Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Rhesus theta defensin-1/2 subunit B (RTD-1 subunit B) (RTD-1b) (Demidefensin-1) (RTD-2)

 RTD1B_MACMU             Reviewed;          76 AA.
P82271;
27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
01-MAY-2000, sequence version 1.
30-NOV-2016, entry version 77.
RecName: Full=Rhesus theta defensin-1/2 subunit B;
Short=RTD-1 subunit B;
Short=RTD-1b;
AltName: Full=Demidefensin-1;
AltName: Full=RTD-2;
Flags: Precursor;
Name=RTD1B;
Macaca mulatta (Rhesus macaque).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
NCBI_TaxID=9544;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], PROTEIN SEQUENCE OF 65-73,
SYNTHESIS OF 65-73, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND
DISULFIDE BONDS.
TISSUE=Bone marrow {ECO:0000269|PubMed:10521339}, and
Leukocyte {ECO:0000269|PubMed:10521339};
PubMed=10521339; DOI=10.1126/science.286.5439.498;
Tang Y.-Q., Yuan J., Oesapay G., Oesapay K., Tran D., Miller C.J.,
Ouellette A.J., Selsted M.E.;
"A cyclic antimicrobial peptide produced in primate leukocytes by the
ligation of two truncated alpha-defensins.";
Science 286:498-502(1999).
[2]
NUCLEOTIDE SEQUENCE [MRNA], AND SYNTHESIS OF RTD-1 AND RTD-2.
TISSUE=Bone marrow;
PubMed=11527997;
Leonova L., Kokryakov V.N., Aleshina G., Hong T., Nguyen T., Zhao C.,
Waring A.J., Lehrer R.I.;
"Circular minidefensins and posttranslational generation of molecular
diversity.";
J. Leukoc. Biol. 70:461-464(2001).
[3]
PROTEIN SEQUENCE OF 65-73, SYNTHESIS OF RTD-2, FUNCTION OF RTD-1 AND
RTD-2, AND MASS SPECTROMETRY.
TISSUE=Leukocyte;
PubMed=11675394; DOI=10.1074/jbc.M109117200;
Tran D., Tran P.A., Tang Y.-Q., Yuan J., Cole T., Selsted M.E.;
"Homodimeric theta-defensins from rhesus macaque leukocytes:
isolation, synthesis, antimicrobial activities, and bacterial binding
properties of the cyclic peptides.";
J. Biol. Chem. 277:3079-3084(2002).
-!- FUNCTION: RTD-1 and RTD-2 have similar antimicrobial activities
against the Gram-positive bacteria S.aureus 502A and
L.monocytogenes, the Gram-negative bacterium S.typhimurium, and
the fungi C.albicans 16820 and C.neoformans 271A. RTD-2 is 2-3-
fold less active than RTD-1 against E.coli ML35.
{ECO:0000269|PubMed:11675394}.
-!- SUBUNIT: RTD-1 is a cyclic heterodimer composed of subunits A and
B; disulfide-linked. RTD-2 is a cyclic homodimer composed of two
subunits B; disulfide-linked. {ECO:0000269|PubMed:10521339}.
-!- TISSUE SPECIFICITY: RTD-1 is expressed in bone marrow. Detected in
promyelocytes, myelocytes and mature neutrophils and monocytes.
{ECO:0000269|PubMed:10521339}.
-!- DEVELOPMENTAL STAGE: RTD-1 expression begins early during
granulocyte myelopoiesis. {ECO:0000269|PubMed:10521339}.
-!- PTM: Forms a cyclic peptide with 1 subunit B (RTD-2) or with 1
subunit A (RTD-1). An additional intersubunit disulfide bond is
formed.
-!- MASS SPECTROMETRY: Mass=2083.0; Method=MALDI; Range=65-73;
Note=RTD-1, heterodimer, cyclized and oxidized.;
Evidence={ECO:0000269|PubMed:11675394};
-!- MASS SPECTROMETRY: Mass=2087.9; Method=MALDI; Range=65-73;
Note=RTD-2, homodimer, cyclized and oxidized.;
Evidence={ECO:0000269|PubMed:11675394};
-!- MASS SPECTROMETRY: Mass=2087.70; Method=MALDI; Range=65-73;
Note=RTD-1, heterodimer and reduced.;
Evidence={ECO:0000269|PubMed:11675394};
-!- MASS SPECTROMETRY: Mass=2094.89; Method=MALDI; Range=65-73;
Note=RTD-2, homodimer and reduced.;
Evidence={ECO:0000269|PubMed:11675394};
-!- MISCELLANEOUS: RTD-1 is 10-fold more present in cells than RTD-2.
-!- SIMILARITY: Belongs to the alpha-defensin family. Theta subfamily.
{ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AF191101; AAF04390.1; -; mRNA.
EMBL; AF191103; AAF04392.1; -; Genomic_DNA.
EMBL; AF184156; AAF07923.1; -; mRNA.
