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Ras-related C3 botulinum toxin substrate 3 (p21-Rac3)
RAC3_MOUSE Reviewed; 192 AA.
P60764; O14658;
13-APR-2004, integrated into UniProtKB/Swiss-Prot.
13-APR-2004, sequence version 1.
28-FEB-2018, entry version 132.
RecName: Full=Ras-related C3 botulinum toxin substrate 3;
AltName: Full=p21-Rac3;
Flags: Precursor;
Name=Rac3;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
Koga H., Sumimoto H.;
"Mouse Rac3.";
Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Swiss Webster; TISSUE=Submandibular gland;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[3]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
-!- FUNCTION: Plasma membrane-associated small GTPase which cycles
between an active GTP-bound and inactive GDP-bound state. In
active state binds to a variety of effector proteins to regulate
cellular responses, such as cell spreading and the formation of
actin-based protusions including lamellipodia and membrane
ruffles. Promotes cell adhesion and spreading on fibrinogen in a
CIB1 and alpha-IIb/beta3 integrin-mediated manner (By similarity).
{ECO:0000250}.
-!- SUBUNIT: Interacts with the GEF protein DOCK7, which promotes the
exchange between GDP and GTP, and therefore activates it.
Interacts with C1D. Interacts (via C-terminal region) with CIB1;
the interaction induces their association with the cytoskeleton
upon alpha-IIb/beta3 integrin-mediated adhesion (By similarity).
{ECO:0000250}.
-!- INTERACTION:
Q99PT1:Arhgdia; NbExp=3; IntAct=EBI-644949, EBI-494354;
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane
{ECO:0000250}; Lipid-anchor {ECO:0000250}. Endomembrane system
{ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}.
Cytoplasm, perinuclear region {ECO:0000250}. Cell membrane
{ECO:0000250}. Cytoplasm, cytoskeleton. Note=Membrane-associated
when activated. Colocalizes with NRBP to endomembranes and at the
cell periphery in lamellipodia. Colocalized with CIB1 in the
perinuclear area and at the cell periphery (By similarity).
{ECO:0000250}.
-!- SIMILARITY: Belongs to the small GTPase superfamily. Rho family.
{ECO:0000305}.
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EMBL; AB040819; BAB40573.1; -; mRNA.
EMBL; AK089930; BAC41001.1; -; mRNA.
CCDS; CCDS25754.1; -.
RefSeq; NP_573486.1; NM_133223.4.
UniGene; Mm.34008; -.
ProteinModelPortal; P60764; -.
SMR; P60764; -.
BioGrid; 228420; 1.
IntAct; P60764; 4.
MINT; P60764; -.
STRING; 10090.ENSMUSP00000018156; -.
iPTMnet; P60764; -.
PhosphoSitePlus; P60764; -.
PaxDb; P60764; -.
PeptideAtlas; P60764; -.
PRIDE; P60764; -.
Ensembl; ENSMUST00000018156; ENSMUSP00000018156; ENSMUSG00000018012.
GeneID; 170758; -.
KEGG; mmu:170758; -.
UCSC; uc007mug.1; mouse.
CTD; 5881; -.
MGI; MGI:2180784; Rac3.
eggNOG; KOG0393; Eukaryota.
eggNOG; COG1100; LUCA.
GeneTree; ENSGT00760000118978; -.
HOGENOM; HOG000233974; -.
HOVERGEN; HBG009351; -.
InParanoid; P60764; -.
KO; K07861; -.
OMA; GKKCTMF; -.
OrthoDB; EOG091G0KCM; -.
PhylomeDB; P60764; -.
TreeFam; TF101109; -.
Reactome; R-MMU-194840; Rho GTPase cycle.
Reactome; R-MMU-4086400; PCP/CE pathway.
PRO; PR:P60764; -.
Proteomes; UP000000589; Chromosome 11.
Bgee; ENSMUSG00000018012; -.
CleanEx; MM_RAC3; -.
ExpressionAtlas; P60764; baseline and differential.
Genevisible; P60764; MM.
GO; GO:0071944; C:cell periphery; ISS:UniProtKB.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0012505; C:endomembrane system; ISS:UniProtKB.
GO; GO:0031941; C:filamentous actin; ISO:MGI.
GO; GO:0030426; C:growth cone; ISO:MGI.
GO; GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
GO; GO:0043005; C:neuron projection; ISO:MGI.
GO; GO:0043025; C:neuronal cell body; ISO:MGI.
