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Regulator of MON1-CCZ1 complex (Colon cancer-associated protein Mic1) (Mic-1) (WD repeat-containing protein 98)

 RMC1_HUMAN              Reviewed;         657 AA.
Q96DM3; Q9BU17; Q9Y5M0;
24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
24-MAY-2004, sequence version 2.
23-MAY-2018, entry version 122.
RecName: Full=Regulator of MON1-CCZ1 complex {ECO:0000303|PubMed:29038162};
AltName: Full=Colon cancer-associated protein Mic1;
Short=Mic-1;
AltName: Full=WD repeat-containing protein 98 {ECO:0000305};
Name=RMC1 {ECO:0000312|HGNC:HGNC:24326};
Synonyms=C18orf8, MIC1, WDR98;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Synovium;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16177791; DOI=10.1038/nature03983;
Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D.,
Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K.,
FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S.,
Bloom T., Bugalter B., Butler J., Cook A., DeCaprio D., Engels R.,
Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T.,
Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E.,
Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H.,
O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K.,
Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R.,
Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.;
"DNA sequence and analysis of human chromosome 18.";
Nature 437:551-555(2005).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Lung;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
NUCLEOTIDE SEQUENCE [MRNA] OF 35-657.
TISSUE=Colon carcinoma;
Linnebacher M., Meuer S.C., Rudy W.;
"Identification of colon-cancer associated sequences by SSH.";
Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
[5]
SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
PubMed=17897319; DOI=10.1111/j.1600-0854.2007.00643.x;
Schroeder B., Wrocklage C., Pan C., Jaeger R., Koesters B.,
Schaefer H., Elsaesser H.-P., Mann M., Hasilik A.;
"Integral and associated lysosomal membrane proteins.";
Traffic 8:1676-1686(2007).
[6]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Erythroleukemia;
PubMed=23186163; DOI=10.1021/pr300630k;
Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
Mohammed S.;
"Toward a comprehensive characterization of a human cancer cell
phosphoproteome.";
J. Proteome Res. 12:260-271(2013).
[7]
IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN A COMPLEX WITH
RMC1; CCZ1; MON1A AND MON1B, SUBCELLULAR LOCATION, AND FUNCTION.
PubMed=29038162; DOI=10.1128/MCB.00392-17;
Pontano Vaites L., Paulo J.A., Huttlin E.L., Harper J.W.;
"Systematic analysis of human cells lacking ATG8 proteins uncovers
roles for GABARAPs and the CCZ1/MON1 regulator C18orf8/RMC1 in macro
and selective autophagic flux.";
Mol. Cell. Biol. 0:0-0(2017).
-!- FUNCTION: Componement of the CCZ1-MON1 RAB7A guanine exchange
factor (GEF). Acts as a positive regulator of CCZ1-MON1A/B
function necessary for endosomal/autophagic flux and efficient
RAB7A localization (PubMed:29038162).
{ECO:0000269|PubMed:29038162}.
-!- SUBUNIT: Found in a complex with RMC1, CCZ1 MON1A and MON1B.
{ECO:0000269|PubMed:29038162}.
-!- SUBCELLULAR LOCATION: Lysosome membrane
{ECO:0000269|PubMed:17897319}. Late endosome membrane
{ECO:0000269|PubMed:29038162}.
-!- SIMILARITY: Belongs to the RMC1 family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAD33909.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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EMBL; AK057192; BAB71377.1; -; mRNA.
EMBL; BC002950; AAH02950.2; -; mRNA.
EMBL; BC008305; AAH08305.2; -; mRNA.
EMBL; AF143536; AAD33909.1; ALT_INIT; mRNA.
EMBL; AC010853; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AC026634; -; NOT_ANNOTATED_CDS; Genomic_DNA.
CCDS; CCDS32803.1; -.
RefSeq; NP_001305636.1; NM_001318707.1.
RefSeq; NP_001305637.1; NM_001318708.1.
RefSeq; NP_001305638.1; NM_001318709.1.
RefSeq; NP_037458.3; NM_013326.4.
UniGene; Hs.464779; -.
ProteinModelPortal; Q96DM3; -.
BioGrid; 118961; 15.
IntAct; Q96DM3; 5.
MINT; Q96DM3; -.
STRING; 9606.ENSP00000269221; -.
iPTMnet; Q96DM3; -.
PhosphoSitePlus; Q96DM3; -.
DMDM; 47605918; -.
EPD; Q96DM3; -.
MaxQB; Q96DM3; -.
PaxDb; Q96DM3; -.
