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Receptor-type tyrosine-protein phosphatase C (EC 3.1.3.48) (Leukocyte common antigen) (CD antigen CD45)

 PTPRC_CYPCA             Reviewed;        1216 AA.
Q9IBD8;
13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
01-OCT-2000, sequence version 1.
10-OCT-2018, entry version 88.
RecName: Full=Receptor-type tyrosine-protein phosphatase C;
EC=3.1.3.48;
AltName: Full=Leukocyte common antigen;
AltName: CD_antigen=CD45;
Flags: Precursor;
Name=ptprc;
Cyprinus carpio (Common carp).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
Cyprinidae; Cyprinus.
NCBI_TaxID=7962;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=11081442; DOI=10.1006/fsim.2000.0294;
Fujiki K., Shin D.H., Nakao M., Yano T.;
"Molecular cloning of carp (Cyprinus carpio) leucocyte cell-derived
chemotaxin 2, glia maturation factor beta, CD45 and lysozyme C by use
of suppression subtractive hybridisation.";
Fish Shellfish Immunol. 10:643-650(2000).
-!- FUNCTION: Protein tyrosine-protein phosphatase required for T-cell
activation through the antigen receptor. {ECO:0000250}.
-!- CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein
tyrosine + phosphate. {ECO:0000255|PROSITE-ProRule:PRU10044}.
-!- SUBCELLULAR LOCATION: Cell membrane
{ECO:0000250|UniProtKB:P08575}; Single-pass type I membrane
protein {ECO:0000255}.
-!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
Receptor class 1/6 subfamily. {ECO:0000305}.
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EMBL; AB031424; BAA92179.1; -; mRNA.
ProteinModelPortal; Q9IBD8; -.
SMR; Q9IBD8; -.
PRIDE; Q9IBD8; -.
HOVERGEN; HBG000066; -.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
GO; GO:0050852; P:T cell receptor signaling pathway; IEA:InterPro.
CDD; cd00063; FN3; 1.
Gene3D; 2.60.40.10; -; 1.
Gene3D; 3.90.190.10; -; 2.
InterPro; IPR003961; FN3_dom.
InterPro; IPR036116; FN3_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
InterPro; IPR000242; PTPase_domain.
InterPro; IPR016335; Ptprc.
InterPro; IPR016130; Tyr_Pase_AS.
InterPro; IPR003595; Tyr_Pase_cat.
InterPro; IPR000387; TYR_PHOSPHATASE_dom.
Pfam; PF00102; Y_phosphatase; 2.
PIRSF; PIRSF002004; Leukocyte_common_antigen; 1.
PRINTS; PR00700; PRTYPHPHTASE.
SMART; SM00194; PTPc; 2.
SMART; SM00404; PTPc_motif; 2.
SUPFAM; SSF49265; SSF49265; 1.
SUPFAM; SSF52799; SSF52799; 2.
PROSITE; PS50853; FN3; 3.
PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
2: Evidence at transcript level;
Cell membrane; Glycoprotein; Hydrolase; Membrane; Phosphoprotein;
Protein phosphatase; Repeat; Signal; Transmembrane;
Transmembrane helix.
SIGNAL 1 26 {ECO:0000255}.
CHAIN 27 1216 Receptor-type tyrosine-protein
phosphatase C.
/FTId=PRO_0000395800.
TOPO_DOM 27 493 Extracellular. {ECO:0000255}.
TRANSMEM 494 514 Helical. {ECO:0000255}.
TOPO_DOM 515 1216 Cytoplasmic. {ECO:0000255}.
DOMAIN 71 165 Fibronectin type-III 1.
{ECO:0000255|PROSITE-ProRule:PRU00316}.
DOMAIN 298 395 Fibronectin type-III 2.
{ECO:0000255|PROSITE-ProRule:PRU00316}.
DOMAIN 401 491 Fibronectin type-III 3.
{ECO:0000255|PROSITE-ProRule:PRU00316}.
DOMAIN 563 819 Tyrosine-protein phosphatase 1.
{ECO:0000255|PROSITE-ProRule:PRU00160}.
