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Ras association (RalGDS/AF-6) domain family 1, isoform CRA_a (Ras association (RalGDS/AF-6) domain family member 1) (Ras association domain family member 1)

 Q68FW0_RAT              Unreviewed;       270 AA.
Q68FW0;
11-OCT-2004, integrated into UniProtKB/TrEMBL.
11-OCT-2004, sequence version 1.
05-DEC-2018, entry version 100.
SubName: Full=Ras association (RalGDS/AF-6) domain family 1, isoform CRA_a {ECO:0000313|EMBL:EDL77248.1};
SubName: Full=Ras association (RalGDS/AF-6) domain family member 1 {ECO:0000313|EMBL:AAH79237.1};
SubName: Full=Ras association domain family member 1 {ECO:0000313|Ensembl:ENSRNOP00000034233};
Name=Rassf1 {ECO:0000313|EMBL:AAH79237.1,
ECO:0000313|Ensembl:ENSRNOP00000034233, ECO:0000313|RGD:1359383};
ORFNames=rCG_25364 {ECO:0000313|EMBL:EDL77248.1};
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116 {ECO:0000313|EMBL:AAH79237.1};
[1] {ECO:0000313|EMBL:AAH79237.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Testis {ECO:0000313|EMBL:AAH79237.1};
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M.,
Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S.,
Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F.,
Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J.,
Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N.,
Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B.,
Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B.,
Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S.,
Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R.,
Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L.,
Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E.,
Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D.,
Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G.,
Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J.,
Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L.,
Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D.,
Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A.,
Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S.,
Makowski K.A., Bosak S., Malek J.;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[2] {ECO:0000313|Ensembl:ENSRNOP00000034233, ECO:0000313|Proteomes:UP000002494}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000034233,
ECO:0000313|Proteomes:UP000002494};
PubMed=15057822; DOI=10.1038/nature02426;
Rat Genome Sequencing Project Consortium;
Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T.,
Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A.,
Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M.,
Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K.,
Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S.,
Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J.,
Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y.,
Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A.,
Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J.,
D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R.,
Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A.,
Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E.,
Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E.,
Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D.,
Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M.,
Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O.,
Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O.,
Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H.,
Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S.,
Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J.,
Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E.,
Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F.,
Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K.,
Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S.,
Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M.,
Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M.,
Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A.,
Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S.,
Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G.,
Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H.,
Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R.,
Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M.,
Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H.,
Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S.,
Collins F.S.;
"Genome sequence of the Brown Norway rat yields insights into
mammalian evolution.";
Nature 428:493-521(2004).
[3] {ECO:0000313|EMBL:EDL77248.1}
NUCLEOTIDE SEQUENCE.
STRAIN=BN {ECO:0000313|EMBL:EDL77248.1};
PubMed=15632090; DOI=10.1101/gr.2889405;
Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M.,
Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z.,
Istrail S., Li P., Sutton G.;
"Gene and alternative splicing annotation with AIR.";
Genome Res. 15:54-66(2005).
[4] {ECO:0000313|EMBL:EDL77248.1}
NUCLEOTIDE SEQUENCE.
STRAIN=BN {ECO:0000313|EMBL:EDL77248.1};
Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H.,
Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M.,
Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L.,
Lu F., Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C.,
Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[5] {ECO:0000313|Ensembl:ENSRNOP00000034233}
IDENTIFICATION.
STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000034233};
Ensembl;
Submitted (FEB-2012) to UniProtKB.
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EMBL; AC139927; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC079237; AAH79237.1; -; mRNA.
EMBL; CH473954; EDL77248.1; -; Genomic_DNA.
RefSeq; NP_001007755.1; NM_001007754.1.
UniGene; Rn.83042; -.
Ensembl; ENSRNOT00000037363; ENSRNOP00000034233; ENSRNOG00000021548.
GeneID; 363140; -.
KEGG; rno:363140; -.
UCSC; RGD:1359383; rat.
CTD; 11186; -.
RGD; 1359383; Rassf1.
eggNOG; ENOG410IPAE; Eukaryota.
eggNOG; ENOG4111HS2; LUCA.
GeneTree; ENSGT00940000155664; -.
HOGENOM; HOG000013025; -.
HOVERGEN; HBG054362; -.
KO; K09850; -.
OMA; TPSFEMT; -.
Proteomes; UP000002494; Chromosome 8.
Bgee; ENSRNOG00000021548; Expressed in 10 organ(s), highest expression level in testis.
GO; GO:0070507; P:regulation of microtubule cytoskeleton organization; IEA:InterPro.
GO; GO:0007165; P:signal transduction; IEA:InterPro.
InterPro; IPR033614; C-RASSF.
InterPro; IPR000159; RA_dom.
InterPro; IPR033600; RASSF1.
InterPro; IPR011524; SARAH_dom.
InterPro; IPR029071; Ubiquitin-like_domsf.
PANTHER; PTHR22738; PTHR22738; 1.
PANTHER; PTHR22738:SF12; PTHR22738:SF12; 1.
Pfam; PF16517; Nore1-SARAH; 1.
Pfam; PF00788; RA; 1.
SMART; SM00314; RA; 1.
SUPFAM; SSF54236; SSF54236; 1.
PROSITE; PS50200; RA; 1.
PROSITE; PS50951; SARAH; 1.
2: Evidence at transcript level;
Complete proteome {ECO:0000313|Proteomes:UP000002494};
Reference proteome {ECO:0000313|Proteomes:UP000002494}.
DOMAIN 124 218 Ras-associating.
{ECO:0000259|PROSITE:PS50200}.
DOMAIN 220 267 SARAH. {ECO:0000259|PROSITE:PS50951}.
SEQUENCE 270 AA; 31227 MW; 17E1BE88FB5EDFFD CRC64;
MGEAETPSFE MTWSSTTSSG YCSQEDSDSE LEQYFTARTS LVRRPRRDQD EAVERETPDL
SQAETEQKIK DYNGQINSNL FMSLNKDGSY TGFIKVQLKL VRPVSVPSSK KPPSLQDARR
GTGRSSAVKR RTSFYLPKDA VKHLHVLSRT RAREVIEALL RKFMVVDDPR KFALFERTER
HGQIYFRKLS DEEQPLKLRL LAGPSEKALS FVLKENDSGE VNWDAFSMPE LHNFLRILQR
EEEEHLRQIL QKYSRCRQKI QEALHACPLG


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