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Riboflavin biosynthesis protein RibBA [Includes: 3,4-dihydroxy-2-butanone 4-phosphate synthase (DHBP synthase) (EC 4.1.99.12); GTP cyclohydrolase-2 (EC 3.5.4.25) (GTP cyclohydrolase II)]

 RIBBA_CHLMU             Reviewed;         424 AA.
Q9PLJ5;
01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
01-OCT-2000, sequence version 1.
23-MAY-2018, entry version 112.
RecName: Full=Riboflavin biosynthesis protein RibBA {ECO:0000255|HAMAP-Rule:MF_01283};
Includes:
RecName: Full=3,4-dihydroxy-2-butanone 4-phosphate synthase {ECO:0000255|HAMAP-Rule:MF_01283};
Short=DHBP synthase {ECO:0000255|HAMAP-Rule:MF_01283};
EC=4.1.99.12 {ECO:0000255|HAMAP-Rule:MF_01283};
Includes:
RecName: Full=GTP cyclohydrolase-2 {ECO:0000255|HAMAP-Rule:MF_01283};
EC=3.5.4.25 {ECO:0000255|HAMAP-Rule:MF_01283};
AltName: Full=GTP cyclohydrolase II {ECO:0000255|HAMAP-Rule:MF_01283};
Name=ribBA {ECO:0000255|HAMAP-Rule:MF_01283}; Synonyms=ribA/B;
OrderedLocusNames=TC_0104;
Chlamydia muridarum (strain MoPn / Nigg).
Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
Chlamydia/Chlamydophila group; Chlamydia.
NCBI_TaxID=243161;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=MoPn / Nigg;
PubMed=10684935; DOI=10.1093/nar/28.6.1397;
Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F.,
White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J.,
Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C.,
Dodson R.J., Gwinn M.L., Nelson W.C., DeBoy R.T., Kolonay J.F.,
McClarty G., Salzberg S.L., Eisen J.A., Fraser C.M.;
"Genome sequences of Chlamydia trachomatis MoPn and Chlamydia
pneumoniae AR39.";
Nucleic Acids Res. 28:1397-1406(2000).
-!- FUNCTION: Catalyzes the conversion of D-ribulose 5-phosphate to
formate and 3,4-dihydroxy-2-butanone 4-phosphate.
{ECO:0000255|HAMAP-Rule:MF_01283}.
-!- FUNCTION: Catalyzes the conversion of GTP to 2,5-diamino-6-
ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and
pyrophosphate. {ECO:0000255|HAMAP-Rule:MF_01283}.
-!- CATALYTIC ACTIVITY: D-ribulose 5-phosphate = formate + L-3,4-
dihydroxybutan-2-one 4-phosphate. {ECO:0000255|HAMAP-
Rule:MF_01283}.
-!- CATALYTIC ACTIVITY: GTP + 3 H(2)O = formate + 2,5-diamino-6-
hydroxy-4-(5-phospho-D-ribosylamino)pyrimidine + diphosphate.
{ECO:0000255|HAMAP-Rule:MF_01283}.
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Evidence={ECO:0000255|HAMAP-Rule:MF_01283};
Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
Evidence={ECO:0000255|HAMAP-Rule:MF_01283};
Note=Binds 2 divalent metal cations per subunit. Magnesium or
manganese. {ECO:0000255|HAMAP-Rule:MF_01283};
-!- COFACTOR:
Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
Evidence={ECO:0000255|HAMAP-Rule:MF_01283};
Note=Binds 1 zinc ion per subunit. {ECO:0000255|HAMAP-
Rule:MF_01283};
-!- PATHWAY: Cofactor biosynthesis; riboflavin biosynthesis; 2-
hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step
1/1. {ECO:0000255|HAMAP-Rule:MF_01283}.
-!- PATHWAY: Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-
6-(D-ribitylamino)uracil from GTP: step 1/4. {ECO:0000255|HAMAP-
Rule:MF_01283}.
-!- SIMILARITY: In the N-terminal section; belongs to the DHBP
synthase family. {ECO:0000255|HAMAP-Rule:MF_01283}.
-!- SIMILARITY: In the C-terminal section; belongs to the GTP
cyclohydrolase II family. {ECO:0000255|HAMAP-Rule:MF_01283}.
-----------------------------------------------------------------------
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EMBL; AE002160; AAF38984.1; -; Genomic_DNA.
PIR; B81740; B81740.
RefSeq; WP_010229383.1; NZ_ACOV01000001.1.
ProteinModelPortal; Q9PLJ5; -.
SMR; Q9PLJ5; -.
STRING; 243161.CmurN_010100000530; -.
PRIDE; Q9PLJ5; -.
EnsemblBacteria; AAF38984; AAF38984; TC_0104.
GeneID; 1245634; -.
KEGG; cmu:TC_0104; -.
eggNOG; ENOG4105C66; Bacteria.
eggNOG; COG0108; LUCA.
eggNOG; COG0807; LUCA.
KO; K14652; -.
OMA; GCTTGIS; -.
UniPathway; UPA00275; UER00399.
UniPathway; UPA00275; UER00400.
Proteomes; UP000000800; Chromosome.
GO; GO:0008686; F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity; IEA:UniProtKB-EC.
GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO; GO:0003935; F:GTP cyclohydrolase II activity; IEA:UniProtKB-EC.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0009231; P:riboflavin biosynthetic process; IEA:UniProtKB-UniPathway.
CDD; cd00641; GTP_cyclohydro2; 1.
Gene3D; 3.40.50.10990; -; 1.
HAMAP; MF_00179; RibA; 1.
HAMAP; MF_01283; RibBA; 1.
InterPro; IPR017945; DHBP_synth_RibB-like_a/b_dom.
InterPro; IPR000422; DHBP_synthase_RibB.
InterPro; IPR032677; GTP_cyclohydro_II.
InterPro; IPR000926; RibA.
InterPro; IPR036144; RibA-like_sf.
InterPro; IPR016299; Riboflavin_synth_RibBA.
Pfam; PF00926; DHBP_synthase; 1.
Pfam; PF00925; GTP_cyclohydro2; 1.
SUPFAM; SSF142695; SSF142695; 1.
SUPFAM; SSF55821; SSF55821; 1.
TIGRFAMs; TIGR00505; ribA; 1.
TIGRFAMs; TIGR00506; ribB; 1.
3: Inferred from homology;
Complete proteome; GTP-binding; Hydrolase; Lyase; Magnesium;
Manganese; Metal-binding; Multifunctional enzyme; Nucleotide-binding;
Riboflavin biosynthesis; Zinc.
CHAIN 1 424 Riboflavin biosynthesis protein RibBA.
/FTId=PRO_0000151723.
NP_BIND 257 261 GTP. {ECO:0000255|HAMAP-Rule:MF_01283}.
NP_BIND 301 303 GTP. {ECO:0000255|HAMAP-Rule:MF_01283}.
REGION 1 206 DHBP synthase.
REGION 32 33 D-ribulose 5-phosphate binding.
{ECO:0000255|HAMAP-Rule:MF_01283}.
REGION 145 149 D-ribulose 5-phosphate binding.
{ECO:0000255|HAMAP-Rule:MF_01283}.
REGION 207 424 GTP cyclohydrolase II.
ACT_SITE 335 335 Proton acceptor; for GTP cyclohydrolase
activity. {ECO:0000255|HAMAP-
Rule:MF_01283}.
ACT_SITE 337 337 Nucleophile; for GTP cyclohydrolase
activity. {ECO:0000255|HAMAP-
Rule:MF_01283}.
METAL 33 33 Magnesium or manganese 1.
{ECO:0000255|HAMAP-Rule:MF_01283}.
METAL 33 33 Magnesium or manganese 2.
{ECO:0000255|HAMAP-Rule:MF_01283}.
METAL 148 148 Magnesium or manganese 2.
{ECO:0000255|HAMAP-Rule:MF_01283}.
METAL 262 262 Zinc; catalytic. {ECO:0000255|HAMAP-
Rule:MF_01283}.
METAL 273 273 Zinc; catalytic. {ECO:0000255|HAMAP-
Rule:MF_01283}.
METAL 275 275 Zinc; catalytic. {ECO:0000255|HAMAP-
Rule:MF_01283}.
BINDING 37 37 D-ribulose 5-phosphate.
{ECO:0000255|HAMAP-Rule:MF_01283}.
BINDING 169 169 D-ribulose 5-phosphate.
{ECO:0000255|HAMAP-Rule:MF_01283}.
BINDING 278 278 GTP. {ECO:0000255|HAMAP-Rule:MF_01283}.
BINDING 323 323 GTP. {ECO:0000255|HAMAP-Rule:MF_01283}.
BINDING 358 358 GTP. {ECO:0000255|HAMAP-Rule:MF_01283}.
BINDING 363 363 GTP. {ECO:0000255|HAMAP-Rule:MF_01283}.
SITE 131 131 Essential for DHBP synthase activity.
{ECO:0000255|HAMAP-Rule:MF_01283}.
SITE 169 169 Essential for DHBP synthase activity.
{ECO:0000255|HAMAP-Rule:MF_01283}.
SEQUENCE 424 AA; 47067 MW; 0298128162BAC016 CRC64;
MVTCEAGIAS VQQAIKDIAD GNFVIVIDRE SRENEGDLIL AGEKVSAEKM AFLLSHTTGI
VCASVTREQA RVLDLPAMVQ ENQCAFKTAF TVSVDASSGI TTGVSAADRT RTVQLLSDPT
SISQSFVRPG HVFPLVSQPG GVVKRPGHTE ASMDLMRLAG MYPCGIFAEL VNADHSMMRQ
QQILDFAEQH GFTVITVDDL ITYRWTFDSL VEHVSSARIP TKYGEFFIHV YKSIIDGTEH
FALVKGDIRE QESVPVRVHS ECLTGDVLGS CRCDCGAQLD MAMRYIAEQG LGVIVYLRGQ
EGRGIGFGHK IQAYALQDLG YDTVEANLQL SFPIDAREYG VAAQILKDLR LTSVRLITHN
PKKFFELQRL GIHILDRIVL PVIVSSENER YLRTKKDRMG HWLNFPVLNE SEDEYETVER
TSCC


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