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Response regulator SaeR (Staphylococcus exoprotein expression protein R)

 SAER_STAAE              Reviewed;         228 AA.
Q840P8; A6QF15; Q9S4L9;
24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
18-MAR-2008, sequence version 2.
30-AUG-2017, entry version 100.
RecName: Full=Response regulator SaeR;
AltName: Full=Staphylococcus exoprotein expression protein R;
Name=saeR; OrderedLocusNames=NWMN_0675;
Staphylococcus aureus (strain Newman).
Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
Staphylococcus.
NCBI_TaxID=426430;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION IN REGULATION OF
EXOPROTEINS SYNTHESIS.
PubMed=10436918; DOI=10.1111/j.1574-6968.1999.tb13707.x;
Giraudo A.T., Calzolari A., Cataldi A.A., Bogni C., Nagel R.;
"The sae locus of Staphylococcus aureus encodes a two-component
regulatory system.";
FEMS Microbiol. Lett. 177:15-22(1999).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION IN REGULATION OF
EXOPROTEINS AND TYPE 5 CAPSULAR POLYSACCHARIDE SYNTHESIS.
PubMed=14563862; DOI=10.1128/JB.185.21.6278-6286.2003;
Steinhuber A., Goerke C., Bayer M.G., Doering G., Wolz C.;
"Molecular architecture of the regulatory locus sae of Staphylococcus
aureus and its impact on expression of virulence factors.";
J. Bacteriol. 185:6278-6286(2003).
[3]
SEQUENCE REVISION TO 189.
Wolz C.;
Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Newman;
PubMed=17951380; DOI=10.1128/JB.01000-07;
Baba T., Bae T., Schneewind O., Takeuchi F., Hiramatsu K.;
"Genome sequence of Staphylococcus aureus strain Newman and
comparative analysis of staphylococcal genomes: polymorphism and
evolution of two major pathogenicity islands.";
J. Bacteriol. 190:300-310(2008).
[5]
FUNCTION IN REGULATION OF EXOPROTEINS SYNTHESIS.
STRAIN=ATCC 13565 / 196E;
PubMed=7922890;
Giraudo A.T., Raspanti C.G., Calzolari A., Nagel R.;
"Characterization of a Tn551-mutant of Staphylococcus aureus defective
in the production of several exoproteins.";
Can. J. Microbiol. 40:677-681(1994).
[6]
FUNCTION IN REGULATION OF EXOPROTEINS SYNTHESIS.
PubMed=9211714; DOI=10.1007/s002030050469;
Giraudo A.T., Cheung A.L., Nagel R.;
"The sae locus of Staphylococcus aureus controls exoprotein synthesis
at the transcriptional level.";
Arch. Microbiol. 168:53-58(1997).
[7]
FUNCTION IN REGULATION OF EXOPROTEINS SYNTHESIS.
PubMed=11442841; DOI=10.1046/j.1365-2958.2001.02494.x;
Goerke C., Fluckiger U., Steinhuber A., Zimmerli W., Wolz C.;
"Impact of the regulatory loci agr, sarA and sae of Staphylococcus
aureus on the induction of alpha-toxin during device-related infection
resolved by direct quantitative transcript analysis.";
Mol. Microbiol. 40:1439-1447(2001).
[8]
FUNCTION IN REGULATION OF EXOPROTEINS SYNTHESIS.
PubMed=15908369; DOI=10.1128/IAI.73.6.3415-3421.2005;
Goerke C., Fluckiger U., Steinhuber A., Bisanzio V., Ulrich M.,
Bischoff M., Patti J.M., Wolz C.;
"Role of Staphylococcus aureus global regulators sae and sigmaB in
virulence gene expression during device-related infection.";
Infect. Immun. 73:3415-3421(2005).
[9]
FUNCTION IN REGULATION OF ADHESIN SYNTHESIS.
PubMed=15941988; DOI=10.1099/mic.0.27902-0;
Harraghy N., Kormanec J., Wolz C., Homerova D., Goerke C., Ohlsen K.,
Qazi S., Hill P., Herrmann M.;
"Sae is essential for expression of the staphylococcal adhesins Eap
and Emp.";
Microbiology 151:1789-1800(2005).
[10]
FUNCTION IN REGULATION OF EXOPROTEINS SYNTHESIS.
STRAIN=Smith;
PubMed=16734776; DOI=10.1111/j.1574-6968.2006.00236.x;
Yamazaki K., Kato F., Kamio Y., Kaneko J.;
"Expression of gamma-hemolysin regulated by sae in Staphylococcus
aureus strain Smith 5R.";
FEMS Microbiol. Lett. 259:174-180(2006).
[11]
FUNCTION IN REGULATION OF EXOPROTEINS SYNTHESIS, AND VIRULENCE.
STRAIN=WCUH29 / NCIMB 40771;
PubMed=16861653; DOI=10.1128/IAI.00322-06;
Liang X., Yu C., Sun J., Liu H., Landwehr C., Holmes D., Ji Y.;
"Inactivation of a two-component signal transduction system, saeRS,
eliminates adherence and attenuates virulence of Staphylococcus
aureus.";
Infect. Immun. 74:4655-4665(2006).
[12]
FUNCTION IN GLOBAL REGULATION.
PubMed=17079681; DOI=10.1128/JB.00555-06;
Rogasch K., Ruehmling V., Pane-Farre J., Hoeper D., Weinberg C.,
Fuchs S., Schmudde M., Broeker B.M., Wolz C., Hecker M., Engelmann S.;
"Influence of the two-component system saeRS on global gene expression
in two different Staphylococcus aureus strains.";
J. Bacteriol. 188:7742-7758(2006).
-!- FUNCTION: Member of the two-component regulatory system SaeR/SaeS
involved in the regulation of staphylococcal virulence factors in
a strain-dependent fashion. Probably functions as a
transcriptional regulator via a specific DNA-binding domain,
recognizing motifs near the promoter sequences of target genes.
SaeR/SaeS activates the expression of exoproteins involved in
adhesion and invasion of host cells, including hemolysins (hla,
Hlb, HlgC), Coa, DNase, Spa and cell wall-associated proteins
(Emp, Eap, FnbA, FnbB, Efb). Represses the expression of type 5
capsular polysaccharide (cap operon). Also modulates the
expression of several other genes. {ECO:0000269|PubMed:10436918,
ECO:0000269|PubMed:11442841, ECO:0000269|PubMed:14563862,
ECO:0000269|PubMed:15908369, ECO:0000269|PubMed:15941988,
ECO:0000269|PubMed:16734776, ECO:0000269|PubMed:16861653,
ECO:0000269|PubMed:17079681, ECO:0000269|PubMed:7922890,
ECO:0000269|PubMed:9211714}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
-!- PTM: Phosphorylated by SaeS. {ECO:0000250}.
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EMBL; AF129010; AAD48402.1; -; Genomic_DNA.
EMBL; AJ556794; CAD89110.2; -; Genomic_DNA.
EMBL; AP009351; BAF66947.1; -; Genomic_DNA.
RefSeq; WP_000149344.1; NC_009641.1.
ProteinModelPortal; Q840P8; -.
SMR; Q840P8; -.
EnsemblBacteria; BAF66947; BAF66947; NWMN_0675.
GeneID; 31213517; -.
KEGG; sae:NWMN_0675; -.
HOGENOM; HOG000034819; -.
KO; K10682; -.
OMA; YLFNERC; -.
Proteomes; UP000006386; Chromosome.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO; GO:0009405; P:pathogenesis; IEA:UniProtKB-KW.
GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
CDD; cd00156; REC; 1.
CDD; cd00383; trans_reg_C; 1.
Gene3D; 1.10.10.10; -; 1.
InterPro; IPR011006; CheY-like_superfamily.
InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
InterPro; IPR011991; WHTH_DNA-bd_dom.
Pfam; PF00072; Response_reg; 1.
Pfam; PF00486; Trans_reg_C; 1.
SMART; SM00448; REC; 1.
SMART; SM00862; Trans_reg_C; 1.
SUPFAM; SSF52172; SSF52172; 1.
PROSITE; PS51755; OMPR_PHOB; 1.
PROSITE; PS50110; RESPONSE_REGULATORY; 1.
1: Evidence at protein level;
Activator; Complete proteome; Cytoplasm; DNA-binding; Phosphoprotein;
Repressor; Sensory transduction; Transcription;
Transcription regulation; Two-component regulatory system; Virulence.
CHAIN 1 228 Response regulator SaeR.
/FTId=PRO_0000295917.
DOMAIN 3 116 Response regulatory.
{ECO:0000255|PROSITE-ProRule:PRU00169}.
DNA_BIND 127 226 OmpR/PhoB-type. {ECO:0000255|PROSITE-
ProRule:PRU01091}.
MOD_RES 51 51 4-aspartylphosphate.
{ECO:0000255|PROSITE-ProRule:PRU00169}.
CONFLICT 112 112 I -> F (in Ref. 1; AAD48402).
{ECO:0000305}.
CONFLICT 142 142 K -> Y (in Ref. 1; AAD48402).
{ECO:0000305}.
CONFLICT 155 157 IKE -> FKQ (in Ref. 1; AAD48402).
{ECO:0000305}.
SEQUENCE 228 AA; 26858 MW; 9364A49366DF1BA5 CRC64;
MTHLLIVDDE QDIVDICQTY FEYEGYKVTT TTSGKEAISL LSNDIDIMVL DIMMPEVNGY
DIVKEMKRQK LDIPFIYLTA KTQEHDTIYA LTLGADDYVK KPFSPRELVL RINNLLTRMK
KYHHQPVEQL SFDELTLINL SKVVTVNGHE VPMRIKEFEL LWYLASRENE VISKSELLEK
VWGYDYYEDA NTVNVHIHRI REKLEKESFT TYTITTVWGL GYKFERSR


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