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Receptor activity-modifying protein 3

 RAMP3_RAT               Reviewed;         147 AA.
Q9JJ73;
24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
01-OCT-2000, sequence version 1.
28-MAR-2018, entry version 104.
RecName: Full=Receptor activity-modifying protein 3;
Flags: Precursor;
Name=Ramp3;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Sprague-Dawley; TISSUE=Brain;
PubMed=11230971; DOI=10.1016/S0008-6363(00)00291-1;
Tomoda Y., Kikumoto K., Isumi Y., Katafuchi T., Tanaka A., Kangawa K.,
Dohi K., Minamino N.;
"Cardiac fibroblasts are major production and target cells of
adrenomedullin in the heart in vitro.";
Cardiovasc. Res. 49:721-730(2001).
[2]
NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
STRAIN=Sprague-Dawley; TISSUE=Heart;
PubMed=11556887; DOI=10.1046/j.0953-816x.2001.01688.x;
Oliver K.R., Kane S.A., Salvatore C.A., Mallee J.J., Kinsey A.M.,
Koblan K.S., Keyvan-Fouladi N., Heavens R.P., Wainwright A.,
Jacobson M., Dickerson I.M., Hill R.G.;
"Cloning, characterization and central nervous system distribution of
receptor activity modifying proteins in the rat.";
Eur. J. Neurosci. 14:618-628(2001).
-!- FUNCTION: Plays a role in cardioprotection by reducing cardiac
hypertrophy and perivascular fibrosis in a GPER1-dependent manner.
Transports the calcitonin gene-related peptide type 1 receptor
(CALCRL) and GPER1 to the plasma membrane. Acts as a receptor for
adrenomedullin (AM) together with CALCRL.
{ECO:0000269|PubMed:11556887}.
-!- SUBUNIT: Heterodimer of CALCRL and RAMP3. Interacts with GPER1.
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass
type I membrane protein {ECO:0000250}. Membrane {ECO:0000250};
Single-pass type I membrane protein {ECO:0000250}. Note=Moves from
intracellular puncta to the plasma membrane in a RAMP3-dependent
manner. {ECO:0000250}.
-!- SIMILARITY: Belongs to the RAMP family. {ECO:0000305}.
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EMBL; AB042889; BAB03506.1; -; mRNA.
EMBL; AF181552; AAG09436.2; -; mRNA.
RefSeq; NP_064485.2; NM_020100.2.
UniGene; Rn.48672; -.
ProteinModelPortal; Q9JJ73; -.
STRING; 10116.ENSRNOP00000010866; -.
GuidetoPHARMACOLOGY; 53; -.
PaxDb; Q9JJ73; -.
Ensembl; ENSRNOT00000086468; ENSRNOP00000074204; ENSRNOG00000053766.
GeneID; 56820; -.
KEGG; rno:56820; -.
UCSC; RGD:61873; rat.
CTD; 10268; -.
RGD; 61873; Ramp3.
eggNOG; ENOG410IXGF; Eukaryota.
eggNOG; ENOG4111U8C; LUCA.
GeneTree; ENSGT00390000016200; -.
HOGENOM; HOG000253018; -.
HOVERGEN; HBG061268; -.
InParanoid; Q9JJ73; -.
KO; K08449; -.
OMA; VDVWKWC; -.
OrthoDB; EOG091G0W6Z; -.
PhylomeDB; Q9JJ73; -.
TreeFam; TF333286; -.
Reactome; R-RNO-418555; G alpha (s) signalling events.
Reactome; R-RNO-419812; Calcitonin-like ligand receptors.
PRO; PR:Q9JJ73; -.
Proteomes; UP000002494; Chromosome 14.
Bgee; ENSRNOG00000053766; -.
Genevisible; Q9JJ73; RN.
GO; GO:1903143; C:adrenomedullin receptor complex; ISO:RGD.
GO; GO:1903440; C:amylin receptor complex; ISO:RGD.
GO; GO:0009986; C:cell surface; ISO:RGD.
GO; GO:0005622; C:intracellular; ISS:UniProtKB.
