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Receptor-like kinase LIP1 (EC 2.7.11.-) (Protein LOST IN POLLEN TUBE GUIDANCE 1) (AtLIP1)

 LIPG1_ARATH             Reviewed;         636 AA.
Q1PDW3; Q9FFD4;
08-JUN-2016, integrated into UniProtKB/Swiss-Prot.
16-MAY-2006, sequence version 1.
27-SEP-2017, entry version 104.
RecName: Full=Receptor-like kinase LIP1 {ECO:0000303|PubMed:23684977};
EC=2.7.11.- {ECO:0000255|PROSITE-ProRule:PRU00159};
AltName: Full=Protein LOST IN POLLEN TUBE GUIDANCE 1 {ECO:0000303|PubMed:23684977};
Short=AtLIP1 {ECO:0000303|PubMed:23684977};
Name=LIP1 {ECO:0000303|PubMed:23684977};
OrderedLocusNames=At5g16500 {ECO:0000312|Araport:AT5G16500};
ORFNames=MQK4.24 {ECO:0000312|EMBL:BAB09618.1};
Arabidopsis thaliana (Mouse-ear cress).
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae;
Arabidopsis.
NCBI_TaxID=3702 {ECO:0000312|EMBL:ABE66160.1};
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=9330910; DOI=10.1093/dnares/4.3.215;
Sato S., Kotani H., Nakamura Y., Kaneko T., Asamizu E., Fukami M.,
Miyajima N., Tabata S.;
"Structural analysis of Arabidopsis thaliana chromosome 5. I. Sequence
features of the 1.6 Mb regions covered by twenty physically assigned
P1 clones.";
DNA Res. 4:215-230(1997).
[2]
GENOME REANNOTATION.
STRAIN=cv. Columbia;
The Arabidopsis Information Portal (Araport);
Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=cv. Columbia;
PubMed=17147637; DOI=10.1111/j.1467-7652.2006.00183.x;
Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P.;
"Simultaneous high-throughput recombinational cloning of open reading
frames in closed and open configurations.";
Plant Biotechnol. J. 4:317-324(2006).
[4]
FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, DISRUPTION
PHENOTYPE, MUTAGENESIS OF CYS-7 AND CYS-10, AND PALMITOYLATION.
PubMed=23684977; DOI=10.1016/j.cub.2013.04.043;
Liu J., Zhong S., Guo X., Hao L., Wei X., Huang Q., Hou Y., Shi J.,
Wang C., Gu H., Qu L.J.;
"Membrane-bound RLCKs LIP1 and LIP2 are essential male factors
controlling male-female attraction in Arabidopsis.";
Curr. Biol. 23:993-998(2013).
[5]
INTERACTION WITH PRK6.
PubMed=26961657; DOI=10.1038/nature17413;
Takeuchi H., Higashiyama T.;
"Tip-localized receptors control pollen tube growth and LURE sensing
in Arabidopsis.";
Nature 531:245-248(2016).
-!- FUNCTION: Involved in pollen tube guidance into micropyle.
Participates in perception of the ovule-secreted peptide signal
LURE1. {ECO:0000269|PubMed:23684977}.
-!- SUBUNIT: Interacts with PRK6. {ECO:0000269|PubMed:26961657}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23684977};
Lipid-anchor {ECO:0000305|PubMed:23684977}. Cytoplasm
{ECO:0000269|PubMed:23684977}. Note=In pollen tubes, mainly
located in the plasma membrane to the tip region.
{ECO:0000269|PubMed:23684977}.
-!- TISSUE SPECIFICITY: Expressed in mature pollen and in germinating
pollen tubes. {ECO:0000269|PubMed:23684977}.
-!- PTM: Palmitoylated. {ECO:0000305|PubMed:23684977}.
-!- DISRUPTION PHENOTYPE: No visible phenotype. Lip1 and lip2 double
mutants have a reduced male transmission.
{ECO:0000269|PubMed:23684977}.
-!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr
protein kinase family. {ECO:0000255|PROSITE-ProRule:PRU00159}.
-!- SEQUENCE CAUTION:
Sequence=BAB09618.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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-----------------------------------------------------------------------
EMBL; AB005242; BAB09618.1; ALT_SEQ; Genomic_DNA.
EMBL; CP002688; AED92301.1; -; Genomic_DNA.
EMBL; DQ446955; ABE66160.1; -; mRNA.
RefSeq; NP_197154.2; NM_121655.3.
UniGene; At.50461; -.
ProteinModelPortal; Q1PDW3; -.
SMR; Q1PDW3; -.
STRING; 3702.AT5G16500.1; -.
iPTMnet; Q1PDW3; -.
