GENTAUR Molecular Products.

 RAC3_MOUSE              Reviewed;         192 AA.
 P60764; O14658;
 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
 13-APR-2004, sequence version 1.
 10-OCT-2018, entry version 135.
 RecName: Full=Ras-related C3 botulinum toxin substrate 3;
 AltName: Full=p21-Rac3;
 Flags: Precursor;
 Name=Rac3;
 Mus musculus (Mouse).
 Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
 Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
 Muroidea; Muridae; Murinae; Mus; Mus.
 NCBI_TaxID=10090;
 [1]
 NUCLEOTIDE SEQUENCE [MRNA].
 Koga H., Sumimoto H.;
 "Mouse Rac3.";
 Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
 [2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
 STRAIN=Swiss Webster; TISSUE=Submandibular gland;
 PubMed=16141072; DOI=10.1126/science.1112014;
 Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
 Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
 Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
 Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
 Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
 Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
 Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
 Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
 di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
 Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
 Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
 Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
 Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
 Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
 Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
 Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
 Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
 Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
 Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
 Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
 Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
 Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
 Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
 Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
 Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
 Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
 Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
 Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
 Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
 Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
 Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
 Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
 Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
 Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
 Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
 Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
 Hayashizaki Y.;
 "The transcriptional landscape of the mammalian genome.";
 Science 309:1559-1563(2005).
 [3]
 IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
 TISSUE=Brain;
 PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
 Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
 Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
 "A tissue-specific atlas of mouse protein phosphorylation and
 expression.";
 Cell 143:1174-1189(2010).
 -!- FUNCTION: Plasma membrane-associated small GTPase which cycles
     between an active GTP-bound and inactive GDP-bound state. In
     active state binds to a variety of effector proteins to regulate
     cellular responses, such as cell spreading and the formation of
     actin-based protusions including lamellipodia and membrane
     ruffles. Promotes cell adhesion and spreading on fibrinogen in a
     CIB1 and alpha-IIb/beta3 integrin-mediated manner (By similarity).
     {ECO:0000250}.
 -!- SUBUNIT: Interacts with the GEF protein DOCK7, which promotes the
     exchange between GDP and GTP, and therefore activates it.
     Interacts with C1D. Interacts (via C-terminal region) with CIB1;
     the interaction induces their association with the cytoskeleton
     upon alpha-IIb/beta3 integrin-mediated adhesion (By similarity).
     {ECO:0000250}.
 -!- INTERACTION:
     Q99PT1:Arhgdia; NbExp=3; IntAct=EBI-644949, EBI-494354;
 -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane
     {ECO:0000250}; Lipid-anchor {ECO:0000250}. Endomembrane system
     {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}.
     Cytoplasm, perinuclear region {ECO:0000250}. Cell membrane
     {ECO:0000250}. Cytoplasm, cytoskeleton. Note=Membrane-associated
     when activated. Colocalizes with NRBP to endomembranes and at the
     cell periphery in lamellipodia. Colocalized with CIB1 in the
     perinuclear area and at the cell periphery (By similarity).
     {ECO:0000250}.
 -!- SIMILARITY: Belongs to the small GTPase superfamily. Rho family.
     {ECO:0000305}.
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 EMBL; AB040819; BAB40573.1; -; mRNA.
 EMBL; AK089930; BAC41001.1; -; mRNA.
 CCDS; CCDS25754.1; -.
 RefSeq; NP_573486.1; NM_133223.4.
 UniGene; Mm.34008; -.
 ProteinModelPortal; P60764; -.
 SMR; P60764; -.
 BioGrid; 228420; 2.
 IntAct; P60764; 4.
 MINT; P60764; -.
 STRING; 10090.ENSMUSP00000018156; -.
 iPTMnet; P60764; -.
 PhosphoSitePlus; P60764; -.
 PaxDb; P60764; -.
 PeptideAtlas; P60764; -.
 PRIDE; P60764; -.
 Ensembl; ENSMUST00000018156; ENSMUSP00000018156; ENSMUSG00000018012.
 GeneID; 170758; -.
 KEGG; mmu:170758; -.
 UCSC; uc007mug.1; mouse.
 CTD; 5881; -.
 MGI; MGI:2180784; Rac3.
 eggNOG; KOG0393; Eukaryota.
 eggNOG; COG1100; LUCA.
 GeneTree; ENSGT00760000118978; -.
 HOGENOM; HOG000233974; -.
 HOVERGEN; HBG009351; -.
 InParanoid; P60764; -.
 KO; K07861; -.
 OMA; GKKCTMF; -.
 OrthoDB; EOG091G0KCM; -.
