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Ras-related protein Rap-1A (Ras-related protein Krev-1)

 RAP1A_RAT               Reviewed;         184 AA.
P62836; P10113;
16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
16-AUG-2004, sequence version 1.
05-DEC-2018, entry version 134.
RecName: Full=Ras-related protein Rap-1A;
AltName: Full=Ras-related protein Krev-1;
Flags: Precursor;
Name=Rap1a; Synonyms=Krev1;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
PubMed=2642744; DOI=10.1016/0092-8674(89)90985-9;
Kitayama H., Sugimoto Y., Matsuzaki T., Ikawa Y., Noda M.;
"A ras-related gene with transformation suppressor activity.";
Cell 56:77-84(1989).
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
PubMed=11179219; DOI=10.1093/emboj/20.4.743;
Kelley G.G., Reks S.E., Ondrako J.M., Smrcka A.V.;
"Phospholipase C(epsilon): a novel Ras effector.";
EMBO J. 20:743-754(2001).
PubMed=17724123; DOI=10.1083/jcb.200610073;
Hisata S., Sakisaka T., Baba T., Yamada T., Aoki K., Matsuda M.,
Takai Y.;
"Rap1-PDZ-GEF1 interacts with a neurotrophin receptor at late
endosomes, leading to sustained activation of Rap1 and ERK and neurite
J. Cell Biol. 178:843-860(2007).
-!- FUNCTION: Induces morphological reversion of a cell line
transformed by a Ras oncogene. Counteracts the mitogenic function
of Ras, at least partly because it can interact with Ras GAPs and
RAF in a competitive manner. Together with ITGB1BP1, regulates
KRIT1 localization to microtubules and membranes (By similarity).
Plays a role in nerve growth factor (NGF)-induced neurite
outgrowth. Plays a role in the regulation of embryonic blood
vessel formation. Involved in the establishment of basal
endothelial barrier function. May be involved in the regulation of
the vascular endothelial growth factor receptor KDR expression at
endothelial cell-cell junctions. {ECO:0000250,
-!- ACTIVITY REGULATION: Activated by guanine nucleotide-exchange
factors (GEF) EPAC and EPAC2 in a cAMP-dependent manner, and GFR.
-!- SUBUNIT: Found in a complex, at least composed of ITGB1BP1, KRIT1
and RAP1A. Interacts (active GTP-bound form preferentially) with
KRIT1 (via C-terminus FERM domain); the interaction does not
induce the opening conformation of KRIT1. In its GTP-bound form
interacts with PLCE1 and RADIL. Interacts with SGSM1, SGSM2 and
SGSM3. Interacts (via GTP-bound active form) with RAPGEF2 (via
Ras-associating domain) (By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor
{ECO:0000250}. Cytoplasm, perinuclear region
{ECO:0000269|PubMed:17724123}. Early endosome
{ECO:0000269|PubMed:17724123}. Late endosome
{ECO:0000269|PubMed:17724123}. Cytoplasm {ECO:0000250}. Cell
junction {ECO:0000250}. Note=Localized with RAPGEF2 at cell-cell
junctions. Colocalized with RAPGEF2 in the perinuclear region (By
similarity). Recruited from early endosome to late endosome
compartment after nerve growth factor (NGF) stimulation.
-!- SIMILARITY: Belongs to the small GTPase superfamily. Ras family.
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
EMBL; BC083813; AAH83813.1; -; mRNA.
PIR; A61216; A61216.
RefSeq; NP_001005765.1; NM_001005765.1.
UniGene; Rn.106321; -.
ProteinModelPortal; P62836; -.
SMR; P62836; -.
BioGrid; 254977; 3.
IntAct; P62836; 1.
STRING; 10116.ENSRNOP00000040409; -.
iPTMnet; P62836; -.
PhosphoSitePlus; P62836; -.
PaxDb; P62836; -.
PRIDE; P62836; -.
Ensembl; ENSRNOT00000047836; ENSRNOP00000040409; ENSRNOG00000032463.
GeneID; 295347; -.
KEGG; rno:295347; -.
UCSC; RGD:1359694; rat.
CTD; 5906; -.
RGD; 1359694; Rap1a.
eggNOG; KOG0395; Eukaryota.
eggNOG; COG1100; LUCA.
GeneTree; ENSGT00940000160251; -.
HOGENOM; HOG000233973; -.
HOVERGEN; HBG009351; -.
InParanoid; P62836; -.
KO; K04353; -.
OrthoDB; EOG091G0OOG; -.
PhylomeDB; P62836; -.
TreeFam; TF313014; -.
Reactome; R-RNO-170984; ARMS-mediated activation.
Reactome; R-RNO-354192; Integrin alphaIIb beta3 signaling.
Reactome; R-RNO-354194; GRB2:SOS provides linkage to MAPK signaling for Integrins.
Reactome; R-RNO-372708; p130Cas linkage to MAPK signaling for integrins.
Reactome; R-RNO-381676; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
Reactome; R-RNO-392517; Rap1 signalling.
