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Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (p185erbB2) (CD antigen CD340)

 ERBB2_MOUSE             Reviewed;        1256 AA.
P70424; Q61525; Q6ZPE0;
15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
27-SEP-2005, sequence version 3.
22-NOV-2017, entry version 189.
RecName: Full=Receptor tyrosine-protein kinase erbB-2;
EC=2.7.10.1;
AltName: Full=Proto-oncogene Neu;
AltName: Full=Proto-oncogene c-ErbB-2;
AltName: Full=p185erbB2;
AltName: CD_antigen=CD340;
Flags: Precursor;
Name=Erbb2; Synonyms=Kiaa3023, Neu;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Embryonic tail;
PubMed=14621295; DOI=10.1093/dnares/10.4.167;
Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
Saga Y., Nagase T., Ohara O., Koga H.;
"Prediction of the coding sequences of mouse homologues of KIAA gene:
III. The complete nucleotide sequences of 500 mouse KIAA-homologous
cDNAs identified by screening of terminal sequences of cDNA clones
randomly sampled from size-fractionated libraries.";
DNA Res. 10:167-180(2003).
[2]
NUCLEOTIDE SEQUENCE [MRNA] OF 786-934.
STRAIN=CD-1; TISSUE=Uterus;
PubMed=9048643; DOI=10.1210/endo.138.3.4991;
Lim J., Dey S.K., Das S.K.;
"Differential expression of the erbB2 gene in the periimplantation
mouse uterus: potential mediator of signaling by epidermal growth
factor-like growth factors.";
Endocrinology 138:1328-1337(1997).
[3]
NUCLEOTIDE SEQUENCE [MRNA] OF 1012-1107.
PubMed=7589796; DOI=10.1006/dbio.1995.0012;
Moscoso L.M., Chu G.C., Gautam M., Noakes P.G., Merlie J.P.,
Sanes J.R.;
"Synapse-associated expression of an acetylcholine receptor-inducing
protein, ARIA/heregulin, and its putative receptors, ErbB2 and ErbB3,
in developing mammalian muscle.";
Dev. Biol. 172:158-169(1995).
[4]
FUNCTION, AND INTERACTION WITH SRC.
PubMed=7542762;
Muthuswamy S.K., Muller W.J.;
"Direct and specific interaction of c-Src with Neu is involved in
signaling by the epidermal growth factor receptor.";
Oncogene 11:271-279(1995).
[5]
INTERACTION WITH PRKCABP.
PubMed=11278603; DOI=10.1074/jbc.M010032200;
Jaulin-Bastard F., Saito H., Le Bivic A., Ollendorff V., Marchetto S.,
Birnbaum D., Borg J.-P.;
"The ERBB2/HER2 receptor differentially interacts with ERBIN and PICK1
PSD-95/DLG/ZO-1 domain proteins.";
J. Biol. Chem. 276:15256-15263(2001).
[6]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Lung;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
[7]
INTERACTION WITH MYOC.
PubMed=23897819; DOI=10.1074/jbc.M112.446138;
Kwon H.S., Johnson T.V., Joe M.K., Abu-Asab M., Zhang J., Chan C.C.,
Tomarev S.I.;
"Myocilin mediates myelination in the peripheral nervous system
through ErbB2/3 signaling.";
J. Biol. Chem. 288:26357-26371(2013).
-!- FUNCTION: Protein tyrosine kinase that is part of several cell
surface receptor complexes, but that apparently needs a coreceptor
for ligand binding. Essential component of a neuregulin-receptor
complex, although neuregulins do not interact with it alone. GP30
is a potential ligand for this receptor. Regulates outgrowth and
stabilization of peripheral microtubules (MTs). Upon ERBB2
activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the
phosphorylation and thus the inhibition of GSK3B at cell membrane.
This prevents the phosphorylation of APC and CLASP2, allowing its
association with the cell membrane. In turn, membrane-bound APC
allows the localization of MACF1 to the cell membrane, which is
required for microtubule capture and stabilization (By
similarity). {ECO:0000250}.
-!- FUNCTION: In the nucleus is involved in transcriptional
regulation. Associates with the 5'-TCAAATTC-3' sequence in the
PTGS2/COX-2 promoter and activates its transcription. Implicated
in transcriptional activation of CDKN1A; the function involves
STAT3 and SRC. Involved in the transcription of rRNA genes by RNA
Pol I and enhances protein synthesis and cell growth (By
similarity). {ECO:0000250}.
