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Replication enhancer (REn)

 H2DGW2_9GEMI            Unreviewed;       134 AA.
H2DGW2;
21-MAR-2012, integrated into UniProtKB/TrEMBL.
21-MAR-2012, sequence version 1.
08-JUN-2016, entry version 8.
RecName: Full=Replication enhancer {ECO:0000256|RuleBase:RU363029};
Short=REn {ECO:0000256|RuleBase:RU363029};
Name=C3 {ECO:0000313|EMBL:AEY77436.1};
Chilli leaf curl virus.
Viruses; ssDNA viruses; Geminiviridae; Begomovirus.
NCBI_TaxID=172278 {ECO:0000313|EMBL:AEY77436.1};
[1] {ECO:0000313|EMBL:AEY77436.1}
NUCLEOTIDE SEQUENCE.
STRAIN=Taq1 {ECO:0000313|EMBL:AEY77436.1};
Khan A.J., Al-Matrushi A.M.O., Haq Q.M.I.;
"Molecular characterization and infectivity of Chilli leaf curl virus
from Oman.";
Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Enhances infectivity and symptom expression.
{ECO:0000256|RuleBase:RU363029}.
-!- FUNCTION: Increases viral DNA accumulation.
{ECO:0000256|RuleBase:RU363029}.
-!- SUBUNIT: Homooligomer. Interacts with the replication-associated
protein (REP). Interacts with host proliferating cell nuclear
antigen (PCNA). Interacts with host retinoblastoma-related protein
1 (RBR1), and may thereby deregulate the host cell cycle.
Oligomerization and interaction with PCNA are necessary for
optimal replication enhancement. {ECO:0000256|RuleBase:RU363029}.
-!- SIMILARITY: Belongs to the geminiviridae replication enhancer
protein family. {ECO:0000256|RuleBase:RU363029}.
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EMBL; JN604492; AEY77436.1; -; Genomic_DNA.
GO; GO:0016032; P:viral process; IEA:UniProtKB-KW.
InterPro; IPR000657; Gemini_AL3.
Pfam; PF01407; Gemini_AL3; 1.
PRINTS; PR00231; GEMCOATAL3.
ProDom; PD001172; Gemini_AL3; 1.
3: Inferred from homology;
Host-virus interaction {ECO:0000256|RuleBase:RU363029}.
SEQUENCE 134 AA; 15814 MW; 1D28587AE16CAE46 CRC64;
MDSRTGEPIT AAQAENGVFI WEITNPLYFK ITKHHNRPFL RSQDIITVQI RFNHNLRKAL
GMHKCFLTYR IWTTLQPQTG HFLRVFKTQV LKVLNNFAVI SINNVNRAVD HVLWNVLDHV
VYVNQSYSIK YNLY


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