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Ras-related protein Rab5

 RAB5_TOBAC              Reviewed;         200 AA.
P29687;
01-APR-1993, integrated into UniProtKB/Swiss-Prot.
01-APR-1993, sequence version 1.
10-MAY-2017, entry version 94.
RecName: Full=Ras-related protein Rab5;
Name=RAB5;
Nicotiana tabacum (Common tobacco).
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
Pentapetalae; asterids; lamiids; Solanales; Solanaceae;
Nicotianoideae; Nicotianeae; Nicotiana.
NCBI_TaxID=4097;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=cv. SR1; TISSUE=Leaf;
PubMed=1643285; DOI=10.1007/BF00027080;
Dallmann G., Sticher L., Marshallsay C., Nagy F.;
"Molecular characterization of tobacco cDNAs encoding two small GTP-
binding proteins.";
Plant Mol. Biol. 19:847-857(1992).
-!- FUNCTION: Protein transport. Probably involved in vesicular
traffic (By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
{ECO:0000305}; Cytoplasmic side {ECO:0000305}.
-!- TISSUE SPECIFICITY: Virtually not expressed in leaves, higher in
stems and roots, and highest in flowers.
-!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
{ECO:0000305}.
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EMBL; X63875; CAA45352.1; -; mRNA.
PIR; S23524; S23524.
UniGene; Nta.3139; -.
ProteinModelPortal; P29687; -.
SMR; P29687; -.
PRIDE; P29687; -.
Proteomes; UP000084051; Genome assembly.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO; GO:0003924; F:GTPase activity; IEA:InterPro.
GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
InterPro; IPR027417; P-loop_NTPase.
InterPro; IPR005225; Small_GTP-bd_dom.
InterPro; IPR001806; Small_GTPase.
Pfam; PF00071; Ras; 1.
SUPFAM; SSF52540; SSF52540; 1.
TIGRFAMs; TIGR00231; small_GTP; 1.
PROSITE; PS51419; RAB; 1.
2: Evidence at transcript level;
Cell membrane; Complete proteome; GTP-binding; Lipoprotein; Membrane;
Nucleotide-binding; Prenylation; Protein transport;
Reference proteome; Transport.
CHAIN 1 200 Ras-related protein Rab5.
/FTId=PRO_0000121278.
NP_BIND 17 25 GTP. {ECO:0000250|UniProtKB:P20339}.
NP_BIND 36 42 GTP. {ECO:0000250|UniProtKB:P20339}.
NP_BIND 65 69 GTP. {ECO:0000250|UniProtKB:P20339}.
NP_BIND 123 126 GTP. {ECO:0000250|UniProtKB:P20339}.
NP_BIND 153 155 GTP. {ECO:0000250|UniProtKB:P20339}.
MOTIF 39 47 Effector region. {ECO:0000255}.
LIPID 198 198 S-geranylgeranyl cysteine. {ECO:0000250}.
LIPID 199 199 S-geranylgeranyl cysteine. {ECO:0000250}.
SEQUENCE 200 AA; 21950 MW; 46643D008C5C7BB6 CRC64;
MASRRHNNLN AKLVLLGDMG AGKSSLVIRF VKGQFLEFQE STIGAAFFSS TVSVNNATVK
FEIWDTAGQE RYHSLAPMYY RGAAAAIIVY DITSTESLAR AKKWVQELQK QGNPNMVMAL
AGNKADLEDK RKVTAEEARL YAEENGLFFM ETSAKTATNV NDIFYEIAKR LPRAQPAQNP
AGMVLEDKPA QGSQAASCCT


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