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Receptor of activated protein C kinase 1 (Guanine nucleotide-binding protein subunit beta-like protein 12.3) (Receptor for activated C kinase) (Receptor of activated protein kinase C 1) (RACK1)

 RACK1_CHICK             Reviewed;         317 AA.
P63247; A5HUK6; P25388; P99049; Q5EVY1;
11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
11-OCT-2004, sequence version 1.
30-AUG-2017, entry version 101.
RecName: Full=Receptor of activated protein C kinase 1;
AltName: Full=Guanine nucleotide-binding protein subunit beta-like protein 12.3;
AltName: Full=Receptor for activated C kinase;
AltName: Full=Receptor of activated protein kinase C 1;
Short=RACK1;
Name=RACK1; Synonyms=GNB2L1;
Gallus gallus (Chicken).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
Phasianidae; Phasianinae; Gallus.
NCBI_TaxID=9031;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Liver;
PubMed=2499885; DOI=10.1073/pnas.86.12.4594;
Guillemot F., Billault A., Auffray C.;
"Physical linkage of a guanine nucleotide-binding protein-related gene
to the chicken major histocompatibility complex.";
Proc. Natl. Acad. Sci. U.S.A. 86:4594-4598(1989).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Liver;
PubMed=15128875; DOI=10.1093/molbev/msh150;
Takezaki N., Figueroa F., Zaleska-Rutczynska Z., Takahata N.,
Klein J.;
"The phylogenetic relationship of tetrapod, coelacanth, and lungfish
revealed by the sequences of forty-four nuclear genes.";
Mol. Biol. Evol. 21:1512-1524(2004).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=15744538; DOI=10.1007/s00251-005-0770-x;
Ruby T., Bed'Hom B., Wittzell H., Morin V., Oudin A., Zoorob R.;
"Characterisation of a cluster of TRIM-B30.2 genes in the chicken MHC
B locus.";
Immunogenetics 57:116-128(2005).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=17513765; DOI=10.4049/jimmunol.178.11.7162;
Shiina T., Briles W.E., Goto R.M., Hosomichi K., Yanagiya K.,
Shimizu S., Inoko H., Miller M.M.;
"Extended gene map reveals tripartite motif, C-type lectin, and Ig
superfamily type genes within a subregion of the chicken MHC-B
affecting infectious disease.";
J. Immunol. 178:7162-7172(2007).
-!- FUNCTION: Involved in the recruitment, assembly and/or regulation
of a variety of signaling molecules. Interacts with a wide variety
of proteins and plays a role in many cellular processes (By
similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cell membrane
{ECO:0000250|UniProtKB:P63244}; Peripheral membrane protein
{ECO:0000250|UniProtKB:P63244}. Cytoplasm
{ECO:0000250|UniProtKB:P63244}. Cytoplasm, perinuclear region
{ECO:0000250|UniProtKB:P63244}. Nucleus
{ECO:0000250|UniProtKB:P63244}. Perikaryon
{ECO:0000250|UniProtKB:P68040}. Cell projection, dendrite
{ECO:0000250|UniProtKB:P68040}. Note=Recruited to the plasma
membrane through interaction with KRT1 which binds to membrane-
bound ITGB1. Also associated with the membrane in oncogene-
transformed cells. PKC activation induces translocation from the
perinuclear region to the cell periphery (By similarity). In the
brain, detected mainly in cell bodies and dendrites with little
expression in axonal fibers or nuclei (By similarity).
{ECO:0000250|UniProtKB:P63244, ECO:0000250|UniProtKB:P68040}.
-!- SIMILARITY: Belongs to the WD repeat G protein beta family.
Ribosomal protein RACK1 subfamily. {ECO:0000305}.
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EMBL; M24193; AAA50559.1; -; mRNA.
EMBL; AY393848; AAS49613.1; -; mRNA.
EMBL; AY694127; AAW82329.1; -; Genomic_DNA.
EMBL; AB268588; BAF62990.1; -; Genomic_DNA.
PIR; A33928; A33928.
RefSeq; NP_001004378.1; NM_001004378.2.
UniGene; Gga.7066; -.
ProteinModelPortal; P63247; -.
SMR; P63247; -.
BioGrid; 678470; 1.
MINT; MINT-92357; -.
STRING; 9031.ENSGALP00000000170; -.
PaxDb; P63247; -.
PRIDE; P63247; -.
