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Ras-related C3 botulinum toxin substrate 3 (Ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3))

 H9EQ53_MACMU            Unreviewed;       192 AA.
H9EQ53; F7FSK9;
16-MAY-2012, integrated into UniProtKB/TrEMBL.
16-MAY-2012, sequence version 1.
20-JUN-2018, entry version 51.
SubName: Full=Rac family small GTPase 3 {ECO:0000313|Ensembl:ENSMMUP00000014294};
SubName: Full=Ras-related C3 botulinum toxin substrate 3 {ECO:0000313|EMBL:AFE64512.1};
Name=RAC3 {ECO:0000313|EMBL:AFE64512.1,
ECO:0000313|Ensembl:ENSMMUP00000014294};
Macaca mulatta (Rhesus macaque).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
NCBI_TaxID=9544 {ECO:0000313|EMBL:AFE64512.1};
[1] {ECO:0000313|Ensembl:ENSMMUP00000014294, ECO:0000313|Proteomes:UP000006718}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000014294,
ECO:0000313|Proteomes:UP000006718};
PubMed=17431167; DOI=10.1126/science.1139247;
Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C.,
Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W.,
Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E.,
Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y.,
Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T.,
Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J.,
Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A.,
Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M.,
Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D.,
Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J.,
Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E.,
Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S.,
Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X.,
Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E.,
Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M.,
Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M.,
Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y.,
Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J.,
Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A.,
Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B.,
Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S.,
Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V.,
Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A.,
Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C.,
Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P.,
Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E.,
Zwieg A.S.;
"Evolutionary and biomedical insights from the rhesus macaque
genome.";
Science 316:222-234(2007).
[2] {ECO:0000313|Ensembl:ENSMMUP00000014294}
IDENTIFICATION.
STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000014294};
Ensembl;
Submitted (JUL-2011) to UniProtKB.
[3] {ECO:0000313|EMBL:AFE64512.1}
NUCLEOTIDE SEQUENCE.
TISSUE=Caudate {ECO:0000313|EMBL:AFE64512.1}, and
Thymus {ECO:0000313|EMBL:AFH33431.1};
PubMed=25319552; DOI=10.1186/1745-6150-9-20;
Zimin A.V., Cornish A.S., Maudhoo M.D., Gibbs R.M., Zhang X.,
Pandey S., Meehan D.T., Wipfler K., Bosinger S.E., Johnson Z.P.,
Tharp G.K., Marcais G., Roberts M., Ferguson B., Fox H.S.,
Treangen T., Salzberg S.L., Yorke J.A., Norgren R.B.Jr.;
"A new rhesus macaque assembly and annotation for next-generation
sequencing analyses.";
Biol. Direct 9:20-20(2014).
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EMBL; JSUE03017652; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; JU320756; AFE64512.1; -; mRNA.
EMBL; JU476627; AFH33431.1; -; mRNA.
RefSeq; XP_014976100.1; XM_015120614.1.
UniGene; Mmu.23343; -.
STRING; 9544.ENSMMUP00000014294; -.
Ensembl; ENSMMUT00000015252; ENSMMUP00000014294; ENSMMUG00000010895.
GeneID; 719305; -.
KEGG; mcc:719305; -.
CTD; 5881; -.
eggNOG; KOG0393; Eukaryota.
eggNOG; COG1100; LUCA.
GeneTree; ENSGT00760000118978; -.
KO; K07861; -.
OrthoDB; EOG091G0KCM; -.
TreeFam; TF101109; -.
Proteomes; UP000006718; Chromosome 16.
Bgee; ENSMMUG00000010895; -.
GO; GO:0071944; C:cell periphery; IEA:Ensembl.
GO; GO:0012505; C:endomembrane system; IEA:Ensembl.
GO; GO:0031941; C:filamentous actin; IEA:Ensembl.
GO; GO:0030426; C:growth cone; IEA:Ensembl.
GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
GO; GO:0048306; F:calcium-dependent protein binding; IEA:Ensembl.
GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO; GO:0003924; F:GTPase activity; IEA:Ensembl.
GO; GO:0030036; P:actin cytoskeleton organization; IEA:Ensembl.
GO; GO:0030031; P:cell projection assembly; IEA:Ensembl.
GO; GO:0021894; P:cerebral cortex GABAergic interneuron development; IEA:Ensembl.
GO; GO:0048873; P:homeostasis of number of cells within a tissue; IEA:Ensembl.
GO; GO:0050885; P:neuromuscular process controlling balance; IEA:Ensembl.
GO; GO:0031175; P:neuron projection development; IEA:Ensembl.
GO; GO:0033630; P:positive regulation of cell adhesion mediated by integrin; IEA:Ensembl.
GO; GO:1900026; P:positive regulation of substrate adhesion-dependent cell spreading; IEA:Ensembl.
GO; GO:0014041; P:regulation of neuron maturation; IEA:Ensembl.
GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
GO; GO:0051932; P:synaptic transmission, GABAergic; IEA:Ensembl.
InterPro; IPR027417; P-loop_NTPase.
InterPro; IPR005225; Small_GTP-bd_dom.
InterPro; IPR001806; Small_GTPase.
InterPro; IPR003578; Small_GTPase_Rho.
Pfam; PF00071; Ras; 1.
SUPFAM; SSF52540; SSF52540; 1.
TIGRFAMs; TIGR00231; small_GTP; 1.
PROSITE; PS51420; RHO; 1.
2: Evidence at transcript level;
Complete proteome {ECO:0000313|Proteomes:UP000006718};
GTP-binding {ECO:0000256|SAAS:SAAS00512948};
Nucleotide-binding {ECO:0000256|SAAS:SAAS00512948};
Reference proteome {ECO:0000313|Proteomes:UP000006718}.
SEQUENCE 192 AA; 21379 MW; 560BBC26BB7CDF4A CRC64;
MQAIKCVVVG DGAVGKTCLL ISYTTNAFPG EYIPTVFDNY SANVMVDGKP VNLGLWDTAG
QEDYDRLRPL SYPQTDVFLI CFSLVSPASF ENVRAKWYPE VRHHCPHTPI LLVGTKLDLR
DDKDTIERLR DKKLAPITYP QGLAMAREIG SVKYLECSAL TQRGLKTVFD EAIRAVLCPP
PVKKPGKKCT VF


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