-!- CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a
[protein]-L-tyrosine phosphate. {ECO:0000255|PROSITE-
ProRule:PRU10028}.
-!- SUBUNIT: Homodimer. Heterodimer with EGFR, ERBB3 and ERBB4. Part
of a complex with EGFR and either PIK3C2A or PIK3C2B. May interact
with PIK3C2B when phosphorylated on Tyr-1197. Interacts with
PLXNB1. Interacts (when phosphorylated on Tyr-1249) with MEMO1.
Interacts with MUC1. Interacts (when phosphorylated on Tyr-1140)
with GRB7 (via SH2 domain). Interacts (when phosphorylated on Tyr-
1249) with ERBIN. Interacts with KPNB1, RANBP2, EEA1, CRM1, CLTC,
PTK6, RPA194 and ACTB. Interacts (preferentially with the tyrosine
phosphorylated form) with CPNE3; this interaction occurs at the
cell membrane and is increased in a growth factor heregulin-
dependent manner. Interacts with HSP90AA1 and HSP90AB1 in an ATP-
dependent manner; the interaction suppresses ERBB2 kinase activity
(By similarity). Interacts with SRC (PubMed:7542762). Interacts
with MYOC (PubMed:23897819). Interacts with PRKCABP
(PubMed:11278603). {ECO:0000250|UniProtKB:P04626,
ECO:0000269|PubMed:11278603, ECO:0000269|PubMed:23897819,
ECO:0000269|PubMed:7542762}.
-!- INTERACTION:
P18762:Adrb2; NbExp=3; IntAct=EBI-2945468, EBI-491143;
Q61526:Erbb3; NbExp=2; IntAct=EBI-2945468, EBI-931878;
P42227:Stat3; NbExp=4; IntAct=EBI-2945468, EBI-602878;
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass
type I membrane protein {ECO:0000250}. Cytoplasm, perinuclear
region {ECO:0000250}. Nucleus {ECO:0000250}.
-!- TISSUE SPECIFICITY: Expressed predominantly in uterine epithelial
cells. In the muscle, expression localizes to the synaptic sites
of muscle fibers.
-!- DEVELOPMENTAL STAGE: On days 1-4 of pregnancy, ERBB2 is detected
primarily in epithelial cells, the day 1 uterus showing the
highest accumulation. On day 5, the epithelium and the
decidualizing stromal cells around the implanting blastocyst
exhibit accumulation of this receptor. On days 6-8, the expression
persists in the epithelium at both the implantation and
interimplantation sites in addition to modest levels in the
secondary decidual zone. On days 7 and 8, accumulation is also
prominent in the trophoblastic giant cells.
-!- PTM: Autophosphorylated. Autophosphorylation occurs in trans, i.e.
one subunit of the dimeric receptor phosphorylates tyrosine
residues on the other subunit. Ligand-binding increases
phosphorylation on tyrosine residues. Signaling via SEMA4C
promotes phosphorylation at Tyr-1249. Dephosphorylated by PTPN12.
{ECO:0000250|UniProtKB:P04626}.
-!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
kinase family. EGF receptor subfamily. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
-!- SEQUENCE CAUTION:
Sequence=BAC98297.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
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EMBL; AK129487; BAC98297.1; ALT_INIT; mRNA.
EMBL; U71126; AAB17380.1; -; mRNA.
EMBL; L47239; AAA93532.1; -; mRNA.
CCDS; CCDS25349.1; -.
RefSeq; NP_001003817.1; NM_001003817.1.
UniGene; Mm.290822; -.
ProteinModelPortal; P70424; -.
SMR; P70424; -.
BioGrid; 199496; 7.
DIP; DIP-40912N; -.
IntAct; P70424; 6.
MINT; MINT-138121; -.
STRING; 10090.ENSMUSP00000053897; -.
ChEMBL; CHEMBL2311234; -.
iPTMnet; P70424; -.
PhosphoSitePlus; P70424; -.
MaxQB; P70424; -.
PaxDb; P70424; -.
PeptideAtlas; P70424; -.
PRIDE; P70424; -.
Ensembl; ENSMUST00000058295; ENSMUSP00000053897; ENSMUSG00000062312.
GeneID; 13866; -.
KEGG; mmu:13866; -.
