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Receptor activity-modifying protein 3 (Calcitonin-receptor-like receptor activity-modifying protein 3) (CRLR activity-modifying protein 3)

 RAMP3_HUMAN             Reviewed;         148 AA.
O60896; Q7Z2Y1;
01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
01-AUG-1998, sequence version 1.
20-DEC-2017, entry version 147.
RecName: Full=Receptor activity-modifying protein 3;
AltName: Full=Calcitonin-receptor-like receptor activity-modifying protein 3;
Short=CRLR activity-modifying protein 3;
Flags: Precursor;
Name=RAMP3;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
TISSUE=Brain;
PubMed=9620797; DOI=10.1038/30666;
McLatchie L.M., Fraser N.J., Main M.J., Wise A., Brown J.,
Thompson N., Solari R., Lee M.G., Foord S.M.;
"RAMPs regulate the transport and ligand specificity of the
calcitonin-receptor-like receptor.";
Nature 393:333-339(1998).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Kopatz S.A., Aronstam R.S., Sharma S.V.;
"cDNA clones of human proteins involved in signal transduction
sequenced by the Guthrie cDNA resource center (www.cdna.org).";
Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=12853948; DOI=10.1038/nature01782;
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
Waterston R.H., Wilson R.K.;
"The DNA sequence of human chromosome 7.";
Nature 424:157-164(2003).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT LEU-33.
TISSUE=Lung, and PNS;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
FUNCTION, INTERACTION WITH GPER1, AND SUBCELLULAR LOCATION.
PubMed=23674134; DOI=10.1530/JME-13-0021;
Lenhart P.M., Broselid S., Barrick C.J., Leeb-Lundberg L.M.,
Caron K.M.;
"G-protein-coupled receptor 30 interacts with receptor activity-
modifying protein 3 and confers sex-dependent cardioprotection.";
J. Mol. Endocrinol. 51:191-202(2013).
-!- FUNCTION: Plays a role in cardioprotection by reducing cardiac
hypertrophy and perivascular fibrosis in a GPER1-dependent manner.
Transports the calcitonin gene-related peptide type 1 receptor
(CALCRL) and GPER1 to the plasma membrane. Acts as a receptor for
adrenomedullin (AM) together with CALCRL.
{ECO:0000269|PubMed:23674134, ECO:0000269|PubMed:9620797}.
-!- SUBUNIT: Heterodimer of CALCRL and RAMP3 (By similarity).
Interacts with GPER1. {ECO:0000250, ECO:0000269|PubMed:23674134}.
-!- INTERACTION:
A8MQ03:CYSRT1; NbExp=4; IntAct=EBI-720447, EBI-3867333;
P26371:KRTAP5-9; NbExp=3; IntAct=EBI-720447, EBI-3958099;
Q7Z3S9:NOTCH2NL; NbExp=7; IntAct=EBI-720447, EBI-945833;
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23674134};
Single-pass type I membrane protein {ECO:0000269|PubMed:23674134}.
Membrane {ECO:0000269|PubMed:23674134}; Single-pass type I
membrane protein {ECO:0000269|PubMed:23674134}. Note=Moves from
intracellular puncta to the plasma membrane in a RAMP3-dependent
manner.
-!- TISSUE SPECIFICITY: Strongly expressed in lung, breast, immune
system and fetal tissues. {ECO:0000269|PubMed:9620797}.
-!- SIMILARITY: Belongs to the RAMP family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; AJ001016; CAA04474.1; -; mRNA.
EMBL; AY265459; AAP23300.1; -; mRNA.
EMBL; AC004844; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC022304; AAH22304.1; -; mRNA.
EMBL; BC053852; AAH53852.1; -; mRNA.
CCDS; CCDS5503.1; -.
RefSeq; NP_005847.1; NM_005856.2.
UniGene; Hs.25691; -.
ProteinModelPortal; O60896; -.
SMR; O60896; -.
BioGrid; 115559; 7.
CORUM; O60896; -.
IntAct; O60896; 9.
MINT; MINT-1384016; -.
STRING; 9606.ENSP00000242249; -.
BindingDB; O60896; -.
ChEMBL; CHEMBL2111191; -.
DrugBank; DB01278; Pramlintide.
GuidetoPHARMACOLOGY; 53; -.
BioMuta; RAMP3; -.
PaxDb; O60896; -.
PeptideAtlas; O60896; -.
PRIDE; O60896; -.
DNASU; 10268; -.
Ensembl; ENST00000242249; ENSP00000242249; ENSG00000122679.
Ensembl; ENST00000481345; ENSP00000419012; ENSG00000122679.
GeneID; 10268; -.
KEGG; hsa:10268; -.
UCSC; uc003tnb.4; human.
CTD; 10268; -.
DisGeNET; 10268; -.
EuPathDB; HostDB:ENSG00000122679.8; -.
GeneCards; RAMP3; -.
HGNC; HGNC:9845; RAMP3.
MIM; 605155; gene.
neXtProt; NX_O60896; -.
OpenTargets; ENSG00000122679; -.
