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Receptor protein-tyrosine kinase (EC 2.7.10.1)

 H0ZJI7_TAEGU            Unreviewed;       970 AA.
H0ZJI7;
22-FEB-2012, integrated into UniProtKB/TrEMBL.
22-FEB-2012, sequence version 1.
28-MAR-2018, entry version 54.
RecName: Full=Receptor protein-tyrosine kinase {ECO:0000256|SAAS:SAAS00593197};
EC=2.7.10.1 {ECO:0000256|SAAS:SAAS00593197};
Name=EPHB3 {ECO:0000313|Ensembl:ENSTGUP00000010755};
Taeniopygia guttata (Zebra finch) (Poephila guttata).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea;
Estrildidae; Estrildinae; Taeniopygia.
NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000010755, ECO:0000313|Proteomes:UP000007754};
[1] {ECO:0000313|Ensembl:ENSTGUP00000010755, ECO:0000313|Proteomes:UP000007754}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=20360741; DOI=10.1038/nature08819;
Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C.,
London S.E., Li Y., Lin Y.C., George J., Sweedler J., Southey B.,
Gunaratne P., Watson M., Nam K., Backstrom N., Smeds L., Nabholz B.,
Itoh Y., Whitney O., Pfenning A.R., Howard J., Volker M.,
Skinner B.M., Griffin D.K., Ye L., McLaren W.M., Flicek P.,
Quesada V., Velasco G., Lopez-Otin C., Puente X.S., Olender T.,
Lancet D., Smit A.F., Hubley R., Konkel M.K., Walker J.A.,
Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z., Eichler E.E.,
Stapley J., Slate J., Ekblom R., Birkhead T., Burke T., Burt D.,
Scharff C., Adam I., Richard H., Sultan M., Soldatov A., Lehrach H.,
Edwards S.V., Yang S.P., Li X., Graves T., Fulton L., Nelson J.,
Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
"The genome of a songbird.";
Nature 464:757-762(2010).
[2] {ECO:0000313|Ensembl:ENSTGUP00000010755}
IDENTIFICATION.
Ensembl;
Submitted (JAN-2012) to UniProtKB.
-!- CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a
[protein]-L-tyrosine phosphate. {ECO:0000256|SAAS:SAAS00594546}.
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EMBL; ABQF01023345; -; NOT_ANNOTATED_CDS; Genomic_DNA.
STRING; 59729.ENSTGUP00000010755; -.
Ensembl; ENSTGUT00000010868; ENSTGUP00000010755; ENSTGUG00000010386.
eggNOG; KOG0196; Eukaryota.
eggNOG; COG0515; LUCA.
GeneTree; ENSGT00760000118975; -.
InParanoid; H0ZJI7; -.
OMA; ELAWTAH; -.
OrthoDB; EOG091G00W0; -.
TreeFam; TF315608; -.
Reactome; R-TGU-2682334; EPH-Ephrin signaling.
Reactome; R-TGU-3928662; EPHB-mediated forward signaling.
Reactome; R-TGU-3928664; Ephrin signaling.
Reactome; R-TGU-3928665; EPH-ephrin mediated repulsion of cells.
Proteomes; UP000007754; Chromosome 9.
GO; GO:0005887; C:integral component of plasma membrane; IEA:Ensembl.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0005003; F:ephrin receptor activity; IEA:Ensembl.
GO; GO:0016477; P:cell migration; IEA:Ensembl.
GO; GO:0046777; P:protein autophosphorylation; IEA:Ensembl.
GO; GO:0022407; P:regulation of cell-cell adhesion; IEA:Ensembl.
GO; GO:0043087; P:regulation of GTPase activity; IEA:Ensembl.
GO; GO:0034446; P:substrate adhesion-dependent cell spreading; IEA:Ensembl.
CDD; cd10478; EphR_LBD_B3; 1.
CDD; cd00063; FN3; 2.
Gene3D; 2.60.120.260; -; 1.
Gene3D; 2.60.40.10; -; 2.
InterPro; IPR027936; Eph_TM.
InterPro; IPR034245; EphB3_rcpt_lig-bd.
InterPro; IPR001090; Ephrin_rcpt_lig-bd_dom.
InterPro; IPR003961; FN3_dom.
InterPro; IPR036116; FN3_sf.
InterPro; IPR008979; Galactose-bd-like_sf.
InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR001660; SAM.
InterPro; IPR013761; SAM/pointed_sf.
InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
InterPro; IPR008266; Tyr_kinase_AS.
InterPro; IPR020635; Tyr_kinase_cat_dom.
InterPro; IPR016257; Tyr_kinase_ephrin_rcpt.
InterPro; IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam; PF14575; EphA2_TM; 1.
Pfam; PF01404; Ephrin_lbd; 1.
Pfam; PF00041; fn3; 2.
Pfam; PF07714; Pkinase_Tyr; 1.
Pfam; PF00536; SAM_1; 1.
PIRSF; PIRSF000666; TyrPK_ephrin_receptor; 1.
PRINTS; PR00109; TYRKINASE.
SMART; SM00615; EPH_lbd; 1.
SMART; SM01411; Ephrin_rec_like; 1.