UCSC; uc007lgi.1; mouse.
CTD; 2064; -.
MGI; MGI:95410; Erbb2.
eggNOG; KOG1025; Eukaryota.
eggNOG; ENOG410XNSR; LUCA.
GeneTree; ENSGT00760000118799; -.
HOGENOM; HOG000230982; -.
HOVERGEN; HBG000490; -.
InParanoid; P70424; -.
KO; K05083; -.
OMA; PINCTHS; -.
OrthoDB; EOG091G00NO; -.
PhylomeDB; P70424; -.
TreeFam; TF106002; -.
BRENDA; 2.7.10.1; 3474.
Reactome; R-MMU-1227986; Signaling by ERBB2.
Reactome; R-MMU-1250196; SHC1 events in ERBB2 signaling.
Reactome; R-MMU-1257604; PIP3 activates AKT signaling.
Reactome; R-MMU-1306955; GRB7 events in ERBB2 signaling.
Reactome; R-MMU-1358803; Downregulation of ERBB2:ERBB3 signaling.
Reactome; R-MMU-1963640; GRB2 events in ERBB2 signaling.
Reactome; R-MMU-1963642; PI3K events in ERBB2 signaling.
Reactome; R-MMU-416572; Sema4D induced cell migration and growth-cone collapse.
Reactome; R-MMU-5673001; RAF/MAP kinase cascade.
Reactome; R-MMU-6785631; ERBB2 Regulates Cell Motility.
Reactome; R-MMU-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
Reactome; R-MMU-8847993; ERBB2 Activates PTK6 Signaling.
Reactome; R-MMU-8863795; Downregulation of ERBB2 signaling.
PRO; PR:P70424; -.
Proteomes; UP000000589; Chromosome 11.
Bgee; ENSMUSG00000062312; -.
Genevisible; P70424; MM.
GO; GO:0016324; C:apical plasma membrane; IDA:MGI.
GO; GO:0016323; C:basolateral plasma membrane; ISO:MGI.
GO; GO:0005737; C:cytoplasm; IDA:MGI.
GO; GO:0031410; C:cytoplasmic vesicle; IDA:MGI.
GO; GO:0005829; C:cytosol; ISO:MGI.
GO; GO:0010008; C:endosome membrane; ISO:MGI.
GO; GO:0016021; C:integral component of membrane; NAS:UniProtKB.
GO; GO:0043209; C:myelin sheath; IDA:MGI.
GO; GO:0005634; C:nucleus; ISO:MGI.
GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0005886; C:plasma membrane; IDA:MGI.
GO; GO:0043235; C:receptor complex; ISO:MGI.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0019838; F:growth factor binding; IEA:Ensembl.
GO; GO:0042802; F:identical protein binding; ISO:MGI.
GO; GO:0008022; F:protein C-terminus binding; ISO:MGI.
GO; GO:0046982; F:protein heterodimerization activity; ISO:MGI.
GO; GO:0019903; F:protein phosphatase binding; ISO:MGI.
GO; GO:0004713; F:protein tyrosine kinase activity; ISO:MGI.
GO; GO:0001042; F:RNA polymerase I core binding; ISS:UniProtKB.
GO; GO:0004716; F:signal transducer, downstream of receptor, with protein tyrosine kinase activity; IEA:InterPro.
GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; ISS:BHF-UCL.
GO; GO:0004888; F:transmembrane signaling receptor activity; ISO:MGI.
GO; GO:0007166; P:cell surface receptor signaling pathway; ISO:MGI.
GO; GO:0071364; P:cellular response to epidermal growth factor stimulus; ISS:UniProtKB.
GO; GO:0071363; P:cellular response to growth factor stimulus; ISS:UniProtKB.
GO; GO:0007507; P:heart development; IMP:MGI.
GO; GO:0008045; P:motor neuron axon guidance; IMP:MGI.
GO; GO:0042552; P:myelination; IMP:MGI.
GO; GO:0033088; P:negative regulation of immature T cell proliferation in thymus; IMP:MGI.
GO; GO:0007399; P:nervous system development; IMP:MGI.
GO; GO:0007528; P:neuromuscular junction development; IMP:MGI.
GO; GO:0048709; P:oligodendrocyte differentiation; IMP:MGI.
GO; GO:0007422; P:peripheral nervous system development; IMP:MGI.
