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Ras-related protein Rab-4A

 RAB4A_BOVIN             Reviewed;         218 AA.
Q2TBH7;
07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
06-MAR-2013, sequence version 3.
25-OCT-2017, entry version 102.
RecName: Full=Ras-related protein Rab-4A;
Name=RAB4A;
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Crossbred X Angus; TISSUE=Liver;
NIH - Mammalian Gene Collection (MGC) project;
Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Protein transport. Probably involved in vesicular
traffic (By similarity). {ECO:0000250}.
-!- SUBUNIT: Interacts with RAB11FIP1, RABEP1, ZFYVE20 and RUFY1.
Interacts with SGSM1, SGSM2 and SGSM3. Interacts (membrane-bound
form) with NDRG1; the interaction involves NDRG1 in vesicular
recycling of E-cadherin. Interacts (in GTP-bound form) with
GRIPAP1. Interacts with RABEP1 and RBSN (By similarity). Does not
interact with HPS4 (By similarity). {ECO:0000250|UniProtKB:P20338,
ECO:0000250|UniProtKB:P56371}.
-!- SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:P20338};
Peripheral membrane protein {ECO:0000250|UniProtKB:P20338}.
Cytoplasm {ECO:0000250|UniProtKB:P20338}. Early endosome membrane
{ECO:0000250|UniProtKB:P05714}; Peripheral membrane protein
{ECO:0000250|UniProtKB:P05714}. Recycling endosome membrane
{ECO:0000250|UniProtKB:P05714}; Peripheral membrane protein
{ECO:0000250|UniProtKB:P05714}. Note=Generally associated with
membranes. Cytoplasmic when phosphorylated by CDK1.
{ECO:0000250|UniProtKB:P20338}.
-!- PTM: Phosphorylated by CDK1 kinase during mitosis. {ECO:0000250}.
-!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
{ECO:0000305}.
-!- CAUTION: It is uncertain whether Met-1 or Met-6 is the initiator.
{ECO:0000305}.
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EMBL; BC110198; AAI10199.1; -; mRNA.
RefSeq; NP_001033774.1; NM_001038685.2.
UniGene; Bt.91385; -.
ProteinModelPortal; Q2TBH7; -.
SMR; Q2TBH7; -.
BioGrid; 543454; 2.
STRING; 9913.ENSBTAP00000046611; -.
PaxDb; Q2TBH7; -.
PRIDE; Q2TBH7; -.
Ensembl; ENSBTAT00000049768; ENSBTAP00000046611; ENSBTAG00000018857.
GeneID; 615849; -.
KEGG; bta:615849; -.
CTD; 5867; -.
eggNOG; KOG0086; Eukaryota.
eggNOG; ENOG410XQ9X; LUCA.
GeneTree; ENSGT00760000118841; -.
HOVERGEN; HBG009351; -.
InParanoid; Q2TBH7; -.
KO; K07879; -.
OMA; QNICILL; -.
OrthoDB; EOG091G0QOB; -.
TreeFam; TF300032; -.
Reactome; R-BTA-1660499; Synthesis of PIPs at the plasma membrane.
Reactome; R-BTA-8854214; TBC/RABGAPs.
Reactome; R-BTA-8875656; MET receptor recycling.
Proteomes; UP000009136; Chromosome 28.
Bgee; ENSBTAG00000018857; -.
GO; GO:0005768; C:endosome; IBA:GO_Central.
GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
GO; GO:0032593; C:insulin-responsive compartment; IBA:GO_Central.
GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
GO; GO:0019003; F:GDP binding; ISS:UniProtKB.
GO; GO:0005525; F:GTP binding; ISS:UniProtKB.
GO; GO:0003924; F:GTPase activity; ISS:UniProtKB.
GO; GO:0008565; F:protein transporter activity; IEA:Ensembl.
GO; GO:0019882; P:antigen processing and presentation; IEA:Ensembl.
GO; GO:0030100; P:regulation of endocytosis; IBA:GO_Central.
InterPro; IPR027417; P-loop_NTPase.
InterPro; IPR005225; Small_GTP-bd_dom.
InterPro; IPR001806; Small_GTPase.
Pfam; PF00071; Ras; 1.
SUPFAM; SSF52540; SSF52540; 1.
TIGRFAMs; TIGR00231; small_GTP; 1.
PROSITE; PS51419; RAB; 1.
2: Evidence at transcript level;
Complete proteome; Cytoplasm; Endosome; GTP-binding; Lipoprotein;
Membrane; Methylation; Nucleotide-binding; Phosphoprotein;
Prenylation; Protein transport; Reference proteome; Transport.
CHAIN 1 218 Ras-related protein Rab-4A.
/FTId=PRO_0000226290.
NP_BIND 20 28 GTP. {ECO:0000250|UniProtKB:P61018}.
NP_BIND 68 72 GTP. {ECO:0000250|UniProtKB:P62820}.
NP_BIND 126 129 GTP. {ECO:0000250|UniProtKB:P61018}.
NP_BIND 156 158 GTP. {ECO:0000250|UniProtKB:P61018}.
MOTIF 42 50 Effector region. {ECO:0000250}.
MOD_RES 190 190 Phosphoserine.
{ECO:0000250|UniProtKB:P20338}.
MOD_RES 204 204 Phosphoserine; by CDK1.
{ECO:0000250|UniProtKB:P20338}.
MOD_RES 218 218 Cysteine methyl ester. {ECO:0000250}.
LIPID 216 216 S-geranylgeranyl cysteine. {ECO:0000250}.
LIPID 218 218 S-geranylgeranyl cysteine. {ECO:0000250}.
SEQUENCE 218 AA; 24393 MW; 6C6C20F553274B5A CRC64;
MSQTAMSETY DFLFKFLVIG NAGTGKSCLL HQFIEKKFKD DSNHTIGVEF GSKIINVGGK
YVKLQIWDTA GQERFRSVTR SYYRGAAGAL LVYDITSRET YNALTNWLTD ARMLASQNIV
IILCGNKKDL DTDREVTFLE ASRFAQENEL MFLETSALTG ENVEEAFVQC ARKILNKIES
GELDPERMGS GIQYGDAALR QLRSPRRAQA PSAQECGC


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