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Response regulator mcs4 (Mitotic catastrophe suppressor 4)

 MCS4_SCHPO              Reviewed;         522 AA.
P87323; Q9UTZ6;
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
01-JUL-1997, sequence version 1.
25-OCT-2017, entry version 121.
RecName: Full=Response regulator mcs4;
AltName: Full=Mitotic catastrophe suppressor 4;
Name=mcs4; ORFNames=SPBC887.10;
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
Schizosaccharomycetes; Schizosaccharomycetales;
Schizosaccharomycetaceae; Schizosaccharomyces.
NCBI_TaxID=284812;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=9383051;
Cottarel G.;
"Mcs4, a two-component system response regulator homologue, regulates
the Schizosaccharomyces pombe cell cycle control.";
Genetics 147:1043-1051(1997).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=972 / ATCC 24843;
PubMed=9136929; DOI=10.1101/gad.11.8.1008;
Shieh J.C., Wilkinson M.G., Buck V., Morgan B.A., Makino K.,
Millar J.B.A.;
"The Mcs4 response regulator coordinately controls the stress-
activated Wak1-Wis1-Sty1 MAP kinase pathway and fission yeast cell
cycle.";
Genes Dev. 11:1008-1022(1997).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=972 / ATCC 24843;
PubMed=11859360; DOI=10.1038/nature724;
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M.,
Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A.,
Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G.,
Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K.,
James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J.,
Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C.,
Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E.,
Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S.,
Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K.,
Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S.,
Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B.,
Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S.,
Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D.,
Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R.,
Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B.,
Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S.,
Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M.,
Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G.,
Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J.,
Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L.,
Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J.,
Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
"The genome sequence of Schizosaccharomyces pombe.";
Nature 415:871-880(2002).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 4-217.
STRAIN=ATCC 38364 / 968;
PubMed=10759889; DOI=10.1046/j.1365-2443.2000.00317.x;
Ding D.-Q., Tomita Y., Yamamoto A., Chikashige Y., Haraguchi T.,
Hiraoka Y.;
"Large-scale screening of intracellular protein localization in living
fission yeast cells by the use of a GFP-fusion genomic DNA library.";
Genes Cells 5:169-190(2000).
[5]
SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
PubMed=16823372; DOI=10.1038/nbt1222;
Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
Yoshida M.;
"ORFeome cloning and global analysis of protein localization in the
fission yeast Schizosaccharomyces pombe.";
Nat. Biotechnol. 24:841-847(2006).
-!- FUNCTION: Response regulator that coordinately controls the stress
activated wak1-wis1-sty1 MAP kinase pathway and fission yeast cell
cycle.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}.
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EMBL; AF004694; AAB88257.1; -; Genomic_DNA.
EMBL; Y11927; CAA72678.1; -; Genomic_DNA.
EMBL; CU329671; CAA21895.1; -; Genomic_DNA.
EMBL; AB027909; BAA87213.1; -; Genomic_DNA.
PIR; T43417; T43417.
RefSeq; NP_596484.1; NM_001022404.2.
ProteinModelPortal; P87323; -.
SMR; P87323; -.
BioGrid; 277723; 24.
MINT; MINT-4693267; -.
STRING; 4896.SPBC887.10.1; -.
iPTMnet; P87323; -.
MaxQB; P87323; -.
PRIDE; P87323; -.
EnsemblFungi; SPBC887.10.1; SPBC887.10.1:pep; SPBC887.10.
GeneID; 2541209; -.
KEGG; spo:SPBC887.10; -.
EuPathDB; FungiDB:SPBC887.10; -.
PomBase; SPBC887.10; mcs4.
HOGENOM; HOG000113503; -.
InParanoid; P87323; -.
KO; K11233; -.
OrthoDB; EOG092C0FN8; -.
PhylomeDB; P87323; -.
PRO; PR:P87323; -.
Proteomes; UP000002485; Chromosome II.
GO; GO:0032153; C:cell division site; IDA:PomBase.
GO; GO:0005737; C:cytoplasm; IDA:PomBase.
GO; GO:1990315; C:Mcs4 RR-MAPKKK complex; IDA:PomBase.
GO; GO:0000156; F:phosphorelay response regulator activity; IPI:PomBase.
GO; GO:0034599; P:cellular response to oxidative stress; IMP:PomBase.
GO; GO:0000160; P:phosphorelay signal transduction system; IDA:PomBase.
GO; GO:0032874; P:positive regulation of stress-activated MAPK cascade; IMP:PomBase.
CDD; cd00156; REC; 1.
InterPro; IPR011006; CheY-like_superfamily.
InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
Pfam; PF00072; Response_reg; 1.
SMART; SM00448; REC; 1.
SUPFAM; SSF52172; SSF52172; 2.
PROSITE; PS50110; RESPONSE_REGULATORY; 1.
4: Predicted;
Complete proteome; Cytoplasm; Phosphoprotein; Reference proteome;
Two-component regulatory system.
CHAIN 1 522 Response regulator mcs4.
/FTId=PRO_0000081407.
DOMAIN 363 505 Response regulatory.
{ECO:0000255|PROSITE-ProRule:PRU00169}.
MOD_RES 412 412 4-aspartylphosphate. {ECO:0000305}.
SEQUENCE 522 AA; 57240 MW; D99169D301F62460 CRC64;
MRIWFKKVPD GITSSVILSE DHLVDDLKDA IARKFPIRIS QYYDAPELSI RVVAPPNASS
ELQSRELSPN ESILFVMETY YPHGQDFNDA LLVASPDTSV ALRYRSSQLS SSTFESTPPV
FSEYPPNIIP TPANETVPRI KQPSIALDSL ESPVSAPSRH QSTYSYKGGP LNYNLRNASR
TRSHQTLPSS NVNKTGVLLL PRSSRQQTLA SRPSLPDLTS ADKSQPSDEA ESITRKNSIG
MSTRSDESTA EKLAKAEVAT PTNSRSISHS SLYTKQSGTA GVLPAVNADI DAANRMNPDI
SSQFPIADNK DPLNADTQAH LGFPSNQIDG IVGTSPVNVL TSPGIGAKAP FASLLEGVIP
PINVLIVEDN IINQKILETF MKKRNISSEV AKDGLEALEK WKKKSFHLIL MDIQLPTMSG
IEVTQEIRRL ERLNAIGVGA PKLTQPIPEK DQLNENKFQS PVIIVALTAS SLMADRNEAL
AAGCNDFLTK PVSLVWLEKK ITEWGCMQAL IDWNGWCRFR GR


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