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Ran-specific GTPase-activating protein

 F7GMJ1_MACMU            Unreviewed;       201 AA.
F7GMJ1; I2CTE7;
27-JUL-2011, integrated into UniProtKB/TrEMBL.
30-NOV-2016, sequence version 2.
12-SEP-2018, entry version 64.
SubName: Full=Ran-specific GTPase-activating protein {ECO:0000313|EMBL:AFJ70232.1, ECO:0000313|Ensembl:ENSMMUP00000026459};
Name=RANBP1 {ECO:0000313|EMBL:AFJ70232.1,
ECO:0000313|Ensembl:ENSMMUP00000026459};
Macaca mulatta (Rhesus macaque).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000026459, ECO:0000313|Proteomes:UP000006718};
[1] {ECO:0000313|Ensembl:ENSMMUP00000026459, ECO:0000313|Proteomes:UP000006718}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000026459,
ECO:0000313|Proteomes:UP000006718};
PubMed=17431167; DOI=10.1126/science.1139247;
Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C.,
Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W.,
Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E.,
Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y.,
Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T.,
Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J.,
Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A.,
Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M.,
Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D.,
Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J.,
Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E.,
Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S.,
Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X.,
Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E.,
Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M.,
Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M.,
Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y.,
Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J.,
Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A.,
Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B.,
Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S.,
Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V.,
Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A.,
Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C.,
Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P.,
Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E.,
Zwieg A.S.;
"Evolutionary and biomedical insights from the rhesus macaque
genome.";
Science 316:222-234(2007).
[2] {ECO:0000313|Ensembl:ENSMMUP00000026459}
IDENTIFICATION.
STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000026459};
Ensembl;
Submitted (JUL-2011) to UniProtKB.
[3] {ECO:0000313|EMBL:AFJ70232.1}
NUCLEOTIDE SEQUENCE.
TISSUE=Brain {ECO:0000313|EMBL:AFJ70232.1};
PubMed=25319552; DOI=10.1186/1745-6150-9-20;
Zimin A.V., Cornish A.S., Maudhoo M.D., Gibbs R.M., Zhang X.,
Pandey S., Meehan D.T., Wipfler K., Bosinger S.E., Johnson Z.P.,
Tharp G.K., Marcais G., Roberts M., Ferguson B., Fox H.S.,
Treangen T., Salzberg S.L., Yorke J.A., Norgren R.B.Jr.;
"A new rhesus macaque assembly and annotation for next-generation
sequencing analyses.";
Biol. Direct 9:20-20(2014).
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EMBL; JSUE03005028; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; JSUE03005029; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; JV527776; AFJ70232.1; -; mRNA.
RefSeq; XP_015005213.1; XM_015149727.1.
UniGene; Mmu.20771; -.
SMR; F7GMJ1; -.
STRING; 9544.ENSMMUP00000026459; -.
Ensembl; ENSMMUT00000028276; ENSMMUP00000026459; ENSMMUG00000020100.
GeneID; 719448; -.
CTD; 5902; -.
eggNOG; KOG0864; Eukaryota.
eggNOG; COG5171; LUCA.
GeneTree; ENSGT00900000141073; -.
OrthoDB; EOG091G0Y8B; -.
Proteomes; UP000006718; Chromosome 10.
Bgee; ENSMMUG00000020100; Expressed in 14 organ(s), highest expression level in testis.
ExpressionAtlas; F7GMJ1; baseline.
GO; GO:0005813; C:centrosome; IBA:GO_Central.
GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
GO; GO:0005634; C:nucleus; IBA:GO_Central.
GO; GO:0008536; F:Ran GTPase binding; IBA:GO_Central.
GO; GO:0000082; P:G1/S transition of mitotic cell cycle; IBA:GO_Central.
GO; GO:0043547; P:positive regulation of GTPase activity; IEA:GOC.
GO; GO:0046604; P:positive regulation of mitotic centrosome separation; IBA:GO_Central.
GO; GO:0006606; P:protein import into nucleus; IBA:GO_Central.
GO; GO:0006405; P:RNA export from nucleus; IBA:GO_Central.
GO; GO:0007051; P:spindle organization; IBA:GO_Central.
GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IBA:GO_Central.
Gene3D; 2.30.29.30; -; 1.
InterPro; IPR011993; PH-like_dom_sf.
InterPro; IPR000156; Ran_bind_dom.
Pfam; PF00638; Ran_BP1; 1.
SMART; SM00160; RanBD; 1.
PROSITE; PS50196; RANBD1; 1.
2: Evidence at transcript level;
Coiled coil {ECO:0000256|SAM:Coils};
Complete proteome {ECO:0000313|Proteomes:UP000006718};
Reference proteome {ECO:0000313|Proteomes:UP000006718}.
DOMAIN 26 164 RanBD1. {ECO:0000259|PROSITE:PS50196}.
COILED 148 168 {ECO:0000256|SAM:Coils}.
COILED 180 200 {ECO:0000256|SAM:Coils}.
SEQUENCE 201 AA; 23310 MW; 05FC9B35DADA48C9 CRC64;
MAAAKDTHED HDTSTENTDE SNHDPQFEPI VSLPEQEIKT LEEDEEELFK MRAKLFRFAS
ENDLPEWKER GTGDVKLLKH KEKGAIRLLM RRDKTLKICA NHYITPMMEL KPNAGSDRAW
VWNTHADFAD ECPKPELLAI RFLNAENAQK FKTKFEECRK EIEEREKKAG SGKNDHAEKV
AEKLEALSVK EETKEDAEEK Q


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