PharmGKB; PA34204; -.
eggNOG; ENOG410IXGF; Eukaryota.
eggNOG; ENOG4111U8C; LUCA.
GeneTree; ENSGT00390000016200; -.
HOGENOM; HOG000253018; -.
HOVERGEN; HBG061268; -.
InParanoid; O60896; -.
KO; K08449; -.
PhylomeDB; O60896; -.
TreeFam; TF333286; -.
Reactome; R-HSA-418555; G alpha (s) signalling events.
Reactome; R-HSA-419812; Calcitonin-like ligand receptors.
ChiTaRS; RAMP3; human.
GeneWiki; RAMP3; -.
GenomeRNAi; 10268; -.
PRO; PR:O60896; -.
Proteomes; UP000005640; Chromosome 7.
Bgee; ENSG00000122679; -.
CleanEx; HS_RAMP3; -.
ExpressionAtlas; O60896; baseline and differential.
Genevisible; O60896; HS.
GO; GO:1903440; C:amylin receptor complex; IDA:ARUK-UCL.
GO; GO:0009986; C:cell surface; IDA:UniProtKB.
GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO; GO:0005622; C:intracellular; IDA:UniProtKB.
GO; GO:0005764; C:lysosome; TAS:ProtInc.
GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO; GO:0043235; C:receptor complex; IDA:UniProtKB.
GO; GO:0015026; F:coreceptor activity; IEA:Ensembl.
GO; GO:0008565; F:protein transporter activity; IDA:UniProtKB.
GO; GO:0004872; F:receptor activity; IDA:UniProtKB.
GO; GO:0097647; P:amylin receptor signaling pathway; IGI:ARUK-UCL.
GO; GO:0006816; P:calcium ion transport; IDA:UniProtKB.
GO; GO:0071392; P:cellular response to estradiol stimulus; ISS:UniProtKB.
GO; GO:0007186; P:G-protein coupled receptor signaling pathway; TAS:Reactome.
GO; GO:0086103; P:G-protein coupled receptor signaling pathway involved in heart process; ISS:UniProtKB.
GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:UniProtKB.
GO; GO:1905665; P:positive regulation of calcium ion import across plasma membrane; IGI:ARUK-UCL.
GO; GO:0030816; P:positive regulation of cAMP metabolic process; IGI:ARUK-UCL.
GO; GO:0010942; P:positive regulation of cell death; IGI:ARUK-UCL.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IGI:ARUK-UCL.
GO; GO:0010628; P:positive regulation of gene expression; IGI:ARUK-UCL.
GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IGI:ARUK-UCL.
GO; GO:0010739; P:positive regulation of protein kinase A signaling; IGI:ARUK-UCL.
GO; GO:0051897; P:positive regulation of protein kinase B signaling; IGI:ARUK-UCL.
GO; GO:1903078; P:positive regulation of protein localization to plasma membrane; IDA:UniProtKB.
GO; GO:0001921; P:positive regulation of receptor recycling; IDA:UniProtKB.
GO; GO:0072659; P:protein localization to plasma membrane; IDA:UniProtKB.
GO; GO:0015031; P:protein transport; IDA:UniProtKB.
GO; GO:0031623; P:receptor internalization; IDA:UniProtKB.
GO; GO:0008277; P:regulation of G-protein coupled receptor protein signaling pathway; IEA:InterPro.
InterPro; IPR006985; RAMP.
PANTHER; PTHR14076; PTHR14076; 1.
Pfam; PF04901; RAMP; 1.
1: Evidence at protein level;
Cell membrane; Complete proteome; Disulfide bond; Glycoprotein;
Membrane; Polymorphism; Receptor; Reference proteome; Signal;
Transmembrane; Transmembrane helix; Transport.
SIGNAL 1 23 {ECO:0000255}.
CHAIN 24 148 Receptor activity-modifying protein 3.
/FTId=PRO_0000030176.
TOPO_DOM 24 118 Extracellular. {ECO:0000255}.
TRANSMEM 119 138 Helical. {ECO:0000255}.
TOPO_DOM 139 148 Cytoplasmic. {ECO:0000255}.
CARBOHYD 29 29 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 58 58 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 71 71 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 103 103 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 40 72 {ECO:0000250}.
DISULFID 57 104 {ECO:0000250}.
VARIANT 26 26 G -> D (in dbSNP:rs10272187).
/FTId=VAR_034437.
VARIANT 33 33 M -> L (in dbSNP:rs11550711).
{ECO:0000269|PubMed:15489334}.
/FTId=VAR_053628.
VARIANT 56 56 W -> R (in dbSNP:rs2074654).
/FTId=VAR_024602.
SEQUENCE 148 AA; 16518 MW; EEEE312496EF513C CRC64;
METGALRRPQ LLPLLLLLCG GCPRAGGCNE TGMLERLPLC GKAFADMMGK VDVWKWCNLS
EFIVYYESFT NCTEMEANVV GCYWPNPLAQ GFITGIHRQF FSNCTVDRVH LEDPPDEVLI
PLIVIPVVLT VAMAGLVVWR SKRTDTLL


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