GO; GO:0014065; P:phosphatidylinositol 3-kinase signaling; ISO:MGI.
GO; GO:0045785; P:positive regulation of cell adhesion; ISO:MGI.
GO; GO:0030307; P:positive regulation of cell growth; ISS:UniProtKB.
GO; GO:0050679; P:positive regulation of epithelial cell proliferation; ISO:MGI.
GO; GO:0010628; P:positive regulation of gene expression; IMP:MGI.
GO; GO:0043547; P:positive regulation of GTPase activity; IMP:BHF-UCL.
GO; GO:0043406; P:positive regulation of MAP kinase activity; ISO:MGI.
GO; GO:0001934; P:positive regulation of protein phosphorylation; IMP:BHF-UCL.
GO; GO:0090314; P:positive regulation of protein targeting to membrane; ISS:UniProtKB.
GO; GO:0045943; P:positive regulation of transcription from RNA polymerase I promoter; ISS:UniProtKB.
GO; GO:0045945; P:positive regulation of transcription from RNA polymerase III promoter; ISS:UniProtKB.
GO; GO:0045727; P:positive regulation of translation; ISS:UniProtKB.
GO; GO:0046777; P:protein autophosphorylation; ISO:MGI.
GO; GO:0070372; P:regulation of ERK1 and ERK2 cascade; ISS:UniProtKB.
GO; GO:0032886; P:regulation of microtubule-based process; ISS:UniProtKB.
GO; GO:0007165; P:signal transduction; ISO:MGI.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; ISS:BHF-UCL.
GO; GO:0042060; P:wound healing; ISO:MGI.
Gene3D; 1.20.5.100; -; 1.
Gene3D; 3.80.20.20; -; 4.
InterPro; IPR021157; Cyt_c1_TM_anchor_C.
InterPro; IPR006211; Furin-like_Cys-rich_dom.
InterPro; IPR006212; Furin_repeat.
InterPro; IPR032778; GF_recep_IV.
InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR032675; LRR_dom_sf.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR000494; Rcpt_L-dom.
InterPro; IPR036941; Rcpt_L-dom_sf.
InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
InterPro; IPR008266; Tyr_kinase_AS.
InterPro; IPR020635; Tyr_kinase_cat_dom.
InterPro; IPR016245; Tyr_kinase_EGF/ERB/XmrK_rcpt.
Pfam; PF00757; Furin-like; 1.
Pfam; PF14843; GF_recep_IV; 1.
Pfam; PF07714; Pkinase_Tyr; 1.
Pfam; PF01030; Recep_L_domain; 2.
PIRSF; PIRSF000619; TyrPK_EGF-R; 1.
PRINTS; PR00109; TYRKINASE.
SMART; SM00261; FU; 4.
SMART; SM00219; TyrKc; 1.
SUPFAM; SSF52058; SSF52058; 2.
SUPFAM; SSF56112; SSF56112; 1.
SUPFAM; SSF57184; SSF57184; 2.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
1: Evidence at protein level;
Activator; ATP-binding; Cell membrane; Complete proteome; Cytoplasm;
Disulfide bond; Glycoprotein; Kinase; Membrane; Nucleotide-binding;
Nucleus; Phosphoprotein; Receptor; Reference proteome; Signal;
Transcription; Transcription regulation; Transferase; Transmembrane;
Transmembrane helix; Tyrosine-protein kinase.
SIGNAL 1 22 {ECO:0000255}.
CHAIN 23 1256 Receptor tyrosine-protein kinase erbB-2.
/FTId=PRO_0000042181.
TOPO_DOM 23 653 Extracellular. {ECO:0000255}.
TRANSMEM 654 674 Helical. {ECO:0000255}.
TOPO_DOM 675 1256 Cytoplasmic. {ECO:0000255}.
DOMAIN 721 988 Protein kinase. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
NP_BIND 727 735 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
REGION 677 690 Required for interaction with KPNB1 and
EEA1. {ECO:0000250}.
REGION 1196 1198 Interaction with PIK3C2B. {ECO:0000250}.
MOTIF 677 690 Nuclear localization signal.
{ECO:0000250}.
COMPBIAS 193 269 Cys-rich.
COMPBIAS 1117 1163 Pro-rich.
ACT_SITE 846 846 Proton acceptor. {ECO:0000255|PROSITE-
ProRule:PRU00159, ECO:0000255|PROSITE-
ProRule:PRU10028}.