PIR; B59089; B59089.
RefSeq; NP_001027990.1; NM_001032818.1.
UniGene; Mmu.3479; -.
UniGene; Mmu.3480; -.
STRING; 9544.ENSMMUP00000024364; -.
GeneID; 574123; -.
KEGG; mcc:574123; -.
CTD; 574123; -.
HOGENOM; HOG000233351; -.
InParanoid; P82271; -.
KO; K05230; -.
OMA; SFTRPEN; -.
Proteomes; UP000006718; Unplaced.
Bgee; ENSMMUG00000029046; -.
GO; GO:0005615; C:extracellular space; IEA:InterPro.
GO; GO:0050832; P:defense response to fungus; IDA:UniProtKB.
GO; GO:0050829; P:defense response to Gram-negative bacterium; IDA:UniProtKB.
GO; GO:0050830; P:defense response to Gram-positive bacterium; IDA:UniProtKB.
GO; GO:0031640; P:killing of cells of other organism; IEA:UniProtKB-KW.
InterPro; IPR016327; Alpha-defensin_pro.
InterPro; IPR002366; Defensin_propep.
PANTHER; PTHR11876; PTHR11876; 1.
Pfam; PF00879; Defensin_propep; 1.
PIRSF; PIRSF001875; Alpha-defensin; 1.
1: Evidence at protein level;
Antibiotic; Antimicrobial; Complete proteome; Defensin;
Direct protein sequencing; Disulfide bond; Fungicide;
Reference proteome; Signal.
SIGNAL 1 22 {ECO:0000255}.
PROPEP 23 64 {ECO:0000255,
ECO:0000269|PubMed:10521339}.
/FTId=PRO_0000006874.
PEPTIDE 65 73 Rhesus theta defensin-1/2 subunit B.
/FTId=PRO_0000006875.
PROPEP 74 76 {ECO:0000269|PubMed:10521339}.
/FTId=PRO_0000006876.
DISULFID 66 66 Interchain (with C-66 in subunit A); in
form RTD-1.
{ECO:0000269|PubMed:10521339}.
DISULFID 66 66 Interchain (with C-66 in subunit B); in
form RTD-2.
{ECO:0000269|PubMed:10521339}.
DISULFID 68 73 {ECO:0000269|PubMed:10521339}.
CROSSLNK 65 65 Cyclopeptide (Arg-Cys) (interchain with
C-73 in subunit A); in form RTD-1.
CROSSLNK 65 65 Cyclopeptide (Arg-Cys) (interchain with
C-73 in subunit B); in form RTD-2.
CROSSLNK 73 73 Cyclopeptide (Cys-Arg) (interchain with
R-65 in subunit A); in form RTD-1.
CROSSLNK 73 73 Cyclopeptide (Cys-Arg) (interchain with
R-65 in subunit B); in form RTD-2.
SEQUENCE 76 AA; 8189 MW; F0B754466156071E CRC64;
MRTFALLTAM LLLVALHAQA EARQARADEA AAQQQPGADD QGMAHSFTRP ENAALPLSES
ARGLRCLCRR GVCQLL


Related products :

Catalog number Product name Quantity
18-003-43134 Gamma-aminobutyric-acid receptor subunit theta - GABA(A) receptor subunit theta Polyclonal 0.05 mg Aff Pur
EIAAB41768 Cct8,Cctq,CCT-theta,Mouse,Mus musculus,T-complex protein 1 subunit theta,TCP-1-theta
EIAAB41767 Bos taurus,Bovine,CCT8,CCT-theta,T-complex protein 1 subunit theta,TCP-1-theta
EIAAB41769 C21orf112,CCT8,CCTQ,CCT-theta,Homo sapiens,Human,KIAA0002,Renal carcinoma antigen NY-REN-15,T-complex protein 1 subunit theta,TCP-1-theta
EIAAB41766 CCT8,CCT-theta,Chicken,Gallus gallus,T-complex protein 1 subunit theta,TCP-1-theta
EIAAB34360 A1 38 kDa subunit,Activator 1 38 kDa subunit,Activator 1 subunit 3,Homo sapiens,Human,Replication factor C 38 kDa subunit,Replication factor C subunit 3,RF-C 38 kDa subunit,RFC3,RFC38
EIAAB34363 A1 36 kDa subunit,Activator 1 36 kDa subunit,Activator 1 subunit 5,Homo sapiens,Human,Replication factor C 36 kDa subunit,Replication factor C subunit 5,RF-C 36 kDa subunit,RFC36,RFC5
EIAAB34361 A1 37 kDa subunit,Activator 1 37 kDa subunit,Activator 1 subunit 4,Homo sapiens,Human,Replication factor C 37 kDa subunit,Replication factor C subunit 4,RF-C 37 kDa subunit,RFC37,RFC4
EIAAB34355 A1 40 kDa subunit,Activator 1 40 kDa subunit,Activator 1 subunit 2,Homo sapiens,Human,Replication factor C 40 kDa subunit,Replication factor C subunit 2,RF-C 40 kDa subunit,RFC2,RFC40
