Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Ras-related C3 botulinum toxin substrate 1 (Rac2) (p21-Rac1)

 RAC1_CANLF              Reviewed;         192 AA.
P62999; O95501; P15154; Q9BTB4;
31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
31-AUG-2004, sequence version 1.
25-OCT-2017, entry version 114.
RecName: Full=Ras-related C3 botulinum toxin substrate 1;
AltName: Full=Rac2;
AltName: Full=p21-Rac1;
Flags: Precursor;
Canis lupus familiaris (Dog) (Canis familiaris).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
STRAIN=Cocker spaniel; TISSUE=Kidney;
PubMed=2123294; DOI=10.1128/MCB.10.12.6578;
Chavrier P., Vingron M., Sander C., Simons K., Zerial M.;
"Molecular cloning of YPT1/SEC4-related cDNAs from an epithelial cell
Mol. Cell. Biol. 10:6578-6585(1990).
-!- FUNCTION: Plasma membrane-associated small GTPase which cycles
between active GTP-bound and inactive GDP-bound states. In its
active state, binds to a variety of effector proteins to regulate
cellular responses such as secretory processes, phagocytosis of
apoptotic cells, epithelial cell polarization and growth-factor
induced formation of membrane ruffles. Rac1 p21/rho GDI
heterodimer is the active component of the cytosolic factor sigma
1, which is involved in stimulation of the NADPH oxidase activity
in macrophages. Essential for the SPATA13-mediated regulation of
cell migration and adhesion assembly and disassembly. Stimulates
PKN2 kinase activity. In concert with RAB7A, plays a role in
regulating the formation of RBs (ruffled borders) in osteoclasts.
In glioma cells, promotes cell migration and invasion. In
podocytes, promotes nuclear shuttling of NR3C2; this modulation is
required for a proper kidney functioning. Required for atypical
chemokine receptor ACKR2-induced LIMK1-PAK1-dependent
phosphorylation of cofilin (CFL1) and for up-regulation of ACKR2
from endosomal compartment to plasma membrane, increasing its
efficiency in chemokine uptake and degradation. In synapses, seems
to mediate the regulation of F-actin cluster formation performed
by SHANK3 (By similarity). {ECO:0000250}.
-!- ENZYME REGULATION: Regulated by guanine nucleotide exchange
factors (GEFs) which promote the exchange of bound GDP for free
GTP, GTPase activating proteins (GAPs) which increase the GTP
hydrolysis activity, and GDP dissociation inhibitors which inhibit
the dissociation of the nucleotide from the GTPase. GTP hydrolysis
is stimulated by ARHGAP30 (By similarity). {ECO:0000250}.
-!- SUBUNIT: Interacts with NISCH. Interacts with PIP5K1A. Interacts
with the GTP-bound form of RAB7A. Interacts with SRGAP2. Interacts
with CYFIP1/SRA-1. Interacts with PLXNB3. Interacts with ARHGDIA;
the interaction is induced by SEMA5A, mediated through PLXNB3 and
inactivates and stabilizes RAC1. Interacts (GTP-bound form
preferentially) with PKN2 (via the REM repeats); the interaction
stimulates autophosphorylation and phosphorylation of PKN2.
Interacts with the GEF proteins PREX1, RASGRF2, FARP1, FARP2,
DOCK1, DOCK2 and DOCK7, which promote the exchange between GDP and
GTP, and therefore activate it. Interacts with PARD6A, PARD6B and
PARD6G in a GTP-dependent manner. Part of a quaternary complex
containing PARD3, some PARD6 protein (PARD6A, PARD6B or PARD6G)
and some atypical PKC protein (PRKCI or PRKCZ), which plays a
central role in epithelial cell polarization. Found in a trimeric
complex composed of DOCK1 and ELMO1, which plays a central role in
phagocytosis of apoptotic cells. Interacts with RALBP1 via its
effector domain. Interacts with PLXNB1. Probably found in a
ternary complex composed of DSCAM, PAK1 and RAC1. Interacts with