BINDING 754 754 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
MOD_RES 1055 1055 Phosphoserine.
{ECO:0000250|UniProtKB:P04626}.
MOD_RES 1079 1079 Phosphoserine.
{ECO:0000250|UniProtKB:P06494}.
MOD_RES 1084 1084 Phosphoserine.
{ECO:0000250|UniProtKB:P04626}.
MOD_RES 1108 1108 Phosphoserine.
{ECO:0000250|UniProtKB:P04626}.
MOD_RES 1113 1113 Phosphotyrosine.
{ECO:0000250|UniProtKB:P04626}.
MOD_RES 1140 1140 Phosphotyrosine; by autocatalysis.
{ECO:0000250|UniProtKB:P04626}.
MOD_RES 1167 1167 Phosphothreonine.
{ECO:0000250|UniProtKB:P04626}.
MOD_RES 1197 1197 Phosphotyrosine.
{ECO:0000250|UniProtKB:P04626}.
MOD_RES 1249 1249 Phosphotyrosine; by autocatalysis.
{ECO:0000250|UniProtKB:P04626}.
CARBOHYD 68 68 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 125 125 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 188 188 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 260 260 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 531 531 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 572 572 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 630 630 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 26 53 {ECO:0000250|UniProtKB:P04626}.
DISULFID 163 193 {ECO:0000250|UniProtKB:P04626}.
DISULFID 196 205 {ECO:0000250|UniProtKB:P04626}.
DISULFID 200 213 {ECO:0000250|UniProtKB:P04626}.
DISULFID 221 228 {ECO:0000250|UniProtKB:P04626}.
DISULFID 225 236 {ECO:0000250|UniProtKB:P04626}.
DISULFID 237 245 {ECO:0000250|UniProtKB:P04626}.
DISULFID 241 253 {ECO:0000250|UniProtKB:P04626}.
DISULFID 256 265 {ECO:0000250|UniProtKB:P04626}.
DISULFID 269 296 {ECO:0000250|UniProtKB:P04626}.
DISULFID 300 312 {ECO:0000250|UniProtKB:P04626}.
DISULFID 316 332 {ECO:0000250|UniProtKB:P04626}.
DISULFID 335 339 {ECO:0000250|UniProtKB:P04626}.
DISULFID 343 368 {ECO:0000250|UniProtKB:P04626}.
DISULFID 476 505 {ECO:0000250|UniProtKB:P04626}.
DISULFID 512 521 {ECO:0000250|UniProtKB:P04626}.
DISULFID 516 529 {ECO:0000250|UniProtKB:P04626}.
DISULFID 532 541 {ECO:0000250|UniProtKB:P04626}.
DISULFID 545 561 {ECO:0000250|UniProtKB:P04626}.
DISULFID 564 577 {ECO:0000250|UniProtKB:P04626}.
DISULFID 568 585 {ECO:0000250|UniProtKB:P04626}.
DISULFID 588 597 {ECO:0000250|UniProtKB:P04626}.
DISULFID 601 624 {ECO:0000250|UniProtKB:P04626}.
DISULFID 627 635 {ECO:0000250|UniProtKB:P04626}.
DISULFID 631 643 {ECO:0000250|UniProtKB:P04626}.
