Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Reactive oxygen species modulator 1 (ROS modulator 1) (Epididymis tissue protein Li 175) (Glyrichin) (Mitochondrial targeting GxxxG motif protein) (MTGM) (Protein MGR2 homolog)

 ROMO1_HUMAN             Reviewed;          79 AA.
P60602; A7M872; E1P5R9; E9KL28; Q3MHD5; Q5QP16; Q9CQ98; Q9H1N2;
15-MAR-2004, integrated into UniProtKB/Swiss-Prot.
15-MAR-2004, sequence version 1.
12-SEP-2018, entry version 118.
RecName: Full=Reactive oxygen species modulator 1;
Short=ROS modulator 1;
AltName: Full=Epididymis tissue protein Li 175;
AltName: Full=Glyrichin;
AltName: Full=Mitochondrial targeting GxxxG motif protein;
Short=MTGM;
AltName: Full=Protein MGR2 homolog;
Name=ROMO1; Synonyms=C20orf52;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY,
AND SUBCELLULAR LOCATION.
TISSUE=Brain;
PubMed=19535734; DOI=10.1242/jcs.038513;
Zhao J., Liu T., Jin S.B., Tomilin N., Castro J., Shupliakov O.,
Lendahl U., Nister M.;
"The novel conserved mitochondrial inner-membrane protein MTGM
regulates mitochondrial morphology and cell proliferation.";
J. Cell Sci. 122:2252-2262(2009).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Epididymis;
PubMed=20736409; DOI=10.1074/mcp.M110.001719;
Li J., Liu F., Wang H., Liu X., Liu J., Li N., Wan F., Wang W.,
Zhang C., Jin S., Liu J., Zhu P., Liu Y.;
"Systematic mapping and functional analysis of a family of human
epididymal secretory sperm-located proteins.";
Mol. Cell. Proteomics 9:2517-2528(2010).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=11780052; DOI=10.1038/414865a;
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M.,
Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J.,
Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P.,
Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M.,
Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R.,
Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M.,
Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H.,
Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S.,
Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E.,
Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A.,
Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M.,
Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A.,
Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S.,
Rogers J.;
"The DNA sequence and comparative analysis of human chromosome 20.";
Nature 414:865-871(2001).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Bone marrow;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
PubMed=16842742; DOI=10.1016/j.bbrc.2006.06.140;
Chung Y.M., Kim J.S., Yoo Y.D.;
"A novel protein, Romo1, induces ROS production in the mitochondria.";
Biochem. Biophys. Res. Commun. 347:649-655(2006).
[7]
FUNCTION, AND INDUCTION.
PubMed=17537404; DOI=10.1016/j.bbrc.2007.05.088;
Hwang I.T., Chung Y.M., Kim J.J., Chung J.S., Kim B.S., Kim H.J.,
Kim J.S., Yoo Y.D.;
"Drug resistance to 5-FU linked to reactive oxygen species modulator
1.";
Biochem. Biophys. Res. Commun. 359:304-310(2007).
[8]
FUNCTION.
PubMed=18313394; DOI=10.1016/j.bbrc.2008.02.098;
Na A.R., Chung Y.M., Lee S.B., Park S.H., Lee M.-S., Yoo Y.D.;
"A critical role for Romo1-derived ROS in cell proliferation.";
Biochem. Biophys. Res. Commun. 369:672-678(2008).
[9]
FUNCTION, AND DEVELOPMENTAL STAGE.
PubMed=18836179; DOI=10.1074/jbc.M805334200;
Chung Y.M., Lee S.B., Kim H.J., Park S.H., Kim J.J., Chung J.S.,
Yoo Y.D.;
"Replicative senescence induced by Romo1-derived reactive oxygen
species.";
J. Biol. Chem. 283:33763-33771(2008).
[10]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=21269460; DOI=10.1186/1752-0509-5-17;
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
"Initial characterization of the human central proteome.";
BMC Syst. Biol. 5:17-17(2011).
[11]
ANTIBACTERIAL FUNCTION.
PubMed=22083756; DOI=10.1002/psc.1421;
Sha J., Zhao G., Chen X., Guan W., He Y., Wang Z.;
"Antibacterial potential of hGlyrichin encoded by a human gene.";
J. Pept. Sci. 18:97-104(2012).
[12]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=22814378; DOI=10.1073/pnas.1210303109;
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E.,
Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K.,
Aldabe R.;
"N-terminal acetylome analyses and functional insights of the N-
terminal acetyltransferase NatB.";
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
[13]
CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=25944712; DOI=10.1002/pmic.201400617;
Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M.,
Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
"N-terminome analysis of the human mitochondrial proteome.";
Proteomics 15:2519-2524(2015).
-!- FUNCTION: Induces production of reactive oxygen species (ROS)
which are necessary for cell proliferation. May play a role in
inducing oxidative DNA damage and replicative senescence. May play
a role in the coordination of mitochondrial morphology and cell
proliferation.