DSCAM; the interaction requires PAK1. Part of a complex with
MAP2K3, MAP3K3, CCM2 and DEF6. Interacts with BAIAP2, BAIAP2L1 and
DEF6. Interacts with Y.pseudotuberculosis YPKA and PLCB2.
Interacts with NOXA1. Interacts with ARHGEF2. Interacts with
TBC1D2. Interacts with UNKL. Interacts with USP6. Interacts with
SPATA13. Interacts with ARHGEF16; mediates activation of RAC1 by
EPHA2. Interacts with ITGB4. Interacts with S100A8 and
calprotectin (S100A8/9). Interacts with PACSIN2. Interacts with
ITGB1BP1. Interacts (when active) with PPP5C (via TPR repeats);
activates PPP5C phosphatase activity and translocates PPP5C to the
cell membrane. Interacts with RAPH1 (via Ras associating and PH
domains). Interacts with MTSS1L (via IMD domain); this interaction
may be important to potentiate PDGF-induced RAC1 activation.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor
{ECO:0000250}; Cytoplasmic side {ECO:0000250}. Melanosome
{ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Inner surface of
plasma membrane possibly with attachment requiring prenylation of
the C-terminal cysteine. Found in the ruffled border (a late
endosomal-like compartment in the plasma membrane) of bone-
resorbing osteoclasts (By similarity). {ECO:0000250}.
-!- DOMAIN: The effector region mediates interaction with DEF6.
-!- PTM: GTP-bound active form is ubiquitinated by HACE1, leading to
its degradation by the proteasome. {ECO:0000250}.
-!- SIMILARITY: Belongs to the small GTPase superfamily. Rho family.
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
EMBL; X56390; CAA39801.1; -; mRNA.
PIR; G36364; G36364.
RefSeq; NP_001003274.1; NM_001003274.2.
UniGene; Cfa.40290; -.
ProteinModelPortal; P62999; -.
SMR; P62999; -.
DIP; DIP-40906N; -.
IntAct; P62999; 2.
MINT; MINT-93844; -.
GeneID; 403955; -.
KEGG; cfa:403955; -.
CTD; 5879; -.
HOGENOM; HOG000233974; -.
HOVERGEN; HBG009351; -.
InParanoid; P62999; -.
KO; K04392; -.
Proteomes; UP000002254; Unplaced.
GO; GO:0005829; C:cytosol; ISS:UniProtKB.
GO; GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
GO; GO:0016020; C:membrane; ISS:UniProtKB.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0005525; F:GTP binding; ISS:UniProtKB.
GO; GO:0003924; F:GTPase activity; IEA:InterPro.
GO; GO:0051022; F:Rho GDP-dissociation inhibitor binding; ISS:UniProtKB.
GO; GO:0048870; P:cell motility; ISS:UniProtKB.
GO; GO:0001934; P:positive regulation of protein phosphorylation; ISS:UniProtKB.
GO; GO:0030334; P:regulation of cell migration; ISS:UniProtKB.
GO; GO:0071526; P:semaphorin-plexin signaling pathway; ISS:UniProtKB.
GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
InterPro; IPR027417; P-loop_NTPase.
InterPro; IPR005225; Small_GTP-bd_dom.
InterPro; IPR001806; Small_GTPase.
InterPro; IPR003578; Small_GTPase_Rho.
Pfam; PF00071; Ras; 1.
SUPFAM; SSF52540; SSF52540; 1.
TIGRFAMs; TIGR00231; small_GTP; 1.
PROSITE; PS51420; RHO; 1.
2: Evidence at transcript level;
Cell membrane; Complete proteome; Cytoplasm; GTP-binding;
Isopeptide bond; Lipoprotein; Membrane; Methylation;
Nucleotide-binding; Prenylation; Reference proteome; Ubl conjugation.
CHAIN 1 189 Ras-related C3 botulinum toxin substrate
PROPEP 190 192 Removed in mature form. {ECO:0000250}.
NP_BIND 10 17 GTP. {ECO:0000250}.
NP_BIND 57 61 GTP. {ECO:0000250}.
NP_BIND 115 118 GTP. {ECO:0000250}.
MOTIF 32 40 Effector region. {ECO:0000255}.
MOD_RES 189 189 Cysteine methyl ester. {ECO:0000250}.
LIPID 189 189 S-geranylgeranyl cysteine. {ECO:0000250}.
CROSSLNK 147 147 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in ubiquitin).
SEQUENCE 192 AA; 21450 MW; ACEDF83A45E5EA67 CRC64;

