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Replication enhancer (REn)

 A6MNQ6_9GEMI            Unreviewed;       134 AA.
A6MNQ6;
24-JUL-2007, integrated into UniProtKB/TrEMBL.
24-JUL-2007, sequence version 1.
11-MAY-2016, entry version 12.
RecName: Full=Replication enhancer {ECO:0000256|RuleBase:RU363029};
Short=REn {ECO:0000256|RuleBase:RU363029};
Tomato yellow leaf curl virus.
Viruses; ssDNA viruses; Geminiviridae; Begomovirus.
NCBI_TaxID=10832 {ECO:0000313|EMBL:ABR27533.1};
[1] {ECO:0000313|EMBL:ABR27533.1}
NUCLEOTIDE SEQUENCE.
STRAIN=Recombinant MmA-C.11 130dpi type IV
{ECO:0000313|EMBL:ABR27539.1},
Recombinant MmA-C.14 130dpi type IV {ECO:0000313|EMBL:ABR27542.1},
Recombinant MmA-C.18 13 dpi type IV {ECO:0000313|EMBL:ABR27545.1},
Recombinant MmA-C.2 130dpi type IV {ECO:0000313|EMBL:ABR27533.1},
Recombinant MmA-C.20 400dpi type IV {ECO:0000313|EMBL:ABR27581.1},
Recombinant MmA-C.21B 400dpi type IV {ECO:0000313|EMBL:ABR27566.1},
Recombinant MmA-C.23 400dpi type IV {ECO:0000313|EMBL:ABR27569.1},
Recombinant MmA-C.24 130dpi type IV {ECO:0000313|EMBL:ABR27548.1},
Recombinant MmA-C.25 400dpi type IV {ECO:0000313|EMBL:ABR27572.1},
Recombinant MmA-C.26 400dpi type IV {ECO:0000313|EMBL:ABR27575.1},
Recombinant MmA-C.30 130dpi type IV {ECO:0000313|EMBL:ABR27551.1},
Recombinant MmA-C.34 130dpi type IV {ECO:0000313|EMBL:ABR27554.1},
Recombinant MmA-C.4 400dpi type IV {ECO:0000313|EMBL:ABR27578.1},
Recombinant MmA-C.42 130dpi type IV {ECO:0000313|EMBL:ABR27557.1},
Recombinant MmA-C.48 400dpi type IV {ECO:0000313|EMBL:ABR27584.1},
Recombinant MmA-C.49 400dpi type IV {ECO:0000313|EMBL:ABR27587.1},
Recombinant MmA-C.6 400dpi type IV {ECO:0000313|EMBL:ABR27560.1},
Recombinant MmA-C.7 400dpi type IV {ECO:0000313|EMBL:ABR27563.1},
Recombinant MmA-C.8 130dpi type IV {ECO:0000313|EMBL:ABR27536.1},
Recombinant MmB-C.45 400dpi type IV {ECO:0000313|EMBL:ABR27590.1},
Recombinant MmB-C.73 400dpi type IV {ECO:0000313|EMBL:ABR27593.1}, and
Recombinant MmB-C.77 400dpi type IV {ECO:0000313|EMBL:ABR27596.1};
PubMed=17467025; DOI=10.1016/j.virol.2007.03.045;
Garcia-Andres S., Tomas D.M., Sanchez-Campos S., Navas-Castillo J.,
Moriones E.;
"Frequent occurrence of recombinants in mixed infections of tomato
yellow leaf curl disease-associated begomoviruses.";
Virology 365:210-219(2007).
-!- FUNCTION: Enhances infectivity and symptom expression.
{ECO:0000256|RuleBase:RU363029}.
-!- FUNCTION: Increases viral DNA accumulation.
{ECO:0000256|RuleBase:RU363029}.
-!- SUBUNIT: Homooligomer. Interacts with the replication-associated
protein (REP). Interacts with host proliferating cell nuclear
antigen (PCNA). Interacts with host retinoblastoma-related protein
1 (RBR1), and may thereby deregulate the host cell cycle.
Oligomerization and interaction with PCNA are necessary for
optimal replication enhancement. {ECO:0000256|RuleBase:RU363029}.
-!- SIMILARITY: Belongs to the geminiviridae replication enhancer
protein family. {ECO:0000256|RuleBase:RU363029}.
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EMBL; EF423645; ABR27533.1; -; Genomic_DNA.
EMBL; EF423646; ABR27536.1; -; Genomic_DNA.
EMBL; EF423647; ABR27539.1; -; Genomic_DNA.
EMBL; EF423648; ABR27542.1; -; Genomic_DNA.
EMBL; EF423649; ABR27545.1; -; Genomic_DNA.
EMBL; EF423650; ABR27548.1; -; Genomic_DNA.
EMBL; EF423651; ABR27551.1; -; Genomic_DNA.
EMBL; EF423652; ABR27554.1; -; Genomic_DNA.
EMBL; EF423653; ABR27557.1; -; Genomic_DNA.
EMBL; EF423654; ABR27560.1; -; Genomic_DNA.
EMBL; EF423655; ABR27563.1; -; Genomic_DNA.
EMBL; EF423656; ABR27566.1; -; Genomic_DNA.
EMBL; EF423657; ABR27569.1; -; Genomic_DNA.
EMBL; EF423658; ABR27572.1; -; Genomic_DNA.
EMBL; EF423659; ABR27575.1; -; Genomic_DNA.
EMBL; EF423660; ABR27578.1; -; Genomic_DNA.
EMBL; EF423661; ABR27581.1; -; Genomic_DNA.
EMBL; EF423662; ABR27584.1; -; Genomic_DNA.
EMBL; EF423663; ABR27587.1; -; Genomic_DNA.
EMBL; EF423664; ABR27590.1; -; Genomic_DNA.
EMBL; EF423665; ABR27593.1; -; Genomic_DNA.
EMBL; EF423666; ABR27596.1; -; Genomic_DNA.
GO; GO:0016032; P:viral process; IEA:UniProtKB-KW.
InterPro; IPR000657; Gemini_AL3.
Pfam; PF01407; Gemini_AL3; 1.
PRINTS; PR00231; GEMCOATAL3.
ProDom; PD001172; Gemini_AL3; 1.
3: Inferred from homology;
Host-virus interaction {ECO:0000256|RuleBase:RU363029}.
SEQUENCE 134 AA; 15923 MW; F9651C0F36D84F31 CRC64;
MDSRTGELIT APQAENGVFI WEINNPLYFK ITEHSQRPFL MNHDIISIQI RFNHNIRKVL
GIHKCFLNFR IWTTLQPQTG RFLKVFRHQV LKYLDSIGVI SINNVIRAVD HVLYDVFENT
INVIEQHEIK YNLY


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