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Riboflavin biosynthesis protein RibBA [Includes: 3,4-dihydroxy-2-butanone 4-phosphate synthase (DHBP synthase) (EC 4.1.99.12); GTP cyclohydrolase-2 (EC 3.5.4.25) (GTP cyclohydrolase II)]

 A0A1Z4L1X1_NOSLI        Unreviewed;       557 AA.
A0A1Z4L1X1;
27-SEP-2017, integrated into UniProtKB/TrEMBL.
27-SEP-2017, sequence version 1.
23-MAY-2018, entry version 9.
RecName: Full=Riboflavin biosynthesis protein RibBA {ECO:0000256|HAMAP-Rule:MF_01283};
Includes:
RecName: Full=GTP cyclohydrolase-2 {ECO:0000256|HAMAP-Rule:MF_01283};
EC=3.5.4.25 {ECO:0000256|HAMAP-Rule:MF_01283};
AltName: Full=GTP cyclohydrolase II {ECO:0000256|HAMAP-Rule:MF_01283};
Includes:
RecName: Full=3,4-dihydroxy-2-butanone 4-phosphate synthase {ECO:0000256|HAMAP-Rule:MF_01283};
Short=DHBP synthase {ECO:0000256|HAMAP-Rule:MF_01283};
EC=4.1.99.12 {ECO:0000256|HAMAP-Rule:MF_01283};
Name=ribBA {ECO:0000256|HAMAP-Rule:MF_01283};
ORFNames=NIES25_15400 {ECO:0000313|EMBL:BAY75122.1};
Nostoc linckia NIES-25.
Bacteria; Cyanobacteria; Nostocales; Nostocaceae; Nostoc.
NCBI_TaxID=1091006 {ECO:0000313|EMBL:BAY75122.1, ECO:0000313|Proteomes:UP000217515};
[1] {ECO:0000313|EMBL:BAY75122.1, ECO:0000313|Proteomes:UP000217515}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=NIES-25 {ECO:0000313|EMBL:BAY75122.1,
ECO:0000313|Proteomes:UP000217515};
Hirose Y., Shimura Y., Fujisawa T., Nakamura Y., Kawachi M.;
"Genome sequencing of cyanobaciteial culture collection at National
Institute for Environmental Studies (NIES).";
Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Catalyzes the conversion of D-ribulose 5-phosphate to
formate and 3,4-dihydroxy-2-butanone 4-phosphate.
{ECO:0000256|HAMAP-Rule:MF_01283}.
-!- FUNCTION: Catalyzes the conversion of GTP to 2,5-diamino-6-
ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and
pyrophosphate. {ECO:0000256|HAMAP-Rule:MF_01283}.
-!- CATALYTIC ACTIVITY: D-ribulose 5-phosphate = formate + L-3,4-
dihydroxybutan-2-one 4-phosphate. {ECO:0000256|HAMAP-
Rule:MF_01283}.
-!- CATALYTIC ACTIVITY: GTP + 3 H(2)O = formate + 2,5-diamino-6-
hydroxy-4-(5-phospho-D-ribosylamino)pyrimidine + diphosphate.
{ECO:0000256|HAMAP-Rule:MF_01283, ECO:0000256|SAAS:SAAS00711742}.
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Evidence={ECO:0000256|HAMAP-Rule:MF_01283};
Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
Evidence={ECO:0000256|HAMAP-Rule:MF_01283};
Note=Binds 2 divalent metal cations per subunit. Magnesium or
manganese. {ECO:0000256|HAMAP-Rule:MF_01283};
-!- PATHWAY: Cofactor biosynthesis; riboflavin biosynthesis; 2-
hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step
1/1. {ECO:0000256|HAMAP-Rule:MF_01283}.
-!- PATHWAY: Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-
6-(D-ribitylamino)uracil from GTP: step 1/4.
{ECO:0000256|SAAS:SAAS00711724}.
-!- SIMILARITY: In the C-terminal section; belongs to the GTP
cyclohydrolase II family. {ECO:0000256|HAMAP-Rule:MF_01283,
ECO:0000256|SAAS:SAAS00789992}.
-!- SIMILARITY: In the N-terminal section; belongs to the DHBP
synthase family. {ECO:0000256|HAMAP-Rule:MF_01283,
ECO:0000256|SAAS:SAAS00534513}.
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EMBL; AP018222; BAY75122.1; -; Genomic_DNA.
UniPathway; UPA00275; UER00399.
UniPathway; UPA00275; UER00400.
Proteomes; UP000217515; Chromosome.
GO; GO:0008686; F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity; IEA:UniProtKB-UniRule.
GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO; GO:0003935; F:GTP cyclohydrolase II activity; IEA:UniProtKB-UniRule.
GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
GO; GO:0030145; F:manganese ion binding; IEA:UniProtKB-UniRule.
GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
GO; GO:0009231; P:riboflavin biosynthetic process; IEA:UniProtKB-UniRule.
CDD; cd00641; GTP_cyclohydro2; 1.
Gene3D; 3.40.50.10990; -; 1.
HAMAP; MF_00179; RibA; 1.
HAMAP; MF_00180; RibB; 1.
HAMAP; MF_01283; RibBA; 1.
InterPro; IPR017945; DHBP_synth_RibB-like_a/b_dom.
InterPro; IPR000422; DHBP_synthase_RibB.
InterPro; IPR032677; GTP_cyclohydro_II.
InterPro; IPR000926; RibA.
InterPro; IPR036144; RibA-like_sf.
InterPro; IPR016299; Riboflavin_synth_RibBA.
Pfam; PF00926; DHBP_synthase; 1.
Pfam; PF00925; GTP_cyclohydro2; 1.