EIAAB29619 Homo sapiens,Human,PAF acetylhydrolase 29 kDa subunit,PAF-AH 29 kDa subunit,PAFAH subunit gamma,PAF-AH subunit gamma,PAFAH1B3,PAFAHG,Platelet-activating factor acetylhydrolase IB subunit gamma
EIAAB29611 Homo sapiens,Human,PAF acetylhydrolase 30 kDa subunit,PAF-AH 30 kDa subunit,PAFAH subunit beta,PAF-AH subunit beta,PAFAH1B2,PAFAHB,Platelet-activating factor acetylhydrolase IB subunit beta
EIAAB29617 Bos taurus,Bovine,PAF acetylhydrolase 29 kDa subunit,PAF-AH 29 kDa subunit,PAFAH subunit gamma,PAF-AH subunit gamma,PAFAH1B3,PAFAHG,Platelet-activating factor acetylhydrolase IB subunit gamma
EIAAB29614 Bos taurus,Bovine,PAF acetylhydrolase 30 kDa subunit,PAF-AH 30 kDa subunit,PAFAH subunit beta,PAF-AH subunit beta,PAFAH1B2,PAFAHB,Platelet-activating factor acetylhydrolase IB subunit beta
EIAAB29612 Mouse,Mus musculus,PAF acetylhydrolase 30 kDa subunit,PAF-AH 30 kDa subunit,PAFAH subunit beta,PAF-AH subunit beta,Pafah1b2,Pafahb,Platelet-activating factor acetylhydrolase IB subunit beta
EIAAB29618 Mouse,Mus musculus,PAF acetylhydrolase 29 kDa subunit,PAF-AH 29 kDa subunit,PAFAH subunit gamma,PAF-AH subunit gamma,Pafah1b3,Pafahg,Platelet-activating factor acetylhydrolase IB subunit gamma
EIAAB34359 A1 38 kDa subunit,Activator 1 38 kDa subunit,Activator 1 subunit 3,Mouse,Mus musculus,Replication factor C 38 kDa subunit,Replication factor C subunit 3,RF-C 38 kDa subunit,Rfc3,RFC38
EIAAB34364 A1 36 kDa subunit,Activator 1 36 kDa subunit,Activator 1 subunit 5,Mouse,Mus musculus,Replication factor C 36 kDa subunit,Replication factor C subunit 5,RF-C 36 kDa subunit,RFC36,Rfc5
EIAAB34358 A1 38 kDa subunit,Activator 1 38 kDa subunit,Activator 1 subunit 3,Bos taurus,Bovine,Replication factor C 38 kDa subunit,Replication factor C subunit 3,RF-C 38 kDa subunit,RFC3,RFC38
EIAAB34354 A1 40 kDa subunit,Activator 1 40 kDa subunit,Activator 1 subunit 2,Mouse,Mus musculus,Replication factor C 40 kDa subunit,Replication factor C subunit 2,RF-C 40 kDa subunit,Rfc2,RFC40
U1345m CLIA Epiligrin subunit alpha,Kalinin subunit alpha,Lama3,Laminin subunit alpha-3,Laminin-5 subunit alpha,Laminin-6 subunit alpha,Laminin-7 subunit alpha,Mouse,Mus musculus,Nicein subunit alpha 96T
E1345m ELISA kit Epiligrin subunit alpha,Kalinin subunit alpha,Lama3,Laminin subunit alpha-3,Laminin-5 subunit alpha,Laminin-6 subunit alpha,Laminin-7 subunit alpha,Mouse,Mus musculus,Nicein subunit alpha 96T
E1345m ELISA Epiligrin subunit alpha,Kalinin subunit alpha,Lama3,Laminin subunit alpha-3,Laminin-5 subunit alpha,Laminin-6 subunit alpha,Laminin-7 subunit alpha,Mouse,Mus musculus,Nicein subunit alpha 96T
U1345h CLIA E170,Epiligrin 170 kDa subunit,Epiligrin subunit alpha,Homo sapiens,Human,Kalinin subunit alpha,LAMA3,Laminin subunit alpha-3,Laminin-5 subunit alpha,Laminin-6 subunit alpha,Laminin-7 subunit alp 96T
E1345h ELISA E170,Epiligrin 170 kDa subunit,Epiligrin subunit alpha,Homo sapiens,Human,Kalinin subunit alpha,LAMA3,Laminin subunit alpha-3,Laminin-5 subunit alpha,Laminin-6 subunit alpha,Laminin-7 subunit al 96T
20-272-191788 RFC1 - Mouse monoclonal [1320] to RFC1; Replication factor C large subunit; RF-C 140 kDa subunit; Activator 1 140 kDa subunit; Activator 1 large subunit; A1 140 kDa subunit; DNA-binding protein PO-GA 0.05 mg


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur