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Receptor protein-tyrosine kinase (EC 2.7.10.1)

 A0A087XJ59_POEFO        Unreviewed;      1168 AA.
A0A087XJ59;
29-OCT-2014, integrated into UniProtKB/TrEMBL.
26-NOV-2014, sequence version 2.
20-JUN-2018, entry version 31.
RecName: Full=Receptor protein-tyrosine kinase {ECO:0000256|SAAS:SAAS00593197};
EC=2.7.10.1 {ECO:0000256|SAAS:SAAS00593197};
Poecilia formosa (Amazon molly) (Limia formosa).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae;
Poeciliinae; Poecilia.
NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000005812, ECO:0000313|Proteomes:UP000028760};
[1] {ECO:0000313|Ensembl:ENSPFOP00000005812, ECO:0000313|Proteomes:UP000028760}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=female {ECO:0000313|Ensembl:ENSPFOP00000005812};
Schartl M., Warren W.;
Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|Ensembl:ENSPFOP00000005812}
IDENTIFICATION.
Ensembl;
Submitted (SEP-2014) to UniProtKB.
-!- CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a
[protein]-L-tyrosine phosphate. {ECO:0000256|SAAS:SAAS00594546}.
-!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
kinase family. {ECO:0000256|SAAS:SAAS00941529}.
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EMBL; AYCK01019779; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AYCK01019780; -; NOT_ANNOTATED_CDS; Genomic_DNA.
RefSeq; XP_007578969.1; XM_007578907.2.
Ensembl; ENSPFOT00000005821; ENSPFOP00000005812; ENSPFOG00000005185.
GeneID; 103156750; -.
GeneTree; ENSGT00760000118799; -.
Proteomes; UP000028760; Unassembled WGS sequence.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:InterPro.
Gene3D; 3.80.20.20; -; 2.
InterPro; IPR006211; Furin-like_Cys-rich_dom.
InterPro; IPR006212; Furin_repeat.
InterPro; IPR032778; GF_recep_IV.
InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR000494; Rcpt_L-dom.
InterPro; IPR036941; Rcpt_L-dom_sf.
InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
InterPro; IPR008266; Tyr_kinase_AS.
InterPro; IPR020635; Tyr_kinase_cat_dom.
InterPro; IPR016245; Tyr_kinase_EGF/ERB/XmrK_rcpt.
Pfam; PF00757; Furin-like; 1.
Pfam; PF14843; GF_recep_IV; 1.
Pfam; PF07714; Pkinase_Tyr; 1.
Pfam; PF01030; Recep_L_domain; 2.
PIRSF; PIRSF000619; TyrPK_EGF-R; 2.
PRINTS; PR00109; TYRKINASE.
SMART; SM00261; FU; 5.
SMART; SM00219; TyrKc; 1.
SUPFAM; SSF56112; SSF56112; 1.
SUPFAM; SSF57184; SSF57184; 2.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
3: Inferred from homology;
ATP-binding {ECO:0000256|PIRSR:PIRSR000619-2,
ECO:0000256|SAAS:SAAS00461464};
Complete proteome {ECO:0000313|Proteomes:UP000028760};
Kinase {ECO:0000256|SAAS:SAAS00594505};
Membrane {ECO:0000256|SAM:Phobius};
Nucleotide-binding {ECO:0000256|PIRSR:PIRSR000619-2,
ECO:0000256|SAAS:SAAS00461464};
Reference proteome {ECO:0000313|Proteomes:UP000028760};
Signal {ECO:0000256|SAM:SignalP};
Transferase {ECO:0000256|SAAS:SAAS00594505};
Transmembrane {ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAM:Phobius};
Tyrosine-protein kinase {ECO:0000256|SAAS:SAAS00594505}.
SIGNAL 1 23 {ECO:0000256|SAM:SignalP}.
CHAIN 24 1168 Receptor protein-tyrosine kinase.
{ECO:0000256|SAM:SignalP}.
/FTId=PRO_5001832990.
TRANSMEM 645 667 Helical. {ECO:0000256|SAM:Phobius}.
DOMAIN 711 978 Protein kinase.
{ECO:0000259|PROSITE:PS50011}.
NP_BIND 717 725 ATP. {ECO:0000256|PIRSR:PIRSR000619-2}.
ACT_SITE 836 836 Proton acceptor.
{ECO:0000256|PIRSR:PIRSR000619-1}.
BINDING 744 744 ATP. {ECO:0000256|PIRSR:PIRSR000619-2}.
SEQUENCE 1168 AA; 130090 MW; 84D4A11AA8CA88E8 CRC64;
MDFLPGGAAL LPLLLLSIGR CCCTDPDRKV CQGMSNQLTM LDNHEHHYHV MKKMYSGCNV
VLENLEITYT QEHQDLSFLQ SIQEVGGYVL IAMNEVSTIP LVNLRLIRGQ NLHEGKYALL
VMSNYFRNLS SSVVYQVGLK QLQLSNLTEI VSGGVKVSHN PLLCNMETIN WWDIVDKTSN
LSMYLTPHTF ERQCQKCDPS CVNGSCWAPG PGHCQKFTKL LCAEQCSRRC RGPKPIDCCN
EHCAAGCTGP RATDCLACRD FNDDGTCKDT CPPPKIYDRA SHQVVDNPNT KYTFGAACVK
ECPSNYVETE GACVRSCGAG MHEVDENGKR SCKPCDGVCP KVCDGIGIGS LTNTIAVNST
NIGSFRNCTK INGDIILNKN SFEGDPHYNI GPMDPEHLWN LTTVKEITGY LVIMWWPENM
TSLSVFENLE IIRGRTTFSR GFSFVVVQVN HLQWLGLRSL KEVSAGNVIL KNMPELRYTN
TVNWRRLFRS KDQVIQNEAS SENQTCNHEC SKDGCWGPGP TMCVSCLHVD RGGRCVAFCN
LLQGEPREAQ VDGRCVQCHQ ECLLQTDSLT CYGPGPANCS KCAHFQDGPQ CIPRCPHGMM
GDGDTLIWKY ADRMGQCQPC HQNCTQGCSG PGLSGCKGGS GHSSLAVGVV SGLLITVIVS
LLILVLLRRR RVKRKRTIRR LLQEKELVEP LTPSGQAPNQ AFLRILKETE FKKDRVLGSG
AFGTVYKGLW NPDGENIRIP VAIKVLREAT SPKVNQEVLD EAYVMASVDH PHVCRLLGIC
LTSAVQLVTQ LMPYGCLLDY VRQHQERICG QWLLNWCVQI AKGMNYLEER HLVHRDLAAR
NVLLKNPNHV KITDFGLSKL LTADEKEYHA DGGKVPIKWM ALESILQWTY THQSDVWSYG
VTVWELMTFG SKPYDGIPAK EIASVLENGE RLPQPPICTI EVYMIILKCW MIDPSSRPRF
RELVGEFSQM ARDPSRYLVI QGNLPSPSDR RLFSRLLSSD DDAVDADEYL LPYKRINRQG
SEPCIPANGH PVRENSIALR YISDPTQNAL DKDLDGHEYV NQPGSETSSR LSDIYNPNYE
DLTEGWGPVS LSSQEAETNF SRPEYLNTNQ NSLPLVSSGS MDDPDYQADY QAAFPPQTGA
LTGNSMFLPA AENLEYLGLG GALYTPVR


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