-!- FUNCTION: Has antibacterial activity against a variety of bacteria
including S.aureus, P.aeruginosa and M.tuberculosis. Acts by
inducing bacterial membrane breakage.
-!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
{ECO:0000269|PubMed:16842742, ECO:0000269|PubMed:19535734};
Single-pass membrane protein {ECO:0000269|PubMed:16842742,
ECO:0000269|PubMed:19535734}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=P60602-1; Sequence=Displayed;
Name=2;
IsoId=P60602-2; Sequence=VSP_036486;
Note=Gene prediction based on EST data.;
-!- TISSUE SPECIFICITY: Up-regulated in a number of cancer cell lines
when compared to a normal lung fibroblast cell line. Highly
expressed in brain tumors. {ECO:0000269|PubMed:16842742,
ECO:0000269|PubMed:19535734}.
-!- DEVELOPMENTAL STAGE: Expression increases in senescent cells.
{ECO:0000269|PubMed:18836179}.
-!- INDUCTION: By the anticancer drug fluorouracil (5FU).
{ECO:0000269|PubMed:17537404}.
-!- MISCELLANEOUS: Enforced expression in IMR-90 cells leads to
increased levels of ROS and induces premature cell senescence and
nuclear DNA damage.
-!- SIMILARITY: Belongs to the MGR2 family. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; AM397244; CAL37002.1; -; mRNA.
EMBL; AM397245; CAL37003.1; -; mRNA.
EMBL; AM397246; CAL37004.1; -; mRNA.
EMBL; GU727625; ADU87627.1; -; mRNA.
EMBL; AL357374; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CH471077; EAW76168.1; -; Genomic_DNA.
EMBL; CH471077; EAW76169.1; -; Genomic_DNA.
EMBL; BC008488; AAH08488.1; -; mRNA.
EMBL; BC105281; AAI05282.1; -; mRNA.
CCDS; CCDS13264.1; -. [P60602-1]
RefSeq; NP_542786.1; NM_080748.2. [P60602-1]
RefSeq; XP_016883167.1; XM_017027678.1. [P60602-1]
UniGene; Hs.472564; -.
ProteinModelPortal; P60602; -.
BioGrid; 126718; 7.
IntAct; P60602; 3.
MINT; P60602; -.
STRING; 9606.ENSP00000338293; -.
TCDB; 1.A.111.1.1; the reactive oxygen species modulator 1 (romo1) family.
BioMuta; ROMO1; -.
DMDM; 45593159; -.
EPD; P60602; -.
MaxQB; P60602; -.
PaxDb; P60602; -.
PeptideAtlas; P60602; -.
PRIDE; P60602; -.
ProteomicsDB; 57216; -.
ProteomicsDB; 57217; -. [P60602-2]
TopDownProteomics; P60602-1; -. [P60602-1]
DNASU; 140823; -.
Ensembl; ENST00000336695; ENSP00000338293; ENSG00000125995. [P60602-1]
Ensembl; ENST00000374072; ENSP00000363185; ENSG00000125995. [P60602-2]
Ensembl; ENST00000374077; ENSP00000363190; ENSG00000125995. [P60602-1]
Ensembl; ENST00000374078; ENSP00000363191; ENSG00000125995. [P60602-1]
Ensembl; ENST00000397416; ENSP00000380561; ENSG00000125995. [P60602-1]
GeneID; 140823; -.
KEGG; hsa:140823; -.
UCSC; uc002xdy.4; human. [P60602-1]
CTD; 140823; -.
DisGeNET; 140823; -.
EuPathDB; HostDB:ENSG00000125995.15; -.
GeneCards; ROMO1; -.
HGNC; HGNC:16185; ROMO1.
HPA; HPA012782; -.
neXtProt; NX_P60602; -.
OpenTargets; ENSG00000125995; -.
PharmGKB; PA164725540; -.
eggNOG; KOG4096; Eukaryota.
eggNOG; ENOG411279J; LUCA.
GeneTree; ENSGT00390000005315; -.
HOVERGEN; HBG051169; -.
InParanoid; P60602; -.
OMA; LKMGAMM; -.
OrthoDB; EOG091G17TT; -.
PhylomeDB; P60602; -.
TreeFam; TF300273; -.
ChiTaRS; ROMO1; human.
GenomeRNAi; 140823; -.
PRO; PR:P60602; -.
Proteomes; UP000005640; Chromosome 20.
Bgee; ENSG00000125995; Expressed in 200 organ(s), highest expression level in quadriceps femoris.
CleanEx; HS_ROMO1; -.
Genevisible; P60602; HS.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
GO; GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IMP:UniProtKB.
GO; GO:0034614; P:cellular response to reactive oxygen species; IMP:UniProtKB.
GO; GO:0051715; P:cytolysis in other organism; IDA:UniProtKB.
GO; GO:0042742; P:defense response to bacterium; IDA:UniProtKB.
