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Ras-like protein 1

 RAS1_DROER              Reviewed;         189 AA.
10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
02-SEP-2008, sequence version 1.
16-JAN-2019, entry version 69.
RecName: Full=Ras-like protein 1 {ECO:0000250|UniProtKB:P08646};
Flags: Precursor;
Name=Ras85D {ECO:0000250|UniProtKB:P08646}; ORFNames=GG17366;
Drosophila erecta (Fruit fly).
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
Ephydroidea; Drosophilidae; Drosophila; Sophophora.
[1] {ECO:0000312|EMBL:EDV49774.1}
STRAIN=Tucson 14021-0224.01 {ECO:0000312|EMBL:EDV49774.1};
PubMed=17994087; DOI=10.1038/nature06341;
Drosophila 12 genomes consortium;
"Evolution of genes and genomes on the Drosophila phylogeny.";
Nature 450:203-218(2007).
-!- FUNCTION: Ras proteins bind GDP/GTP and possess intrinsic GTPase
activity. Plays a role in eye development by regulating cell
growth, survival of postmitotic ommatidial cells and
differentiation of photoreceptor cells. During larval development,
mediates Ptth/tor signaling leading to the production of ecdysone,
an hormone required for the initiation of metamorphosis.
{ECO:0000250|UniProtKB:P01112, ECO:0000250|UniProtKB:P08646}.
-!- ACTIVITY REGULATION: Alternates between an inactive form bound to
GDP and an active form bound to GTP. Activated by a guanine
nucleotide-exchange factor (GEF) and inactivated by a GTPase-
activating protein (GAP).
{ECO:0000250|UniProtKB:P08646}; Lipid-anchor
{ECO:0000250|UniProtKB:P08646}; Cytoplasmic side
-!- SIMILARITY: Belongs to the small GTPase superfamily. Ras family.
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
EMBL; CH954181; EDV49774.1; -; Genomic_DNA.
RefSeq; XP_001980816.1; XM_001980780.2.
ProteinModelPortal; B3NZR4; -.
SMR; B3NZR4; -.
EnsemblMetazoa; FBtr0137420; FBpp0135912; FBgn0109593.
GeneID; 6551803; -.
KEGG; der:Dere_GG17366; -.
FlyBase; FBgn0109593; Dere\GG17366.
KO; K07827; -.
OrthoDB; 1259506at2759; -.
PhylomeDB; B3NZR4; -.
ChiTaRS; Ras85D; fly.
Proteomes; UP000008711; Unassembled WGS sequence.
GO; GO:0016020; C:membrane; ISS:UniProtKB.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO; GO:0003924; F:GTPase activity; IEA:EnsemblMetazoa.
GO; GO:0007298; P:border follicle cell migration; IEA:EnsemblMetazoa.
GO; GO:0009267; P:cellular response to starvation; IEA:EnsemblMetazoa.
GO; GO:0030381; P:chorion-containing eggshell pattern formation; IEA:EnsemblMetazoa.
GO; GO:0051607; P:defense response to virus; IEA:EnsemblMetazoa.
GO; GO:0008340; P:determination of adult lifespan; IEA:EnsemblMetazoa.
GO; GO:0007395; P:dorsal closure, spreading of leading edge cells; IEA:EnsemblMetazoa.
GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; IEA:EnsemblMetazoa.
GO; GO:0007427; P:epithelial cell migration, open tracheal system; IEA:EnsemblMetazoa.
GO; GO:0035088; P:establishment or maintenance of apical/basal cell polarity; IEA:EnsemblMetazoa.
GO; GO:0007455; P:eye-antennal disc morphogenesis; IEA:EnsemblMetazoa.
GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; IEA:EnsemblMetazoa.
GO; GO:0035099; P:hemocyte migration; IEA:EnsemblMetazoa.
GO; GO:0008586; P:imaginal disc-derived wing vein morphogenesis; IEA:EnsemblMetazoa.
GO; GO:0007474; P:imaginal disc-derived wing vein specification; IEA:EnsemblMetazoa.
GO; GO:0002168; P:instar larval development; IEA:EnsemblMetazoa.
GO; GO:0036335; P:intestinal stem cell homeostasis; IEA:EnsemblMetazoa.
GO; GO:0007479; P:leg disc proximal/distal pattern formation; IEA:EnsemblMetazoa.