SEQUENCE 1256 AA; 138579 MW; 6040978428B93A28 CRC64;
MELAAWCRWG FLLALLSPGA AGTQVCTGTD MKLRLPASPE THLDMLRHLY QGCQVVQGNL
ELTYLPANAS LSFLQDIQEV QGYMLIAHNR VKHVPLQRLR IVRGTQLFED KYALAVLDNR
DPLDNVTTAA PGRTPEGLRE LQLRSLTEIL KGGVLIRGNP QLCYQDMVLW KDVLRKNNQL
APVDMDTNRS RACPPCAPTC KDNHCWGESP EDCQILTGTI CTSGCARCKG RLPTDCCHEQ
CAAGCTGPKH SDCLACLHFN HSGICELHCP ALITYNTDTF ESMLNPEGRY TFGASCVTTC
PYNYLSTEVG SCTLVCPPNN QEVTAEDGTQ RCEKCSKPCA GVCYGLGMEH LRGARAITSD
NIQEFAGCKK IFGSLAFLPE SFDGNPSSGV APLKPEHLQV FETLEEITGY LYISAWPESF
QDLSVFQNLR VIRGRILHDG AYSLTLQGLG IHSLGLRSLR ELGSGLALIH RNTHLCFVNT
VPWDQLFRNP HQALLHSGNR PEEACGLEGL VCNSLCARGH CWGPGPTQCV NCSQFLRGQE
CVEECRVWKG LPREYVRGKH CLPCHPECQP QNSSETCYGS EADQCEACAH YKDSSSCVAR
CPSGVKPDLS YMPIWKYPDE EGICQPCPIN CTHSCVDLDE RGCPAEQRAS PVTFIIATVV
GVLLFLIIVV VIGILIKRRR QKIRKYTMRR LLQETELVEP LTPSGAVPNQ AQMRILKETE
LRKLKVLGSG AFGTVYKGIW IPDGENVKIP VAIKVLRENT SPKANKEILD EAYVMAGVGS
PYVSRLLGIC LTSTVQLVTQ LMPYGCLLDH VREHRGRLGS QDLLNWCVQI AKGMSYLEEV
RLVHRDLAAR NVLVKSPNHV KITDFGLARL LDIDETEYHA DGGKVPIKWM ALESILRRRF
THQSDVWSYG VTVWELMTFG AKPYDGIPAR EIPDLLEKGE RLPQPPICTI DVYMIMVKCW
MIDSECRPRF RELVSEFSRM ARDPQRFVVI QNEDLGPSSP MDSTFYRSLL EDDDMGELVD
AEEYLVPQQG FFSPDPALGT GSTAHRRHRS SSARSGGGEL TLGLEPSEEE PPRSPLAPSE
GAGSDVFDGD LAVGVTKGLQ SLSPHDLSPL QRYSEDPTLP LPPETDGYVA PLACSPQPEY
VNQPEVRPQS PLTPEGPPPP IRPAGATLER PKTLSPGKNG VVKDVFAFGG AVENPEYLAP
RAGTASQPHP SPAFSPAFDN LYYWDQNSSE QGPPPSTFEG TPTAENPEYL GLDVPV


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E0978m ELISA kit Erbb2,Kiaa3023,Mouse,Mus musculus,Neu,p185erbB2,Proto-oncogene c-ErbB-2,Proto-oncogene Neu,Receptor tyrosine-protein kinase erbB-2 96T
E0978h ELISA ERBB2,HER2,Homo sapiens,Human,Metastatic lymph node gene 19 protein,MLN 19,MLN19,NEU,NGL,p185erbB2,Proto-oncogene c-ErbB-2,Proto-oncogene Neu,Receptor tyrosine-protein kinase erbB-2,Tyrosine kin 96T
U0978h CLIA ERBB2,HER2,Homo sapiens,Human,Metastatic lymph node gene 19 protein,MLN 19,MLN19,NEU,NGL,p185erbB2,Proto-oncogene c-ErbB-2,Proto-oncogene Neu,Receptor tyrosine-protein kinase erbB-2,Tyrosine kina 96T
E0978h ELISA kit ERBB2,HER2,Homo sapiens,Human,Metastatic lymph node gene 19 protein,MLN 19,MLN19,NEU,NGL,p185erbB2,Proto-oncogene c-ErbB-2,Proto-oncogene Neu,Receptor tyrosine-protein kinase erbB-2,Tyrosin 96T
E0978r ELISA kit Epidermal growth factor receptor-related protein,Erbb2,Neu,p185erbB2,p185neu,Proto-oncogene c-ErbB-2,Proto-oncogene Neu,Rat,Rattus norvegicus,Receptor tyrosine-protein kinase erbB-2 96T
E0978r ELISA Epidermal growth factor receptor-related protein,Erbb2,Neu,p185erbB2,p185neu,Proto-oncogene c-ErbB-2,Proto-oncogene Neu,Rat,Rattus norvegicus,Receptor tyrosine-protein kinase erbB-2 96T
U0978r CLIA Epidermal growth factor receptor-related protein,Erbb2,Neu,p185erbB2,p185neu,Proto-oncogene c-ErbB-2,Proto-oncogene Neu,Rat,Rattus norvegicus,Receptor tyrosine-protein kinase erbB-2 96T
