RasGEFN; 1.
SUPFAM; SSF48366; SSF48366; 2.
SUPFAM; SSF54236; SSF54236; 1.
PROSITE; PS50200; RA; 1.
PROSITE; PS00720; RASGEF; 1.
PROSITE; PS50009; RASGEF_CAT; 1.
PROSITE; PS50212; RASGEF_NTER; 1.
1: Evidence at protein level;
3D-structure; Complete proteome; Guanine-nucleotide releasing factor;
Phosphoprotein; Reference proteome.
CHAIN 1 768 Ral guanine nucleotide dissociation
stimulator-like 1.
/FTId=PRO_0000068886.
DOMAIN 65 196 N-terminal Ras-GEF. {ECO:0000255|PROSITE-
ProRule:PRU00135}.
DOMAIN 232 501 Ras-GEF. {ECO:0000255|PROSITE-
ProRule:PRU00168}.
DOMAIN 648 735 Ras-associating. {ECO:0000255|PROSITE-
ProRule:PRU00166}.
COMPBIAS 541 613 Ser-rich.
MOD_RES 520 520 Phosphoserine.
{ECO:0000244|PubMed:21183079}.
CONFLICT 662 662 N -> H (in Ref. 1; AAA64950).
{ECO:0000305}.
STRAND 652 658 {ECO:0000244|PDB:1EF5}.
HELIX 676 682 {ECO:0000244|PDB:1EF5}.
TURN 683 687 {ECO:0000244|PDB:1EF5}.
STRAND 692 701 {ECO:0000244|PDB:1EF5}.
STRAND 703 705 {ECO:0000244|PDB:1EF5}.
STRAND 708 711 {ECO:0000244|PDB:1EF5}.
TURN 716 720 {ECO:0000244|PDB:1EF5}.
STRAND 726 732 {ECO:0000244|PDB:1EF5}.
SEQUENCE 768 AA; 86324 MW; F59853A281DD52F6 CRC64;
MKLLWQAKMS SIQDWGEEVE EGAVYHVTLK RVQIQQAANK GARWLGVEGD QLPPGHTVSQ
YETCKIRTIK AGTLEKLVEN LLTAFGDNDF TYISIFLSTY RGFASTKEVL ELLLDRYGNL
TGPNCEDDGS QSSPESKAVI RNAIASILRA WLDQCAEDFR EPPHFPCLQK LLEYLKQMMP
GSDPERRAQN LLEQFQKQDV DSDNGLLNTS SFSLEEEEEL ESGGSAEFTN FSEDLVAEQL
TYMDAQLFKK VVPHHCLGCI WSQRDKKENK HLAPTIRATI SQFNTLTKCV VSTVLGSKEL
KTQQRARVIE KWINIAHECR ILKNFSSLRA IVSALQSNSI YRLKKAWAAV PKDRMLMFEE
LSDIFSDHNN HLTSRELLMK EGTSKFANLD SSVKENQKRT QRRLQLQKDM GVMQGTVPYL
GTFLTDLTML DTALQDYIEG GLINFEKRRR EFEVIAQIKL LQSACNSYCM GPDQKFIQWF
QRQQLLSEEE SYALSCEIEA AADANTTSPK PRKSMVKRLS LLFLGSDIIP GSTPTKEQPK
SAASGSSGES MDSVSVSSCE SNHSEAEEGP VTPMDTPDEP QKKLSESSSS CSSIHSMDTN
SSGMSSLINP LSSPPTCNNN PKIHKRSVSV TSITSTVLPP VYNQQNEDTC IIRISVEDNN
GNMYKSIMLT SQDKTPAVIQ RAMSKHNLES DPAEEYELVQ VISEDKELVI PDSANVFYAM
NSQVNFDFIL RKKNSVEEQV KLRSRTSLTL PRTAKRGCWS NRHSKITL


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