 PhylomeDB; P60764; -.
 TreeFam; TF101109; -.
 Reactome; R-MMU-194840; Rho GTPase cycle.
 Reactome; R-MMU-4086400; PCP/CE pathway.
 PRO; PR:P60764; -.
 Proteomes; UP000000589; Chromosome 11.
 Bgee; ENSMUSG00000018012; Expressed in 208 organ(s), highest expression level in brain.
 CleanEx; MM_RAC3; -.
 ExpressionAtlas; P60764; baseline and differential.
 Genevisible; P60764; MM.
 GO; GO:0071944; C:cell periphery; ISS:UniProtKB.
 GO; GO:0005856; C:cytoskeleton; ISO:MGI.
 GO; GO:0005829; C:cytosol; ISO:MGI.
 GO; GO:0012505; C:endomembrane system; ISS:UniProtKB.
 GO; GO:0031941; C:filamentous actin; ISO:MGI.
 GO; GO:0030426; C:growth cone; ISO:MGI.
 GO; GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
 GO; GO:0043005; C:neuron projection; ISO:MGI.
 GO; GO:0043025; C:neuronal cell body; ISO:MGI.
 GO; GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
 GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO; GO:0048306; F:calcium-dependent protein binding; ISO:MGI.
 GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO; GO:0003924; F:GTPase activity; ISS:UniProtKB.
 GO; GO:0030036; P:actin cytoskeleton organization; ISS:UniProtKB.
 GO; GO:0030031; P:cell projection assembly; ISS:UniProtKB.
 GO; GO:0021894; P:cerebral cortex GABAergic interneuron development; IGI:MGI.
 GO; GO:0048873; P:homeostasis of number of cells within a tissue; IGI:MGI.
 GO; GO:0050905; P:neuromuscular process; IMP:MGI.
 GO; GO:0050885; P:neuromuscular process controlling balance; IMP:MGI.
 GO; GO:0031175; P:neuron projection development; IDA:MGI.
 GO; GO:0033630; P:positive regulation of cell adhesion mediated by integrin; ISS:UniProtKB.
 GO; GO:1900026; P:positive regulation of substrate adhesion-dependent cell spreading; ISS:UniProtKB.
 GO; GO:0022604; P:regulation of cell morphogenesis; IGI:MGI.
 GO; GO:0014041; P:regulation of neuron maturation; IGI:MGI.
 GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
 GO; GO:0051932; P:synaptic transmission, GABAergic; IGI:MGI.
 InterPro; IPR027417; P-loop_NTPase.
 InterPro; IPR005225; Small_GTP-bd_dom.
 InterPro; IPR001806; Small_GTPase.
 InterPro; IPR003578; Small_GTPase_Rho.
 Pfam; PF00071; Ras; 1.
 SUPFAM; SSF52540; SSF52540; 1.
 TIGRFAMs; TIGR00231; small_GTP; 1.
 PROSITE; PS51420; RHO; 1.
 1: Evidence at protein level;
 Cell membrane; Cell projection; Complete proteome; Cytoplasm;
 Cytoskeleton; GTP-binding; Lipoprotein; Membrane; Methylation;
 Nucleotide-binding; Prenylation; Reference proteome.
 CHAIN         1    189       Ras-related C3 botulinum toxin substrate
                              3.
                              /FTId=PRO_0000198890.
 PROPEP      190    192       Removed in mature form. {ECO:0000250}.
                              /FTId=PRO_0000281241.
 NP_BIND      10     17       GTP. {ECO:0000250}.
 NP_BIND      57     61       GTP. {ECO:0000250}.
 NP_BIND     115    118       GTP. {ECO:0000250}.
 MOTIF        32     40       Effector region. {ECO:0000255}.
 MOD_RES     189    189       Cysteine methyl ester. {ECO:0000250}.
 LIPID       189    189       S-geranylgeranyl cysteine. {ECO:0000250}.
 SEQUENCE   192 AA;  21379 MW;  560BBC26BB7CDF4A CRC64;
 MQAIKCVVVG DGAVGKTCLL ISYTTNAFPG EYIPTVFDNY SANVMVDGKP VNLGLWDTAG
 QEDYDRLRPL SYPQTDVFLI CFSLVSPASF ENVRAKWYPE VRHHCPHTPI LLVGTKLDLR
 DDKDTIERLR DKKLAPITYP QGLAMAREIG SVKYLECSAL TQRGLKTVFD EAIRAVLCPP
 PVKKPGKKCT VF

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