GO; GO:0005764; C:lysosome; IEA:Ensembl.
GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
GO; GO:0043235; C:receptor complex; ISO:RGD.
GO; GO:0001605; F:adrenomedullin receptor activity; ISO:RGD.
GO; GO:0097643; F:amylin receptor activity; IEA:Ensembl.
GO; GO:0015026; F:coreceptor activity; IDA:RGD.
GO; GO:0001664; F:G-protein coupled receptor binding; NAS:RGD.
GO; GO:0046982; F:protein heterodimerization activity; NAS:RGD.
GO; GO:0008565; F:protein transporter activity; ISO:RGD.
GO; GO:0004872; F:receptor activity; ISO:RGD.
GO; GO:0007189; P:adenylate cyclase-activating G-protein coupled receptor signaling pathway; ISO:RGD.
GO; GO:1990410; P:adrenomedullin receptor signaling pathway; ISO:RGD.
GO; GO:0097647; P:amylin receptor signaling pathway; ISO:RGD.
GO; GO:0006816; P:calcium ion transport; ISO:RGD.
GO; GO:0071392; P:cellular response to estradiol stimulus; ISS:UniProtKB.
GO; GO:0007186; P:G-protein coupled receptor signaling pathway; ISO:RGD.
GO; GO:0086103; P:G-protein coupled receptor signaling pathway involved in heart process; ISS:UniProtKB.
GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISO:RGD.
GO; GO:1905665; P:positive regulation of calcium ion import across plasma membrane; ISO:RGD.
GO; GO:0030816; P:positive regulation of cAMP metabolic process; ISO:RGD.
GO; GO:0010942; P:positive regulation of cell death; ISO:RGD.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISO:RGD.
GO; GO:0010628; P:positive regulation of gene expression; ISO:RGD.
GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; ISO:RGD.
GO; GO:0010739; P:positive regulation of protein kinase A signaling; ISO:RGD.
GO; GO:0051897; P:positive regulation of protein kinase B signaling; ISO:RGD.
GO; GO:1903078; P:positive regulation of protein localization to plasma membrane; ISS:UniProtKB.
GO; GO:0001921; P:positive regulation of receptor recycling; ISO:RGD.
GO; GO:0072659; P:protein localization to plasma membrane; ISO:RGD.
GO; GO:0015031; P:protein transport; ISO:RGD.
GO; GO:0031623; P:receptor internalization; ISO:RGD.
GO; GO:0008277; P:regulation of G-protein coupled receptor protein signaling pathway; IEA:InterPro.
Gene3D; 1.10.150.510; -; 1.
InterPro; IPR006985; RAMP.
InterPro; IPR038126; RAMP_sf.
PANTHER; PTHR14076; PTHR14076; 1.
Pfam; PF04901; RAMP; 1.
2: Evidence at transcript level;
Cell membrane; Complete proteome; Disulfide bond; Glycoprotein;
Membrane; Receptor; Reference proteome; Signal; Transmembrane;
Transmembrane helix; Transport.
SIGNAL 1 22 {ECO:0000255}.
CHAIN 23 147 Receptor activity-modifying protein 3.
/FTId=PRO_0000030178.
TOPO_DOM 23 117 Extracellular. {ECO:0000255}.
TRANSMEM 118 137 Helical. {ECO:0000255}.
TOPO_DOM 138 147 Cytoplasmic. {ECO:0000255}.
CARBOHYD 28 28 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 57 57 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 70 70 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 102 102 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 39 71 {ECO:0000250}.
DISULFID 56 103 {ECO:0000250}.
SEQUENCE 147 AA; 16781 MW; FCD518954AC5E52B CRC64;
MATPAQRLHL LPLLLLLCGE CAQVCGCNET GMLERLPRCG KAFAEMMQKV DVWKWCNLSE
FIVYYESFTN CTEMETNIVG CYWPNPLAQS FITGIHRQFF SNCTVDRTHW EDPPDEVLIP
LIAVPVLLTV AMAGLVVWRS KRTDRLL


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