Reactome; R-RNO-5674135; MAP2K and MAPK activation.
Reactome; R-RNO-6798695; Neutrophil degranulation.
Reactome; R-RNO-8875555; MET activates RAP1 and RAC1.
PRO; PR:P62836; -.
Proteomes; UP000002494; Chromosome 2.
Bgee; ENSRNOG00000032463; Expressed in 9 organ(s), highest expression level in Ammon's horn.
Genevisible; P62836; RN.
GO; GO:0030054; C:cell junction; ISS:UniProtKB.
GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO; GO:0005829; C:cytosol; TAS:Reactome.
GO; GO:0005769; C:early endosome; IDA:UniProtKB.
GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
GO; GO:0032045; C:guanyl-nucleotide exchange factor complex; IEA:Ensembl.
GO; GO:0005770; C:late endosome; IDA:UniProtKB.
GO; GO:0043209; C:myelin sheath; IEA:Ensembl.
GO; GO:0043005; C:neuron projection; IEA:Ensembl.
GO; GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO; GO:0045335; C:phagocytic vesicle; IDA:RGD.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0005525; F:GTP binding; IDA:RGD.
GO; GO:0003924; F:GTPase activity; IEA:Ensembl.
GO; GO:0008565; F:protein transporter activity; ISS:UniProtKB.
GO; GO:0044877; F:protein-containing complex binding; ISS:UniProtKB.
GO; GO:0017034; F:Rap guanyl-nucleotide exchange factor activity; IMP:UniProtKB.
GO; GO:0071320; P:cellular response to cAMP; IEP:RGD.
GO; GO:0035690; P:cellular response to drug; IDA:RGD.
GO; GO:0071333; P:cellular response to glucose stimulus; IEP:RGD.
GO; GO:1990090; P:cellular response to nerve growth factor stimulus; IDA:UniProtKB.
GO; GO:0071407; P:cellular response to organic cyclic compound; IDA:RGD.
GO; GO:0061028; P:establishment of endothelial barrier; ISS:UniProtKB.
GO; GO:0097421; P:liver regeneration; IEP:RGD.
GO; GO:0032966; P:negative regulation of collagen biosynthetic process; IMP:RGD.
GO; GO:2000301; P:negative regulation of synaptic vesicle exocytosis; IEA:Ensembl.
GO; GO:0038180; P:nerve growth factor signaling pathway; IDA:UniProtKB.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IMP:UniProtKB.
GO; GO:1905451; P:positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis; IMP:RGD.
GO; GO:0046326; P:positive regulation of glucose import; IMP:RGD.
GO; GO:0043547; P:positive regulation of GTPase activity; IMP:UniProtKB.
GO; GO:0010976; P:positive regulation of neuron projection development; IMP:UniProtKB.
GO; GO:0045860; P:positive regulation of protein kinase activity; IMP:UniProtKB.
GO; GO:2001214; P:positive regulation of vasculogenesis; ISS:UniProtKB.
GO; GO:0015031; P:protein transport; ISS:UniProtKB.
GO; GO:0032486; P:Rap protein signal transduction; ISS:UniProtKB.
GO; GO:1901888; P:regulation of cell junction assembly; ISS:UniProtKB.
GO; GO:0098696; P:regulation of neurotransmitter receptor localization to postsynaptic specialization membrane; IEA:Ensembl.
GO; GO:0097327; P:response to antineoplastic agent; IDA:RGD.
GO; GO:0009743; P:response to carbohydrate; IEP:RGD.
CDD; cd04175; Rap1; 1.
InterPro; IPR027417; P-loop_NTPase.
InterPro; IPR038851; Rap1.
InterPro; IPR005225; Small_GTP-bd_dom.
InterPro; IPR001806; Small_GTPase.
InterPro; IPR020849; Small_GTPase_Ras-type.
PANTHER; PTHR24070; PTHR24070; 1.
Pfam; PF00071; Ras; 1.
SUPFAM; SSF52540; SSF52540; 1.
TIGRFAMs; TIGR00231; small_GTP; 1.
PROSITE; PS51421; RAS; 1.
1: Evidence at protein level;
Cell junction; Cell membrane; Complete proteome; Cytoplasm; Endosome;
GTP-binding; Lipoprotein; Membrane; Methylation; Neurogenesis;
Nucleotide-binding; Prenylation; Reference proteome; Tumor suppressor.
CHAIN 1 181 Ras-related protein Rap-1A.
PROPEP 182 184 Removed in mature form. {ECO:0000250}.
NP_BIND 10 17 GTP. {ECO:0000250}.
NP_BIND 57 61 GTP. {ECO:0000250}.
NP_BIND 116 119 GTP. {ECO:0000250}.
MOTIF 32 40 Effector region. {ECO:0000305}.
MOD_RES 181 181 Cysteine methyl ester. {ECO:0000250}.
LIPID 181 181 S-geranylgeranyl cysteine. {ECO:0000250}.
SEQUENCE 184 AA; 20987 MW; 42C39290C98E0A92 CRC64;

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