DOMAIN 850 1129 Tyrosine-protein phosphatase 2.
{ECO:0000255|PROSITE-ProRule:PRU00160}.
REGION 760 766 Substrate binding. {ECO:0000250}.
COMPBIAS 915 918 Poly-Glu.
ACT_SITE 760 760 Phosphocysteine intermediate.
{ECO:0000250}.
ACT_SITE 1070 1070 Phosphocysteine intermediate.
{ECO:0000250}.
BINDING 728 728 Substrate. {ECO:0000250}.
BINDING 804 804 Substrate. {ECO:0000250}.
MOD_RES 881 881 Phosphoserine. {ECO:0000250}.
MOD_RES 903 903 Phosphoserine. {ECO:0000250}.
CARBOHYD 64 64 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 92 92 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 98 98 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 135 135 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 160 160 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 179 179 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 185 185 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 205 205 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 240 240 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 283 283 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 301 301 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 349 349 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 365 365 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 375 375 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 393 393 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 478 478 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
SEQUENCE 1216 AA; 138252 MW; 9D2E45F41721D2CF CRC64;
MARFFALGPL VLVLCLVLFL SPTSTSEQDT DTKVTGSSNS PTIMQSATPT PALPTGSVKG
VKANDSGTTE VPCQYRLIVN GYEKNSLLVN INGSKSQNYT IRIKDKKSEK KIPVSIVSDT
TTIDILFEWL KPCTNYSVNI DNCNVVGENH FNLNVLKSVN HSAEPKGDEQ VCFKDSKWNL
TKCVNITTED SCVQKPIQIN LETCNYTMNV HMPPVKPEIT FSESIPTKFV WSNKPLSSDN
VTSQCKDTFK VKCTDDTEYD LDKDVFLKPS EEYTCTGKYK YYNTSIDSKS KQVNIHCEWI
NETVFSEVTS NSIVIFWNLS PGDKCKGITW EKFSAICKKS HDQKCRKVND TTAECVFSEL
KSYINYTCTL SAEVNKSIGV FPIYTRDFNQ RTNSSNPSFE DHDNVKVKET SHNSFNVNCK
NLKPDEWNGP KGIYIAKLLS NRPPVTKENP KSCSFTFENL YYHTEYTIEI IAINGNKNES
SAKATHSTRY NDKALIGFLV FLILVTSLAL LFVLYKLFLL KRKRTAEDEE ILLTQPLRRV
EPIYAGGLVE AYKNKIADEG RLFMDEFQSI PRIFSNYTIK EAKKSENQYK NRYVDILPYD
YNRVTLSTGG EDNYINASFI EGYREPKKYI AAQGPKDETV VDFWRMVWEQ KSSIIVMVTR
CEEGNKTKCA QYWPSLDREA EIFEEFVVKI RSEEHCPDYV IRHLILNNKR EKGSEREVTH
IQFISWPDHG VPGDPSLLLK LRRRVNSFKN FFSGPVVVHC SAGVGRTGTY MSIDAMIESL
EAEGRVDIYG FVAKLRRQRC LMVQVEAQYI LIHTALIEYN QFGETEVSLS EFHSVLNTLR
QKNGSDPSLL EKEFQKLPKF KKWRTMNTGS SEDNKKKNRD SAVIPYDFNR VIFRLDIEGN
QTSDPEDEEE YSSDEEEESN QYINASFIDG YWCNKSLIAA QGPLQSTAEE FLLMLYQQQT
KTLVMLTDCQ EDGKDYCFQY WGDEKKTYGD MEIEVKKTET FPTYVRRHLE IQSLKKKEVL
KVDQYQFLKW RGRELPENAQ ELVEMASIIR ENGHYDNSKT NRNVPIVVHC NNGSSRTGIF
CALWNLLDSA YTEKLVDVLQ EVKNLRKLRQ GMVETIEQYQ FLYTALEGAF PVQNGAVKTP
PAKDAAQVIN ETTALLTEPN STSGADQKEA EESTAAESNE QGAKESSTAE APAAEGDGEK
ATSEGPTNGP TATVEV


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