SMART; SM00060; FN3; 2.
SMART; SM00454; SAM; 1.
SMART; SM00219; TyrKc; 1.
SUPFAM; SSF47769; SSF47769; 1.
SUPFAM; SSF49265; SSF49265; 1.
SUPFAM; SSF49785; SSF49785; 1.
SUPFAM; SSF56112; SSF56112; 1.
SUPFAM; SSF57184; SSF57184; 2.
PROSITE; PS51550; EPH_LBD; 1.
PROSITE; PS50853; FN3; 2.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PROSITE; PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PROSITE; PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PROSITE; PS50105; SAM_DOMAIN; 1.
4: Predicted;
ATP-binding {ECO:0000256|PIRSR:PIRSR000666-2,
ECO:0000256|SAAS:SAAS00461464};
Complete proteome {ECO:0000313|Proteomes:UP000007754};
Kinase {ECO:0000256|SAAS:SAAS00594505};
Membrane {ECO:0000256|SAAS:SAAS00602683, ECO:0000256|SAM:Phobius};
Nucleotide-binding {ECO:0000256|PIRSR:PIRSR000666-2,
ECO:0000256|SAAS:SAAS00461464};
Receptor {ECO:0000256|SAAS:SAAS00600436};
Reference proteome {ECO:0000313|Proteomes:UP000007754};
Repeat {ECO:0000256|SAAS:SAAS00786331};
Transferase {ECO:0000256|SAAS:SAAS00594505};
Transmembrane {ECO:0000256|SAAS:SAAS00602683,
ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAAS:SAAS00602683,
ECO:0000256|SAM:Phobius};
Tyrosine-protein kinase {ECO:0000256|SAAS:SAAS00594505}.
TRANSMEM 530 553 Helical. {ECO:0000256|SAM:Phobius}.
DOMAIN 10 188 Eph LBD. {ECO:0000259|PROSITE:PS51550}.
DOMAIN 310 420 Fibronectin type-III.
{ECO:0000259|PROSITE:PS50853}.
DOMAIN 421 518 Fibronectin type-III.
{ECO:0000259|PROSITE:PS50853}.
DOMAIN 605 868 Protein kinase.
{ECO:0000259|PROSITE:PS50011}.
DOMAIN 897 961 SAM. {ECO:0000259|PROSITE:PS50105}.
NP_BIND 612 619 ATP. {ECO:0000256|PIRSR:PIRSR000666-2}.
ACT_SITE 730 730 Proton acceptor.
{ECO:0000256|PIRSR:PIRSR000666-1}.
BINDING 637 637 ATP. {ECO:0000256|PIRSR:PIRSR000666-2}.
SEQUENCE 970 AA; 108102 MW; DD0B8BEB5C519A6D CRC64;
LILSLLPFSP ETLMDTKWVT SELAWTTHPE TGWEEVSGYD EAMNPIRTYQ VCNVREANQN
NWLRTKFIQR QDVQRVYVEL KFTVRDCNSI PNIPGSCKET FNLFYYESDT DSASANSPFW
MENPYIKVDT IAPDESFSKL ESGRVNTKVR SFGPLSKNGF YLAFQDLGAC MSLISVRAFY
KKCSNTIAGF AIFPETLTGA EPTSLVIAPG TCIPNAVEVS VPLKLYCNGD GEWMVPVGAC
TCAAGYEPAM KDTQCQACGP GTFKSKQGEG PCSPCPPNSR TTSGAAMVCT CRNGFFRADT
DPADSACTSV PSAPRNVISN VNETSLVLEW SEPQDTGGRD DLLYNVICKK CSVERRLCTR
CDDNVEFVPR QLGLTERRIY ISNLMAHTQY TFEIQAVNGI SNKSPYPPHF ASVNITTNQA
APSAVPTMHL HSSTGNSMTL SWTPPERPNG IILDYEIKYS EKQGQSDGIA NTVTSQKNSV
RLDGLKANAR YMVQVRARTV AGYGRYSLPT EFQTTAEGGS TSKTFQELPL IVGSATAGLV
FVIVVVVIAI VCFRKQRNNT DPEYTEKLQQ YGEFTPGMKV YIDPFTYEDP NEAVREFAKE
IDISCVKIEE VIGAGFGEVC RGRLKLPGRR EIFVAIKTLK VGYTERQRRD FLSEASIMGQ
FDHPNIIHLE GVVTKSRPVM IITEFMENCA LDSFLRLNDG QFTVIQLVGM MRGIAAGMKY
LSEMNYVHRD LAARNILVNS NLVCKVSDFG LSRFLEDDPA DPTYTSSLGG KIPIRWTAPE
AIAYRKFTSA SDVWSYGIVM WEVMSYGERP YWDMSNQDVI NAVEQDYRLP PPMDCPTALH
QLMLDCWVRD RNLRPKFAQI VNTLDKLIRN AASLKVIASV QSGISQPLLD RTVPDYTTFT
TVGDWLDAIK MGRYKENFVN AGFASFDLVA QMTAEDLLRI GVTLAGHQKK ILSSIQDMRL
QMNQTLPVQV


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