Ensembl; ENSGALT00000089517; ENSGALP00000060527; ENSGALG00000000122.
GeneID; 417044; -.
KEGG; gga:417044; -.
CTD; 10399; -.
eggNOG; KOG0279; Eukaryota.
eggNOG; ENOG410XQGZ; LUCA.
GeneTree; ENSGT00890000139419; -.
HOGENOM; HOG000091643; -.
HOVERGEN; HBG000277; -.
InParanoid; P63247; -.
KO; K14753; -.
OMA; QYGYPKR; -.
OrthoDB; EOG091G0KZQ; -.
PhylomeDB; P63247; -.
Reactome; R-GGA-5626978; TNFR1-mediated ceramide production.
PRO; PR:P63247; -.
Proteomes; UP000000539; Chromosome 16.
Bgee; ENSGALG00000000122; -.
ExpressionAtlas; P63247; baseline.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.
GO; GO:0043025; C:neuronal cell body; ISS:UniProtKB.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0005840; C:ribosome; IEA:UniProtKB-KW.
GO; GO:0043022; F:ribosome binding; ISS:UniProtKB.
GO; GO:0030178; P:negative regulation of Wnt signaling pathway; ISS:UniProtKB.
GO; GO:2000543; P:positive regulation of gastrulation; ISS:UniProtKB.
GO; GO:0016567; P:protein ubiquitination; ISS:UniProtKB.
GO; GO:0051302; P:regulation of cell division; ISS:UniProtKB.
GO; GO:2000114; P:regulation of establishment of cell polarity; ISS:UniProtKB.
GO; GO:0032880; P:regulation of protein localization; ISS:UniProtKB.
GO; GO:0072344; P:rescue of stalled ribosome; ISS:UniProtKB.
GO; GO:0007165; P:signal transduction; TAS:UniProtKB.
Gene3D; 2.130.10.10; -; 2.
InterPro; IPR020472; G-protein_beta_WD-40_rep.
InterPro; IPR015943; WD40/YVTN_repeat-like_dom.
InterPro; IPR001680; WD40_repeat.
InterPro; IPR019775; WD40_repeat_CS.
InterPro; IPR017986; WD40_repeat_dom.
Pfam; PF00400; WD40; 7.
PRINTS; PR00320; GPROTEINBRPT.
SMART; SM00320; WD40; 7.
SUPFAM; SSF50978; SSF50978; 1.
PROSITE; PS00678; WD_REPEATS_1; 4.
PROSITE; PS50082; WD_REPEATS_2; 6.
PROSITE; PS50294; WD_REPEATS_REGION; 1.
2: Evidence at transcript level;
Acetylation; Cell membrane; Cell projection; Complete proteome;
Cytoplasm; Membrane; Nucleus; Phosphoprotein; Reference proteome;
Repeat; Ribonucleoprotein; Ribosomal protein; WD repeat.
INIT_MET 1 1 Removed. {ECO:0000250}.
CHAIN 2 317 Receptor of activated protein C kinase 1.
/FTId=PRO_0000127735.
REPEAT 13 44 WD 1.
REPEAT 61 91 WD 2.
REPEAT 103 133 WD 3.
REPEAT 146 178 WD 4.
REPEAT 190 220 WD 5.
REPEAT 231 260 WD 6.
REPEAT 281 311 WD 7.
MOD_RES 2 2 N-acetylthreonine. {ECO:0000250}.
MOD_RES 228 228 Phosphotyrosine. {ECO:0000250}.
SEQUENCE 317 AA; 35077 MW; 257F91E369ED2044 CRC64;
MTEQMTLRGT LKGHNGWVTQ IATTPQFPDM ILSASRDKTI IMWKLTRDET NYGIPQRALR
GHSHFVSDVV ISSDGQFALS GSWDGTLRLW DLTTGTTTRR FVGHTKDVLS VAFSSDNRQI
VSGSRDKTIK LWNTLGVCKY TVQDESHSEW VSCVRFSPNS SNPIIVSCGW DKLVKVWNLA
NCKLKTNHIG HTGYLNTVTV SPDGSLCASG GKDGQAMLWD LNEGKHLYTL DGGDIINALC
FSPNRYWLCA ATGPSIKIWD LEGKIIVDEL KQEVISTSSK AEPPQCTSLA WSADGQTLFA
GYTDNLVRVW QVTIGTR


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