15-288-22631 Receptor tyrosine-protein kinase erbB-2 - EC 2.7.10.1; p185erbB2; C-erbB-2; NEU proto-oncogene; Tyrosine kinase-type cell surface receptor HER2; MLN 19 Polyclonal 0.1 mg
15-288-22631 Receptor tyrosine-protein kinase erbB-2 - EC 2.7.10.1; p185erbB2; C-erbB-2; NEU proto-oncogene; Tyrosine kinase-type cell surface receptor HER2; MLN 19 Polyclonal 0.05 mg
18-785-210195 HER2 (Ab-877) - EC 2.7.10.1; p185erbB2; C-erbB-2; NEU proto-oncogene; Tyrosine kinase-type cell surface receptor HER2; MLN 19; CD340 antigen Polyclonal 0.05 mg
18-785-210195 HER2 (Ab-877) - EC 2.7.10.1; p185erbB2; C-erbB-2; NEU proto-oncogene; Tyrosine kinase-type cell surface receptor HER2; MLN 19; CD340 antigen Polyclonal 0.1 mg
18-785-210196 HER2 (Ab-1221_1222) - EC 2.7.10.1; p185erbB2; C-erbB-2; NEU proto-oncogene; Tyrosine kinase-type cell surface receptor HER2; MLN 19; CD340 antigen Polyclonal 0.05 mg
18-785-210196 HER2 (Ab-1221_1222) - EC 2.7.10.1; p185erbB2; C-erbB-2; NEU proto-oncogene; Tyrosine kinase-type cell surface receptor HER2; MLN 19; CD340 antigen Polyclonal 0.1 mg
18-785-210197 HER2 (Ab-1248) - EC 2.7.10.1; p185erbB2; C-erbB-2; NEU proto-oncogene; Tyrosine kinase-type cell surface receptor HER2; MLN 19; CD340 antigen Polyclonal 0.05 mg
18-785-210197 HER2 (Ab-1248) - EC 2.7.10.1; p185erbB2; C-erbB-2; NEU proto-oncogene; Tyrosine kinase-type cell surface receptor HER2; MLN 19; CD340 antigen Polyclonal 0.1 mg
18-785-210192 HER2 (Phospho-Tyr877) - EC 2.7.10.1; p185erbB2; C-erbB-2; NEU proto-oncogene; Tyrosine kinase-type cell surface receptor HER2; MLN 19; CD340 antigen Polyclonal 0.05 mg
18-785-210192 HER2 (Phospho-Tyr877) - EC 2.7.10.1; p185erbB2; C-erbB-2; NEU proto-oncogene; Tyrosine kinase-type cell surface receptor HER2; MLN 19; CD340 antigen Polyclonal 0.1 mg
18-785-210193 HER2 (Phospho-Tyr1221_Tyr1222) - EC 2.7.10.1; p185erbB2; C-erbB-2; NEU proto-oncogene; Tyrosine kinase-type cell surface receptor HER2; MLN 19; CD340 antigen Polyclonal 0.05 mg
18-785-210194 HER2 (Phospho-Tyr1248) - EC 2.7.10.1; p185erbB2; C-erbB-2; NEU proto-oncogene; Tyrosine kinase-type cell surface receptor HER2; MLN 19; CD340 antigen Polyclonal 0.1 mg
18-785-210193 HER2 (Phospho-Tyr1221_Tyr1222) - EC 2.7.10.1; p185erbB2; C-erbB-2; NEU proto-oncogene; Tyrosine kinase-type cell surface receptor HER2; MLN 19; CD340 antigen Polyclonal 0.1 mg
18-785-210194 HER2 (Phospho-Tyr1248) - EC 2.7.10.1; p185erbB2; C-erbB-2; NEU proto-oncogene; Tyrosine kinase-type cell surface receptor HER2; MLN 19; CD340 antigen Polyclonal 0.05 mg
18-272-197098 ErbB2 - Rabbit polyclonal to ErbB2; EC 2.7.10.1; p185erbB2; C-erbB-2; NEU proto-oncogene; Tyrosine kinase-type cell surface receptor HER2; MLN 19; CD340 antigen Polyclonal 1 ml
20-272-190599 ErbB2 - Rat monoclonal [ICR55] to ErbB2; EC 2.7.10.1; p185erbB2; C-erbB-2; NEU proto-oncogene; Tyrosine kinase-type cell surface receptor HER2; MLN 19; CD340 antigen Monoclonal 0.1 mg


 

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