GO; GO:0050829; P:defense response to Gram-negative bacterium; IDA:UniProtKB.
GO; GO:0050830; P:defense response to Gram-positive bacterium; IDA:UniProtKB.
GO; GO:0031640; P:killing of cells of other organism; IDA:UniProtKB.
GO; GO:0008284; P:positive regulation of cell proliferation; IDA:UniProtKB.
GO; GO:2000379; P:positive regulation of reactive oxygen species metabolic process; IDA:UniProtKB.
GO; GO:0001302; P:replicative cell aging; IMP:UniProtKB.
InterPro; IPR018450; Romo1/Mgr2.
PANTHER; PTHR28525; PTHR28525; 1.
Pfam; PF10247; Romo1; 1.
SMART; SM01378; Romo1; 1.
1: Evidence at protein level;
Alternative splicing; Antibiotic; Antimicrobial; Complete proteome;
Membrane; Mitochondrion; Mitochondrion inner membrane; Polymorphism;
Reference proteome; Transmembrane; Transmembrane helix.
INIT_MET 1 1 Removed. {ECO:0000244|PubMed:25944712}.
CHAIN 2 79 Reactive oxygen species modulator 1.
/FTId=PRO_0000079433.
TRANSMEM 22 44 Helical. {ECO:0000255}.
REGION 42 60 Sufficient for antibacterial activity.
VAR_SEQ 44 79 RIGMRGRELMGGIGKTMMQSGGTFGTFMAIGMGIRC -> S
SILVSSSGSECGVES (in isoform 2).
{ECO:0000305}.
/FTId=VSP_036486.
VARIANT 28 28 A -> P (in dbSNP:rs1044521).
/FTId=VAR_014127.
SEQUENCE 79 AA; 8183 MW; AD959C88C89EF80A CRC64;
MPVAVGPYGQ SQPSCFDRVK MGFVMGCAVG MAAGALFGTF SCLRIGMRGR ELMGGIGKTM
MQSGGTFGTF MAIGMGIRC


Related products :

Catalog number Product name Quantity
EIAAB35695 Pig,Protein MGR2 homolog,Reactive oxygen species modulator 1,ROMO1,ROS modulator 1,Sus scrofa
EIAAB35697 Mouse,Mus musculus,Protein MGR2 homolog,Reactive oxygen species modulator 1,Romo1,ROS modulator 1
EIAAB35694 Bos taurus,Bovine,Protein MGR2 homolog,Reactive oxygen species modulator 1,ROMO1,ROS modulator 1
EIAAB35696 C20orf52,Homo sapiens,Human,Protein MGR2 homolog,Reactive oxygen species modulator 1,ROMO1,ROS modulator 1
EH2003 Reactive oxygen species modulator 1 Elisa Kit 96T
EM699 Reactive oxygen species modulator 1 Elisa Kit 96T
E6264h Human Reactive Oxygen Species Modulator 1 ELISA Ki 96T
E0900Ra Rat Reactive oxygen species modulator 1(ROMO1)ELISA Kit 96T
E0899Ra Rat Reactive oxygen species modulator 1(ROMO1)ELISA Kit 48T
YHB0934Ra Rat Reactive oxygen species modulator 1(ROMO1)ELISA Kit 96T
E0900Ra Rat Reactive oxygen species modulator 1(ROMO1)ELISA Kit 48T
G6785 Reactive oxygen species modulator 1 (ROMO1), Pig, ELISA Kit 96T
G6786 Reactive oxygen species modulator 1 (ROMO1), Rat, ELISA kit 96T
CSB-EL020063RA Rat Reactive oxygen species modulator 1(ROMO1) ELISA kit 96T
YHB0934Ra Rat Reactive oxygen species modulator 1(ROMO1)ELISA Kit 48T
G6783 Reactive oxygen species modulator 1 (ROMO1), Human, ELISA Kit 96T
YHB0328Po Porcine Reactive oxygen species modulator 1(ROMO1)ELISA Kit 96T
CSB-EL020063PI Pig Reactive oxygen species modulator 1(ROMO1) ELISA kit SpeciesPig 96T
G6782 Reactive oxygen species modulator 1 (ROMO1), Bovine, ELISA Kit 96T
YHB2545Hu Human Reactive oxygen species modulator 1(ROMO1)ELISA Kit 96T
CSB-EL020063MO Mouse Reactive oxygen species modulator 1(ROMO1) ELISA kit 96T
YHB2545Hu Human Reactive oxygen species modulator 1(ROMO1)ELISA Kit 48T
E0338Po Porcine Reactive oxygen species modulator 1(ROMO1)ELISA Kit 96T
YHB0184Bo Bovine Reactive oxygen species modulator 1(ROMO1)ELISA Kit 96T
E2143Hu Human Reactive oxygen species modulator 1(ROMO1)ELISA Kit 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur