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Replication protein 1a [Includes: ATP-dependent helicase (EC 3.6.4.-); Methyltransferase (EC 2.1.1.-)]

 1A_CMVO                 Reviewed;         993 AA.
P20122;
01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
01-FEB-1991, sequence version 1.
15-FEB-2017, entry version 61.
RecName: Full=Replication protein 1a;
Includes:
RecName: Full=ATP-dependent helicase;
EC=3.6.4.-;
Includes:
RecName: Full=Methyltransferase;
EC=2.1.1.-;
ORFNames=ORF1a;
Cucumber mosaic virus (strain O) (CMV).
Viruses; ssRNA viruses; ssRNA positive-strand viruses, no DNA stage;
Bromoviridae; Cucumovirus.
NCBI_TaxID=12309;
NCBI_TaxID=3659; Cucumis sativus (Cucumber).
NCBI_TaxID=4097; Nicotiana tabacum (Common tobacco).
NCBI_TaxID=4081; Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
[1]
NUCLEOTIDE SEQUENCE.
PubMed=2628183; DOI=10.1016/0378-1119(89)90448-4;
Hayakawa T., Mizukami M., Nakamura I., Suzuki M.;
"Cloning and sequencing of RNA-1 cDNA from cucumber mosaic virus
strain O.";
Gene 85:533-540(1989).
-!- FUNCTION: Involved in the virus replication. Contains a helicase
domain and a methyltransferase domain. The methyltransferase
domain is probably involved in viral RNA capping. Involved in the
formation of ER membrane spherular invaginations in which RNA
replication complexes form (By similarity). {ECO:0000250}.
-!- SUBUNIT: Interacts with RNA-directed RNA polymerase 2a.
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Host endoplasmic reticulum membrane
{ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
-!- SIMILARITY: Belongs to the bromoviridae replication protein 1a
family. {ECO:0000305}.
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PIR; JQ0379; P1VXCM.
GO; GO:0044167; C:host cell endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
GO; GO:0008174; F:mRNA methyltransferase activity; IEA:InterPro.
GO; GO:0003723; F:RNA binding; IEA:InterPro.
GO; GO:0006396; P:RNA processing; IEA:InterPro.
InterPro; IPR027351; (+)RNA_virus_helicase_core_dom.
InterPro; IPR021002; 1a_necrotic_phenotyp-det_dom.
InterPro; IPR002588; Alphavirus-like_MT_dom.
InterPro; IPR022184; CMV_1a_C.
InterPro; IPR027417; P-loop_NTPase.
Pfam; PF12467; CMV_1a; 1.
Pfam; PF12503; CMV_1a_C; 1.
Pfam; PF01443; Viral_helicase1; 1.
Pfam; PF01660; Vmethyltransf; 1.
SUPFAM; SSF52540; SSF52540; 1.
PROSITE; PS51743; ALPHAVIRUS_MT; 1.
PROSITE; PS51657; PSRV_HELICASE; 1.
3: Inferred from homology;
ATP-binding; Helicase; Host endoplasmic reticulum; Host membrane;
Hydrolase; Membrane; Methyltransferase; Nucleotide-binding;
Transferase.
CHAIN 1 993 Replication protein 1a.
/FTId=PRO_0000083262.
DOMAIN 72 290 Alphavirus-like MT. {ECO:0000255|PROSITE-
ProRule:PRU01079}.
DOMAIN 687 838 (+)RNA virus helicase ATP-binding.
DOMAIN 839 993 (+)RNA virus helicase C-terminal.
NP_BIND 714 721 ATP. {ECO:0000255}.
REGION 50 409 Methyltransferase.
REGION 712 975 ATP-dependent helicase.
SEQUENCE 993 AA; 111266 MW; 8FDEC1F3C66EBB4C CRC64;
MATSSFNINE LVASHGDKGL LATALVDKAA HEQLEEQLQH QRRGRKVYVR NVLSVKDSEV
IRNRYGGKYD LHLTQQEFAP HGLAGALRLC ETLDCLDSFP SSGLRQDLVL DFGGSWVTHY
LRGHNVHCCS PCLGIRDKMR HTERLMNMRK IILNDPQQFD GRQPDFCTHP AADCKVQAHF
AISIHGGYDM GFRGLCEAMN AHGTTILKGT MMFDGAMMFD DQGIIPELNC QWRKIRNAFS
ETEDVTPLVG KLNSTVFSRV RKFKTLVAFD FINESTMSYV HDWENIKSFL TDQTYSYKGM
TYGIERCVIN AGIMTYKIIG VPGMCPPELI RHCIWFPSIK DYVGLKIPAS QDLVEWKTVR
ILTSTLRETE EIAMRCYNDK KAWMEQFKVI LGVLSAKSST IVINGMSMQS GERIDINDYH
YIGFAILLHT KMKYEQLGKM YDMWNASSIS KWFAALTRPV RVFFSSAVHA LFPTLRPREE
KEFLIKLSTF VTFNEECSFD GGEEWDVISS AAYVATQAVT DGKVLAAQKA EKLAEKLAQP
VDEVSDSPEV PSSTPDDTAD VCGKEQEVSE LDSLSAQTRS PITRVAERAT AMLEYAAYEK
QLHDTTVSNL KRIWNMAGGD DKRNSLEGNL KFVFDTYFTV DPMVNIHFST GRWMRPVPEG
IVYSVGYNER GLGPKSDGEL FIVNSECVIC NSESLSAVTR SLQAPTGTIS QVDGVAGCGK
TTAIKSIFEP STDMIVTANK KSAQDVRMAL FKSSDSKEAC AFVRTADSVL LNECPTVSRV
LVDEVVLLHF GQLCAVMSKL KAVRAICFGD SEQIAFSSRD ASFDMRFSKI IPDETSDADT
TFRSPQDVVP LVRLMATKAL PKGTHSKYTK WVSQSKVKRS VTSRSIASVT LVDLDSSRFY
ITMTQADKAS LISRAKEMNL PKTFWNERIK TVHESQGISE DHVTLVRLKS TKCDLFKQFS
YCLVALTRHK VTFRYEYCGV LNGDLIAECI ARA


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