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Receptor activity-modifying protein 3

 RAMP3_MOUSE             Reviewed;         147 AA.
Q9WUP1; Q5SWP4;
10-JAN-2003, integrated into UniProtKB/Swiss-Prot.
01-NOV-1999, sequence version 1.
18-JUL-2018, entry version 121.
RecName: Full=Receptor activity-modifying protein 3;
Flags: Precursor;
Name=Ramp3;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
Derst C., Preisig-Mueller R., Gerhardus J., Daut J.;
"Cloning and sequencing of mouse CGRP/adrenomedullin receptor
subunits.";
Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
PubMed=10854696; DOI=10.1016/S0303-7207(00)00212-4;
Husmann K., Sexton P.M., Fischer J.A., Born W.;
"Mouse receptor-activity-modifying proteins 1, -2 and -3: amino acid
sequence, expression and function.";
Mol. Cell. Endocrinol. 162:35-43(2000).
[3]
NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
STRAIN=C57BL/6J; TISSUE=Lung;
PubMed=10777702; DOI=10.1006/bbrc.2000.2606;
Ono Y., Okano I., Kojima M., Okada K., Kangawa K.;
"Decreased gene expression of adrenomedullin receptor in mouse lungs
during sepsis.";
Biochem. Biophys. Res. Commun. 271:197-202(2000).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J;
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
Lindblad-Toh K., Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of
the mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Eye;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
FUNCTION, AND SUBCELLULAR LOCATION.
PubMed=23674134; DOI=10.1530/JME-13-0021;
Lenhart P.M., Broselid S., Barrick C.J., Leeb-Lundberg L.M.,
Caron K.M.;
"G-protein-coupled receptor 30 interacts with receptor activity-
modifying protein 3 and confers sex-dependent cardioprotection.";
J. Mol. Endocrinol. 51:191-202(2013).
-!- FUNCTION: Plays a role in cardioprotection by reducing cardiac
hypertrophy and perivascular fibrosis in a GPER1-dependent manner.
Transports the calcitonin gene-related peptide type 1 receptor
(CALCRL) to the plasma membrane. Acts as a receptor for
adrenomedullin (AM) together with CALCRL.
{ECO:0000269|PubMed:10854696, ECO:0000269|PubMed:23674134}.
-!- SUBUNIT: Interacts with GPER1 (By similarity). Heterodimer of
CALCRL and RAMP3. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23674134};
Single-pass type I membrane protein {ECO:0000269|PubMed:23674134}.
Membrane {ECO:0000250}; Single-pass type I membrane protein
{ECO:0000250}.
-!- TISSUE SPECIFICITY: Expressed predominantly in the testis,
embryonic and adult brain and in kidney.
{ECO:0000269|PubMed:10777702, ECO:0000269|PubMed:10854696}.
-!- SIMILARITY: Belongs to the RAMP family. {ECO:0000305}.
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EMBL; AF146524; AAD35020.1; -; mRNA.
EMBL; AJ250491; CAB59513.1; -; mRNA.
EMBL; AF209907; AAF21039.1; -; mRNA.
EMBL; AL603787; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC024765; AAH24765.1; -; mRNA.
CCDS; CCDS24425.1; -.
PIR; JC7263; JC7263.
RefSeq; NP_062384.1; NM_019511.3.
UniGene; Mm.39884; -.
ProteinModelPortal; Q9WUP1; -.
ComplexPortal; CPX-3151; Adrenomedullin receptor AM2 complex.
ComplexPortal; CPX-3237; Amylin receptor 3 complex.
STRING; 10090.ENSMUSP00000047518; -.
GuidetoPHARMACOLOGY; 53; -.
PaxDb; Q9WUP1; -.
PRIDE; Q9WUP1; -.
Ensembl; ENSMUST00000045374; ENSMUSP00000047518; ENSMUSG00000041046.
GeneID; 56089; -.
KEGG; mmu:56089; -.
UCSC; uc007hzd.1; mouse.
CTD; 10268; -.
MGI; MGI:1860292; Ramp3.
eggNOG; ENOG410IXGF; Eukaryota.
eggNOG; ENOG4111U8C; LUCA.
GeneTree; ENSGT00390000016200; -.
HOGENOM; HOG000253018; -.
HOVERGEN; HBG061268; -.
InParanoid; Q9WUP1; -.
KO; K08449; -.
OMA; VDVWKWC; -.
OrthoDB; EOG091G0W6Z; -.
PhylomeDB; Q9WUP1; -.
TreeFam; TF333286; -.
Reactome; R-MMU-418555; G alpha (s) signalling events.
Reactome; R-MMU-419812; Calcitonin-like ligand receptors.
PRO; PR:Q9WUP1; -.
Proteomes; UP000000589; Chromosome 11.
Bgee; ENSMUSG00000041046; -.
Genevisible; Q9WUP1; MM.
GO; GO:1903143; C:adrenomedullin receptor complex; ISO:MGI.
GO; GO:1903440; C:amylin receptor complex; ISO:MGI.
GO; GO:0009986; C:cell surface; ISO:MGI.
GO; GO:0005622; C:intracellular; ISS:UniProtKB.
GO; GO:0005764; C:lysosome; IEA:Ensembl.
GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO; GO:0043235; C:receptor complex; ISO:MGI.
GO; GO:0001605; F:adrenomedullin receptor activity; ISO:MGI.
GO; GO:0097643; F:amylin receptor activity; IEA:Ensembl.
GO; GO:0015026; F:coreceptor activity; IDA:MGI.
GO; GO:0008565; F:protein transporter activity; ISO:MGI.
GO; GO:0007189; P:adenylate cyclase-activating G-protein coupled receptor signaling pathway; ISO:MGI.
GO; GO:1990410; P:adrenomedullin receptor signaling pathway; ISO:MGI.
GO; GO:0097647; P:amylin receptor signaling pathway; ISO:MGI.
GO; GO:0006816; P:calcium ion transport; ISO:MGI.
GO; GO:0071392; P:cellular response to estradiol stimulus; IDA:UniProtKB.
GO; GO:0038041; P:cross-receptor inhibition within G-protein coupled receptor heterodimer; ISO:MGI.
GO; GO:0007186; P:G-protein coupled receptor signaling pathway; IPI:MGI.
GO; GO:0086103; P:G-protein coupled receptor signaling pathway involved in heart process; IMP:UniProtKB.
GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
GO; GO:1905665; P:positive regulation of calcium ion import across plasma membrane; ISO:MGI.
GO; GO:0030816; P:positive regulation of cAMP metabolic process; ISO:MGI.
GO; GO:0010942; P:positive regulation of cell death; ISO:MGI.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISO:MGI.
GO; GO:0010628; P:positive regulation of gene expression; ISO:MGI.
GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; ISO:MGI.
GO; GO:0010739; P:positive regulation of protein kinase A signaling; ISO:MGI.
GO; GO:0051897; P:positive regulation of protein kinase B signaling; ISO:MGI.
GO; GO:1903078; P:positive regulation of protein localization to plasma membrane; ISS:UniProtKB.
GO; GO:0001921; P:positive regulation of receptor recycling; ISO:MGI.
GO; GO:0072659; P:protein localization to plasma membrane; ISO:MGI.
GO; GO:0015031; P:protein transport; ISO:MGI.
GO; GO:0031623; P:receptor internalization; ISO:MGI.
Gene3D; 1.10.150.510; -; 1.
InterPro; IPR006985; RAMP.
InterPro; IPR038126; RAMP_sf.
PANTHER; PTHR14076; PTHR14076; 1.
Pfam; PF04901; RAMP; 1.
2: Evidence at transcript level;
Cell membrane; Complete proteome; Disulfide bond; Glycoprotein;
Membrane; Receptor; Reference proteome; Signal; Transmembrane;
Transmembrane helix; Transport.
SIGNAL 1 22 {ECO:0000255}.
CHAIN 23 147 Receptor activity-modifying protein 3.
/FTId=PRO_0000030177.
TOPO_DOM 23 117 Extracellular. {ECO:0000255}.
TRANSMEM 118 137 Helical. {ECO:0000255}.
TOPO_DOM 138 147 Cytoplasmic. {ECO:0000255}.
CARBOHYD 28 28 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 57 57 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 70 70 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 102 102 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 39 71 {ECO:0000250}.
DISULFID 56 103 {ECO:0000250}.
SEQUENCE 147 AA; 16779 MW; 359EE741034C34E8 CRC64;
MKTPAQRLHL LPLLLLLCGE CAQVCGCNET GMLERLPRCG KAFADMMQKV AVWKWCNLSE
FIVYYESFTN CTEMETNIMG CYWPNPLAQS FITGIHRQFF SNCTVDRTHW EDPPDEVLIP
LIAVPVVLTV AMAGLVVWRS KHTDRLL


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