SUPFAM; SSF142695; SSF142695; 1.
SUPFAM; SSF55821; SSF55821; 1.
TIGRFAMs; TIGR00505; ribA; 1.
TIGRFAMs; TIGR00506; ribB; 1.
3: Inferred from homology;
Complete proteome {ECO:0000313|Proteomes:UP000217515};
GTP-binding {ECO:0000256|HAMAP-Rule:MF_01283,
ECO:0000256|SAAS:SAAS00711691};
Hydrolase {ECO:0000256|HAMAP-Rule:MF_01283,
ECO:0000256|SAAS:SAAS01033620};
Lyase {ECO:0000256|HAMAP-Rule:MF_01283};
Magnesium {ECO:0000256|HAMAP-Rule:MF_01283};
Manganese {ECO:0000256|HAMAP-Rule:MF_01283};
Metal-binding {ECO:0000256|HAMAP-Rule:MF_01283,
ECO:0000256|SAAS:SAAS00037896};
Multifunctional enzyme {ECO:0000256|HAMAP-Rule:MF_01283};
Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_01283,
ECO:0000256|SAAS:SAAS00711691};
Reference proteome {ECO:0000313|Proteomes:UP000217515};
Riboflavin biosynthesis {ECO:0000256|HAMAP-Rule:MF_01283,
ECO:0000256|SAAS:SAAS00037880};
Zinc {ECO:0000256|HAMAP-Rule:MF_01283, ECO:0000256|SAAS:SAAS00711685}.
DOMAIN 222 386 GTP_cyclohydro2.
{ECO:0000259|Pfam:PF00925}.
NP_BIND 265 269 GTP. {ECO:0000256|HAMAP-Rule:MF_01283}.
NP_BIND 308 310 GTP. {ECO:0000256|HAMAP-Rule:MF_01283}.
REGION 1 212 DHBP synthase. {ECO:0000256|HAMAP-
Rule:MF_01283}.
REGION 36 37 D-ribulose 5-phosphate binding.
{ECO:0000256|HAMAP-Rule:MF_01283}.
REGION 151 155 D-ribulose 5-phosphate binding.
{ECO:0000256|HAMAP-Rule:MF_01283}.
REGION 213 557 GTP cyclohydrolase II.
{ECO:0000256|HAMAP-Rule:MF_01283}.
ACT_SITE 342 342 Proton acceptor; for GTP cyclohydrolase
activity. {ECO:0000256|HAMAP-
Rule:MF_01283}.
ACT_SITE 344 344 Nucleophile; for GTP cyclohydrolase
activity. {ECO:0000256|HAMAP-
Rule:MF_01283}.
METAL 37 37 Magnesium or manganese 1.
{ECO:0000256|HAMAP-Rule:MF_01283}.
METAL 37 37 Magnesium or manganese 2.
{ECO:0000256|HAMAP-Rule:MF_01283}.
METAL 154 154 Magnesium or manganese 2.
{ECO:0000256|HAMAP-Rule:MF_01283}.
METAL 270 270 Zinc; catalytic. {ECO:0000256|HAMAP-
Rule:MF_01283}.
METAL 281 281 Zinc; catalytic. {ECO:0000256|HAMAP-
Rule:MF_01283}.
METAL 283 283 Zinc; catalytic. {ECO:0000256|HAMAP-
Rule:MF_01283}.
BINDING 41 41 D-ribulose 5-phosphate.
{ECO:0000256|HAMAP-Rule:MF_01283}.
BINDING 175 175 D-ribulose 5-phosphate.
{ECO:0000256|HAMAP-Rule:MF_01283}.
BINDING 286 286 GTP. {ECO:0000256|HAMAP-Rule:MF_01283}.
BINDING 330 330 GTP. {ECO:0000256|HAMAP-Rule:MF_01283}.
BINDING 365 365 GTP. {ECO:0000256|HAMAP-Rule:MF_01283}.
BINDING 370 370 GTP. {ECO:0000256|HAMAP-Rule:MF_01283}.
SITE 137 137 Essential for DHBP synthase activity.
{ECO:0000256|HAMAP-Rule:MF_01283}.
SITE 175 175 Essential for DHBP synthase activity.
{ECO:0000256|HAMAP-Rule:MF_01283}.
SEQUENCE 557 AA; 62079 MW; 1C5E34EF4BF1199A CRC64;
MSQPKTTQVF QFDTIDAALA DLKAGRVIVV VDDENRENEG DLICAAQFAT PDTINFMAVE
ARGLICLAMT GDRLDELDLP LMVSNITDTN QTAFTVSIDA GPHLGVSTGI SAEDRARTIQ
VTLNPATTPT DLRRPGHIFP IRAKAGGVLK RAGHTEAAVD LARLAGLYPA GVICEIQNPD
GSMARLQQLI EYAKHHNLKI ISIADLISYR LKHDRLVYRE VVTKLPSQFG QFEIYAYRHT
LDNTEHVAIV KGDPANFKDE PVMVRMHSEC LTGDALGSLR CDCRMQLVAA LKMIENAGQG
VVVYLRQEGR GIGLINKLKA YSLQDMGLDT VEANERLGFP ADLRDYGMGA QMLMDLGVKK
IRLITNNPRK IAGVKGYGLE VVDRVPLLIE ANDYNSYYLA TKAKKLGHML LQTYLVTVAI
HWQDDPQLVT KRYERLEKLR HIARTHDLLL QEEARPLAIA LFDEPSLTIH LGFDQPKVAS
CDWYRQNGHP YLQAIFQILD KLVTLPYIQK LEFLISSGSD PLSNLQVQLD RQVFSDGTLP
SSISDRLETQ QIYSFSK


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