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Receptor activity modifying protein 2

 G1LJT5_AILME            Unreviewed;       177 AA.
G1LJT5;
19-OCT-2011, integrated into UniProtKB/TrEMBL.
19-OCT-2011, sequence version 1.
28-MAR-2018, entry version 32.
SubName: Full=Receptor activity modifying protein 2 {ECO:0000313|Ensembl:ENSAMEP00000007193};
Name=RAMP2 {ECO:0000313|Ensembl:ENSAMEP00000007193};
Ailuropoda melanoleuca (Giant panda).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae;
Ailuropoda.
NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000007193, ECO:0000313|Proteomes:UP000008912};
[1] {ECO:0000313|Ensembl:ENSAMEP00000007193}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=20010809; DOI=10.1038/nature08696;
Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q.,
Li B., Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H.,
Jian M., Li J., Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z.,
Ryder O.A., Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X.,
Guo X., Wang B., Hou R., Shen F., Mu B., Ni P., Lin R., Qian W.,
Wang G., Yu C., Nie W., Wang J., Wu Z., Liang H., Min J., Wu Q.,
Cheng S., Ruan J., Wang M., Shi Z., Wen M., Liu B., Ren X., Zheng H.,
Dong D., Cook K., Shan G., Zhang H., Kosiol C., Xie X., Lu Z.,
Zheng H., Li Y., Steiner C.C., Lam T.T., Lin S., Zhang Q., Li G.,
Tian J., Gong T., Liu H., Zhang D., Fang L., Ye C., Zhang J., Hu W.,
Xu A., Ren Y., Zhang G., Bruford M.W., Li Q., Ma L., Guo Y., An N.,
Hu Y., Zheng Y., Shi Y., Li Z., Liu Q., Chen Y., Zhao J., Qu N.,
Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X., Vinar T., Wang Y.,
Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y., Wang X.,
Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H.,
Wang J., Wang J.;
"The sequence and de novo assembly of the giant panda genome.";
Nature 463:311-317(2010).
[2] {ECO:0000313|Ensembl:ENSAMEP00000007193}
IDENTIFICATION.
Ensembl;
Submitted (SEP-2011) to UniProtKB.
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EMBL; ACTA01068010; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ACTA01076010; -; NOT_ANNOTATED_CDS; Genomic_DNA.
STRING; 9646.ENSAMEP00000007193; -.
Ensembl; ENSAMET00000007498; ENSAMEP00000007193; ENSAMEG00000006821.
eggNOG; ENOG410IYPR; Eukaryota.
eggNOG; ENOG4112A9G; LUCA.
GeneTree; ENSGT00390000016200; -.
InParanoid; G1LJT5; -.
OMA; DLGFPNP; -.
OrthoDB; EOG091G0RMZ; -.
TreeFam; TF333286; -.
Proteomes; UP000008912; Unassembled WGS sequence.
GO; GO:1903143; C:adrenomedullin receptor complex; IEA:Ensembl.
GO; GO:1903440; C:amylin receptor complex; IEA:Ensembl.
GO; GO:0009986; C:cell surface; ISS:UniProtKB.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0043235; C:receptor complex; ISS:UniProtKB.
GO; GO:1990409; F:adrenomedullin binding; IEA:Ensembl.
GO; GO:0001605; F:adrenomedullin receptor activity; IEA:Ensembl.
GO; GO:0097643; F:amylin receptor activity; IEA:Ensembl.
GO; GO:0015026; F:coreceptor activity; ISS:UniProtKB.
GO; GO:0008565; F:protein transporter activity; ISS:UniProtKB.
GO; GO:0007189; P:adenylate cyclase-activating G-protein coupled receptor signaling pathway; IEA:Ensembl.
GO; GO:0034333; P:adherens junction assembly; ISS:UniProtKB.
GO; GO:1990410; P:adrenomedullin receptor signaling pathway; IEA:Ensembl.
GO; GO:0097647; P:amylin receptor signaling pathway; IEA:Ensembl.
GO; GO:0001525; P:angiogenesis; ISS:UniProtKB.
GO; GO:0070831; P:basement membrane assembly; ISS:UniProtKB.
GO; GO:0070830; P:bicellular tight junction assembly; ISS:UniProtKB.
GO; GO:0006816; P:calcium ion transport; ISS:UniProtKB.
GO; GO:0035924; P:cellular response to vascular endothelial growth factor stimulus; ISS:UniProtKB.
GO; GO:0007507; P:heart development; ISS:UniProtKB.
GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
GO; GO:2000352; P:negative regulation of endothelial cell apoptotic process; ISS:UniProtKB.
GO; GO:0043116; P:negative regulation of vascular permeability; ISS:UniProtKB.
GO; GO:0045766; P:positive regulation of angiogenesis; ISS:UniProtKB.
GO; GO:0030816; P:positive regulation of cAMP metabolic process; IEA:Ensembl.
GO; GO:0010628; P:positive regulation of gene expression; ISS:UniProtKB.
GO; GO:2001214; P:positive regulation of vasculogenesis; IEA:Ensembl.
GO; GO:0072659; P:protein localization to plasma membrane; ISS:UniProtKB.
GO; GO:0015031; P:protein transport; ISS:UniProtKB.
GO; GO:0031623; P:receptor internalization; ISS:UniProtKB.
GO; GO:0008217; P:regulation of blood pressure; ISS:UniProtKB.
GO; GO:0008277; P:regulation of G-protein coupled receptor protein signaling pathway; IEA:InterPro.
GO; GO:0002040; P:sprouting angiogenesis; ISS:UniProtKB.
GO; GO:0097084; P:vascular smooth muscle cell development; ISS:UniProtKB.
GO; GO:0001570; P:vasculogenesis; ISS:UniProtKB.
Gene3D; 1.10.150.510; -; 1.
InterPro; IPR006985; RAMP.
InterPro; IPR038126; RAMP_sf.
PANTHER; PTHR14076; PTHR14076; 1.
Pfam; PF04901; RAMP; 1.
4: Predicted;
Complete proteome {ECO:0000313|Proteomes:UP000008912};
Membrane {ECO:0000256|SAM:Phobius};
Reference proteome {ECO:0000313|Proteomes:UP000008912};
Transmembrane {ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAM:Phobius}.
TRANSMEM 147 168 Helical. {ECO:0000256|SAM:Phobius}.
SEQUENCE 177 AA; 20149 MW; 50AEDFCBF1DB1E86 CRC64;
SGGRQGRVGH PRPPRGRSRP SPCEEAARLP LLLGAVLKPQ ESLAQVPPTE SILKSKEDKM
ENYERTIQFC WQSYKEEMDS IPKDWCDWAM ISRPYSDLQY CLEHFADLFQ LGFPNPRAEE
IIFETHQIHF ANCSLVQPTL SDPPEDVLLA MIIAPICLIP FLVTLVVWRS KDSEAQA


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