PaxDb; Q1PDW3; -.
EnsemblPlants; AT5G16500.1; AT5G16500.1; AT5G16500.
GeneID; 831511; -.
Gramene; AT5G16500.1; AT5G16500.1; AT5G16500.
KEGG; ath:AT5G16500; -.
Araport; AT5G16500; -.
TAIR; locus:2171342; AT5G16500.
eggNOG; KOG1187; Eukaryota.
eggNOG; COG0515; LUCA.
HOGENOM; HOG000116550; -.
OMA; NTSMRIN; -.
OrthoDB; EOG09360AED; -.
PhylomeDB; Q1PDW3; -.
Reactome; R-ATH-446652; Interleukin-1 family signaling.
PRO; PR:Q1PDW3; -.
Proteomes; UP000006548; Chromosome 5.
GO; GO:0005737; C:cytoplasm; IDA:TAIR.
GO; GO:0005886; C:plasma membrane; IDA:TAIR.
GO; GO:0090404; C:pollen tube tip; IDA:TAIR.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0004675; F:transmembrane receptor protein serine/threonine kinase activity; IBA:GO_Central.
GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
GO; GO:0010183; P:pollen tube guidance; IGI:TAIR.
GO; GO:0006468; P:protein phosphorylation; IBA:GO_Central.
InterPro; IPR011009; Kinase-like_dom.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR008271; Ser/Thr_kinase_AS.
Pfam; PF00069; Pkinase; 1.
SMART; SM00220; S_TKc; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
1: Evidence at protein level;
ATP-binding; Cell membrane; Coiled coil; Complete proteome; Cytoplasm;
Kinase; Lipoprotein; Membrane; Nucleotide-binding; Phosphoprotein;
Reference proteome; Serine/threonine-protein kinase; Transferase.
CHAIN 1 636 Receptor-like kinase LIP1.
/FTId=PRO_0000436434.
DOMAIN 74 352 Protein kinase. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
NP_BIND 80 88 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
COILED 403 434 {ECO:0000255}.
COMPBIAS 373 535 Ser-rich. {ECO:0000255|PROSITE-
ProRule:PRU00016}.
COMPBIAS 407 629 Glu-rich. {ECO:0000255|PROSITE-
ProRule:PRU00007}.
ACT_SITE 201 201 Proton acceptor. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
BINDING 103 103 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
MOD_RES 205 205 Phosphoserine.
{ECO:0000250|UniProtKB:O48814}.
MOD_RES 236 236 Phosphoserine.
{ECO:0000250|UniProtKB:O48814}.
MOD_RES 242 242 Phosphothreonine.
{ECO:0000250|UniProtKB:O48814}.
MOD_RES 250 250 Phosphotyrosine.
{ECO:0000250|UniProtKB:O48814}.
MUTAGEN 7 7 C->S: Loss of membrane localization; when
associated with S-10.
{ECO:0000269|PubMed:23684977}.
MUTAGEN 10 10 C->S: Loss of membrane localization; when
associated with S-7.
{ECO:0000269|PubMed:23684977}.
SEQUENCE 636 AA; 71552 MW; C76FD6B1A557487C CRC64;
MIIMMNCFPC FTSQKSRNAP CTTNETNDDN VEHDEFRPPV VATTKRTEER EPAEQQPPVK
TFNFRELATA TKNFRQECLL GEGGFGRVYK GTLQSTGQLV AVKQLDKHGL HGNKEFLAEV
LSLAKLEHPN LVKLIGYCAD GDQRLLVFEY VSGGSLQDHL YEQKPGQKPM DWITRMKIAF
GAAQGLDYLH DKVTPAVIYR DLKASNILLD AEFYPKLCDF GLHNLEPGTG DSLFLSSRVM
DTYGYSAPEY TRGDDLTVKS DVYSFGVVLL ELITGRRAID TTKPNDEQNL VAWAQPIFKD
PKRYPDMADP LLRKNFSERG LNQAVAITSM CLQEEPTARP LISDVMVALS FLSMSTEDGI
PATVPMESFR DKSMSIALSR HGSCSVTPFC ISRKDVGNKS SSSSDSEDEE EEKEQKAEKE
EESTSKKRQE QEETATDSDD ESDSNSEKDQ EEEQSQLEKA RESSSSSSDS GSERRSIDET
NATAQSLKIS YSNYSSEEED NEKLSSKSSC KSNEESTFSR YDSGRDHDDS SRNTSMRINS
LAHDDKEEDE EENHETRSYS DHDDSPRNTS MRINSLSHDD DEEEEEENHQ TRLEHIHSSK
SEDQSVYSDD DAGESGESSL HRIEAKEEEH ISSDHD


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