GO; GO:0035170; P:lymph gland crystal cell differentiation; IEA:EnsemblMetazoa.
GO; GO:0035169; P:lymph gland plasmatocyte differentiation; IEA:EnsemblMetazoa.
GO; GO:0072002; P:Malpighian tubule development; IEA:EnsemblMetazoa.
GO; GO:0000165; P:MAPK cascade; IEA:EnsemblMetazoa.
GO; GO:0001710; P:mesodermal cell fate commitment; IEA:EnsemblMetazoa.
GO; GO:0048626; P:myoblast fate specification; IEA:EnsemblMetazoa.
GO; GO:2001234; P:negative regulation of apoptotic signaling pathway; IEA:EnsemblMetazoa.
GO; GO:0046673; P:negative regulation of compound eye retinal cell programmed cell death; IEA:EnsemblMetazoa.
GO; GO:0010629; P:negative regulation of gene expression; IEA:EnsemblMetazoa.
GO; GO:0016242; P:negative regulation of macroautophagy; IEA:EnsemblMetazoa.
GO; GO:0016318; P:ommatidial rotation; IEA:EnsemblMetazoa.
GO; GO:0007309; P:oocyte axis specification; IEA:EnsemblMetazoa.
GO; GO:0007422; P:peripheral nervous system development; IEA:EnsemblMetazoa.
GO; GO:0043703; P:photoreceptor cell fate determination; IEA:EnsemblMetazoa.
GO; GO:0008594; P:photoreceptor cell morphogenesis; IEA:EnsemblMetazoa.
GO; GO:0045793; P:positive regulation of cell size; IEA:EnsemblMetazoa.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:EnsemblMetazoa.
GO; GO:0035208; P:positive regulation of hemocyte proliferation; IEA:EnsemblMetazoa.
GO; GO:0046534; P:positive regulation of photoreceptor cell differentiation; IEA:EnsemblMetazoa.
GO; GO:1904263; P:positive regulation of TORC1 signaling; IEA:EnsemblMetazoa.
GO; GO:0007265; P:Ras protein signal transduction; IEA:EnsemblMetazoa.
GO; GO:0040014; P:regulation of multicellular organism growth; IEA:EnsemblMetazoa.
GO; GO:0045500; P:sevenless signaling pathway; IEA:EnsemblMetazoa.
GO; GO:0048865; P:stem cell fate commitment; IEA:EnsemblMetazoa.
GO; GO:0072089; P:stem cell proliferation; IEA:EnsemblMetazoa.
GO; GO:0007430; P:terminal branching, open tracheal system; IEA:EnsemblMetazoa.
GO; GO:0007362; P:terminal region determination; IEA:EnsemblMetazoa.
GO; GO:0008293; P:torso signaling pathway; IEA:EnsemblMetazoa.
GO; GO:0060438; P:trachea development; IEA:EnsemblMetazoa.
GO; GO:0007426; P:tracheal outgrowth, open tracheal system; IEA:EnsemblMetazoa.
InterPro; IPR027417; P-loop_NTPase.
InterPro; IPR005225; Small_GTP-bd_dom.
InterPro; IPR001806; Small_GTPase.
InterPro; IPR020849; Small_GTPase_Ras-type.
PANTHER; PTHR24070; PTHR24070; 1.
Pfam; PF00071; Ras; 1.
SUPFAM; SSF52540; SSF52540; 1.
TIGRFAMs; TIGR00231; small_GTP; 1.
PROSITE; PS51421; RAS; 1.
3: Inferred from homology;
Cell membrane; Complete proteome; GTP-binding; Lipoprotein; Membrane;
Methylation; Nucleotide-binding; Prenylation.
CHAIN 1 186 Ras-like protein 1.
PROPEP 187 189 Removed in mature form.
NP_BIND 10 17 GTP. {ECO:0000250|UniProtKB:P01112}.
NP_BIND 57 61 GTP. {ECO:0000250|UniProtKB:P01112}.
NP_BIND 116 119 GTP. {ECO:0000250|UniProtKB:P01112}.
MOTIF 32 40 Effector region.
MOD_RES 186 186 Cysteine methyl ester.
LIPID 186 186 S-geranylgeranyl cysteine.
SEQUENCE 189 AA; 21594 MW; 14236DCD65EACCD2 CRC64;

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