GO; GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0048306; F:calcium-dependent protein binding; ISO:MGI.
GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO; GO:0003924; F:GTPase activity; ISS:UniProtKB.
GO; GO:0030036; P:actin cytoskeleton organization; ISS:UniProtKB.
GO; GO:0030031; P:cell projection assembly; ISS:UniProtKB.
GO; GO:0021894; P:cerebral cortex GABAergic interneuron development; IGI:MGI.
GO; GO:0048873; P:homeostasis of number of cells within a tissue; IGI:MGI.
GO; GO:0050905; P:neuromuscular process; IMP:MGI.
GO; GO:0050885; P:neuromuscular process controlling balance; IMP:MGI.
GO; GO:0031175; P:neuron projection development; IDA:MGI.
GO; GO:0033630; P:positive regulation of cell adhesion mediated by integrin; ISS:UniProtKB.
GO; GO:1900026; P:positive regulation of substrate adhesion-dependent cell spreading; ISS:UniProtKB.
GO; GO:0022604; P:regulation of cell morphogenesis; IGI:MGI.
GO; GO:0014041; P:regulation of neuron maturation; IGI:MGI.
GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
GO; GO:0051932; P:synaptic transmission, GABAergic; IGI:MGI.
InterPro; IPR027417; P-loop_NTPase.
InterPro; IPR005225; Small_GTP-bd_dom.
InterPro; IPR001806; Small_GTPase.
InterPro; IPR003578; Small_GTPase_Rho.
Pfam; PF00071; Ras; 1.
SUPFAM; SSF52540; SSF52540; 1.
TIGRFAMs; TIGR00231; small_GTP; 1.
PROSITE; PS51420; RHO; 1.
1: Evidence at protein level;
Cell membrane; Cell projection; Complete proteome; Cytoplasm;
Cytoskeleton; GTP-binding; Lipoprotein; Membrane; Methylation;
Nucleotide-binding; Prenylation; Reference proteome.
CHAIN 1 189 Ras-related C3 botulinum toxin substrate
3.
/FTId=PRO_0000198890.
PROPEP 190 192 Removed in mature form. {ECO:0000250}.
/FTId=PRO_0000281241.
NP_BIND 10 17 GTP. {ECO:0000250}.
NP_BIND 57 61 GTP. {ECO:0000250}.
NP_BIND 115 118 GTP. {ECO:0000250}.
MOTIF 32 40 Effector region. {ECO:0000255}.
MOD_RES 189 189 Cysteine methyl ester. {ECO:0000250}.
LIPID 189 189 S-geranylgeranyl cysteine. {ECO:0000250}.
SEQUENCE 192 AA; 21379 MW; 560BBC26BB7CDF4A CRC64;
MQAIKCVVVG DGAVGKTCLL ISYTTNAFPG EYIPTVFDNY SANVMVDGKP VNLGLWDTAG
QEDYDRLRPL SYPQTDVFLI CFSLVSPASF ENVRAKWYPE VRHHCPHTPI LLVGTKLDLR
DDKDTIERLR DKKLAPITYP QGLAMAREIG SVKYLECSAL TQRGLKTVFD EAIRAVLCPP
PVKKPGKKCT VF
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Pathways :
WP1062: Regulation of Actin Cytoskeleton
WP1069: Integrin-mediated cell adhesion
WP1077: cytochrome P450
WP1178: Regulation of Actin Cytoskeleton
WP1185: Integrin-mediated cell adhesion
WP1194: cytochrome P450
WP1219: cytochrome P450
WP1274: cytochrome P450
WP1348: Androgen Receptor Signaling Pathway
WP1380: Regulation of Actin Cytoskeleton
WP1386: Integrin-mediated cell adhesion
WP1390: cytochrome P450
WP1497: Hedgehog-related genes
WP1559: TFs Regulate miRNAs related to cardiac hypertrophy
WP1770: One carbon metabolism and related pathways
WP185: Integrin-mediated cell adhesion
WP188: Focal Adhesion
WP1937: Transport of vitamins, nucleosides, and related molecules
WP201: Ptf1a related regulatory pathway
WP2080: TFs Regulate miRNAs related to cardiac hypertrophy
WP215: noncanonical wnt pathway
WP2199: Seed Development
WP2272: Pathogenic Escherichia coli infection
WP2290: RalA downstream regulated genes
WP252: Androgen Receptor Signaling Pathway
Related Genes :
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