Related products :

Catalog number Product name Quantity
EIAAB33632 Canis familiaris,Canis lupus familiaris,Dog,p21-Rac1,RAC1,Rac2,Ras-related C3 botulinum toxin substrate 1
RAC2 RAC2 Gene ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RAC1 RAC1 Gene ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
EIAAB33635 Bos taurus,Bovine,p21-Rac2,RAC2,Ras-related C3 botulinum toxin substrate 2
EIAAB33636 Mouse,Mus musculus,p21-Rac2,Protein EN-7,Rac2,Ras-related C3 botulinum toxin substrate 2
201-20-6722 RAC2{ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)}mouse.mAb 0.2ml
EIAAB33637 GX,Homo sapiens,Human,p21-Rac2,RAC2,Ras-related C3 botulinum toxin substrate 2,Small G protein
201-20-0064 RAC2{ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)}goat.pAb 0.2ml
201-20-4719 RAC2{ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)}rabbit.pAb 0.2ml
EIAAB33631 Bos taurus,Bovine,p21-Rac1,RAC1,Ras-related C3 botulinum toxin substrate 1
EIAAB33634 p21-Rac1,Rac1,Ras-related C3 botulinum toxin substrate 1,Rat,Rattus norvegicus
EIAAB33633 Mouse,Mus musculus,p21-Rac1,Rac1,Ras-related C3 botulinum toxin substrate 1
DL-Rac1-Hu Human Ras Related C3 Botulinum Toxin Substrate 1 (Rac1) ELISA Kit 96T
201-20-4718 RAC1{ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)}rabbit.pAb 0.2ml
201-20-6903 RAC1{ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)}mouse.mAb 0.2ml
CSB-EL019242DO Dog ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) (RAC1) ELISA kit, Species Dog, Sample Type serum, plasma 96T
pro-619 Recombinant Human Ras-Related C3 Botulinum Toxin Substrate 2 RAC2 20
pro-719 Recombinant Human Ras-Related C3 Botulinum Toxin Substrate 2 (1-189) RAC2 (189) 20
pro-619 Recombinant Human Ras-Related C3 Botulinum Toxin Substrate 2 RAC2 5
pro-719 Recombinant Human Ras-Related C3 Botulinum Toxin Substrate 2 (1-189) RAC2 (189) 5
pro-619 Recombinant Human Ras-Related C3 Botulinum Toxin Substrate 2 RAC2 1mg
pro-719 Recombinant Human Ras-Related C3 Botulinum Toxin Substrate 2 (1-189) RAC2 (189) 1mg
CSB-EL019248MO Mouse Ras-related C3 botulinum toxin substrate 2(RAC2) ELISA kit 96T
CSB-EL019248GU Guinea pig Ras-related C3 botulinum toxin substrate 2(RAC2) ELISA kit 96T
G6451 Ras-related C3 botulinum toxin substrate 2 (RAC2), Bovine, ELISA Kit 96T


GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur

Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur



9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017


france@gentaur.com | Gentaur

Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123

GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U

spain@gentaur.com | Gentaur

ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636

GENTAUR Poland Sp. z o.o.

ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556


Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur