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Riboflavin biosynthesis protein RibBA [Includes: 3,4-dihydroxy-2-butanone 4-phosphate synthase (DHBP synthase) (EC 4.1.99.12); GTP cyclohydrolase-2 (EC 3.5.4.25) (GTP cyclohydrolase II)]

 RIBBA_CHLPN             Reviewed;         418 AA.
Q9Z734; Q9JQ68;
01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
01-MAY-1999, sequence version 1.
10-OCT-2018, entry version 125.
RecName: Full=Riboflavin biosynthesis protein RibBA {ECO:0000255|HAMAP-Rule:MF_01283};
Includes:
RecName: Full=3,4-dihydroxy-2-butanone 4-phosphate synthase {ECO:0000255|HAMAP-Rule:MF_01283};
Short=DHBP synthase {ECO:0000255|HAMAP-Rule:MF_01283};
EC=4.1.99.12 {ECO:0000255|HAMAP-Rule:MF_01283};
Includes:
RecName: Full=GTP cyclohydrolase-2 {ECO:0000255|HAMAP-Rule:MF_01283};
EC=3.5.4.25 {ECO:0000255|HAMAP-Rule:MF_01283};
AltName: Full=GTP cyclohydrolase II {ECO:0000255|HAMAP-Rule:MF_01283};
Name=ribBA {ECO:0000255|HAMAP-Rule:MF_01283}; Synonyms=ribA/ribB;
OrderedLocusNames=CPn_0872, CP_0997, CpB0901;
Chlamydia pneumoniae (Chlamydophila pneumoniae).
Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
Chlamydia/Chlamydophila group; Chlamydia.
NCBI_TaxID=83558;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=CWL029;
PubMed=10192388; DOI=10.1038/7716;
Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W.,
Olinger L., Grimwood J., Davis R.W., Stephens R.S.;
"Comparative genomes of Chlamydia pneumoniae and C. trachomatis.";
Nat. Genet. 21:385-389(1999).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=AR39;
PubMed=10684935; DOI=10.1093/nar/28.6.1397;
Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F.,
White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J.,
Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C.,
Dodson R.J., Gwinn M.L., Nelson W.C., DeBoy R.T., Kolonay J.F.,
McClarty G., Salzberg S.L., Eisen J.A., Fraser C.M.;
"Genome sequences of Chlamydia trachomatis MoPn and Chlamydia
pneumoniae AR39.";
Nucleic Acids Res. 28:1397-1406(2000).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=J138;
PubMed=10871362; DOI=10.1093/nar/28.12.2311;
Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K.,
Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.;
"Comparison of whole genome sequences of Chlamydia pneumoniae J138
from Japan and CWL029 from USA.";
Nucleic Acids Res. 28:2311-2314(2000).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=TW-183;
Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P.,
Schneider S., Pohl T., Essig A., Marre R., Melchers K.;
"The genome sequence of Chlamydia pneumoniae TW183 and comparison with
other Chlamydia strains based on whole genome sequence analysis.";
Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Catalyzes the conversion of D-ribulose 5-phosphate to
formate and 3,4-dihydroxy-2-butanone 4-phosphate.
{ECO:0000255|HAMAP-Rule:MF_01283}.
-!- FUNCTION: Catalyzes the conversion of GTP to 2,5-diamino-6-
ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and
pyrophosphate. {ECO:0000255|HAMAP-Rule:MF_01283}.
-!- CATALYTIC ACTIVITY: D-ribulose 5-phosphate = formate + L-3,4-
dihydroxybutan-2-one 4-phosphate. {ECO:0000255|HAMAP-
Rule:MF_01283}.
-!- CATALYTIC ACTIVITY: GTP + 3 H(2)O = formate + 2,5-diamino-6-
hydroxy-4-(5-phospho-D-ribosylamino)pyrimidine + diphosphate.
{ECO:0000255|HAMAP-Rule:MF_01283}.
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Evidence={ECO:0000255|HAMAP-Rule:MF_01283};
Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
Evidence={ECO:0000255|HAMAP-Rule:MF_01283};
Note=Binds 2 divalent metal cations per subunit. Magnesium or
manganese. {ECO:0000255|HAMAP-Rule:MF_01283};
-!- COFACTOR:
Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
Evidence={ECO:0000255|HAMAP-Rule:MF_01283};
Note=Binds 1 zinc ion per subunit. {ECO:0000255|HAMAP-
Rule:MF_01283};
-!- PATHWAY: Cofactor biosynthesis; riboflavin biosynthesis; 2-
hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step
1/1. {ECO:0000255|HAMAP-Rule:MF_01283}.
-!- PATHWAY: Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-
6-(D-ribitylamino)uracil from GTP: step 1/4. {ECO:0000255|HAMAP-
Rule:MF_01283}.
-!- SIMILARITY: In the N-terminal section; belongs to the DHBP
synthase family. {ECO:0000255|HAMAP-Rule:MF_01283}.
-!- SIMILARITY: In the C-terminal section; belongs to the GTP
cyclohydrolase II family. {ECO:0000255|HAMAP-Rule:MF_01283}.
-----------------------------------------------------------------------
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EMBL; AE001363; AAD19010.1; -; Genomic_DNA.
EMBL; AE002161; AAF38775.1; -; Genomic_DNA.
EMBL; BA000008; BAA99080.1; -; Genomic_DNA.
EMBL; AE009440; AAP98830.1; -; Genomic_DNA.
PIR; F86599; F86599.
PIR; H72026; H72026.
RefSeq; NP_225067.1; NC_000922.1.
RefSeq; WP_010883507.1; NZ_LN847257.1.
ProteinModelPortal; Q9Z734; -.
SMR; Q9Z734; -.
STRING; 182082.CpB0901; -.
EnsemblBacteria; AAD19010; AAD19010; CPn_0872.
EnsemblBacteria; AAF38775; AAF38775; CP_0997.
EnsemblBacteria; AAP98830; AAP98830; CpB0901.
EnsemblBacteria; BAA99080; BAA99080; BAA99080.
GeneID; 895694; -.
KEGG; cpa:CP_0997; -.
KEGG; cpj:ribA_ribB; -.
KEGG; cpn:CPn0872; -.
KEGG; cpt:CpB0901; -.
PATRIC; fig|115713.3.peg.952; -.
eggNOG; ENOG4105C66; Bacteria.
eggNOG; COG0108; LUCA.
eggNOG; COG0807; LUCA.
HOGENOM; HOG000115440; -.
KO; K14652; -.
OMA; GCTTGIS; -.
OrthoDB; POG091H008U; -.
UniPathway; UPA00275; UER00399.
UniPathway; UPA00275; UER00400.
Proteomes; UP000000583; Chromosome.
Proteomes; UP000000801; Chromosome.
GO; GO:0008686; F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity; IEA:UniProtKB-UniRule.
GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO; GO:0003935; F:GTP cyclohydrolase II activity; IEA:UniProtKB-UniRule.
GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
GO; GO:0030145; F:manganese ion binding; IEA:UniProtKB-UniRule.
GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
GO; GO:0009231; P:riboflavin biosynthetic process; IEA:UniProtKB-UniRule.
CDD; cd00641; GTP_cyclohydro2; 1.
Gene3D; 3.40.50.10990; -; 1.
HAMAP; MF_00179; RibA; 1.
HAMAP; MF_01283; RibBA; 1.
InterPro; IPR017945; DHBP_synth_RibB-like_a/b_dom.
InterPro; IPR000422; DHBP_synthase_RibB.
InterPro; IPR032677; GTP_cyclohydro_II.
InterPro; IPR000926; RibA.
InterPro; IPR036144; RibA-like_sf.
InterPro; IPR016299; Riboflavin_synth_RibBA.
Pfam; PF00926; DHBP_synthase; 1.
Pfam; PF00925; GTP_cyclohydro2; 1.
SUPFAM; SSF142695; SSF142695; 1.
SUPFAM; SSF55821; SSF55821; 1.
TIGRFAMs; TIGR00505; ribA; 1.
TIGRFAMs; TIGR00506; ribB; 1.
3: Inferred from homology;
Complete proteome; GTP-binding; Hydrolase; Lyase; Magnesium;
Manganese; Metal-binding; Multifunctional enzyme; Nucleotide-binding;
Reference proteome; Riboflavin biosynthesis; Zinc.
CHAIN 1 418 Riboflavin biosynthesis protein RibBA.
/FTId=PRO_0000151724.
NP_BIND 262 266 GTP. {ECO:0000255|HAMAP-Rule:MF_01283}.
NP_BIND 306 308 GTP. {ECO:0000255|HAMAP-Rule:MF_01283}.
REGION 1 211 DHBP synthase.
REGION 37 38 D-ribulose 5-phosphate binding.
{ECO:0000255|HAMAP-Rule:MF_01283}.
REGION 150 154 D-ribulose 5-phosphate binding.
{ECO:0000255|HAMAP-Rule:MF_01283}.
REGION 212 418 GTP cyclohydrolase II.
ACT_SITE 340 340 Proton acceptor; for GTP cyclohydrolase
activity. {ECO:0000255|HAMAP-
Rule:MF_01283}.
ACT_SITE 342 342 Nucleophile; for GTP cyclohydrolase
activity. {ECO:0000255|HAMAP-
Rule:MF_01283}.
METAL 38 38 Magnesium or manganese 1.
{ECO:0000255|HAMAP-Rule:MF_01283}.
METAL 38 38 Magnesium or manganese 2.
{ECO:0000255|HAMAP-Rule:MF_01283}.
METAL 153 153 Magnesium or manganese 2.
{ECO:0000255|HAMAP-Rule:MF_01283}.
METAL 267 267 Zinc; catalytic. {ECO:0000255|HAMAP-
Rule:MF_01283}.
METAL 278 278 Zinc; catalytic. {ECO:0000255|HAMAP-
Rule:MF_01283}.
METAL 280 280 Zinc; catalytic. {ECO:0000255|HAMAP-
Rule:MF_01283}.
BINDING 42 42 D-ribulose 5-phosphate.
{ECO:0000255|HAMAP-Rule:MF_01283}.
BINDING 174 174 D-ribulose 5-phosphate.
{ECO:0000255|HAMAP-Rule:MF_01283}.
BINDING 283 283 GTP. {ECO:0000255|HAMAP-Rule:MF_01283}.
BINDING 328 328 GTP. {ECO:0000255|HAMAP-Rule:MF_01283}.
BINDING 363 363 GTP. {ECO:0000255|HAMAP-Rule:MF_01283}.
BINDING 368 368 GTP. {ECO:0000255|HAMAP-Rule:MF_01283}.
SITE 136 136 Essential for DHBP synthase activity.
{ECO:0000255|HAMAP-Rule:MF_01283}.
SITE 174 174 Essential for DHBP synthase activity.
{ECO:0000255|HAMAP-Rule:MF_01283}.
SEQUENCE 418 AA; 45846 MW; 7A5A214BB0EC0E32 CRC64;
MIETREEVGS ANFVSLERAI EDLRAGKFVI VVDEASREDE GDLIIAGEKI TVEKMTFLLQ
HTTGVVCAAL SQERLLSLDL PPMVKDNRCR FKTPFTVSVD AAHGVTTGVS AADRTKVVQL
LADPKSKPED FISPGHFFPL ASSPGGVLKR AGHTESTVDL MELAGLQPCG VLAELVNEDY
SMMRLPQILE FARKHNIAVI PVTSIIAHRM LSDRLVSKIS SARLPTIYGD FTIHVYESLL
EGMQHLALVK GNVAGKSNVL VRVHSECVTG DILGSKRCDC GEQLSSAMSY IAEKGTGVLV
YLRGQEGRGI GLGHKVRAYA LQDNGYDTVD ANLAMGFPVD SREYGIGAQI LVDLKLTTIK
LITHNPQKYF GLQGFGLSIT ERVPLPVRIS EDNEQYLRTK QERMGHWLDL PCCNNRVQ


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