PeptideAtlas; Q96DM3; -.
PRIDE; Q96DM3; -.
Ensembl; ENST00000269221; ENSP00000269221; ENSG00000141452.
GeneID; 29919; -.
KEGG; hsa:29919; -.
UCSC; uc021uie.3; human.
CTD; 29919; -.
DisGeNET; 29919; -.
EuPathDB; HostDB:ENSG00000141452.9; -.
GeneCards; RMC1; -.
H-InvDB; HIX0020388; -.
HGNC; HGNC:24326; RMC1.
HPA; HPA043589; -.
neXtProt; NX_Q96DM3; -.
OpenTargets; ENSG00000141452; -.
PharmGKB; PA134862561; -.
eggNOG; KOG2377; Eukaryota.
eggNOG; ENOG410YC1K; LUCA.
GeneTree; ENSGT00390000009127; -.
HOGENOM; HOG000006772; -.
HOVERGEN; HBG052473; -.
InParanoid; Q96DM3; -.
OMA; KLNHEYK; -.
OrthoDB; EOG091G05FE; -.
PhylomeDB; Q96DM3; -.
TreeFam; TF105850; -.
GenomeRNAi; 29919; -.
PRO; PR:Q96DM3; -.
Proteomes; UP000005640; Chromosome 18.
Bgee; ENSG00000141452; -.
CleanEx; HS_C18orf8; -.
ExpressionAtlas; Q96DM3; baseline and differential.
Genevisible; Q96DM3; HS.
GO; GO:0031902; C:late endosome membrane; IDA:UniProtKB.
GO; GO:0005765; C:lysosomal membrane; HDA:UniProtKB.
GO; GO:0035658; C:Mon1-Ccz1 complex; IDA:UniProtKB.
GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
GO; GO:0010506; P:regulation of autophagy; IMP:UniProtKB.
Gene3D; 2.130.10.10; -; 1.
InterPro; IPR009755; Mic1.
InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
InterPro; IPR036322; WD40_repeat_dom_sf.
Pfam; PF07035; Mic1; 1.
SUPFAM; SSF50978; SSF50978; 1.
1: Evidence at protein level;
Autophagy; Complete proteome; Endosome; Lysosome; Membrane;
Reference proteome.
CHAIN 1 657 Regulator of MON1-CCZ1 complex.
/FTId=PRO_0000096481.
DOMAIN 471 637 Mic1.
CONFLICT 163 163 S -> R (in Ref. 1; BAB71377).
{ECO:0000305}.
CONFLICT 178 178 Q -> L (in Ref. 4; AAD33909).
{ECO:0000305}.
CONFLICT 470 470 E -> DFFLYGVFKHYRQ (in Ref. 4; AAD33909).
{ECO:0000305}.
SEQUENCE 657 AA; 74975 MW; DFDC8B304ADCA88C CRC64;
MGEEDYYLEL CERPVQFEKA NPVNCVFFDE ANKQVFAVRS GGATGVVVKG PDDRNPISFR
MDDKGEVKCI KFSLENKILA VQRTSKTVDF CNFIPDNSQL EYTQECKTKN ANILGFCWTS
STEIVFITDQ GIEFYQVLPE KRSLKLLKSH NLNVNWYMYC PESAVILLST TVLENVLQPF
HFRAGTMSKL PKFEIELPAA PKSTKPSLSE RDIAMATIYG QLYVLFLRHH SRTSNSTGAE
VVLYHLPREG ACKKMHILKL NRTGKFALNV VDNLVVVHHQ DTETSVIFDI KLRGEFDGSV
TFHHPVLPAR SIQPYQIPIT GPAAVTSQSP VPCKLYSSSW IVFQPDIIIS ASQGYLWNLQ
VKLEPIVNLL PDKGRLMDFL LQRKECKMVI LSVCSQMLSE SDRASLPVIA TVFDKLNHEY
KKYLDAEQSY AMAVEAGQSR SSPLLKRPVR TQAVLDQSDV YTHVLSAFVE KKEMPHKFVI
AVLMEYIRSL NQFQIAVQHY LHELVIKTLV QHNLFYMLHQ FLQYHVLSDS KPLACLLLSL
ESFYPPAHQL SLDMLKRLST ANDEIVEVLL SKHQVLAALR FIRGIGGHDN ISARKFLDAA
KQTEDNMLFY TIFRFFEQRN QRLRGSPNFT PGEHCEEHVA FFKQIFGDQA LMRPTTF


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