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Replication enhancer (REn)

 A6MNX2_9GEMI            Unreviewed;       134 AA.
A6MNX2;
24-JUL-2007, integrated into UniProtKB/TrEMBL.
24-JUL-2007, sequence version 1.
11-MAY-2016, entry version 12.
RecName: Full=Replication enhancer {ECO:0000256|RuleBase:RU363029};
Short=REn {ECO:0000256|RuleBase:RU363029};
Tomato yellow leaf curl virus.
Viruses; ssDNA viruses; Geminiviridae; Begomovirus.
NCBI_TaxID=10832 {ECO:0000313|EMBL:ABR27599.1};
[1] {ECO:0000313|EMBL:ABR27599.1}
NUCLEOTIDE SEQUENCE.
STRAIN=Recombinant Ty-1S-C.3 400dpi type VII
{ECO:0000313|EMBL:ABR27599.1},
Recombinant Ty-1S-C.4 400dpi type VII {ECO:0000313|EMBL:ABR27602.1},
Recombinant Ty-1S-C.5 400dpi type VII {ECO:0000313|EMBL:ABR27605.1},
Recombinant Ty-1S-C.78 400dpi type VII {ECO:0000313|EMBL:ABR27608.1},
Recombinant Ty-1S-C.87 400dpi type VII {ECO:0000313|EMBL:ABR27611.1},
Recombinant Ty-1St-C.10 15dpt type VII {ECO:0000313|EMBL:ABR27620.1},
Recombinant Ty-1St-C.11 15dpt type VII {ECO:0000313|EMBL:ABR27623.1},
Recombinant Ty-1St-C.13 15dpt type VII {ECO:0000313|EMBL:ABR27626.1},
Recombinant Ty-1St-C.14 15dpt type VII {ECO:0000313|EMBL:ABR27629.1},
Recombinant Ty-1St-C.19 15dpt type VII {ECO:0000313|EMBL:ABR27632.1},
Recombinant Ty-1St-C.20 15dpt type VII {ECO:0000313|EMBL:ABR27635.1},
Recombinant Ty-1St-C.21 15dpt type VII {ECO:0000313|EMBL:ABR27638.1},
Recombinant Ty-1St-C.33 15dpt type VII {ECO:0000313|EMBL:ABR27641.1},
Recombinant Ty-1St-C.42 15dpt type VII {ECO:0000313|EMBL:ABR27644.1},
Recombinant Ty-1St-C.48 15dpt type VII {ECO:0000313|EMBL:ABR27647.1},
Recombinant Ty-1St-C.49 15dpt type VII {ECO:0000313|EMBL:ABR27650.1},
Recombinant Ty-1St-C.51 15dpt type VII {ECO:0000313|EMBL:ABR27653.1},
Recombinant Ty-1St-C.66 15dpt type VII {ECO:0000313|EMBL:ABR27656.1},
Recombinant Ty-1St-C.7 15dpt type VII {ECO:0000313|EMBL:ABR27614.1},
Recombinant Ty-1St-C.73 15dpt type VII {ECO:0000313|EMBL:ABR27659.1},
Recombinant Ty-1St-C.79 15dpt type VII {ECO:0000313|EMBL:ABR27662.1},
and Recombinant Ty-1St-C.9 15dpt type VII
{ECO:0000313|EMBL:ABR27617.1};
PubMed=17467025; DOI=10.1016/j.virol.2007.03.045;
Garcia-Andres S., Tomas D.M., Sanchez-Campos S., Navas-Castillo J.,
Moriones E.;
"Frequent occurrence of recombinants in mixed infections of tomato
yellow leaf curl disease-associated begomoviruses.";
Virology 365:210-219(2007).
-!- FUNCTION: Enhances infectivity and symptom expression.
{ECO:0000256|RuleBase:RU363029}.
-!- FUNCTION: Increases viral DNA accumulation.
{ECO:0000256|RuleBase:RU363029}.
-!- SUBUNIT: Homooligomer. Interacts with the replication-associated
protein (REP). Interacts with host proliferating cell nuclear
antigen (PCNA). Interacts with host retinoblastoma-related protein
1 (RBR1), and may thereby deregulate the host cell cycle.
Oligomerization and interaction with PCNA are necessary for
optimal replication enhancement. {ECO:0000256|RuleBase:RU363029}.
-!- SIMILARITY: Belongs to the geminiviridae replication enhancer
protein family. {ECO:0000256|RuleBase:RU363029}.
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EMBL; EF423676; ABR27599.1; -; Genomic_DNA.
EMBL; EF423677; ABR27602.1; -; Genomic_DNA.
EMBL; EF423678; ABR27605.1; -; Genomic_DNA.
EMBL; EF423679; ABR27608.1; -; Genomic_DNA.
EMBL; EF423680; ABR27611.1; -; Genomic_DNA.
EMBL; EF423681; ABR27614.1; -; Genomic_DNA.
EMBL; EF423682; ABR27617.1; -; Genomic_DNA.
EMBL; EF423683; ABR27620.1; -; Genomic_DNA.
EMBL; EF423684; ABR27623.1; -; Genomic_DNA.
EMBL; EF423685; ABR27626.1; -; Genomic_DNA.
EMBL; EF423686; ABR27629.1; -; Genomic_DNA.
EMBL; EF423687; ABR27632.1; -; Genomic_DNA.
EMBL; EF423688; ABR27635.1; -; Genomic_DNA.
EMBL; EF423689; ABR27638.1; -; Genomic_DNA.
EMBL; EF423690; ABR27641.1; -; Genomic_DNA.
EMBL; EF423691; ABR27644.1; -; Genomic_DNA.
EMBL; EF423692; ABR27647.1; -; Genomic_DNA.
EMBL; EF423693; ABR27650.1; -; Genomic_DNA.
EMBL; EF423694; ABR27653.1; -; Genomic_DNA.
EMBL; EF423695; ABR27656.1; -; Genomic_DNA.
EMBL; EF423696; ABR27659.1; -; Genomic_DNA.
EMBL; EF423697; ABR27662.1; -; Genomic_DNA.
GO; GO:0016032; P:viral process; IEA:UniProtKB-KW.
InterPro; IPR000657; Gemini_AL3.
Pfam; PF01407; Gemini_AL3; 1.
PRINTS; PR00231; GEMCOATAL3.
ProDom; PD001172; Gemini_AL3; 1.
3: Inferred from homology;
Host-virus interaction {ECO:0000256|RuleBase:RU363029}.
SEQUENCE 134 AA; 16053 MW; E8491232090B5ABF CRC64;
MDSRTGELIT APQAENGVFI WEINNPLYFT ITRHNQQPFN SKYNFLTFQI RFNHNLRKAL
GIHKCFLNFR IWTTLQSPTG HFLRVFRYQV YKYLNNIGVI SLNNVIRAVD YVLFDVFENT
IDVIEQHEIK YNLY


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