Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Rho-related GTP-binding protein RhoQ (Ras-like protein TC10)

 RHOQ_RAT                Reviewed;         205 AA.
Q9JJL4;
26-APR-2005, integrated into UniProtKB/Swiss-Prot.
01-OCT-2000, sequence version 1.
28-MAR-2018, entry version 134.
RecName: Full=Rho-related GTP-binding protein RhoQ;
AltName: Full=Ras-like protein TC10;
Flags: Precursor;
Name=Rhoq; Synonyms=Tc10;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Sprague-Dawley; TISSUE=Brain;
PubMed=10818149;
Tanabe K., Tachibana T., Yamashita T., Che Y.H., Yoneda Y., Ochi T.,
Tohyama M., Yoshikawa H., Kiyama H.;
"The small GTP-binding protein TC10 promotes nerve elongation in
neuronal cells, and its expression is induced during nerve
regeneration in rats.";
J. Neurosci. 20:4138-4144(2000).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Prostate;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
-!- FUNCTION: Plasma membrane-associated small GTPase which cycles
between an active GTP-bound and an inactive GDP-bound state. In
active state binds to a variety of effector proteins to regulate
cellular responses. Involved in epithelial cell polarization
processes. May play a role in CFTR trafficking to the plasma
membrane. Causes the formation of thin, actin-rich surface
projections called filopodia.
-!- ENZYME REGULATION: Regulated by guanine nucleotide exchange
factors (GEFs) which promote the exchange of bound GDP for free
GTP, GTPase activating proteins (GAPs) which increase the GTP
hydrolysis activity, and GDP dissociation inhibitors which inhibit
the dissociation of the nucleotide from the GTPase. {ECO:0000250}.
-!- SUBUNIT: Interacts with CDC42EP1, CDC42EP2, CDC42EP3, CDC42EP4 and
EXO70 in a GTP-dependent manner. Interacts with ARHGAP33/TCGAP and
GOPC (By similarity). Interacts with PARD6A, PARD6G (and probably
PARD6B) in a GTP-dependent manner. Part of a quaternary complex
containing PARD3, some PARD6 protein (PARD6A, PARD6B or PARD6G)
and some atypical PKC protein (PRKCI or PRKCZ). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane
{ECO:0000250}; Lipid-anchor {ECO:0000250}.
-!- PTM: May be post-translationally modified by both palmitoylation
and polyisoprenylation. {ECO:0000250}.
-!- SIMILARITY: Belongs to the small GTPase superfamily. Rho family.
{ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AB031482; BAA96292.1; -; mRNA.
EMBL; BC061760; AAH61760.1; -; mRNA.
RefSeq; NP_445974.1; NM_053522.1.
UniGene; Rn.4169; -.
ProteinModelPortal; Q9JJL4; -.
SMR; Q9JJL4; -.
STRING; 10116.ENSRNOP00000020822; -.
PaxDb; Q9JJL4; -.
PRIDE; Q9JJL4; -.
Ensembl; ENSRNOT00000020822; ENSRNOP00000020822; ENSRNOG00000015415.
GeneID; 85428; -.
KEGG; rno:85428; -.
UCSC; RGD:621626; rat.
CTD; 23433; -.
RGD; 621626; Rhoq.
eggNOG; KOG0393; Eukaryota.
eggNOG; COG1100; LUCA.
GeneTree; ENSGT00760000118978; -.
HOGENOM; HOG000233974; -.
HOVERGEN; HBG009351; -.
InParanoid; Q9JJL4; -.
KO; K07194; -.
OMA; IMANGTG; -.
OrthoDB; EOG091G0KCM; -.
PhylomeDB; Q9JJL4; -.
TreeFam; TF101109; -.
Reactome; R-RNO-194840; Rho GTPase cycle.
PRO; PR:Q9JJL4; -.
Proteomes; UP000002494; Chromosome 6.
Bgee; ENSRNOG00000015415; -.
Genevisible; Q9JJL4; RN.
GO; GO:0005884; C:actin filament; ISO:RGD.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0070062; C:extracellular exosome; ISO:RGD.
GO; GO:0045121; C:membrane raft; ISO:RGD.
GO; GO:0005886; C:plasma membrane; IDA:RGD.
GO; GO:0032427; F:GBD domain binding; ISO:RGD.
GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO; GO:0003924; F:GTPase activity; ISO:RGD.
GO; GO:0005522; F:profilin binding; ISO:RGD.
GO; GO:0032869; P:cellular response to insulin stimulus; ISO:RGD.
GO; GO:0030866; P:cortical actin cytoskeleton organization; ISO:RGD.
GO; GO:0046039; P:GTP metabolic process; ISO:RGD.
GO; GO:0008286; P:insulin receptor signaling pathway; ISO:RGD.
GO; GO:1903077; P:negative regulation of protein localization to plasma membrane; ISO:RGD.
GO; GO:0051491; P:positive regulation of filopodium assembly; ISO:RGD.
GO; GO:0046326; P:positive regulation of glucose import; ISO:RGD.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
GO; GO:0008360; P:regulation of cell shape; ISO:RGD.
GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
InterPro; IPR027417; P-loop_NTPase.
InterPro; IPR005225; Small_GTP-bd_dom.
InterPro; IPR001806; Small_GTPase.
InterPro; IPR003578; Small_GTPase_Rho.
Pfam; PF00071; Ras; 1.
SUPFAM; SSF52540; SSF52540; 1.
TIGRFAMs; TIGR00231; small_GTP; 1.
PROSITE; PS51420; RHO; 1.
2: Evidence at transcript level;
Acetylation; Cell membrane; Complete proteome; Cytoplasm; GTP-binding;
Isopeptide bond; Lipoprotein; Membrane; Methylation;
Nucleotide-binding; Phosphoprotein; Prenylation; Reference proteome;
Ubl conjugation.
CHAIN 1 202 Rho-related GTP-binding protein RhoQ.
/FTId=PRO_0000198873.
PROPEP 203 205 Removed in mature form. {ECO:0000250}.
/FTId=PRO_0000281224.
NP_BIND 16 23 GTP. {ECO:0000250}.
NP_BIND 63 67 GTP. {ECO:0000250}.
NP_BIND 121 124 GTP. {ECO:0000250}.
MOTIF 38 46 Effector region. {ECO:0000250}.
MOD_RES 70 70 Phosphotyrosine.
{ECO:0000250|UniProtKB:P60953}.
MOD_RES 153 153 N6-acetyllysine; alternate.
{ECO:0000250|UniProtKB:P15153}.
MOD_RES 202 202 Cysteine methyl ester. {ECO:0000250}.
LIPID 202 202 S-farnesyl cysteine. {ECO:0000250}.
CROSSLNK 153 153 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in ubiquitin);
alternate.
{ECO:0000250|UniProtKB:P63000}.
SEQUENCE 205 AA; 22645 MW; 827BD9DF8FBF146A CRC64;
MAHGPGALML KCVVVGDGAV GKTCLLMSYA NDAFPEEYVP TVFDHYAVSV TVGGKQYLLG
LYDTAGQEDY DRLRPLSYPM TDVFLICFSV VNPASFQNVK EEWVPELKEY APNVPFLLIG
TQIDLRDDPK TLARLNDMKE KPVCVEQGQK LAKEIGACCY VECSALTQKG LKTVFDEAII
AILTPKKHTV KKRIGSRCIN CCLIT


Related products :

Catalog number Product name Quantity
EIAAB34768 ARHQ,Homo sapiens,Human,RASL7A,Ras-like protein family member 7A,Ras-like protein TC10,RHOQ,Rho-related GTP-binding protein RhoQ,TC10
EIAAB34766 Arhq,Mouse,Mus musculus,Ras-like protein TC10,Rhoq,Rho-related GTP-binding protein RhoQ,Tc10
EIAAB34767 Ras-like protein TC10,Rat,Rattus norvegicus,Rhoq,Rho-related GTP-binding protein RhoQ,Tc10
CSB-EL019693MO Mouse Rho-related GTP-binding protein RhoQ(RHOQ) ELISA kit SpeciesMouse 96T
CSB-EL019693HU Human Rho-related GTP-binding protein RhoQ(RHOQ) ELISA kit SpeciesHuman 96T
RHOQ_RAT ELISA Kit FOR Rho-related GTP-binding protein RhoQ; organism: Rat; gene name: Rhoq 96T
CSB-EL019693MO Mouse Rho-related GTP-binding protein RhoQ(RHOQ) ELISA kit 96T
G7717 Rho-related GTP-binding protein RhoQ (RHOQ), Mouse, ELISA Kit 96T
CSB-EL019693RA Rat Rho-related GTP-binding protein RhoQ(RHOQ) ELISA kit SpeciesRat 96T
G7716 Rho-related GTP-binding protein RhoQ (RHOQ), Human, ELISA Kit 96T
CSB-EL019693HU Human Rho-related GTP-binding protein RhoQ(RHOQ) ELISA kit 96T
RHOQ_MOUSE ELISA Kit FOR Rho-related GTP-binding protein RhoQ; organism: Mouse; gene name: Rhoq 96T
CSB-EL019693RA Rat Rho-related GTP-binding protein RhoQ(RHOQ) ELISA kit 96T
G7718 Rho-related GTP-binding protein RhoQ (RHOQ), Rat, ELISA Kit 96T
EIAAB34765 ARHJ,Homo sapiens,Human,RASL7B,Ras-like protein family member 7B,RHOI,RHOJ,Rho-related GTP-binding protein RhoJ,Tc10-like GTP-binding protein,TCL
EIAAB34764 Arhj,Mouse,Mus musculus,Rhoi,Rhoj,Rho-related GTP-binding protein RhoJ,Rhot,Tc10l,Tc10-like GTP-binding protein,Tcl
SP5174P RHOQ _ TC10 0.1 mg
GTX115991 RHOQ _ TC10 0.1 ml
GTX82847 RHOQ _ TC10 100 µg
NB110-57616 RHOQ _ TC10 0.1 ml
'H00023433-Q01-10 RHOQ _ TC10 antigen 10
NB110-57616 RHOQ _ TC10 0.1 ml
'H00023433-Q01-25 RHOQ _ TC10 antigen 25
SP5174CP RHOQ _ TC10 control peptide 50 µg
'H00023433-B01 RHOQ _ TC10 antibody Host Mouse 50


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur